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BupropionNaltrexoneNarcotic AntagonistsAntidepressive Agents, Second-GenerationDopamine Uptake InhibitorsSmoking CessationDelayed-Action PreparationsOxidoreductases, N-DemethylatingNicotineReceptors, Opioid, muAlcoholismSubstance Withdrawal SyndromeOpioid-Related DisordersNicotinic AgonistsTobacco Use DisorderNarcoticsReceptors, OpioidMorphineTobacco Use Cessation ProductsDouble-Blind MethodBenzazepinesTaurineSertralineMethadyl AcetateHeroin DependenceBehavior, AddictiveAlcohol AbstinenceQuinoxalinesDose-Response Relationship, DrugAmphetamine-Related DisordersNomifensineNalorphineDisulfiramNalbuphineTemperanceDrug InteractionsAnalgesics, OpioidBuprenorphineTreatment OutcomeAryl Hydrocarbon HydroxylasesNaloxoneDipyroneHydroxylationAdministration, CutaneousHerb-Drug InteractionsMethamphetamineAntidepressive AgentsEthanolHydromorphoneEndorphinsConditioning, OperantSmokingPropiophenonesSubstance Abuse Detection
ContraveOrlistatAntidepressantDose of naltrexoneHydrochlorideOpioid antagonistMedicationsPlaceboMysimbaSmoking CessationCombinationAntidepressantsObesityNeuronsDopamineSuicidalTabletsMedicationEquivalentReducesDepressionRiskQuitAddictionNeuropsychiatricAlcohol use disorderPregnancyInitiallyTrialsPreventsDosageWithdrawal symptomsMedicineSide effectsPatientsFeelingsWorkSimilarClass
Contrave16
  • The prescription weight loss medicine Contrave contains a blend of two drugs, namely naltrexone and bupropion. (phentermine.com)
  • Furthermore, those taking a dose of naltrexone equivalent to the full dose in Contrave were more successful than those taking a half dose ( 4 ). (phentermine.com)
  • Deerfield, Ill., October 20, 2014 and Osaka, Japan, October 21, 2014 - Takeda Pharmaceutical Company Limited ("Takeda"), its wholly-owned subsidiary Takeda Pharmaceuticals U.S.A., Inc. and Orexigen ® Therapeutics, Inc. (Nasdaq: OREX) jointly announced today that Contrave ® (naltrexone HCl and bupropion HCl) extended-release tablets are now available to patients by prescription in pharmacies across the United States. (takeda.com)
  • CONTRAVE contains bupropion, the same active ingredient as some other antidepressant medications (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL and APLENZIN). (takeda.com)
  • One of the ingredients in CONTRAVE is bupropion. (contrave.com)
  • Contrave is a combination of two FDA-approved drugs, naltrexone, and bupropion, in an extended-release formula. (webmd.com)
  • Contrave has a boxed warning about the increased risk of suicidal thoughts and behaviors associated with bupropion. (webmd.com)
  • Contrave Naltrexone HCl and Bupropion Tablets In Pakistan CONTRAVE is not approved for smoking cessation. (salepakistan.pk)
  • Bupropion, a component of CONTRAVE, can cause seizures. (salepakistan.pk)
  • The weight loss at 1year with naltrexone/bupropion (trade name is Contrave) is about 4% of body weight compared to placebo, with people continuing to take the medication through a year (i.e. excluding those who dropped out of the study) losing 8.1% body weight in combination with lifestyle modification. (drsue.ca)
  • Question from a Member: I love the idea of naltrexone/bupropion combination but brand name Contrave is not covered by insurance. (simpleandpractical.com)
  • How much does Bupropion/Naltrexone (Contrave) cost in Singapore? (thesire.sg)
  • Contrave (naltrexone/bupropion) is a brand-name prescription medication. (medicalnewstoday.com)
  • FDA angry over interim data release suggesting CV benefit of naltrexone/bupropion (Contrave). (medpagetoday.com)
  • The naltrexone/bupropion (Contrave) weight loss pill might nearly halve the risk of myocardial infarction, stroke, or heart disease death, according to interim data released from the Light trial . (medpagetoday.com)
  • LIGHT, the cardiovascular safety study of the weight-loss drug Contrave (Orexigen, Takeda Pharmaceuticals), a naltrexone/bupropion combination, broke down over a very public dispute between the study's leadership, sponsors, and the US Food and Drug Administration. (tctmd.com)
Orlistat1
  • In the USA, while there are several available drugs for use as short-term adjuncts to weight loss including diethylpropion, benzphetamine, phentermine and phendimetrazine, here the authors will focus on those agents intended for longer term treatment: orlistat, phentermine/topiramate modified release, lorcaserin and, as yet unapproved, naltrexone/bupropion. (medscape.com)
Antidepressant6
  • This medication contains bupropion, the same active ingredient as some antidepressant medications (Wellbutrin, Aplenzin) and a medication used to help people stop smoking (Zyban). (medlineplus.gov)
  • The second is bupropion, an antidepressant. (phentermine.com)
  • Bupropion is a drug to treat depression, called an antidepressant, and a drug to help people stop smoking, called a quit-smoking aid. (mayoclinic.org)
  • Bupropion is an antidepressant medication (called Wellbutrin), and is also used as a smoking cessation agent (called Zyban). (drsue.ca)
  • Bupropion, sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. (wikipedia.org)
  • The pill contains bupropion, an antidepressant also used to quit smoking, and naltrexone, a treatment for alcohol and painkiller addiction. (anh-usa.org)
Dose of naltrexone1
  • The dose of naltrexone/bupropion for weight management is gradually escalated from the starting dose of one 8mg/90mg tablet once a day, to the full dose of two tablets twice per day, over about 4 weeks. (drsue.ca)
Hydrochloride3
Opioid antagonist1
  • Naltrexone is an opioid antagonist, which has been used for many years in the treatment of alcohol dependence and prevention of relapse to opioid dependence. (drsue.ca)
Medications5
Placebo10
  • They were then divided into groups that either took a combination of naltrexone and bupropion or a placebo pill. (phentermine.com)
  • Those who took naltrexone and bupropion lost more weight than those taking a placebo pill. (phentermine.com)
  • The purpose of this study is to determine the efficacy and safety of 3 combinations of naltrexone and bupropion SR compared to naltrexone alone, bupropion SR alone or placebo. (drugpatentwatch.com)
  • The purpose of this study is to compare the effects of bupropion + placebo to bupropion + naltrexone as treatments to help smokers quit. (drugpatentwatch.com)
  • The most common side effects of naltrexone/bupropion are nausea (in 32% of people vs 7% on placebo), constipation, dizziness, vomiting, and dry mouth.Gastrointestinal side effects tend to abate after about 4 weeks on treatment. (drsue.ca)
  • In terms of rare but serious side effects, there is a slightly increased risk of seizures with bupropion (0.1% of people in the weight loss studies vs 0% on placebo), so this medication should not be used in people at risk of seizures. (drsue.ca)
  • The evidence overall supports the efficacy of bupropion over placebo for the treatment of depression. (wikipedia.org)
  • Over the fall and winter months, bupropion prevents development of depression in those who have recurring seasonal affective disorder: 15% of participants on bupropion experienced a major depressive episode vs. 27% of those on placebo. (wikipedia.org)
  • Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo. (wikipedia.org)
  • In fact, the interim analysis showed that treatment with naltrexone/bupropion reduced the risk of major adverse cardiovascular events by 41% compared with placebo. (tctmd.com)
Mysimba1
  • Assessment report for Mysimba (naltrexone/bupropion) 18 December 2014 EMA/805547/2015. (janusinfo.se)
Smoking Cessation3
Combination13
  • The combination of naltrexone and bupropion is not approved for use in children under 18 years of age. (medlineplus.gov)
  • You should know that your mental health may change in unexpected ways when you take the combination of naltrexone and bupropion even if you are an adult over 24 years of age. (medlineplus.gov)
  • Your healthcare provider will want to see you often while you are taking the combination of naltrexone and bupropion, especially at the beginning of your treatment. (medlineplus.gov)
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with the combination of naltrexone and bupropion and each time you refill your prescription. (medlineplus.gov)
  • Talk to your doctor about the risks of taking the combination of naltrexone and bupropion. (medlineplus.gov)
  • The combination of naltrexone and bupropion is used along with a reduced calorie diet and exercise plan to help adults who are obese, or who are overweight and have weight-related medical problems, to lose weight and then to keep from gaining back that weight. (medlineplus.gov)
  • The combination of naltrexone and bupropion comes as an extended-release (long-acting) tablet to take by mouth. (medlineplus.gov)
  • Your doctor will probably start you on a low dose of the combination of naltrexone and bupropion and gradually increase your dose, not more than once every week, for 4 weeks. (medlineplus.gov)
  • If you have not lost a certain amount of weight, your doctor may tell you to stop taking the combination of naltrexone and bupropion as it is unlikely that you will benefit from continuing your treatment. (medlineplus.gov)
  • The combination of sustained release (SR) naltrexone and SR bupropion (NB32) has been used in weight-loss and obesity management. (nature.com)
  • Combination naltrexone-sustained release (SR) 32 mg and bupropion SR 360 mg (NB32) is a fixed-dose drug combination that was approved by Food and Drug Administration for treatment of obesity in 2014. (nature.com)
  • Bupropion-naltrexone is a combination drug. (mayoclinic.org)
  • Combination bupropion/naltrexone caused modest weight loss (approximately 5%) but was associated with increased blood pressure and heart rate. (pharmacytimes.com)
Antidepressants6
  • A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (medlineplus.gov)
  • Like all antidepressants, bupropion carries a warning about suicide risk. (mayoclinic.org)
  • Bupropion, particularly the immediate release formulation, carries a higher risk of seizure than many other antidepressants, hence caution is recommended in patients with a history of seizure disorder. (wikipedia.org)
  • Evidence suggests that the efficacy of bupropion for depression is similar to that of other antidepressants. (wikipedia.org)
  • Bupropion also improves depression in bipolar disorder, with the efficacy and risk of affective switch being similar to other antidepressants. (wikipedia.org)
  • Bupropion treatment also is not associated with the sleepiness that may be produced by other antidepressants. (wikipedia.org)
Obesity2
  • Note: On this page, I am not discussing how effective naltrexone/ bupropion is or whether or in whom we should consider prescribing naltrexone/bupropion to treat obesity. (simpleandpractical.com)
  • Surgical management (gastric banding, sleeve gastrectomy, and Roux-en Y gastric bypass) can produce remarkable health improvement and reduce mortality for patients with severe obesity. (foodpolitics.com)
Neurons1
  • The neurobiological mechanisms underlying the weight loss effects of NB32 are not fully understood but are thought to relate to bupropion stimulation of hypothalamic pro-opiomelanocortin neurons with downstream effects resulting in reduced food intake and increased energy expenditure. (nature.com)
Dopamine1
  • Bupropion acts as a norepinephrine-dopamine reuptake inhibitor and a nicotinic receptor antagonist. (wikipedia.org)
Suicidal3
  • Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. (contrave.com)
  • Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. (contrave.com)
  • Though it is an antidepression medication, bupropion can temporarily worsen depression or suicidal thoughts (there were no suicide attempts in any of the naltrexone/bupropion weight loss studies). (drsue.ca)
Tablets1
  • In patients with moderate or severe renal impairment, the maximum recommended daily dose for naltrexone/bupropion is two tablets (one tablet in the morning and one tablet in the evening) (see sections 4.4, 4.8 and 5.2). (medicines.org.uk)
Medication4
  • Naltrexone is a medication that isn't habit-forming. (alcoholism.org)
  • Bupropion is a medication that helps to lessen feelings of depression. (alcoholism.org)
  • Investigators analyzed 10-year data on more than 125,000 Swedish residents with AUD and found that naltrexone, used as monotherapy or combined with acamprosate or disulfiram, was associated with significantly lower risk for AUD hospitalization or all-cause hospitalization in comparison with patients who did not use AUD medication. (medscape.com)
  • The within-individual analysis showed that naltrexone - whether used as monotherapy or adjunctively with disulfiram or acamprosate - "was associated with a significantly lower risk of AUD-related hospitalization, compared to those time periods in which the same individual did not use any AUD medication," the authors report. (medscape.com)
Equivalent1
  • The effectiveness of bupropion for anxious depression is equivalent to that of SSRIs in the case of depression with low or moderate anxiety, whereas SSRIs show a modest effectiveness advantage in terms of response rates for depression with high anxiety. (wikipedia.org)
Reduces2
  • Naltrexone is a medicine that severely reduces feelings of withdrawal, plus it makes alcohol's effects less desirable. (alcoholism.org)
  • Naltrexone reduces the risk for hospitalization for alcohol use disorder (AUD), regardless of whether it is used alone or in conjunction with disulfiram or acamprosate, new research suggests. (medscape.com)
Depression4
  • If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment. (contrave.com)
  • Bupropion is approved to treat depression, and seasonal affective disorder, and help people stop smoking. (webmd.com)
  • Most meta-analyses report that bupropion has an at-most small effect size for depression. (wikipedia.org)
  • Bupropion is effective in the treatment of anxious depression and, contrary to common belief, does not exacerbate anxiety in this context. (wikipedia.org)
Risk6
  • Longer duration of naltrexone use was associated with lower risk for AUD-related hospitalization. (medscape.com)
  • For individuals who are at elevated risk for renal impairment, in particular patients with diabetes or elderly individuals, estimated glomerular filtration rate (eGFR) should be assessed prior to initiating therapy with naltrexone/bupropion. (medicines.org.uk)
  • Risk of environmental impact of naltrexone cannot be excluded, due to the lack of environmental toxicity data. (janusinfo.se)
  • Naltrexone: the environmental risk assessment cannot be completed at present, as the studies are not yet completed, and therefore no results are available. (janusinfo.se)
  • The Applicant is requested to perform all the planned studies for the environmental risk assessment for bupropion (e.g. (janusinfo.se)
  • The researchers found that compared with bupropion-naltrexone use, GLP-1 RA therapy for weight loss was associated with increased risk for bowel obstruction, gastroparesis, and pancreatitis but not biliary disease. (medscape.com)
Quit1
  • Bupropion has been prescribed for people who have quit drinking alcohol and passed the beginning stages of recovery. (alcoholism.org)
Addiction3
  • The first is naltrexone, a drug that is prescribed on its own to treat addiction. (phentermine.com)
  • Naltrexone is used to treat alcohol and opioid addiction. (mayoclinic.org)
  • The take-home message for practicing clinicians would be that especially naltrexone use is associated with favorable treatment outcomes and should be utilized as part of the treatment protocol for AUD," study investigator Milja Heikkinen, MD, specialist in forensic psychiatry and addiction medicine, University of Eastern Finland, Kuopio, Finland, told Medscape Medical News . (medscape.com)
Neuropsychiatric1
  • The warning also notes that serious neuropsychiatric issues linked to bupropion have been reported. (webmd.com)
Alcohol use disorder1
  • Naltrexone and Bupropion are beneficial for those recovering from alcohol use disorder because those physical effects and emotions are stabilized. (alcoholism.org)
Pregnancy1
  • Bupropion use during pregnancy may be associated with increased odds of congenital heart defects. (wikipedia.org)
Initially2
  • The recommended dosage for bupropion is usually one-hundred-fifty milligrams initially depending on the needs of the individual. (alcoholism.org)
  • Initially, bupropion slows the weight gain that often occurs in the first weeks after quitting smoking. (wikipedia.org)
Trials1
  • Previous research has shown that disulfiram, acamprosate, naltrexone, and nalmefene are efficacious in treating AUD, but most studies have been randomized controlled trials or meta-analyses, the authors write. (medscape.com)
Prevents1
  • Naltrexone enters the system and prevents the body from desiring the drug. (alcoholism.org)
Dosage4
  • The total daily dosage is therefore, 32mg of naltrexone and 360mg of bupropion ( 7 ). (phentermine.com)
  • The recommended dosage for naltrexone is different for every individual. (alcoholism.org)
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Withdrawal symptoms1
  • Naltrexone aids in the physical/emotional withdrawal symptoms that come with the stopping of alcohol. (alcoholism.org)
Medicine2
  • Bupropion is a medicine that helps with the emotional side of recovery. (alcoholism.org)
  • People who already take bupropion should not take this medicine. (epnet.com)
Side effects2
Patients5
  • Bupropion is more effective than selective serotonin reuptake inhibitors (SSRIs) at improving symptoms of hypersomnia and fatigue in depressed patients. (wikipedia.org)
  • Naltrexone/bupropion should be used with caution in patients over 65 years of age and is not recommended in patients over 75 years of age (see sections 4.4, 4.8 and 5.2). (medicines.org.uk)
  • Naltrexone/bupropion is contraindicated in patients with end-stage renal failure (see section 4.3). (medicines.org.uk)
  • Naltrexone/bupropion is contraindicated in patients with severe hepatic impairment (see section 4.3). (medicines.org.uk)
  • Naltrexone/bupropion is not recommended in patients with moderate hepatic impairment (see sections 4.4 and 5.2). (medicines.org.uk)
Feelings1
  • Bupropion helps with the mental and emotional feelings that occur from the body fighting the urge of wanting alcohol. (alcoholism.org)
Work1
Similar1
Class1
  • Chemically, bupropion is an aminoketone that belongs to the class of substituted cathinones and more generally that of substituted amphetamines and substituted phenethylamines. (wikipedia.org)