Busulfan drug bone marrow transplantation. Medical search. Frequent questions

Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation. (uchicago.edu)
Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
In this first response, a patient with prior allogeneic hematopoietic cell transplantation (line 30), which is a procedure that involves a patient receiving a donor's bone marrow or blood may feel nauseated when given Busulfan. (drugbank.dev)

Busulfan is an alkylating agent and functions as a myeloablative and anti-leukemic chemotherapy drug. (bvsalud.org)
Drugs used in chemotherapy, such as busulfan, fludarabine phosphate and cyclophosphamide work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mdanderson.org)
Giving chemotherapy such as busulfan and fludarabine phosphate before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (mdanderson.org)
It is important to keep a record of the cancer treatment, including a list of specific chemotherapy drugs or other medications, you or your child received. (cancer.net)
Bone marrow transplants from healthy donors are used successfully to treat certain blood cancers for which the course of the disease is so severe that the destruction of the patient's own immune system through high-dose chemotherapy and radiation seems an effective compromise. (nih.gov)
The objective of the study is to prepare the patient's body before a stem cell transplant by using an antibody-drug instead of radiation/chemotherapy to make transplants safer. (fanconi.org)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Myleran Busulfan tablets What do busulfan tablets do?BUSULFAN (Myleran(R)) is a type of chemotherapy used for treating chronic myelogenous leukemia. (tcds.com)
It may also be used as part of the chemotherapy given before bone marrow transplantation. (tcds.com)
Busulfan may be used in combination with other cancer chemotherapy agents. (tcds.com)
Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (wikidoc.org)
The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)

Busulfan is used in pediatrics and adults in combination with cyclophosphamide or fludarabine/clofarabine as a conditioning agent prior to bone marrow transplantation, especially in chronic myelogenous leukemia (CML) and other leukemias, lymphomas, and myeloproliferative disorders. (wikipedia.org)
As an adjunct therapy with cyclophosphamide for conditioning prior to bone marrow transplantation in adults and children >12 kg, intravenous (IV) busulfan (Bulsulfex) is dosed at 0.8 mg/kg every six hours for 16 doses (four days). (wikipedia.org)
It is widely used with cyclophosphamide for conditioning patients undergoing bone marrow transplantation for myeloid leukemia. (bvsalud.org)
This phase II trial studies the side effect of busulfan, fludarabine phosphate, and post-transplant cyclophosphamide in treating patients with blood cancer undergoing donor stem cell transplant. (mdanderson.org)
Pharmacokinetics The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (clustermed.info)
Cyclophosphamide can cause myelosuppression (leukopenia, neutropenia, thrombocytopenia and anemia), bone marrow failure, and severe immunosuppression which may lead to serious and sometimes fatal infections, including sepsis and septic shock. (edrugswiki.com)
Mild Acute Graft-Versus-Host Disease Improves Outcomes After HLA-Haploidentical-Related Donor Transplantation Using Posttransplant Cyclophosphamide and Cord Blood Transplantation. (kyoto-u.ac.jp)
The patient was treated with chemotherapeutic drugs (cyclophosphamide, vincristine, therarubicin, and cisplatin), irradiation of the abdominal cavity, and surgical resection of the adrenal gland, followed by autologous peripheral blood stem cell transplantation (PBSCT). (biomedcentral.com)

Busulfan (BU) is a widely used myeloablative and antineoplastic agent in clinical bone marrow transplantation (BMT). (umn.edu)
Children receive busulfan orally as part of myeloablative therapy before bone marrow transplantation for malignant and nonmalignant conditions. (johnshopkins.edu)
Busulfan is a chemotherapeutic agent used as a component in a myeloablative preconditioning regimen before hematological stem cell transplantation. (labroots.com)
We decided to perform cord blood stem cell transplantation (CBSCT) for hematopoietic rescue after the myeloablative therapies. (biomedcentral.com)

Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)

Fludarabine + busulfan is a typical example of this use. (wikipedia.org)
Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease. (uchicago.edu)
Adding venetoclax to fludarabine/busulfan RIC transplant for high risk MDS and AML is feasible, safe, and active. (harvard.edu)

This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)

Busulfan was approved by the US Food and Drug Administration (FDA) for treatment of chronic myeloid leukemia (CML) in 1999. (wikipedia.org)
Busulfan was the mainstay of the chemotherapeutic treatment of chronic myeloid leukemia (CML) until it was displaced by the new gold standard, imatinib, though it is still in use to a degree as a result of the drug's relative low cost. (wikipedia.org)
Atovaquone is an FDA-approved antiparasitic and antifungal therapeutic that is currently used as a prophylactic agent to prevent Pneumocystis carinii pneumonia (PCP) infections in acute myeloid leukemia (AML) patients after receiving hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
Myelogenous or myeloid leukemia is one that involves marrow cells creating platelets, red blood cells, and various kinds of white blood cells. (shekhawatihospital.com)
Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes. (uchicago.edu)
This has also caused more attention to be focused on the evolution of lower- and higher-risk MDS into more aggressive forms of either MDS or acute myeloid leukemia (AML), and has necessitated a clearer description of how these drugs are being used across the country. (jnccn.org)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)

Prospective Clinical Trial of BUSULFEX: The prospective trial was a single-arm, open-label study in 61 patients who received BUSULFEX as part of a conditioning regimen for allogeneic hematopoietic stem cell transplantation. (clustermed.info)
Have problems from the disease that call for stem cell transplantation. (zhihuiya.com)
It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. (nih.gov)
Curative options for sickle cell disease: haploidentical stem cell transplantation or gene therapy? (nih.gov)
This study investigated the clinical characteristics of primary hemophagocytic lymphohistiocytosis (HLH) in adults, including immunological markers, pedigree findings, and conditions of allogeneic hematopoietic stem cell transplantation (Allo-HSCT). (biomedcentral.com)
Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. (uchicago.edu)
Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience. (uchicago.edu)
Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia. (uchicago.edu)
Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (uchicago.edu)
National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
Minimal important difference of the 6-minute walk test after allogenic hematopoietic stem cell transplantation. (kyoto-u.ac.jp)
Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
Iodine-131-metaiodiobenzylguanidine ( 131 I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. (biomedcentral.com)
The pharmacist has become an integral member of the multidisciplinary stem cell transplantation team. (ebmt.org)
The EBMT Pharmacist Committee has been established to structure and develop scientific and educational activities designed for pharmacists and clinical pharmacologists involved in the field of stem cell transplantation and cellular therapy. (ebmt.org)
Consensus recommendations for the role and competencies of the EBMT clinical pharmacist and clinical pharmacologist involved in hematopoietic stem cell transplantation. (ebmt.org)

Studies have shown that the busulfan plasma concentration correlates better with clinical efficacy and toxicity than the patient's administered dosage. (bvsalud.org)
In a recent study, they demonstrated that they could transplant bone marrow cells from HLA-matched sibling donors without needing to completely destroy the patient's immune system. (nih.gov)
After extracting and isolating precursor CD34+ cells from patients, they use viral transduction to insert a correct copy of the β-globin gene before returning the cells to the patient's bone marrow. (nih.gov)

Pharmacokinetic and dynamic studies support this use, that has prompted its usage in transplantation regimes, particularly in frail patients. (wikipedia.org)

However, clinical studies of busulfan were completed with patients taking phenytoin, so no empiric dose adjustment is necessary if patients are taking phenytoin with busulfan. (wikipedia.org)
Drug screening is an important diagnostic tool in patient management and is an indispensable part of clinical toxicology laboratory services. (bvsalud.org)
CLINICAL PHARMACOLOGY Mechanism Of Action Busulfan is a bifunctional alkylating agent in which two labile methanesulfonate groups are attached to opposite ends of a four-carbon alkyl chain. (clustermed.info)
Describe a clinical method to measure Busulfan in plasma by LC-MS/MS. (labroots.com)
The clinical course of individuals with MF is heterogeneous and characterized by constitutional symptoms, bone marrow myeloproliferation and fibrosis, progressive cytopenias, and symptomatic splenomegaly. (cancernetwork.com)
The clinical course of individuals with MF is characterized by constitutional symptoms (fevers, night sweats, and weight loss), bone marrow myeloproliferation and reticulin/collagen fibrosis, worsening cytopenias, thrombosis, and progressive symptomatic splenomegaly. (cancernetwork.com)
This response reads, "The drug Busulfan (line 4) was administered intravenously (line 8) in a clinical trial (line 12) that was carried out in the US (line 14). (drugbank.dev)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
Launch survey for assessment of extent of clinical pharmacists' and pharmacologists' involvement in HSCT in Europe on the basis of the 2020 published publication (Bone Marrow Transplant, 2020 Jan;55(1):62-69). (ebmt.org)

Busulfan is a bifunctional alkylating agent known chemically as 1,4- butanediol, dimethanesulfonate. (nih.gov)

After 2002, a great interest has appeared for intravenous presentations of busulfan. (wikipedia.org)
Busulfex is supplied as an intravenous solution with 6 mg/ml busulfan. (wikipedia.org)
BUSULFEX ® (busulfan) Injection is intended for intravenous administration. (nih.gov)
Clinicopathologic features of late-onset veno-occlusive disease/sinusoidal obstruction syndrome after high dose intravenous busulfan and hematopoietic cell transplant. (uchicago.edu)

The high variability in atovaquone bioavailability prompts the need for therapeutic drug monitoring, especially in pediatric patients. (bvsalud.org)
How the Busulfan testing improved the management of Bone Marrow Transplant Patients? (labroots.com)
Therapeutic drug monitoring (TDM) of Busulfan is essential for management of Bone Marrow Transplant (BMT) patients, by optimizing dose, supporting compliance, and minimizing toxicity. (labroots.com)
The TDM and timely plasma concentration reporting of Busulfan would provide an improvement in the quality-of-care for BMT patients. (labroots.com)
Identify our purpose to measure Busulfan in BMT patients' samples. (labroots.com)
This study uses transplantation to treat patients with problems in their immune system. (zhihuiya.com)
Conditioning' treatments are given to patients to create space in their bone marrow. (zhihuiya.com)
Patients who do not have a matched sibling donor but have a donor that matches in the National Marrow Donor Program. (zhihuiya.com)
To create space in the bone marrow, patients are given two drugs, Campath-1H and busulfan. (zhihuiya.com)
Of the 15 responding patients, 6 had post-clofarabine bone marrow transplantation. (bionity.com)
In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)
Dr. Tisdale has an active research program in trying to characterize tolerance and create conditions in which patients will more easily tolerate donor cells and tissues without the need for destroying the immune system or perpetual use of immunosuppressant drugs. (nih.gov)
Dr. Tisdale and his colleagues recently completed a modified bone marrow transplant strategy for the first time in adult patients with sickle cell disease. (nih.gov)
Successful allogeneic transplantation of patients with suspected prior invasive mold infection. (uchicago.edu)
Knowing the adverse effects of a drug is important because not only do we want to ensure patients are benefiting from the drug, we want to ensure any associated health risks are minimal. (drugbank.dev)
98% of the patients (line 18) who took the experimental drug (line 17) reported an adverse effect of nausea (line 22). (drugbank.dev)
Patients should not receive Sargramostim until the post marrow infusion ANC is less than 500 cells/mm3. (wikidoc.org)

Busulfex has proved equally effective as oral busulfan, with presumedly less toxic side effects. (wikipedia.org)
however, the literature on oral busulfan is relevant. (nih.gov)

Busulfan therapeutic drug monitoring is completed based on trough (pre-dose) levels with a target six-hour area under the curve (AUC) of between 900 and 1500 micromolxmin. (wikipedia.org)
These studies suggest that, in young children, BSA-based dosing of BU (40 mg/m 2 ) provides drug exposures (AUCs) closer to adult values with acceptable toxicities and may improve therapeutic effects. (umn.edu)
Therapeutic drug monitoring (TDM) of busulfan plasma concentration guides the dosage adjustment to optimally achieve complete bone marrow ablation while minimizing the dosage-dependent toxicity. (bvsalud.org)
Combining drugs with different mechanisms of action can produce larger therapeutic effects with fewer side effects. (doctorlib.info)

Este estudio es una revisión integradora de la literatura a través de bases de datos de análisis médicos, literatura y recuperación de sistema en línea (MEDLINE), SCOPUS, Cumulative Index de Enfermería y Salud Aliada Literatura (CINAHL) y Science Direct. (sld.cu)

This lets the cells of the donor go into the bone marrow and produce normal immune cells. (zhihuiya.com)
This is know as matched unrelated donor transplantation. (zhihuiya.com)
Eligibility includes having developed cytopenias (reduced blood cell counts) and not having an HLA-identical matched sibling donor for bone marrow transplant (BMT). (fanconi.org)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)

Busulfex is also known as Busulfan. (clustermed.info)
BUSULFEX ® (busulfan) Injection is a potent cytotoxic drug that causes profound myelosuppression at the recommended dosage. (nih.gov)
Each vial of BUSULFEX contains 60 mg (6 mg/mL) of busulfan, the active ingredient, a white crystalline powder with a molecular formula of CH 3 SO 2 O(CH 2 ) 4 OSO 2 CH 3 and a molecular weight of 246 g/mole. (nih.gov)
The solubility of busulfan in water is 0.1 g/L and the pH of BUSULFEX diluted to approximately 0.5 mg/mL busulfan in 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP as recommended for infusion reflects the pH of the diluent used and ranges from 3.4 to 3.9. (nih.gov)

Toxicity may include interstitial pulmonary fibrosis ("busulfan lung"), hyperpigmentation, seizures, hepatic (veno-occlusive disease) (VOD) or sinusoidal obstruction syndrome (SOS), emesis, and wasting syndrome. (wikipedia.org)
My overall research ambition stems from the need to improve efficacy and reduce toxicity of anticancer drug therapy through the application of quantitative pharmacology. (amsterdamumc.org)
Here, we combine relevant preclinical mechanistic data of physicochemical drug properties related to PK and efficacy/toxicity, pathologic and physiological factors and apply mathematics to describe the mechanisms that control the uptake, distribution, and elimination of drug into blood and (tumor) tissues. (amsterdamumc.org)

Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)

Both IV and oral formulations require prophylactic antiemetic agents administered prior to the busulfan dose and scheduled antiemetics administered thereafter. (wikipedia.org)

Busulfan also induces impotence in males (kills germ cells), thrombocytopenia, a condition of lowered blood platelet count and activity, and sometimes medullary aplasia. (wikipedia.org)
Clofarabine can stop the bone marrow from making enough red blood cells , white blood cells , and platelets . (bionity.com)
The Cellular and Molecular Therapeutics Laboratory, led by Dr. John F. Tisdale, is working on multiple strategies both in the laboratory and in the clinic to cure sickle cell disease by repairing or replacing the precursor bone marrow cells that give rise to sickled red blood cells. (nih.gov)
A lymphocytic or lymphoblastic leukemia comprises bone marrow cells that turn into a kind of white blood cell known as lymphocytes. (shekhawatihospital.com)
Regular bone marrow and blood tests are run to examine the effect of this treatment on killing leukemia cells. (shekhawatihospital.com)
In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
Biology of Blood and Marrow Transplantation. (elsevierpure.com)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)

The immune system cells come from the bone marrow where they grow from special cells called stem cells. (zhihuiya.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)

Phenytoin increases hepatic clearance of busulfan (resulting in decreased busulfan AUC). (wikipedia.org)

CEP has been cured with allogenic bone marrow transplant. (medscape.com)

For example, most chemotherapeutic drugs work by impairing mitosis (cell division), effectively targeting fast-dividing cells. (justia.com)

We evaluated the disposition of busulfan in children between 2 months and 3.6 years of age with lysosomal storage diseases, leukemia, and immunodeficiency disorders receiving oral doses of 1 or 2 mg/kg using a gas chromatographic assay. (johnshopkins.edu)
Leukemia occurs as a result of malfunctioning of marrow leading to cancerous cell formation. (shekhawatihospital.com)

Busulfan clearance rate normalized to surface area is twice as high in children (200 ± 100 mL/min/m 2 ) as it is in adults (95 ± 54 mL/min/m 2 ). (johnshopkins.edu)
To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)

Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is progressive and fatal, and lung transplantation is the only therapy that has been shown to prolong survival [ 1 ], [ 2 ]. (ersjournals.com)

The cells make their way to the bone marrow space and slowly refill the marrow over the next several weeks. (zhihuiya.com)
As these drugs cause damage to cells they are termed cytotoxic. (justia.com)

About 30% of the drug is bound to plasma proteins, such as albumin. (wikipedia.org)
Irreversible binding to plasma elements, primarily albumin, has been estimated to be 32.4 ± 2.2% which is consistent with the reactive electrophilic properties of busulfan. (nih.gov)

Levetiracetam, has shown efficacy for the prophylaxis against busulfan-induced seizures. (wikipedia.org)

Myleran is supplied in white film coated tablets with 2 mg of busulfan per tablet. (wikipedia.org)

The drug was recently used in a study to examine the role of platelet-transported serotonin in liver regeneration. (wikipedia.org)
Liver transplant alone is not curative for erythropoietic protoporphyria (EPP) but instead needs to be combined with bone marrow transplant. (medscape.com)

20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)

Transplantation and Cellular Therapy, Jul. (kyoto-u.ac.jp)
Transplantation and Cellular Therapy, Jun. (kyoto-u.ac.jp)

Seizures and VOD are serious concerns with busulfan therapy and prophylaxis is often utilized to avoid these effects. (wikipedia.org)
He observed that this highly aggressive bone cancer was remarkably sensitive to radiation therapy. (sarcomahelp.org)
These inhibitors block the protein and may also be used for stem cell therapy for replacing the cancerous bone marrow with a healthy one. (shekhawatihospital.com)

Busulfan can control tumor burden but cannot prevent transformation or correct cytogenic abnormalities. (wikipedia.org)
This class of carcinogens includes various hormones (e.g., estrogen and diethylstilbestrol), immunosuppressive drugs (e.g., azathioprine), solid-state carcinogens (e.g., asbestos), and promoting agents (agents that increase tumor development when given after a genotoxic chemical). (doctorlib.info)

Drug treatment regimens for cancer usually involve combinations of agents given intermittently. (doctorlib.info)

Serious side effects that can happen because of bone marrow suppression include severe infection ( sepsis ), bleeding, and anemia . (bionity.com)

This study will use lower doses of a drug called busulfan and lower doses of radiation than what are currently being used in other kinds of bone marrow transplantation for other diseases. (zhihuiya.com)
Several neoplastic diseases can be cured with drugs alone or with a combination of drugs and other treatment modalities. (doctorlib.info)

Anatomy25

Organisms15

Diseases62

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology2

Phenomena and Processes39

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups3

Health Care15

Allogeneic hematopoietic cell6

Chemotherapy12

Cyclophosphamide8

Myeloablative4

Hematopoietic stem2

Fludarabine3

Graft-versus-1

Myeloid leukemia7

Cell Transplantation26

Patient's3

Pharmacokinetic1

Clinical9

Bifunctional alkyl1

Intravenous4

Patients17

Oral busulfan2

Therapeutic4

Scopus1

Donor5

Busulfex4

Toxicity3

Peripheral1

Dose1

Blood8

Stem cells2

Phenytoin1

Allogenic1

Chemotherapeutic drugs1

Leukemia2

Adults2

Pulmonary fibrosis2

Cells2

Albumin2

Efficacy1

Myleran1

Liver2

Lymphoma1

Cellular Therapy2

Therapy3

Tumor2

Regimens1

Severe1

Diseases2