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  • interactions
  • At the mossy fiber terminals of hippocampus, nectin-1 and nectin-3 localize at the presynaptic and postsynaptic sides of synaptic junctions, respectively, and their trans-interactions play a role in formation of synapses in cooperation with N-cadherin. (uniprot.org)
  • PMID
  • Cadherin-16 (CDH16) or kidney-specific (Kps) cadherin was first described as a kidney-specific adhesion molecule [ PMID: 15886705 ] and thereafter also found expressed in the thyroid gland. (ebi.ac.uk)
  • CDH16 colocalises with CDH1/E-cadherin on the basolateral plasma membrane of thyrocytes, and might play a role during thyroid development [ PMID: 22028439 ]. (ebi.ac.uk)
  • Crystal structures have revealed that multiple cadherin domains form Ca 2+ -dependent rod-like structures with a conserved Ca 2+ -binding pocket at the domain-domain interface [ PMID: 11909544 ]. (ebi.ac.uk)
  • specificity
  • One current model proposes that cells distinguish cadherin subtypes based on kinetic specificity rather than thermodynamic specificity, as different types of cadherin homotypic bonds have different lifetimes. (wikipedia.org)
  • synapses
  • Furthermore, N-cadherin is preferentially recruited to activated synapses. (rupress.org)
  • B) Synaptic activity promotes the localization of N-cadherin to activated synapses. (rupress.org)
  • During embryonic development, cadherins are initially widely distributed, but they become gradually more localized to pre- and post-synaptic sites while synapses are being formed. (wikipedia.org)
  • expression
  • Loss of E-cadherin expression. (springer.com)
  • Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. (ebi.ac.uk)
  • Regulation of cadherin expression can occur through promoter methylation among other epigenetic mechanisms. (wikipedia.org)
  • The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions. (nih.gov)
  • Expression of E-cadherin in lung carcinoma, other than those with small cells (NSCLC). (nih.gov)
  • T-cadherin expression results in LDL-induced migration of T-cadherin expressing cells compared to control. (wikipedia.org)
  • Expression of T-cadherin is upregulated in atherosclerotic lesions and post-angioplasty restenosis -conditions associated with pathological angiogenesis. (wikipedia.org)
  • T-cadherin expression is upregulated in ECs, pericytes and VSMC of atherosclerotic lesions. (wikipedia.org)
  • T-cadherin expression in arterial wall after balloon angioplasty correlates with late stages of neointima formation and coincidentally with the peak in proliferation and differentiation of vascular cells. (wikipedia.org)
  • Down-regulation of E-cadherin expression has been observed in a number of carcinomas and is usually associated with advanced stage and progression. (agilent.com)
  • One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E Cadherin expression. (abcam.com)
  • Furthermore, knockdown of N-cadherin or expression of a dominant-negative construct of N-cadherin that is deficient in mediating adhesion and can compete for endogenous intracellular N-cadherin-mediated signaling decreases spine stability. (rupress.org)
  • The authors further demonstrate that the expression of EGFP-N-cadherin is restricted to some spines and that this expression correlates with the stability of spines. (rupress.org)
  • The expression of the dominant-negative construct of N-cadherin prevents this activity-dependent enlargement of the spine head. (rupress.org)
  • Interestingly, this effect is also prevented by the expression of the full-length N-cadherin, suggesting that a physiological level of N-cadherin is critical for its ability to regulate the spine head width. (rupress.org)
  • NMDAR activity reduces phosphorylation of β-catenin at tyr-654, thereby inhibiting N-cadherin endocytosis and facilitating surface retention and expression. (wikipedia.org)
  • Cadherin expression is also regulated by activity-induced internalization, which occurs much later than surface stabilization (an average of 4 hours after the stimulus). (wikipedia.org)
  • N-cadherin is widely expressed in the embryo post-implantation, showing high levels in the mesoderm with sustained expression through adulthood. (wikipedia.org)
  • Expression of a mutant form of N-cadherin harboring a large deletion in the extracellular domain inhibited the function of endogenous N-cadherin in adult ventricular cardiomyocytes, and neighboring cardiomyocytes lost cell-cell contact and gap junction plaques as well. (wikipedia.org)
  • Mice with altered expression of N-cadherin and/or E-cadherin showed a dilated cardiomyopathy phenotype, likely due to malfunction of intercalated discs. (wikipedia.org)
  • catenins
  • Even genomes of ancestral metazoan species such as cnidarians and placozoans encode a limited number of distinct cadherins and catenins, emphasizing the conservation and functional importance of these gene families. (ovid.com)
  • α-catenins, when in monomeric form, will associate with the cadherin-catenin complex via β-catenins. (wikipedia.org)
  • N-cadherin complexed to catenins has been described as a master regulator of intercalated disc function. (wikipedia.org)
  • N-cadherins interact with catenins to play an important role in learning and memory (For full article see Cadherin-catenin complex in learning and memory). (wikipedia.org)
  • CDH1
  • CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). (nih.gov)
  • complexes
  • High-molecular weight (HMW) complexes of adiponectin were suggested to be a specific ligand for T-cadherin. (wikipedia.org)
  • In turn, these forces elicit mechanosensory signals from cadherin complexes that ultimately impact on cell phenotype and function in multiple cell types ( 29 , 30 ), including pancreatic islets ( 31 ). (diabetesjournals.org)
  • receptors
  • The properties of T-cadherin as an LDL receptor were markedly different from the presently known types of LDL receptors. (wikipedia.org)
  • Evidence suggest that N-Cadherins stabilize the connection between the presynaptic terminal and postsynaptic spine and that this stabilization increases the likelihood that released glutamate will bind receptors on the postsynaptic neuron. (wikipedia.org)
  • tissue
  • Cadherins are also important in other aspects of cell organization, like the formation of boundaries, coordinated cell movements, and maintenance of structural and functional cell and tissue polarity. (news-medical.net)
  • There are multiple classes of cadherin molecule, each designated with a prefix (in general, noting the type of tissue with which it is associated). (wikipedia.org)
  • After development, cadherins play a role in maintaining cell and tissue structure, and in cellular movement. (wikipedia.org)
  • Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. (abcam.com)
  • adhesive
  • At basal levels of synaptic activity, N-cadherins are largely monomers and are thus weakly adhesive to cadherins located in the cell on the opposite side of the synapse. (wikipedia.org)
  • Inhibition of N-cadherin binding via blocking antibodies prevents the induction of late phase L-long term potentiation, suggesting that the adhesive property of dimeric N-cadherin is necessary for late phase L-LTP. (wikipedia.org)
  • N-cadherin, as well as other cadherins, interact with N-cadherin on an adjacent cell in an anti-parallel conformation, thus creating a linear, adhesive "zipper" between cells. (wikipedia.org)
  • CDH13
  • The single nucleotide polymorphisms (SNPs) rs12596316AG genotype of the T-cadherin (CDH13) gene is associated with the susceptibility to metabolic syndrome (MS) among ethnic Han Chinese. (nih.gov)
  • endocytosis
  • By reconstituting endocytosis in membrane bilayers, the group shows that clathrin-dependent endocytosis removes E-cadherin that is not interacting in trans with other E-cadherins. (rupress.org)