• The elevation of cancer antigen 125 (CA125) levels in the serum of asymptomatic patients precedes the radiologic detection of high-grade serous ovarian cancer by at least 2 mo and the final clinical diagnosis by 5 mo. (snmjournals.org)
  • High-grade serous ovarian cancer (HGSOC) comprises the major malignant histotype (70%) of epithelial ovarian cancers and bears a molecular signature in the overexpression of MUC16/cancer antigen 125 (CA125), a serum biomarker for ovarian cancer ( 3 ). (snmjournals.org)
  • Recent clinical evidence suggests that high serum levels of the tumor‑produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. (spandidos-publications.com)
  • Ca125 (cancer antigen 125) is a protein found in greater concentration in tumor cells than in normal cells. (survivingmesothelioma.com)
  • One of the most commonly studied markers is Cancer Antigen 125 (CA125) - a biomarker that is secreted from the derivatives of the embryonic coelomic epithelium which is shown to be significantly increased in the later stages of endometriosis in previous studies. (endonews.com)
  • High concentrations of CA 125 antigen are associated with ovarian cancer and other malignant disease (pancreatic, lung, cervical, etc. (mrlabtest.com)
  • Cyst fluid analysis revealed markedly increased concentrations of carcinoembryonic antigen and CA 125 and increased fluid viscosity. (johnshopkins.edu)
  • Her C-reactive protein concentration was 11 mg/L. Her CA-125 and carcinoembryonic antigen levels were within normal range. (biomedcentral.com)
  • Prostate-specific antigen (PSA), a glycoprotein located in ductal epithelial cells of the prostate gland, can be detected in low concentrations in the sera of healthy men. (msdmanuals.com)
  • CA125 plays a key role in the diagnosis of ovarian cancer. (edu.pl)
  • The aim of study was to assess the clinical usefulness of marker concentrations in the serum of women with ovarian cancer and ROMA determination, as well as to compare the results of those obtained from patients with endometrial cancer and from healthy women. (edu.pl)
  • Simultaneous measurements of CA125 and HE4 concentrations as well as determining ROMA for the differential diagnosis of pelvic tumors and gynecological cancers (ovarian, endometrial cancer) were proven useful. (edu.pl)
  • Dahl Steffensen K., Waldstrøm M., Brandslund I., Jakobsen A. Prognostic impact of prechemotherapy serum levels of HER2, CA125, and HE4 in ovarian cancer patients. (edu.pl)
  • PET imaging of CA125 expression by ovarian cancer cells may enhance the evaluation of the extent of disease and provide a roadmap to surgery as well as detect recurrence and metastases. (snmjournals.org)
  • 89 Zr-labeled mAb-B43.13 was synthesized to target CA125 and evaluated via PET imaging and biodistribution studies in mice bearing OVCAR3 human ovarian adenocarcinoma xenografts. (snmjournals.org)
  • Indeed, among epithelial ovarian cancers, the frequency of CA125 positivity is higher in serous histotypes than in mucinous or clear cell disease ( 4 ). (snmjournals.org)
  • The CA125 is a measure of a protien in the blood that can indicate Ovarian Cancer. (cancer.org)
  • The other 20% of ovarian cancer patients do not show any increase in CA-125 concentrations. (cancer.org)
  • If the high level is due to an ovarian cancer the concentration of CA 125 correlates with tumor size and staging. (mrlabtest.com)
  • Increased concentrations were found in 21 of 27 patients with epithelial ovarian cancer and two of three patients with ovarian teratoma. (ox.ac.uk)
  • M. Szubert, J. Suzin, T. Wierzbowski and K. Kowalczyk-Amico, "CA-125 Concentration in Serum and Peritoneal Fluid in Patients with Endometriosis-Preliminary Results," Archives of Medical Science, Vol. 8, No. 3, 2012, pp. 504-508. (scirp.org)
  • The peritoneal concentration-time profile of paclitaxel rose during the 2 days after dosing to peritoneal fluid concentrations 450-2900 times greater than peak plasma drug concentrations and remained elevated through the entire dose cycle. (doczz.net)
  • concentration of CA 125 and glycodelin A was recorded in serum and peritoneal fluid. (morfolhum.ru)
  • In severe endometriosis CA125 and glycodelin A showed the highest concentrations of serum and peritoneal fluid and high level of expression in endometriotic cyst wall. (morfolhum.ru)
  • Serum concentrations were higher in patients with Sp17 tissue expression, and the highest concentrations were noted among patients with serous and clear cell adenocarcinomas. (biomedcentral.com)
  • Our results showed that anemia and increased Ca125 might be considered negative prognostic parameters in malignant pleural mesothelioma patients," writes medical oncologist Rossana Berardi, whose name appears first on the paper. (survivingmesothelioma.com)
  • 3]CA50 and CA724 could supplement CEA in monitoring recurrence and metastasis.CA125 represents a significant and independent prognostic factor in CRC patients, superior to CEA. (autobio.com.cn)
  • Serum biomarkers CA125 and brain-derived neurotrophic factor (BDNF) when used in combination with some clinical data may show promising results to be used as a novel in vitro diagnostic test for endometriosis. (endonews.com)
  • A new in vitro diagnostic test was developed using serum biomarkers CA125 and BDNF along with some clinical variables to be used in diagnosing endometriosis. (endonews.com)
  • 1]A wide range of serum tumor biomarkers, including CA19-9, CA242, CA72-4, CA50, and CA125, has been studied in association with colorectal cancer (CRC). (autobio.com.cn)
  • ROC curve analyses set a cutoff of 83% (percentage increment of CA125 level during menstruation compared with that on days without menstrual bleeding), which gives a sensitivity of 93% and specificity of 92%, with a corresponding likelihood ratio of 11.3. (endometriosi.it)
  • A sandwich enzyme-linked immunosorbent assay (ELISA) was performed to measure Sp17 sera concentrations. (biomedcentral.com)
  • CA125 and BDNF concentrations were determined quantitatively by the ELISA method. (endonews.com)
  • In order to determine the concentrations of the markers, the immunological method with electrochemiluminescence technology was applied. (edu.pl)
  • The concentration of tumour markers were measured by IMMULITE 2000 Analyzer. (edu.mk)
  • Results: Obtained results have shown significant differences between concentration of tumour markers before and after surgery. (edu.mk)
  • Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer. (autobio.com.cn)
  • CA125 and CA242 markers' role in colorectal cancer diagnosis and management-a 30 year review. (autobio.com.cn)
  • The receiver operating characteristic curve was applied to assess the usefulness of CA125 level changes during the menstrual cycle in the clinical diagnosis of endometriosis. (endometriosi.it)
  • Objective: To elucidate whether endometriosis can be diagnosed clinically by assessing the differences between serum CA125 levels during menstruation and during the rest of the menstrual cycle. (endometriosi.it)
  • Conclusions: It may be possible to diagnose endometriosis clinically by assessment of the differences in CA125 level during menstruation as against the remainder of the menstrual cycle. (endometriosi.it)
  • CA125 and BDNF were able to statistically significantly distinguish all stages of endometriosis cases from controls when used in combination. (endonews.com)
  • BDNF was elevated in lower stages and CA125 was elevated in higher stages of endometriosis. (endonews.com)
  • Taken together, these findings warranted further investigation on NAV‑006 as a next generation anti‑CD20 antibody that could improve the efficacy of parent RTX in NHL patients with high levels of CA125. (spandidos-publications.com)
  • Emerging PK profile: after 1 hour infusion, total antibody concentrations declined in a log-linear manner with a 22-84 h half-life, dose-exposure relationship appeared linear without accumulation after repeat administration. (sutrobio.com)
  • however, despite its prevalence in FL and other cancers, the role of CA125 in tumor biology and immunity has been only recently elucidated. (spandidos-publications.com)
  • In recurrent HGSOC, the elevation in serum CA125 levels precedes radiologic detection by 3 mo and predates the clinical presentation of symptoms and diagnosis by a median lag time of 5 mo ( 3 ). (snmjournals.org)
  • Blood specimens were taken for CA125 determination during menstruation and during the rest of the menstrual cycle. (endometriosi.it)
  • However, elevated serum CA125 levels alone do not qualify as a criterion to initiate treatment in the absence of radiologic evidence of recurrent disease. (snmjournals.org)
  • Ten percent of HGSOCs are reported to be biochemically silent (i.e., have normal serum CA125 levels), and 50% of patients with normal serum CA125 levels at the completion of chemotherapy are found to have active small-volume disease during second-look surgery ( 5 , 6 ). (snmjournals.org)
  • Previous studies have established CA125 as a tumor-microenvironment factor that can be detected and found elevated (above normal 35 U/ml levels) in the serum of up to 40% of FL patients and other NHL patients. (spandidos-publications.com)
  • Previous clinical evidence suggested that high levels of serum CA125 have a negative impact on the effectiveness of the experimental therapeutic antibodies farletuzumab and amatuximab ( 13 - 15 ). (spandidos-publications.com)
  • Both anemia and Ca125 levels can be determined with a blood test. (survivingmesothelioma.com)
  • Neither Sp17 tissue expression nor serum concentration correlated with survival outcomes. (biomedcentral.com)
  • therefore, cellular and molecular analyses of RTX and CA125 interaction were peformed, and a library of RTX variants was generated using a proprietary technology called Block‑Removed Immunoglobulin Technology that combines randomized amino acid substitutions and high‑throughput functional screenings to identify CA125‑refractory RTX variants. (spandidos-publications.com)
  • the combination of GDF-15 with Ca125 is remarkably useful in differentiating pancreatic mass. (cusabio.com)
  • The extracellular domain name is rich in and is the?standard deviation of low concentration calibrators measurements. (angiogenesis-blog.com)
  • Peak blood biotin concentrations occur 1-2 h after biotin ingestion and then rapidly decrease. (aacc.org)
  • In healthy volunteers, median (minimum-maximum) peak serum biotin concentrations 1 h after the ingestion of 5, 10, and 20 mg biotin were 41 (10-73), 91 (53-141), and 184 (80-355) ng/mL, respectively. (aacc.org)
  • By understanding the electrical signals' frequency and amplitude, both the concentration and size distribution profiles can be collected for each EV sample quickly and efficiently. (ku.edu)
  • High serum level of CA125 is used as an indicator of tumor abdominal involvement, advanced staging, relapse rates and survival in NHL patients ( 8 - 12 ). (spandidos-publications.com)
  • Results: The mean CA125 concentrations of healthy women during menstruation and during the rest of the menstrual cycle were 12.2 and 10Uml(-1), respectively. (endometriosi.it)
  • Dosedependent response to IV paclitaxel has been demonstrated in several clinical trials [7-10], with results suggesting that IP delivery of paclitaxel would improve cytotoxic effects due to increased local drug concentration. (doczz.net)
  • Findings indicate that global platelet function was positively correlated with serum GDF-15 concentration. (cusabio.com)
  • Current enumeration platforms for EVs consist of nanoparticle tracking analysis (NTA), electron microscopy (EM), high-resolution flow cytometry (hFC) and are used for both EV size distribution and concentration analysis. (ku.edu)
  • concentrations tend to be lower in postmenopausal Asian and African women than in their white counterparts. (medscape.com)
  • As compared with newborn and adult females, injection of LPS to prepubertal rats induced more pronounced changes in hepatocytes, increased endotoxin level, lowered corticosterone and estradiol blood concentration. (morfolhum.ru)
  • Mean serum CA125 concentrations were compared by the two-sample t-test for between-group comparisons and the paired t-test for within-group comparisons. (endometriosi.it)
  • CA125 concentration seems to be a better tumor marker than CEA concentration for predicting PD in CRC in both men and women. (autobio.com.cn)
  • Yang, Shung-Haur MD, PhD.Serum CA125 concentration as a predictor of peritoneal dissemination of colorectal cancer in men and women. (autobio.com.cn)
  • similarly, low-activity concentrations of 89 Zr-DFO-mAb-B43.13 accumulated in CA125-negative SKOV3 tumors. (snmjournals.org)
  • This finding suggests that CA125 concentration should be measured as part of the pretreatment evaluation. (autobio.com.cn)
  • The present study demonstrated that CA125 could bind to RTX and reduce its tumor cell killing activity. (spandidos-publications.com)
  • Furthermore, the study characterized an RTX variant, named NAV‑006 (RTX‑N109D), which was more refractory to the immunosuppressive effects mediated by CA125 as evidenced by its reduced CA125 interaction and increased activity of ADCC and CDC when compared with parent RTX. (spandidos-publications.com)
  • Most interestingly, activity concentrations greater than 50 %ID/g were observed in the ipsilateral lymph nodes of the xenograft-bearing mice. (snmjournals.org)
  • A decrease in the CA 125 concentration by a factor of 10 after the first cycle of chemotherapy is indicative of improvement. (mrlabtest.com)
  • Moreover, this electrode is found that exhibit a wide linear range like a 1-500 ng/mL concentration range. (yyu.edu.tr)
  • PET imaging using 89 Zr-DFO-mAb-B43.13 (DFO is desferrioxamine) clearly delineated CA125-positive OVCAR3 xenografts as early as 24 h after the administration of the radioimmunoconjugate. (snmjournals.org)