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  • doses
  • Nausea, vomiting, loss of appetite, mouth sores, and diarrhea are rare side effects from busulfan at normal doses, but are common at the higher doses used for bone marrow transplant. (encyclopedia.com)
  • Although it is uncommon, severe liver problems may occur due to busulfan administration at higher doses. (encyclopedia.com)
  • Busulfan 0.8 mg per kg (ideal body weight or actual body weight, whichever is lower) intravenously via a central venous catheter as a two-hour infusion every six hours for four consecutive days for a total of 16 doses (Days -7, -6, -5 and -4). (drugs.com)
  • leukemia
  • Rare reactions to busulfan include: lung problems, cataracts, fatigue, heart problems, low blood pressure, development of another type of cancer or leukemia, enlarged breast tissue (referred to as gynecomastia), and increased uric acid levels (which can lead to kidney problems and gout). (encyclopedia.com)
  • Busulfan oral (taken by mouth) is used to treat the symptoms of chronic myelogenous leukemia (a type of blood cancer). (drugs.com)
  • Busulfan is not a cure for leukemia . (drugs.com)
  • Busulfan was approved by the US Food and Drug Administration (FDA) for treatment of chronic myeloid leukemia (CML) in 1999. (wikipedia.org)
  • bleomycin
  • Infections Certain medications, e.g. amiodarone, bleomycin (pingyangmycin), busulfan, methotrexate, apomorphine, and nitrofurantoin Radiation therapy to the chest Pulmonary fibrosis involves gradual exchange of normal lung parenchyma with fibrotic tissue. (wikipedia.org)
  • spermatogenesis
  • Tsumura Co., Ltd., Tokyo, Japan) to mice suffering from severe aspermatogenesis after busulfan treatment to determine whether TJ107 can recover spermatogenesis. (mdpi.com)
  • Additionally, mice lacking PAX7 had delayed recovery of spermatogenesis following exposure to busulfan when compared to control mice. (wikipedia.org)
  • treatment
  • Before you begin treatment with busulfan, you and your doctor should talk about the benefits this medicine will do as well as the risks of using it. (mayoclinic.org)
  • After busulfan treatment, the weight of the testes and the epididymal sperm count progressively decreased in the normal diet group. (mdpi.com)
  • These results suggest that busulfan-induced aspermatogenesis is irreversible if appropriate treatment is not administered. (mdpi.com)
  • patients
  • Dosing busulfan based on actual body weight, ideal body weight or other factors can produce significant differences in busulfan clearance among lean, normal and obese patients. (drugs.com)