• Total serum homocysteine--a predictor of extracranial carotid artery stenosis in male patients with symptomatic peripheral arterial disease. (cdc.gov)
  • Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. (cdc.gov)
  • We acknowledged grownup CAAD conditions with unilateral or bilateral carotid artery stenosis and controls with out proof of stenosis from digital properly being information at eight eMERGE internet sites. (stjosephs-hospital.com)
  • Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (cdc.gov)
  • We used a genome-wide affiliation (GWAS) approach to hunt out genetic variants related to CAAD in members contained in the digital Medical Knowledge and Genomics (eMERGE) Group. (stjosephs-hospital.com)
  • Elevated lipoprotein(a) concentrations ([Lp(a)]) and LPA variants related to elevated [Lp(a)] have beforehand been related to CAAD and CHD, together with rs10455872. (stjosephs-hospital.com)
  • TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects. (cdc.gov)
  • Conclusions: Carotid atherosclerosis is very common in stable ambulatory patients with CAD regularly taking statins. (tau.ac.il)
  • Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. (cdc.gov)
  • Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (cdc.gov)
  • CCHMC brings an extraordinary faculty to eMERGE III who are committed to gain a better understanding of the genesis of disease and to elucidate the mechanisms of diseases that afflict children, specifically pediatric disease phenotypes that will leverage the available eMERGE adult genomic data and electronic medical records (EMRs) to discover meaningful use results. (nih.gov)
  • OBJECTIVE: The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated. (nih.gov)
  • Additional investigations of genetic and environmental factors that influence PON1 activity as a risk factor for vascular disease are warranted. (nih.gov)
  • The Gene Partnership (TGP) is a prospective longitudinal registry at Boston Children's Hospital (BCH) to study the genetic and environmental contributions to childhood health and disease, collect genetic information on a large number of children who have been phenotyped, and implement the Informed Cohort and the Informed Cohort Oversight Board (ICOB). (nih.gov)
  • Chronic kidney disease (CKD) is defined as an abnormality of kidney structure or function present for longer than 3 months. (phekb.org)
  • TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects. (cdc.gov)
  • Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. (nih.gov)
  • The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status. (cdc.gov)
  • Breast cancer is the most common cancer and the second leading cause of cancer-related death among women in the U.S. Known breast cancer risk factors include age, race/ethnicity, reproductive factors, and benign breast disease. (phekb.org)
  • Family history of breast cancer and hereditary cancer syndromes, such as BRCA1/BRCA2 mutations, confer the strongest risk for this disease. (phekb.org)
  • The reported prevalence and risk factors for concomitant CaAD in CAD patients varied among previous studies. (tau.ac.il)
  • A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk. (cdc.gov)
  • various autoimmunity diseases share similar immune effector mechanisms. (phekb.org)
  • We used the full sequences in 23 white subjects to determine the linkage disequilibrium (LD) structure of the PON1 region and to direct the grouping of haplotypes for disease association testing. (nih.gov)
  • PON1 hydrolysis activity predicted CAAD status, but this was not attributable to the promoter or coding region polymorphisms or haplotype or to the effects of smoking or statin use on PON1 activity. (nih.gov)
  • PON1 activity predicts CAAD, yet 4 functional polymorphisms do not. (nih.gov)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Background: Concomitant carotid artery disease (CaAD) in patients with coronary artery disease (CAD) is associated with worse cardiac and neurologic outcomes. (tau.ac.il)
  • Association of the -159C/T polymorphism of the endotoxin receptor (CD14) with carotid artery disease and cardiovascular mortality in dialysis patients. (cdc.gov)
  • Children who are treated at the Children's Hospital Healthcare Network and their parents may be eligible to take part in a major initiative to collect more than 100,000 blood samples, covering a wide range of pediatric diseases. (nih.gov)