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  • substrate
  • The inhibition of HSV-1 TK by BVDU, IDU, (+)-C-BVDU, and (+)-C-IDU was purely competitive with regard to the natural substrate (thymidine), whereas (-)-C-BVDU, (-)-C-IDU, (+/-)-C-BVDU, and (+/-)C-IDU showed a linear mixed-type inhibition of HSV-1 TK. (aspetjournals.org)
  • Employing the technique of Weigle-type reactivation (WR), HSV-1 inactivated by uv irradiation but not by growth in BVDU is a substrate for induced cellular repair pathways. (kuleuven.be)
  • herpes
  • Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1. (aspetjournals.org)
  • Both the (+)- and (-)-enantiomers of C-BVDU and C-IDU were markedly inhibitory to herpes simplex virus type 1 (HSV-1) replication. (aspetjournals.org)
  • Less known, but equally striking, is the antiviral herpes treatment BVDU, which has a positive effect in cancer. (tu-dresden.de)
  • equally
  • Also, the (+)- and (-)-enantiomers of C-BVDU were equally inhibitory to the growth of murine mammary carcinoma cells transformed by the HSV-1 or HSV-2 thymidine kinase (TK) gene (designated FM3A TK-/HSV-1 TK+ and FM3A TK-/HSV-2 TK+). (aspetjournals.org)
  • regard
  • CycloSal-BVDUMP triesters 32-34 5-[(E)-2-bromovinyl]-2'-deoxyuridine (BVDU 2) have been studied with regard to their potential anti-EBV activity. (ebscohost.com)
  • growth
  • Growth of HSV-1 in (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) results in incorporation of the analog into HSV-1 DNA. (kuleuven.be)
  • Growth of mammalian cells in BVDU does not induce cellular repair pathways detected by WR. (kuleuven.be)
  • HSV-1 temperature sensitive (ts) mutants demonstrate an increased reversion frequency to the nonpermissive phenotype (ts+) following growth in a high concentration of BVDU. (kuleuven.be)