Bupivacaine versus bupivacaine. Medical search. Frequent questions

A sustained-release DepoFoam injection formulation of bupivacaine (EXPAREL, 15 mg/mL) is currently being investigated for postsurgical analgesia via peripheral nerve block (PNB). (hindawi.com)
Single-dose toxicology studies of EXPAREL (9, 18, and 30 mg/kg), bupivacaine solution (Bsol, 9 mg/kg), and saline injected around the brachial plexus nerve bundle were performed in rabbits and dogs. (hindawi.com)
EXPAREL (bupivacaine liposome injectable suspension) is a sterile suspension of multivesicular liposomes using proprietary DepoFoam formulation technology to release bupivacaine over several days. (hindawi.com)
Specifically, the study was designed to assess whether EXPAREL did not produce nerve damage in the setting of peripheral nerve block by comparison with unencapsulated bupivacaine or saline control. (hindawi.com)
Liposomal formulations of bupivacaine (brand name EXPAREL) have not shown clinical benefit compared to plain bupivacaine when used in traditional perineural injections, although some industry-funded studies have suggested benefits when used in local infiltration. (wikipedia.org)
The US Food and Drug Administration's (FDA's) Anesthetic and Analgesic Drug Products Advisory Committee voted 6 to 4 against recommending bupivacaine liposomal injectable suspension ( Exparel , Pacira Pharmaceuticals Inc) as a nerve block to treat regional postsurgical pain. (medscape.com)
Results from a phase 4, double-blind, randomized, controlled trial that compared the efficacy and safety of EXPAREL 266 mg (20 mL) (n=70) and bupivacaine HCl (n=69) in a TKA study. (squintmetrics.com)
Primary end point: EXPAREL reduced opioid consumption by 52%, compared with standard bupivacaine, over 72 hours and maintained a significant opioid-minimizing effect over 2 weeks. (squintmetrics.com)
The ASCRS/SAGES guidelines state that local anesthetics, such as EXPAREL ® (bupivacaine liposome injectable suspension), that are administered via wound infiltration or transverse abdominis plane (TAP) block may effectively manage pain associated with both open and laparoscopic colorectal surgery. (hcplive.com)
The US Food and Drug Administration (FDA) has approved a supplemental new drug application for bupivacaine liposomal injectable suspension ( Exparel , Pacira Pharmaceuticals Inc) for use as an interscalene brachial plexus nerve block to provide regional analgesia following shoulder surgery in adults. (medscape.com)

Spinal anaesthesia for caesarean section: plain vs hyperbaric bupivacaine. (aku.edu)
To compare the clinical characteristics of sensory and motor block as well as haemodynamic stability using plain and hyperbaric bupivacaine in spinal anaesthesia for caesarean section. (aku.edu)
Equal volume of plain and hyperbaric bupivacaine 10 mg with 25 mcg of fentanyl was used for spinal anaesthesia in the two groups that were formed on the basis of random allocation. (aku.edu)
In obstetric population, both plain and hyperbaric bupivacaine 10 mg, with fentanyl produced adequate anaesthesia for caesarean section without any differences in the time of onset, extent of the block and haemodynamic parameters. (aku.edu)
Dive into the research topics of 'Spinal anaesthesia for caesarean section: plain vs hyperbaric bupivacaine. (aku.edu)
Spinal anaesthesia with hyperbaric bupivacaine hydrochloride is popular for longer procedure due to its prolonged duration but there is need to intensify and increased duration of sensory blocked without increasing the intensity and duration of motor blocked and thus prolong the duration of post operative analgesia. (ispub.com)
In the present study we tried to find out effectiveness of 1mcg/kg intrathecal clonidine added to hyperbaric bupivacaine on onset, quality, duration of analgesia and side effects if any in paediatric patients undergoing surgeries below T8 dermatome. (ispub.com)
RCT: a Comparison between a fixed intrathecal dose of 0.5% Hyperbaric Bupivacaine, and tailored intrathecal dose of 0.5% Hyperbaric Bupivacaine based on a modified Harten's Chart in non pregnant patients. (who.int)
After securing informed consent, each patient will be allocated to either group: Arm 1 (Controls group with fixed dose of 0.5% Hyperbaric Bupivacaine (FD Group)), and Arm2: (Cases group with modified dose of 0.5% Hyperbaric Bupivacaine (MD Group)), using the two sides of a coin, where Head is for Arm1 and Tails for Arm2. (who.int)
Arm 2 (MD Group): Spinal Anesthesia with dose of 0.5% hyperbaric Bupivacaine chosen accorded to height and weight following a modified Harten's chart table + 25 micrograms of Fentanyl. (who.int)
the dose administered will be: 0.5% Hyperbaric Bupivacaine according to Harten's chart + 1 ml 0.5% Hyperbaric Bupivacaine + 25 micrograms Fentanyl, will be administered intrathecally immediately after placing the standard anesthesiology monitors (blood pressure cuff for blood pressure, pulse oximeter for heart rate and oxygen saturation) and before the operation room timeout for surgery. (who.int)

Researchers hope to learn whether giving the longer-acting local anesthetic liposomal bupivacaine prior to closing the sternum is more effective in managing pain following sternotomy, than in patients who received standard bupivacaine before sternal closure. (centerwatch.com)

Patients who received a liposomal bupivacaine transversus abdominis plane block used statistically significantly less intravenous and total postoperative narcotics in milligrams and milligrams per kilogram per day compared with all other cohorts. (duke.edu)
The authors were able to demonstrate a significant reduction in intravenous and total narcotic use when a liposomal bupivacaine transversus abdominis plane block was used. (duke.edu)
Conclusions The intraperitoneal administration of combination of magnesium sulphate and bupivacaine is a safe and effective method in the management of postoperative pain after laparoscopic surgeries more than intravenous administration of ordinary analgesics in laparoscopic surgeries in pediatrics. (bmj.com)
There have been reports of cardiac arrest and death during the use of bupivacaine for intravenous regional anesthesia (Bier Block). (nih.gov)
Epidural anesthesia with bupivacaine, bupivacaine and fentanyl, or bupivacaine and sufentanil during intravenous administration of propofol for ovariohysterectomy in dogs. (scielo.br)
Sufentanil analgesia following cesarean section: epidural versus intravenous administration. (scielo.br)
Torske KE, Dyson DH, Pettifer G. End tidal halothane concentration and postoperative analgesia requirements in dogs: a comparison between intravenous oxymorphone and epidural bupivacaine alone and in combination with oxymorphone. (scielo.br)
The exact etiology of ED is still unidentified but several risk factors that have been noted to increase the predilection for emergence agitation such as preschool age, preoperative anxiety, certain surgical procedures like otolaryngologic or ophthalmologic surgeries, anesthesia technique (inhalational vs. intravenous agent or regional block), and postoperative pain (Kanaya, 2016 ). (springeropen.com)

As reported by Medscape Medical News , the FDA approved bupivacaine liposomal injectable suspension in 2011 for "administration into the surgical site to produce postsurgical analgesia. (medscape.com)
In February, as reported by Medscape Medical News , the FDA Anesthetic and Analgesic Drug Products Advisory Committee voted 6 to 4 against recommending bupivacaine liposomal injectable suspension as a nerve block to treat general regional postsurgical pain. (medscape.com)
In line with that recommendation, the FDA has concluded that clinical trial data are "not sufficient" to support the general use of bupivacaine liposomal injectable suspension for regional nerve blocks for analgesia after surgeries other than shoulder surgery. (medscape.com)
Bupivacaine liposomal injectable suspension was first approved by the FDA in 2011 for administration into the local surgical site to provide postsurgical analgesia. (medscape.com)

Doses of ≤50 mg bupivacaine equivalents (20 ml 0.25% bupivacaine on each side, for example) are recommended on each side to balance analgesia efficacy with risk of local anesthetic systemic toxicity (LAST). (asra.com)
Blood samples of 1.0 ml were drawn from the jugular vein prior to bupivacaine administration (0 hour) and at 0.25, 0.5, 1, 2, 3, 4, 6, and 12 hours after administration. (vin.com)
Patients of group B received caudal injectate of 1 ml/kg bupivacaine 0.25%, while group BK patients received caudal injectate of 1 ml/kg bupivacaine 0.25% mixed with ketamine 0.5 mg/kg, and group BD patients received caudal injectate of 1 ml/kg bupivacaine 0.25% mixed with dexmedetomidine 1 μg/kg. (springeropen.com)

Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. (wikipedia.org)

The purpose of this study is to compare the efficacy, duration of motor block until return to normal function in the non-operated leg after the start of injection, of ropivacaine 5 mg/ml and bupivacaine 5 mg/ml when used for spinal anaesthesia in patients undergoing unilateral lower limb surgery. (astrazenecaclinicaltrials.com)
Bupivacaine and Ropivacaine, the long acting Local Anaesthetics when given intraperitoneally provide effective pain relief when the pain peaks within 4-6 hours of surgery. (researchbib.com)
Aim: To compare the efficacy of intraperitoneally nebulised Ropivacaine 0.75% and Bupivacaine 0.5% for postoperative analgesia in Laparoscopic surgeries. (researchbib.com)
They were randomly divided into two groups of 30 patients each: Group R (Ropivacaine) - received intra-peritoneal nebulization of Ropivacaine 0.75% 4 ml (30 mg) after the placement of umbilical port and Group B (Bupivacaine) - received intra peritoneal nebulization of Bupivacaine 0.5% 4 ml (20 mg) after the placement of umbilical port. (researchbib.com)
Conclusion: From the present study, it is concluded that both Bupivacaine and Ropivacaine are safe and similarly efficacious in reducing postoperative pain following intra-peritoneal nebulization in laparoscopic surgeries. (researchbib.com)
We aimed to compare the effects of bupivacaine and ropivacaine on QT interval, corrected QT, dispersion of QT, and corrected dispersion of QT in patients undergoing lung resection under thoracic epidural anaesthesia combined with general anaesthesia. (balkanmedicaljournal.org)
Patients were randomly assigned to two groups, which were allocated to receive either bupivacaine (Group B) or ropivacaine (Group R) during thoracic epidural anaesthesia. (balkanmedicaljournal.org)
The corrected QT, dispersion of QT, and corrected dispersion of QT intervals were slightly longer in the patients receiving bupivacaine compared with those receiving ropivacaine in various phases of the present study. (balkanmedicaljournal.org)
This study also included a group of patients treated with Zynrelef plus ropivacaine, as well as those who received bupivacaine only. (empr.com)
The present study aims the evaluation of hemodynamic reaction and efficiency of Intrathecal hyperbaric 0.5% Bupivacaine with isobaric 0.75% Ropivacaine utilizing Fentanyl in subjects who were planned for infra umbilical surgeries. (aijournals.com)
All the patients were included in one of the 2 underneath declared groups as Bupivacaine group (Group B) n=25 and Ropivacaine group (Group R) n=25. (aijournals.com)

However, plain bupivacaine took more time for two dermatomes sensory level regression below T4, and resulted in prolonged block duration. (aku.edu)

A total of 215 American Society of Anesthesiologists physical status II, laboring parturients requesting labor epidural analgesia consented to the study and were randomized to receive 0.125% bupivacaine with the addition of either fentanyl (2 μg/ml) or neostigmine (2, 4, or 8 μg/ml). (silverchair.com)
The primary outcome was total hourly local anesthetic consumption, defined as total patient-controlled epidural analgesia use and top-ups (expressed as milliliters of 0.125% bupivacaine) divided by the infusion duration. (silverchair.com)
Determination of the analgesic dose-response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients. (scielo.br)
Methods: Forty adult patients of American Society of Anesthesiologists grade I-II undergoing upper abdominal surgery were randomly allocated into two groups to receive 50 µg fentanyl or 50 µg dexmedetomidine as an adjunct to 10 ml 0.125% bupivacaine via thoracic epidural. (bvsalud.org)

Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. (wikipedia.org)

These highlights do not include all the information needed to use BUPIVACAINE HYDROCHLORIDE INJECTION safely and effectively. (nih.gov)
There have been reports of cardiac arrest with difficult resuscitation or death during use of bupivacaine hydrochloride for epidural anesthesia in obstetrical patients. (nih.gov)
The 0.75% (7.5 mg/mL) concentration of bupivacaine hydrochloride is not recommended for obstetrical anesthesia and should be reserved for surgical procedures where a high degree of muscle relaxation and prolonged effect are necessary ( 5.1 ). (nih.gov)
Bupivacaine hydrochloride injection contains bupivacaine hydrochloride, an amide local anesthetic indicated in adults for the production of local or regional anesthesia or analgesia for surgery, oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. (nih.gov)
Recommended concentrations and dosages of bupivacaine hydrochloride injection according to type of block. (nih.gov)
Bupivacaine hydrochloride injection is available in multiple concentrations. (nih.gov)
Known hypersensitivity to bupivacaine or to any local anesthetic agent of the amide-type or to other components of bupivacaine hydrochloride injection. (nih.gov)
Monitor cardiovascular and respiratory vital signs and patient's state of consciousness after injection of bupivacaine hydrochloride. (nih.gov)
Intra-articular infusions of local anesthetics including bupivacaine hydrochloride following arthroscopic and other surgical procedures is an unapproved use, and there have been post-marketing reports of chondrolysis in patients receiving such infusions. (nih.gov)

Zynrelef is a dual-acting local anesthetic that delivers a fixed-dose combination of bupivacaine, an amide local anesthetic, and meloxicam, a nonsteroidal anti-inflammatory drug (NSAID). (empr.com)
2 , this drug is classified as an amide local anesthetic, such as lidocaine, mepivacaine, prilocaine and bupivacaine. (bvsalud.org)

In this report, we present two exceptional cases of female patients who developed Nicolau syndrome after receiving a spinal anesthetic injection of bupivacaine. (journalajrdes.com)

Efficacy of lidocaine vs combination of lidocaine and bupivacaine in management of maxillofacial trauma: a clinical comparative study. (covidnewscast.com)
The aim of the study was to evaluate the onset, duration, depth, required volume of anaesthesia of lidocaine with epinephrine versus combination of lidocaine and bupivacaine with epinephrine anaesthetic agents in surgical management of isolated mandibular fracture patients. (covidnewscast.com)
345). The study found that the combination of lidocaine and bupivacaine could serve as a potential anaesthetic cocktail in effective surgical management of isolated mandibular fractures. (covidnewscast.com)
Maxillofacial injuries can be managed efficiently under local anaesthesia using combination of lidocaine and bupivacaine. (covidnewscast.com)
Local anesthetics, such as lidocaine and bupivacaine, function by blocking ion channels thereby preventing impulse conduction of pain. (vin.com)

Campoy L, Martin-Flores M, Ludders JW, Erb HN, Gleed RD. Comparison of bupivacaine femoral and sciatic nerve block versus bupivacaine and morphine epidural for stifle surgery in dogs. (scielo.br)
Al-Zahrani T, Doais KS, Aljassir F, Alshaygy I, Albishi W, Terkawi AS (2015) Randomized clinical trial of continuous femoral nerve block combined with sciatic nerve block versus epidural analgesia for unilateral total knee arthroplasty. (springer.com)

A formulation of bupivacaine that provides prolonged release of the active ingredient after a single administration would simplify pain management in the postoperative period and eliminate the undesired peak plasma concentrations as a result of excessively high concentrations and reduce the risk of local and systemic reactions [ 7 ]. (hindawi.com)
An implantable formulation of bupivacaine (Xaracoll) was approved for medical use in the United States in August 2020. (wikipedia.org)

The authors hypothesized that epidural bupivacaine with neostigmine would decrease total hourly bupivacaine use compared with epidural bupivacaine with fentanyl for patient-controlled epidural analgesia. (silverchair.com)
The total median hourly bupivacaine consumption in the fentanyl group was 16.0 ml/h compared with 15.3, 14.6, and 16.2 ml/h in the 2, 4, and 8 μg/ml neostigmine groups, respectively ( P = 0.55). (silverchair.com)

Among patients undergoing unilateral simple bunionectomy (N=412), treatment with Zynrelef was associated with a significant reduction in pain intensity compared with either bupivacaine HCl or saline placebo for up to 72 hours. (empr.com)

The fixed-dose combination of bupivacaine with Type I collagen (brand name Xaracoll) is indicated for acute postsurgical analgesia (pain relief) for up to 24 hours in adults following open inguinal hernia repair. (wikipedia.org)

The study was done to compare the efficacy, duration, quality and side effects of intrathecal bupivacaine alone and bupivacaine plus clonidine. (ispub.com)
Aim of the work studying analgesic efficacy of intraperitoneal instillation of a combination of Magnesium sulphate with bupivacaine versus ordinary parentral analgesics for pain relief after laparoscopic surgeries in pediatrics. (bmj.com)
The aim of this study was to compare the efficacy and side effect profile of dexmedetomidine as an adjunct to bupivacaine in single dose FICB for femur surgeries in two different r. (researchgate.net)
This study did not find efficacy of the study drug against placebo. (medscape.com)
The aim of the study was to compare the efficacy of dexmedetomidine against propofol infusion when used for controlled hypotension during FESS. (bvsalud.org)

Objective: Compare transversus abdominis plane (TAP) blocks with liposomal bupivacaine were to epidural analgesia for pain at rest and opioid consumption in patients recovering from abdominal surgery. (utmb.edu)
Methods: Patients having major abdominal surgery were enrolled at six sites and randomly assigned 1:1 to thoracic epidural analgesia or bilateral/4-quadrant TAP blocks with liposomal bupivacaine. (utmb.edu)

Patients were randomized to one of three groups: liposomal bupivacaine transversus abdominis plane block, or bupivacaine pain pump. (duke.edu)
There were eight patients in the liposomal bupivacaine and bupivacaine transversus abdominis plane block groups and five patients in the pain pump group. (duke.edu)
Mean total rescue analgesic required was 95+33.3 mg Diclofenac in group R vs. 112.6+38.4 in group B with 26% of group R requiring 2nd dose of rescue analgesic and 50% of patients in group B required 2nd dose and was not statistically significant. (researchbib.com)
Part 1 of PERSIST consists of 92 patients receiving either POSIMIR or placebo, and Part 2 consists of 296 patients receiving either POSIMIR or standard bupivacaine HCl. (prnewswire.com)
In a previous clinical trial of 50 patients undergoing laparoscopic cholecystectomy, POSIMIR was compared with the active control bupivacaine HCl, against which POSIMIR demonstrated in a post hoc analysis an approximately 25% reduction in pain intensity on movement for the first 3 days after surgery (p=0.024) and for the first 2 days after surgery (p=0.0198), using the same statistical methodology specified for the current trial. (prnewswire.com)
Additionally, a significant proportion of patients in the Zynrelef arm did not receive opioid analgesia (29% vs 11% for bupivacaine HCl and 2% for saline placebo). (empr.com)
Bupivacaine extended release liposome injection for prolonged postsurgical analgesia in patients undergoing hemorrhoidectomy: a multicenter, randomized, double-blind, placebo-controlled trial. (squintmetrics.com)
The aim of this study was to compare the effect of dexmedetomidine versus ketamine when added to caudal bupivacaine on the incidence of emergence delerium (ED), postoperative sedation, and analgesia in pediatric patients undergoing inguinal hernia repair under sevoflurane anesthesia. (springeropen.com)
It was hypothesized that patients who received an interscalene block with both bupivacaine and liposomal bupivacaine would have a decreased diaphragmatic excursion when compared to bupivacaine alone at 24 h. (umn.edu)
METHODS: This was a double-blinded study of adult patients who were randomized to receive an interscalene block with either 20 ml 0.5% bupivacaine (bupivacaine group) or 10 ml 0.5% bupivacaine plus 10 ml liposomal bupivacaine (liposomal bupivacaine group). (umn.edu)
Five patients in the liposomal bupivacaine group had a greater than 25% reduction in diaphragmatic excursion at 24 h versus zero in the bupivacaine group. (umn.edu)
Patients were divided into two groups: one group received Bupivacaine with clonidine, and the other group received only bupivacaine at a dose of 15 mg. (bvsalud.org)
The researchers conducted a randomized clinical trial protocol to assess autonomic function at motor recovery in patients receiving spinal anesthesia with isobaric bupivacaine alone or clonidine-associated isobaric bupivacaine. (bvsalud.org)

Additionally, bupivacaine can cause chondrolysis after continuous infusion into a joint space. (wikipedia.org)
The court found as a matter of law that the information allegedly possessed by defendant was insufficient to trigger AstraZeneca's duty to warn of the risk of cartilage damage from continuous infusion of bupivacaine into a patient's joint. (masstortdefense.com)

The goal of this prospective, randomized, controlled, blinded study was to examine the effect that liposomal bupivacaine delivered by means of a transversus abdominis plane block has on pain control in women undergoing unilateral deep inferior epigastric perforator flap reconstruction. (duke.edu)
This is the first study to investigate liposomal bupivacaine delivered as a transversus abdominis plane block in a prospective, randomized, blinded study in women undergoing unilateral, delayed, abdominally based autologous breast reconstruction. (duke.edu)

Andersen KV, Nikolajsen L, Haraldsted V, Odgaard A, Søballe K (2013) Local infiltration analgesia for total knee arthroplasty: should ketorolac be added? (springer.com)
Local infiltration analgesia with liposomal bupivacaine improves pain scores and reduces opioid use after total knee arthroplasty: results of a randomized controlled trial. (squintmetrics.com)

Bupivacaine (Posimir) is indicated in adults for administration into the subacromial space under direct arthroscopic visualization to produce post-surgical analgesia for up to 72 hours following arthroscopic subacromial decompression. (wikipedia.org)

10. Abelson AL, Armitage-Chan E, Lindsey JC, Wetmore LA. A comparison of epidural morphine with low dose bupivacaine versus epidural morphine alone on motor and respiratory function in dogs following splenectomy. (scielo.br)
Zynrelef extended-release solution is supplied in 4 dosage strengths as single-dose vials: 400mg bupivacaine/12mg meloxicam, 300mg bupivacaine/9mg meloxicam, 200mg bupivacaine/6mg meloxicam, and 60mg bupivacaine/1.8mg meloxicam. (empr.com)

Intrathecal Bupivacaine Vs. Bupivacaine And Clonidine In Paediatrics Age Group: A Comparative Evaluation. (ispub.com)

DRRX ) today announced that patient enrollment has been completed in PERSIST, the pivotal Phase 3 clinical trial of POSIMIR® (SABER®-Bupivacaine), an investigational locally acting, non-opioid analgesic intended to provide up to three days of continuous pain relief after surgery. (prnewswire.com)
POSIMIR is an investigational extended-release depot utilizing DURECT's patented SABER technology intended to continuously deliver bupivacaine to the surgical site for 72 hours, to provide up to three days of continuous pain relief after surgery. (prnewswire.com)
One late-stage product candidate in this category is POSIMIR ® (SABER ® -Bupivacaine), an investigational locally-acting, non-opioid analgesic intended to provide up to 3 days of continuous pain relief after surgery. (prnewswire.com)

Browne C, Copp S, Reden L, Pulido P, Colwell C Jr (2004) Bupivacaine bolus injection versus placebo for pain management following total knee arthroplasty. (springer.com)
Carli F, Clemente A, Asenjo JF, Kim DJ, Mistraletti G, Gomarasca M, Morabito A, Tanzer M (2010) Analgesia and functional outcome after total knee arthroplasty: periarticular infiltration versus continuous femoral nerve block. (springer.com)
The Food and Drug Administration (FDA) has approved Zynrelef™ (bupivacaine and meloxicam) extended-release solution for use in adults for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours in adults after bunionectomy, open inguinal herniorrhaphy and total knee arthroplasty. (empr.com)
Zynrelef also showed a significant reduction in pain intensity vs saline placebo for the first 48-hour and 72-hour postoperative periods in patient who underwent primary unilateral total knee arthroplasty (N=222). (empr.com)

From a systemic standpoint, high doses of bupivacaine may be associated with a wide range of systemic complications, such as central nervous and cardiovascular effects [ 6 ]. (hindawi.com)
Large doses of lidocaine (up to 55 mg/kg, versus the conventional maximum of 4.5 mg/kg) are used for tumescent anesthesia, in which a dilute local anesthetic solution is injected into subcutaneous tissue until it becomes firm and tense. (medscape.com)

Clinically significant adverse events result from systemic absorption of bupivacaine and primarily involve the central nervous and cardiovascular systems. (wikipedia.org)

Bupivacaine is a local anesthetic/analgesic widely used in the perioperative and postsurgical settings. (hindawi.com)
Compared to other local anaesthetics, bupivacaine is markedly cardiotoxic. (wikipedia.org)
Birds may be more sensitive to the toxic effects of local anesthetics compared to mammals, but the pharmacokinetics of bupivacaine are unknown in birds. (vin.com)
The appearance of subsequent high levels of plasma bupivacaine is unique to this study and may also contribute to the apparent avian sensitivity to toxic effects of local anesthetics. (vin.com)
the local anesthetic-bupivacaine Hcl - was manufactured and sold by defendant AstraZeneca. (masstortdefense.com)
el bloqueo del nervio dentario inferior es el método más usado por los endodoncistas para obtener anestesia local en sus tratamientos. (bvsalud.org)
No se encontraron diferencias estadísticamente significativas al comparar la local, lidocaína, eficacia anestésica en molares con pulpa normal y molares con pulpa inflamada (aunque el porcentaje de articaína éxito en pulpa normal fue mayor que en dientes con pulpitis irreversible). (bvsalud.org)

Liposomal bupivacaine is approved for use in interscalene blocks with the potential to provide longer pain control. (umn.edu)
CONCLUSIONS: The addition of liposomal bupivacaine to bupivacaine in an interscalene block results in statistically significant reductions in diaphragm excursion and pulmonary function testing 24 h after block placement when compared to bupivacaine alone. (umn.edu)

The patient's head needs to be shielded against unexpected impacts with the robot arms because the robot arms' range can be quite extensive. (pulsus.com)

The effectiveness and comparative effectiveness (benefits [KQ 1] and harms [KQ 2]) of long-term opioid therapy versus placebo, no opioid therapy, or nonopioid therapy. (cdc.gov)
Results vs placebo through 72 hours. (squintmetrics.com)

The investigators hypothesized that a lower concentration of bupivacaine would cause less weakness of the diaphragm but still provide good pain relief. (druglib.com)
High levels were also evident in five of eight ducks at 360 min (0.061±0.05 µg/ml) and in six of eight ducks at 720 min ( and 0.074±0.04 µg/ml) The plasma concentration vs. time distribution is shown in Fig 1. (vin.com)
Plasma concentration of bupivacaine (µg/ml) following subcutaneous injection of 2 mg/kg of a 0.5% solution in female mallard ducks. (vin.com)
Six and 12 hour samples represent high levels in plasma bupivacaine concentration. (vin.com)

Epidural morphine vs. intercostal bupivacaine. (scielo.br)

21 The role of liposomal bupivacaine, which provides longer duration of analgesia, shows some promise in the CD setting. (asra.com)

Awake sedation score with clonidine was better than bupivacaine alone. (ispub.com)

An MRI allegedly revealed that plaintiff had developed chondrolysis in her shoulder, which she alleged was caused by the post-surgery administration of the bupivacaine with the pain pump. (masstortdefense.com)

Bupivacaine solutions have been used for many years by multiple routes for the relief of postoperative pain [ 1 ]. (hindawi.com)

In group B that is Bupivacaine the sensory block was found to be elevated as compared to group R. the dissimilarity was establish to be statistical important. (aijournals.com)

In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage. (nih.gov)

Concentrations of bupivacaine in plasma were determined by high-performance liquid chromatography. (vin.com)

Anatomy3

Diseases2

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Psychiatry and Psychology1

Phenomena and Processes6

Health Care1

Exparel10

Hyperbaric bupivacaine11

Received standard bupivacaine1

Intravenous8

Injectable suspension4

0.253

Contraindicated in patients with1

Ropivacaine11

Plain bupivacaine1

0.1254

Peripheral nerve1

Hydrochloride9

Amide2

Injection of bupivacaine1

Lidocaine and bupivacaine5

Sciatic nerve block versus2

Formulation of bupivacaine2

Fentanyl2

Either bupivacaine1

Fixed-dose combin1

Efficacy5

Epidural analgesia2

Patients13

Infusion2

Transversus abdominis plane2

Infiltration analgesia2

Arthroscopic1

Dose2

Intrathecal1

Posimir3

Total knee arthroplasty4

Doses2

Systemic1

Local7

Interscalene2

Patient's1

Placebo2

Concentration4

Morphine1

Duration1

Clonidine1

Pain pump1

Postoperative1

Sensory1

Cartilage1

Concentrations1