• We also investigated the potential effect of the C677T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) to the sUA level in different dementia types. (mdpi.com)
  • RESULTS: The MTRR and MTHFR genes were associated with DFS and CRC-specific survival in CRC patients at the gene level. (bvsalud.org)
  • CONCLUSIONS: Polymorphic variants in MTRR and MTHFR genes that code for key enzymes for folate metabolism may be associated with survival in patients with CRC. (bvsalud.org)
  • Association of factor VII gene polymorphisms with Budd Chiari syndrome. (cdc.gov)
  • The present study undertaken to identify the contribution of genetic polymorphisms in the MTRR gene on the selected polymorphic sites including c.66A>G and c.524C>T towards urinary bladder cancer risk. (bvsalud.org)
  • Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known interaction that in pregnant women may affect embryo viability and the health of the newborn. (bvsalud.org)
  • When a molecule receives a methyl group, this "starts" a reaction (such as turning a gene on or activating an enzyme). (truemedicine.com.au)
  • Methionine synthase reductase (MTRR) gene involved in the signaling for production of enzyme called methionine synthase reductase that use for the synthesis of methionine, which further used in DNA replication and repair. (bvsalud.org)
  • The occurrence and progression of CRC may be influenced by variants in some key enzyme coding genes in the folate metabolic pathway. (bvsalud.org)
  • The gene-CRC outcome association seems modulated by alcohol drinking and fruit intake. (bvsalud.org)
  • Methylenetetrahydrofolate reductase gene polymorphism and glucocorticoid intake in children with ALL and aseptic osteonecrosis. (cdc.gov)
  • Genetic association between methylenetetrahydrofolate reductase gene polymorphism and risk of osteonecrosis of the femoral head. (cdc.gov)
  • Folate metabolism pathway genes have been examined for association with neural tube defects (NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect. (nih.gov)
  • Plasma concentrations of folate, homocysteine (Hcy), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) and genotypes and alleles distributions of 52 SNPs in 8 genes were compared for 61 women with NTDs-affected offspring and 61 women with healthy ones. (biomedcentral.com)
  • Our study evaluates several folate pathway genes for association with human NTDs, incorporating an environmental cofactor: maternal folate supplementation. (nih.gov)
  • Further investigation of folate and methionine cycle genes will require extensive SNP genotyping and/or resequencing to identify novel variants, inclusion of environmental factors, and investigation of gene-gene interactions in large data sets. (nih.gov)
  • HNPCC families in which mutations in hMLH1 and hMSH2 are not identified may harbor pathogenic mutations in other mismatch repair genes, such as hMSH6 and hPMS2 . (cdc.gov)
  • The adenomatous polyposis coli ( APC ) gene is a tumor suppressor gene, and mutations resulting in loss of APC protein function are associated with carcinogenesis. (cdc.gov)
  • Evidence to support a role for the mismatch repair genes hMLH1 and hMSH2 in the etiology of colorectal cancer has come from linkage analysis, segregation studies, and molecular-biologic analysis. (cdc.gov)
  • 9 Accurate information on such distribution can contribute to studies of gene-disease associations (by providing reference population data) and population genetics (by highlighting geographical and ethnic variations suggestive of evolutionary pressures), 10 as well as help to evaluate health impact (by allowing estimates of population attributable fraction). (bmj.com)
  • Most studies addressed these genes individually, often with different populations providing conflicting results. (nih.gov)