BCHEBuChEAChEAcetylcholinesterase and butyrylcholinesterase inhibitorsOrganophosphateCholinesteraseInhibitorsPseudocholinesteraseChang-Guo ZhanCocaine hydrolysisVariantHumanMivacuriumAssayGhrelinPlasmaActivityBrainFormPotentialRoleReleaseAcetylcholinesterase and butyrylcholinesteraseEnzymeAcetylCholinergic-systemDeficiencyCocainePublicationsMouseAnalysis
BCHE12
- The quaternary structures of the cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), are essential for their localization and function. (rcsb.org)
- Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. (cdc.gov)
- Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. (simulations-plus.com)
- The production and N -glycosylation of recombinant human butyrylcholinesterase (BChE), a model highly glycosylated therapeutic protein, in a transgenic rice cell suspension culture treated with kifunensine, a strong α-mannosidase I inhibitor, was studied in a 5 L bioreactor. (preprints.org)
- A novel computational protocol based on free energy perturbation (FEP) simulations on both the free enzyme and transition state structures has been developed and tested to predict the mutation-caused shift of the free energy change from the free enzyme to the rate-determining transition state for human butyrylcholinesterase (BChE)-catalyzed hydrolysis of (-)-cocaine. (uky.edu)
- 4.5 × 10 -9 ), is also an expression quantitative trait locus for BCHE (butyrylcholinesterase), expressed in thalamus tissue. (nih.gov)
- Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents, pesticide intoxication, and cocaine overdose. (nebraska.edu)
- There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. (ox.ac.uk)
- We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue. (ox.ac.uk)
- Electrophoresis of human plasma yields 4 butyrylcholinesterase (BChE) protein bands, i.e. (ui.ac.id)
- A sandwich enzyme-linked immunosorbent assay (sELISA) has been developed for detection of organophosphorylated butyrylcholinesterase (OP-BChE), a potential biomarker for human exposure to organophosphate insecticides and nerve agents. (cdc.gov)
- it's regulated by the enzymes enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). (gulfnews.com)
BuChE2
- Elevated levels of human butyrylcholinesterase (BuChE) confer protection from chemical warfare nerve agents and other organophosphorous chemicals. (sbir.gov)
- Rivastigmine also inhibits butyrylcholinesterase (BuChE). (medscape.com)
AChE1
- These results suggest that TAK-147 activates the central cholinergic system by specific inhibition of AChE activity without affecting peripheral butyrylcholinesterase activity, and that TAK-147 also moderately activates the monoaminergic systems. (aspetjournals.org)
Acetylcholinesterase and butyrylcholinesterase inhibitors2
- Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors. (yyu.edu.tr)
- Szwajgier D, Borowiec K. Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors. (aaem.pl)
Organophosphate2
- Butyrylcholinesterase is a prophylactic countermeasure against organophosphate nerve agents. (wikipedia.org)
- Enzyme-linked immunosorbent assay for detection of organophosphorylated butyrylcholinesterase: a biomarker of exposure to organophosphate agents. (cdc.gov)
Cholinesterase1
- Butyrylcholinesterase is a glycoprotein enzyme used in the diagnosis of toxicosis by cholinesterase-inhibitor agents like organophosphates and carbamates. (bioone.org)
Inhibitors2
- Gilmer, JF Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. (bindingdb.org)
- The only present treatment of this disease is the use of acetyl- and butyrylcholinesterase inhibitors. (aaem.pl)
Pseudocholinesterase1
- butyrylcholinesterase (pseudocholinesterase) found in the blood plasma and acetylcholinesterase found in red blood cells. (labtestsonline.org.uk)
Chang-Guo Zhan1
- High-Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis " by Chang-Guo Zhan, Hoon Cho et al. (uky.edu)
Cocaine hydrolysis1
- A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. (uky.edu)
Variant1
- Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients. (ox.ac.uk)
Human3
- Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for the catalytic hydrolysis or stoichiometric binding of organophosphates (OPs). (aspetjournals.org)
- Probing the peripheral site of human butyrylcholinesterase. (nih.gov)
- Model of Human Butyrylcholinesterase Tetramer by Homology Modeling and Dynamics Simulation. (acs.org)
Mivacurium1
- The enzyme butyrylcholinesterase metabolises suxamethonium (and another surgical muscle relaxant mivacurium). (labtestsonline.org.uk)
Assay1
- Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. (wikipedia.org)
Ghrelin1
- Butyrylcholinesterase may be a physiological ghrelin regulator. (wikipedia.org)
Plasma3
- By contrast, TAK-147 was the least potent inhibitor of butyrylcholinesterase activity in rat plasma (IC 50 = 23,500 nM). (aspetjournals.org)
- To establish reference values of plasma butyrylcholinesterase concentrations in common psittacine species, plasma butyrylcholinesterase concentrations were measured in 1942 companion psittacine birds. (bioone.org)
- Plasma butyrylcholinesterase concentrations varied by age, health status, and season but not by sex. (bioone.org)
Activity2
- Tacrine and physostigmine inhibited butyrylcholinesterase activity potently and nonselectively. (aspetjournals.org)
- Butyrylcholinesterase activity in multiple sclerosis neuropathology. (nih.gov)
Brain1
- Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. (acs.org)
Form1
- Transplantation of skin cells modified to express the enhanced form of butyrylcholinesterase into mice enables the long-term release of the enzyme and efficiently protects the mice from cocaine-seeking behavior and cocaine overdose. (wikipedia.org)
Potential1
- Is butyrylcholinesterase a potential biomarker for sudden infant death syndrome's prevention? (udg.edu)
Role1
- Butyrylcholinesterase may have a role in a number of metabolic functions and could affect the expression of insulin resistance syndrome. (manipal.edu)
Release1
- Development of a long-acting, injectable controlled release butyrylcholinesterase formulation using predictive modeling. (sbir.gov)
Acetylcholinesterase and butyrylcholinesterase4
- It is used as a tool to distinguish between acetylcholinesterase and butyrylcholinesterase. (wikipedia.org)
- Acetylcholinesterase and butyrylcholinesterase activities emerge in association with plaques and tangles in Alzheimer's disease. (nih.gov)
- The present experiment assessed the ability of rivastigmine, a clinically utilized agent that inhibits acetylcholinesterase and butyrylcholinesterase activities, to inhibit cholinesterases in plaques and tangles. (nih.gov)
- Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors. (yyu.edu.tr)
Enzyme2
- Transplantation of skin cells modified to express the enhanced form of butyrylcholinesterase into mice enables the long-term release of the enzyme and efficiently protects the mice from cocaine-seeking behavior and cocaine overdose. (wikipedia.org)
- Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for the catalytic hydrolysis or stoichiometric binding of organophosphates (OPs). (aspetjournals.org)
Acetyl1
- The present group of studies first optimized the variables for extraction and solubilization of cholinesterase activity from various rat tissues and then refined an existing automated method, in order to differentially assess acetyl and butyrylcholinesterase activity in those tissues. (nih.gov)
Cholinergic-system1
- 8. Butyrylcholinesterase and the cholinergic system. (nih.gov)
Deficiency1
- Prolonged neuromuscular block in a patient with butyrylcholinesterase deficiency]. (nih.gov)
Cocaine1
- A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. (adicciones.es)
Publications1
- Choose from 1 of 20 Butyrylcholinesterase antibodies, which have been validated in experiments with 12 publications and 36 images featured in our data gallery. (thermofisher.com)
Mouse1
- Our Butyrylcholinesterase polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit and Mouse. (thermofisher.com)
Analysis1
- Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. (cdc.gov)