Although many acquired conditions may affect BChE activity, BChE deficiency is mainly due to mutations in the BCHE gene (OMIM 177400). (nih.gov)
Patients with butyrylcholinesterase (BChE) deficiency can experience prolonged paralysis after receiving suxamethonium or mivacurium. (nih.gov)
We hypothesized that patients suspected of BChE deficiency had a higher risk of being awakened while paralysed and having respiratory complications if neuromuscular monitoring was not applied before awakening. (nih.gov)
We retrospectively included patients referred to the Danish Cholinesterase Research Unit between 2004 and 2012 on suspicion of BChE deficiency. (nih.gov)
Butyrylcholinesterase (BChE) is an important enzyme for metabolism of ester drugs. (nebraska.edu)
Many humans have partial or complete BChE deficiency due to genetic variation. (nebraska.edu)
Our goal was to create a mouse model of BChE deficiency to allow testing of drug toxicity. (nebraska.edu)
In conclusion, the BChE -/- mouse is a suitable model for human BChE deficiency. (nebraska.edu)
Pseudocholinesterase deficiency can be caused by mutations in the BCHE gene. (medlineplus.gov)
Some BCHE gene mutations that cause pseudocholinesterase deficiency result in an abnormal pseudocholinesterase enzyme that does not function properly. (medlineplus.gov)
Garcia DF, Oliveira TG, Molfetta GA, Garcia LV, Ferreira CA, Marques AA, Silva WA Jr. Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine. (medlineplus.gov)
Biomarkers of CPO exposure inhibited in maternal tissues included brain acetylcholinesterase (AChE), red blood cell acylpeptide hydrolase (APH), and plasma butyrylcholinesterase (BChE) and carboxylesterase (CES). (nih.gov)
As a proof-of-concept application, highly sensitive biosensing of butyrylcholinesterase (BChE) activity using the Fe-N-C SAN as a substitute for natural HRP was further verified. (cdc.gov)
A series of new compounds in which uracil and 3,6-dimethyluracil moieties are bridged with different spacers were prepared and evaluated in vitro for the acetyl- and butyrylcholinesterase (AChE and BChE) inhibitory activities. (inra.fr)
A novel sandwich immunoassay based immunochromatographic test strip (ICTS) has been developed for simultaneously measuring both butyrylcholinesterase (BChE) activity and the total amount of BChE (including inhibited and active enzyme) from 70 μLpost-exposure human plasma sample. (cdc.gov)
Rivastigmine is an inhibitor of acetylcholinesterase and carbamate-type butyrylcholinesterase, which promotes cholinergic neurotransmission, slowing down the degradation of acetylcholine, which is. (interchem.ua)
Pseudocholinesterase deficiency7
Pseudocholinesterase deficiency results in delayed metabolism of only a few compounds of clinical significance, including the following: succinylcholine, mivacurium, procaine, heroin, and cocaine. (wikipedia.org)
Pseudocholinesterase deficiency can result in higher levels of intact succinylcholine molecules reaching receptors in the neuromuscular junction, causing the duration of paralytic effect to continue for as long as eight hours. (wikipedia.org)
Pseudocholinesterase deficiency is a condition that results in increased sensitivity to certain muscle relaxant drugs used during general anesthesia, called choline esters. (medlineplus.gov)
However, people with pseudocholinesterase deficiency may not be able to move or breathe on their own for a few hours after the drugs are administered. (medlineplus.gov)
People with pseudocholinesterase deficiency may also have increased sensitivity to certain other drugs, including the local anesthetic procaine, and to specific agricultural pesticides. (medlineplus.gov)
Pseudocholinesterase deficiency occurs in 1 in 3,200 to 1 in 5,000 people. (medlineplus.gov)
Pseudocholinesterase deficiency can also have nongenetic causes. (medlineplus.gov)
Enzymes2
The role of inheritable variations in predisposing to ADRs was shown by the correlation between drug responses and inherited deficiencies of metabolic enzymes such as pseudocholinesterase (butyrylcholinesterase) and glucose-6-phosphate dehydrogenase (G6PD).Genetic polymorphisms (variants alleles present at least in 1% of the normal population) are a source of genetic variation to drug responses. (nih.gov)
However, most of currently developed nanozymes show much lower activity in comparison with natural enzymes, and the deficiency greatly hinders their use in sensing and biomedicine. (cdc.gov)
PChE (BuChE, EC 3.1.1.8): Also known as plasma cholinesterase, butyrylcholinesterase, or acylcholine acylhydrolase: Found primarily in the liver and is responsible for the metabolism of succinylcholine, mivacurium, and local anesthetics chloroprocaine, tetracaine, procaine, and benzocaine. (jicajournal.in)
10. Identification of hybrid cholinesterase forms consisting of acetyl- and butyrylcholinesterase subunits in human glioma. (nih.gov)
Knockout1
17. Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. (nih.gov)
Mivacurium1
PChE or butyrylcholinesterase deficiency is a rare, acquired, or inherited condition where the PChE levels are absent or lower than normal with a reduced ability to metabolize succinylcholine and mivacurium leading to prolonged muscular paralysis from standard doses. (jicajournal.in)
[1] The delayed reversal from neuromuscular blockade after administration of succinylcholine, was unlike the classic complete prolonged neuromuscular block seen in a patient with PChE deficiency. (jicajournal.in)
Cholinergic1
Cholinesterase inhibitors (ChEIs) are used to palliate cholinergic deficiency. (medscape.com)
Enzyme3
Transplantation of skin cells modified to express the enhanced form of butyrylcholinesterase into mice enables the long-term release of the enzyme and efficiently protects the mice from cocaine-seeking behavior and cocaine overdose. (wikipedia.org)
This gene provides instructions for making the pseudocholinesterase enzyme, also known as butyrylcholinesterase, which is produced by the liver and circulates in the blood. (medlineplus.gov)
The presence of PChE deficiency was confirmed by low levels on plasma assay of the enzyme. (jicajournal.in)
PChE6
This issue describes an interesting case of an unusual presentation of pseudocholinesterase (PChE) deficiency in a parturient undergoing emergent cesarean section by Upadaya and Garg. (jicajournal.in)
However, an undiagnosed PChE deficiency can convert this into a potentially life-threatening situation. (jicajournal.in)
With the decline in the use of succinylcholine and the availability of safer alternatives such as rocuronium and sugammadex, less and less is being written in textbooks about PChE deficiency. (jicajournal.in)
It is thus important to revisit PChE deficiency, and start a conversation on this life-threatening but relatively easy-to-manage complication following succinylcholine administration. (jicajournal.in)
Although PChE deficiency is a rare disorder, it is a serious condition since it is difficult to diagnose clinically preoperatively and can be potentially fatal. (jicajournal.in)
Pseudocholinesterase (PChE), also known as Butyrylcholinesterase or Serumcholinesterase, hydrolyses butyrylcholine. (human.de)
Inhibitory1
Some coumarins (isoimperatorin, bergomottin, and oxypeucedanin) inhibit butyrylcholinesterase at varying half-maximal inhibitory concentrations (IC 50 ). (news-medical.net)
Assay1
Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. (wikipedia.org)
Autosomal recessive1
Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY. (nih.gov)
Levels1
GeniusPlyus (5-HTP + Ginkgo biloba) as an additional source of 5-HTP helps to normalize serotonin levels and a decrease in the manifestations of its deficiency in the body. (interchem.ua)
Nerve1
Butyrylcholinesterase is a prophylactic countermeasure against organophosphate nerve agents. (wikipedia.org)
Leads1
Besides, hesperidin has also been used as a supplemental dietary product since its deficiency leads to weakness, aches, and nocturnal leg cramps. (news-medical.net)