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  • gene
  • Wightman, B., Ha, I., and Ruvkun, G. (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans . (springer.com)
  • 1999) The rde-1 gene, RNA interference, and transposon silencing in C. elegans . (springer.com)
  • Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). (genetics.org)
  • These groups published back-to-back papers on the lin-4 gene, which was known to control the timing of C. elegans larval development by repressing the lin-14 gene. (wikipedia.org)
  • lineage
  • In fact, we know an adult C. elegans has exactly 959 somatic cells , and their full lineage all the way back to the zygote . (everything2.com)
  • developmental
  • C. elegans has been thoroughly studied by geneticists , developmental biologists and neurologists . (everything2.com)
  • Here, using the developmental event of anchor cell (AC) invasion in Caenorhabditis elegans , we observe that the AC deforms the BM and underlying tissue just before invasion, exerting forces in the tens of nanonewtons range. (pnas.org)
  • In 2000, a second small RNA was characterized: let-7 RNA, which represses lin-41 to promote a later developmental transition in C. elegans. (wikipedia.org)
  • progeny
  • Princeton University researchers have discovered that learned behaviors can be inherited for multiple generations in C. elegans, transmitted from parent to progeny via eggs and sperm cells. (news-medical.net)
  • strain
  • In contrast, C. elegans strains that are cultivated in laboratories for research purposes have lost their naturally associated microbial communities and are commonly maintained on a single bacterial strain, Escherichia coli OP50. (wikipedia.org)
  • Most of the studies on C. elegans are based on the N2 strain, which has adapted to laboratory conditions. (wikipedia.org)
  • 1963
  • In June 1963, he wrote to Max Perutz, then the head of the MRC Laboratory of Molecular Biology, Cambridge, proposing future research: By the end of that year, his thoughts were more concrete: Brenner obtained C. elegans from Dougherty and began to study them in the laboratory by December 1963. (wikipedia.org)
  • RNAi
  • 2002) Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. (springer.com)
  • soil
  • C. elegans were previously considered a soil-living nematode, but in the last 10 years it was shown that natural habitats of C. elegans are microbe-rich, such as compost heaps, rotten plant material, and rotten fruits. (wikipedia.org)
  • In these studies, C. elegans was exposed to various soil bacteria, either isolated in a different context or from C. elegans lab strains transferred to soil. (wikipedia.org)
  • lifespan
  • Mutations have been found in C. elegans that slow down its metabolic rate and at the same time increase its lifespan . (everything2.com)
  • Beneficial bacteria can have a positive effect on the lifespan, generate certain pathogen resistances, or influence the development of C. elegans. (wikipedia.org)
  • The lifespan of C. elegans is prolonged when grown on plates with Pseudomonas sp. (wikipedia.org)
  • biology
  • My studies are focused on this question and seek to understand the cell biology of synapses in the thermotaxis circuit of C. elegans , a model system that facilitates in vivo inspection of neuronal cell biology. (mbl.edu)
  • Genome sequence of the nematode C. elegans: a platform for investigating biology. (nih.gov)
  • intestine
  • As C. elegans feeds on bacteria (microbivory), the intestine of worms isolated from the wild is usually filled with a large number of bacteria. (wikipedia.org)
  • The basic anatomy of C. elegans includes a mouth, pharynx , intestine , gonad , and collagenous cuticle. (wikipedia.org)
  • Numerous gut granules are present in the intestine of C. elegans , the functions of which are still not fully known, as are many other aspects of this nematode, despite the many years that it has been studied. (wikipedia.org)
  • cleavage
  • Analysis of this expanded and corrected data set suggested that the high A/U content of C. elegans 3'UTRs facilitated genome compaction, because the elements specifying cleavage and polyadenylation, which are A/U rich, can more readily emerge in A/U-rich regions. (nih.gov)
  • describe
  • We describe methods to use Caenorhabditis elegans as an alternative model for studying mitochondrial division, taking advantage of the many wonderful resources provided by the C. elegans community. (springer.com)
  • Here we describe a high-throughput method for reliable identification of polyadenylated RNA termini, and we apply this method, called poly(A)-position profiling by sequencing (3P-Seq), to determine C. elegans 3'UTRs. (nih.gov)
  • fungi
  • We have shown that the escape response allows C. elegans increases it chances to escape from predacious fungi that use constricting rings to entrap nematodes. (mbl.edu)
  • worms
  • Bleaching is a common method in the laboratory to clean C. elegans of contaminations and to synchronize a population of worms. (wikipedia.org)
  • For example, when C. elegans is grown on Bacillus megaterium or Pseudomonas mendocina, worms are more resistant to infection with the pathogenic bacterium Pseudomonas aeruginosa , which is a common bacterium in C. elegans' natural environment and therefore a potential natural pathogen. (wikipedia.org)
  • grown
  • Since then C. elegans has rapidly grown in popularity and is now utilized in numerous research endeavors, from studying the forces at work during locomotion to studies of neural circuitry. (jove.com)
  • methods
  • Compared to standard methods also recently applied to C. elegans UTRs, 3P-Seq identified 8,580 additional UTRs while excluding thousands of shorter UTR isoforms that do not seem to be authentic. (nih.gov)
  • cells
  • Another reason C. elegans is so easy to study is that it has a transparent body and each of its cells can be examined individually under a microscope without dissecting it. (everything2.com)
  • The C.elegans cells are diploid. (citizendium.org)
  • Here we show that invading cells in C. elegans apply forces via actin assembly to break through basement membrane, and that force production is one of the key features of invasion. (pnas.org)
  • Overall force production emerges from this study as one of the main tools that invading cells use to promote BM disruption in C. elegans . (pnas.org)