• B. cepacia was discovered by Walter Burkholder in 1949 as the cause of onion skin rot, and first described as a human pathogen in the 1950s. (wikipedia.org)
  • B. cepacia complex is an environmental pathogen. (cdc.gov)
  • While understanding the mechanism of conversion to mucoidy in P. aeruginosa has progressed to the point where this phenomenon has evolved into a model system for studying bacterial stress response in microbial pathogenesis, the more recent challenge with B. cepacia, which has emerged as a potent bona fide CF pathogen, is discussed in the context of clinical issues, taxonomy, transmission, and potential modes of pathogenicity. (asm.org)
  • The presence of the cable pilus subunit gene ( cblA ) ( 26 ) and B. cepacia epidemic strain marker (BCESM) were determined as described previously ( 20 ). (asm.org)
  • Pulmonary colonization of B. cepacia can cause accelerated decline in lung funtions and cause "cepacia syndrome," which is a progressive pneumonic illness that is fatal and essentially untreatable . (kenyon.edu)
  • Clustering of new cases in some centers and the decrease of colonization of new patients following segregation of colonized and noncolonized patients in other centers suggested that " B. cepacia " could be transmitted between CF patients. (asm.org)
  • A recent study of CF patients over a 20-year period concluded that colonization with B. cepacia significantly increased the risk of mortality at all levels of pulmonary function and that the risk was significantly higher for children ( 6 ). (asm.org)
  • Susceptible persons can acquire B. cepacia organisms through person-to-person contact, contact with contaminated surfaces, and exposure to it in the enviroment (i.e. soil and water) . (kenyon.edu)
  • Caraher E, Reynolds G, Murphy P, McClean S, Callaghan M (2007) Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro. (springer.com)
  • For more information see the Notice to Readers: Nosocomial Burkholderia cepacia Infections Associated with Exposure to Sublingual Probes - Texas, 2004 . (cdc.gov)
  • CDC is collaborating with the Food and Drug Administration (FDA), state and local health departments, and healthcare facilities to investigate recent outbreak of Burkholderia cepacia infections associated with exposure to liquid docusate. (cdc.gov)
  • In the early 1980s Burkholderia cepaciabecame associated with epidemics of severe lung infections ('cepacia syndrome') traced, in many cases, to CF treatment centers and social gatherings where CF patients apparently acquired the disease from other B. cepacia-infected individuals (19). (apsnet.org)
  • Most troublesome is the fact that lung infections with BCC can culminate in a rapidly fatal condition in which patients develop a progressive, necrotizing pneumonia and sepsis commonly referred to as "cepacia syndrome" ( 23 ). (asm.org)
  • The aim of this project was to investigate novel antimicrobial strategies against B. cepacia , based on natural antimicrobial compounds present in plants and human airways as protection against bacterial disease. (bl.uk)
  • In contrast, two hours incubation with AGE produced morphological changes in the cellular structure of B. cepacia consistent with much slower damage to the bacterial cell membrane. (bl.uk)
  • In 2004, CDC was notified of a voluntary recall of over-the-counter nasal spray due to contamination with B. cepacia complex. (cdc.gov)
  • Also in 2004, B. cepacia was linked to nosocomial infections among intensive care unit patients and associated with exposure to sublingual probes. (cdc.gov)
  • B. cepacia " infections in immunocompetent patients occur only sporadically, but several cases of pseudoepidemics and nosocomial infections, often caused by contaminated disinfectants and anesthetic solutions, have been reported ( 3 , 43 , 50 , 107 ). (asm.org)
  • The susceptibility of the B. cepacia strain panel to plant extracts was investigated, in particular the activity of aqueous garlic extract (AGE) and thyme oil. (bl.uk)
  • B. cepacia " can also cause lung infections in chronic granulomatous disease patients, and infections in these patients are associated with pneumonia and septicemia and are often lethal ( 2 , 58 , 72 , 96 ). (asm.org)
  • In the 1980s, outbreaks of B. cepacia in individuals with CF were associated with a 35% death rate. (wikipedia.org)
  • Reports of B. cepacia in CF patients appeared in the late 1970s and early 1980s. (kenyon.edu)
  • For example, it was shown that the B. cepacia type strain ATCC 25416T (isolated from rotting onions in the 1940s) was also isolated from sputum of a CF patient in the UK (32). (apsnet.org)
  • Hubner A, Hendrickson W. A fusion promoter created by a new insertion sequence, IS1490, aciivates transcription of 2,4,5-trichlorophenoxyacetic acid catabolic genes in Burkholderia cepacia AC1100. (atcc.org)
  • Other glucose nonfermenters, like Stenotrophomonas maltophilia , Alcaligenes xylosoxidans , R. pickettii , and Burkholderia gladioli , can frequently be found as well, but their role in the decline of pulmonary function is unclear ( 14 , 19 , 30 ). (asm.org)
  • Transposon insertion mutants of B. cepacia K56-2 which hyperproduced siderophores on chrome azurol S agar were identified. (asm.org)
  • Burkholderia cepacia complex vertebral osteomyelitis has been infrequently described in the literature thus far with varied antibiotic treatment regimens. (hindawi.com)
  • There have been scarce case reports of Burkholderia cepacia complex vertebral osteomyelitis in the literature [ 6 - 8 ], and antibiotic therapy has been historically varied. (hindawi.com)
  • Subsequently, P. cepacia was renamed Burkholderia cepacia (2) and transferred to the beta subdivision of the proteobacteria (3). (apsnet.org)
  • B. cepacia has a large genome, containing twice the amount of genetic material as E. coli. (wikipedia.org)
  • Members of the Burkholderia cepacia complex (Bcc), found in many environments, are associated with clinical infections. (thefreelibrary.com)
  • Cescutti P, Bosco M, Picotti F, Impallomeni G, Leitão JH, Richau JA, Sá-Correia I (2000) Structural study of the exopolysaccharide produced by a clinical isolate of Burkholderia cepacia . (springer.com)
  • B cepacia is a known cause of infections in hospitalized patients. (cdc.gov)
  • Because of these factors, management of B. cepacia complex patients is difficult . (kenyon.edu)
  • Burkholderia cepacia complex should be considered among pathogenic etiologies of pyogenic vertebral osteomyelitis, particularly among patients with intravenous drug use. (hindawi.com)
  • Despite the advances that have been made in the understanding of the epidemiology, " B. cepacia " infections still have a considerable impact on morbidity and mortality in CF patients ( 18 , 61 , 62 , 63). (asm.org)
  • Burkholderia genus in 1992 on the basis of phenotypic characteristics, 16S rRNA sequences, DNA-DNA homology values, and cellular lipid and fatty acid composition . (kenyon.edu)
  • Click here to see other related B. cepacia biocontrol articles from APS Journals. (apsnet.org)
  • As a result of these findings, new guidelines were issued to reduce the risk of " B. cepacia " acquisition. (asm.org)
  • In 2005, CDC was notified by several states of clusters of pneumonia and other infections caused by B. cepacia and associated with contaminated mouthwash. (cdc.gov)
  • In contrast, there is potential for the B. cepacia complex to act as a biofertiliser for rice that is cultivated in low fertile, low acidic soils . (kenyon.edu)