LeucineGenesMember of the bZIPEukaryoticTranscriptionalEukaryotesPlantCharacterizationOrthologousCollarNrf2AspergillusRoles in the regulationProteins playStress responsesNFE2L2Genome-wideAbiotic stressesMotifBindsHomeoboxPathwaysNumerousOverexpressionNrf1Ethylene-responsive elementRegulatoryDifferentiationStressesAminoPromoterRedoxActivatorInvestigationHomeodomainPlantsTranscriptome
Leucine12
- Background: Plant bZIP proteins characteristically harbor a highly conserved bZIP domain with two structural features: a DNA-binding basic region and a leucine (Leu) zipper dimerization region. (datadryad.org)
- The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)
- The basic leucine zipper (bZIP) transcription factor represents exclusively in eukaryotes and can be related to many biological processes. (biomedcentral.com)
- The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. (wikipedia.org)
- Background: In plants, basic leucine zipper transcription factors (TFs) play important roles in multiple biological processes such as anthesis, fruit growth & development and stress responses. (udl.cat)
- Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
- To describe the clinical phenotype and genetic basis of non-syndromic retinitis pigmentosa (RP) in one family and two sporadic cases with biallelic mutations in the transcription factor neural retina leucine zipper ( NRL) . (molvis.org)
- Nuclear factor erythroid-2-related factor 2 (NRF2) is the most studied member of the Cap 'n' collar basic leucine zipper (CNC-bZIP) family of transcription factors. (hindawi.com)
- A basic Leucine Zipper (bZIP) transcription factor protein is the candidate gene for bc-u. bZIP protein gene Phvul.005G124100 carries a unique non-synonymous mutation at codon 14 in the first exon (Pv05: 36,114,516 bases), resulting in a premature termination codon that causes a nonfunctional protein. (usda.gov)
- MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. (techscience.com)
- DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. (avivasysbio.com)
- The protein is not essential for circadian rhythm generation, but modulates important clock output genes.DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family (Khatib et al. (avivasysbio.com)
Genes24
- The legume bZIP genes were categorized into 11 groups according to their phylogenetic relationships with genes from Arabidopsis. (datadryad.org)
- The chromosome distribution and analysis for WGD-derived duplicated blocks revealed that the legume bZIP genes have expanded mainly by segmental duplication rather than tandem duplication. (datadryad.org)
- Expression data further revealed that the legume bZIP genes were expressed constitutively or in an organ-specific, development-dependent manner playing roles in multiple seed developmental stages and tissues. (datadryad.org)
- We also detected several key legume bZIP genes involved in drought- and salt-responses by comparing fold changes of expression values in drought-stressed or salt-stressed roots and leaves. (datadryad.org)
- Conclusions: In summary, this genome-wide identification, characterization and expression analysis of legume bZIP genes provides valuable information for understanding the molecular functions and evolution of the legume bZIP transcription factor family, and highlights potential legume bZIP genes involved in regulating tissue development and abiotic stress responses. (datadryad.org)
- Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
- Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
- they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
- The function divergence within the bZIP orthologous genes might be limited. (biomedcentral.com)
- Biological processes over-represented in the down-regulated genes include those belonging to central metabolic pathways, translation and transcription. (tu-berlin.de)
- A remarkable transcriptional response in the HacACA strain was the down-regulation of the AmyR transcription factor and its target genes. (tu-berlin.de)
- An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants. (wikipedia.org)
- Results: In this study, 62 bZIP genes were comprehensively identified from Chinese Pear, and 54 genes were distributed among 17 chromosomes. (udl.cat)
- Synteny analysis of bZIP genes revealed that 196 orthologous gene pairs were identified between Pyrus bretschneideri, Fragaria vesca, Prunus mume, and Prunus persica. (udl.cat)
- Transcription factors (TFs) are proteins that bind to specific DNA sequences of their target genes to regulate gene transcription and thus play an essential role in modulating growth, development, and stress tolerance (Lambert et al. (biomedcentral.com)
- 2018 ). The apple bZIP protein MdHY5 regulates the transcription of MdMYB10 and anthocyanin biosynthesis genes, promoting the expression of nitrate reductase genes and nitrate uptake genes and thereby playing essential roles in anthocyanin accumulation and nitrate assimilation (An et al. (biomedcentral.com)
- 2013 ). Under H 2 O 2 stress conditions, fission yeast increases the expression levels of bZIP TF genes ATF1 and PCR1 to successfully adapt to oxidative stress (Fernández-Vázquez et al. (biomedcentral.com)
- String-based protein-protein interaction analysis suggested that bZIP53, a transcription factor might be involved in the activation of transcription of ELO / KCS genes. (nature.com)
- The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
- The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
- Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
- NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
- As a consequence, both factors are transported to the nucleus to induce the expression of their target genes. (hindawi.com)
- While significant advances have been made in understanding the plant adaptation in stress environments, there are still challenges to translate this acquired knowledge for improved crop performance and productivity under stress environments due to complex genetics involving multitude of genes and stress tolerance mechanisms and interaction with numerous environmental factors pose. (eurekaselect.com)
Member of the bZIP1
- Therefore, we aimed to analyze the biological roles of UvbZIP6 , a member of the bZIP family in U. virens . (biomedcentral.com)
Eukaryotic1
- Background: HacA/Xbp1 is a conserved bZIP transcription factor in eukaryotic cells which regulates gene expression in response to various forms of secretion stress and as part of secretory cell differentiation. (tu-berlin.de)
Transcriptional2
- Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. (ugent.be)
- How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)
Eukaryotes1
- bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs. (wikipedia.org)
Plant5
- Previous studies have shown that the bZIP TF family is involved in plant growth, development, and stress responses. (biomedcentral.com)
- Transcription factors (TFs) play vital roles in almost all plant biological processes. (biomedcentral.com)
- As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
- The NAC domain transcription factors in Arabidopsis function in plant development, senescence, and stress regulation. (frontiersin.org)
- PInTFDB: updated content and new features of the plant transcription factor database. (mpg.de)
Characterization1
- However, systematic investigation and characterization of bZIP-TFs remain unclear in Chinese white pear. (udl.cat)
Orthologous1
- Moreover, we identified the bZIP members in 3 other Amaranthaceae species, and 41, 32, and 16 orthologous gene pairs were identified between quinoa and S. oleracea , B. vulgaris , and A. hypochondriacus , respectively. (biomedcentral.com)
Collar1
- Nrf2, an antioxidant-activated cap 'n' collar bZip transcription factor, has recently emerged as a critical regulator of cellular defense against oxidative stress, a prominent component in the pathogenesis of a broad range of disease and chemical toxicity including metal-induced cancer and toxicity. (cdc.gov)
Nrf24
- This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
- The prognostic significance of the major redox regulator nuclear factor erythroid-2-related factor (NRF2) is recognized in many cancers, but the role of NRF1 is not generally well understood in cancer. (hindawi.com)
- OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
- Nrf2 regulates the transcription of a battery of protective and metabolic enzymes. (diabetesjournals.org)
Aspergillus2
- In the present study, we replaced the endogenous hacA gene of an Aspergillus niger strain with a gene encoding a constitutively active form of the HacA transcription factor (HacACA). (tu-berlin.de)
- Overexpression of RsmA , a bZIP TF-coding gene in Aspergillus nidulans , significantly increases secondary metabolite production and confers resistance against predation. (biomedcentral.com)
Roles in the regulation2
- Many bZIP s may play vital roles in the regulation of organ development, growth, and responses to abiotic stresses. (biomedcentral.com)
- S1-bZIP transcription factors play important roles in the regulation of fruit quality and stress responses. (usda.gov)
Proteins play1
- In plants, bZIP proteins play a variety of functions, including the development of seeds and flowers, hormone synthesis and signal transduction, and response to abiotic and biotic stresses. (biomedcentral.com)
Stress responses1
- Numerous bZIP proteins have been identified in filamentous fungi and oomycetes, a few of which are involved in the development, nutrient utilization, and stress responses. (biomedcentral.com)
NFE2L21
- encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Genome-wide1
- However, information about the bZIPs in these Amaranthaceae species is limited, and genome-wide analysis of the bZIP family is lacking in quinoa. (biomedcentral.com)
Abiotic stresses2
- Quantitative real-time polymerase chain reaction analysis identified that expression patterns of bZIP s differed, including in different organs and under various abiotic stresses. (biomedcentral.com)
- Sixty-two bZIP-TFs in Chinese pear were identified, and their expression profiles were comprehensively analyzed under ABA, SA, and MeJa hormones, which respond to multiple abiotic stresses and fruit growth and development. (udl.cat)
Motif1
- The present study provided the first systematic analysis for the phylogenetic classification, motif and gene structure, expansion pattern, and expression profile of the bZIP family in quinoa. (biomedcentral.com)
Binds1
- The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. (evms.edu)
Homeobox1
- Among these are traits that depend on functional meristems, populations of stem cells maintained by the CLAVATA-WUSCHEL (CLV-WUS) negative feedback-loop that controls the expression of the WUS homeobox transcription factor. (nature.com)
Pathways2
- We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)
- Our results indicated that CmNAC1 is a critical factor in ABA signaling pathways and it can be utilized in transgenic breeding to improve the abiotic stress tolerance of crops. (frontiersin.org)
Numerous1
- Interactions between bZIP transcription factors are numerous and complex and play important roles in cancer development in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues, factors affecting reproductive functions, and several other phenomena that affect human health. (wikipedia.org)
Overexpression1
- Overexpression of ZmWUS1-B is due to multimerized binding sites for type-B RESPONSE REGULATORs (RRs), key transcription factors in cytokinin signaling. (nature.com)
Nrf11
- From the same family of transcription factors, NRF1 is generally far less studied and its role in carcinogenesis is insufficiently explored. (hindawi.com)
Ethylene-responsive element1
- PhERF2, an ethylene-responsive element binding factor, plays an essential role in waterlogging tolerance of petunia. (usda.gov)
Regulatory2
- Gene regulatory networks and transcription factor transcriptomics. (mpg.de)
- The role of the regulatory T cell transcription factor Foxp3 in shaping the transcriptosomes of natural and induced regulatory T cells was analyzed using mice expressing a mutant FOXP3-EGFP fusion protein (Foxp3deltaEGFP). (gsea-msigdb.org)
Differentiation1
- We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
Stresses1
- The bZIP proteins are involved in various biological processes, such as resistance to abiotic and biotic stresses, seed germination and development, morphogenesis, and hormonal regulation (Zhang et al. (biomedcentral.com)
Amino1
- The bZIP protein sequence contains 2 conserved bZIP domains with a total length of ~ 60-80 amino acids. (biomedcentral.com)
Promoter2
- 2012 ). The plasma membrane-associated NAC transcription factor OsNTL3 regulates the expression of OsbZIP74 by binding to its promoter under heat stress, and in turn, OsbZIP74 also regulates the expression of OsNTL3 . (biomedcentral.com)
- Here we show that the maize dominant Barren inflorescence3 ( Bif3 ) mutant harbors a tandem duplicated copy of the ZmWUS1 gene, ZmWUS1-B , whose novel promoter enhances transcription in a ring-like pattern. (nature.com)
Redox1
- Our aim was to investigate these redox transcription factors in conjunction with redox-related microRNAs in naevi and melanoma. (hindawi.com)
Activator1
- Transactivation assay in yeast cells revealed that CmNAC1 functions as a transcription activator, and its transactivation domain is located in the C-terminus. (frontiersin.org)
Investigation1
- Despite the availability of six completely sequenced legume genomes, a comprehensive investigation of bZIP family members in legumes has yet to be presented. (datadryad.org)
Homeodomain1
- WUS is a homeodomain transcription factor (TF) produced in the organizing center (OC) domain of apical meristems and is transported via plasmodesmata into the apical domain (called central zone, CZ) to promote proliferation of stem cells 3 . (nature.com)
Plants3
- This research has great significance for the functional characterisation of the tobacco bZIP family and our understanding of the bZIP family in higher plants. (biomedcentral.com)
- NAC transcription factors regulate the stress response in plants. (frontiersin.org)
- Plants show stress-specific regulation of transcription that affects their transcriptome under stress conditions. (intechopen.com)
Transcriptome1
- In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)