AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
BupivacaineAnesthetics, LocalAnesthesia, SpinalAnalgesia, EpiduralAmidesAnalgesia, ObstetricalAnesthesia, EpiduralAnesthesia, ObstetricalNerve BlockLidocainePain, PostoperativeAnesthesia, CaudalEtidocaineAnesthesia, LocalSufentanilFentanylAnesthetics, CombinedDouble-Blind MethodAdjuvants, AnesthesiaMepivacaineInjections, SpinalCesarean SectionCarticaineAnalgesics, OpioidPain MeasurementAnalgesiaStereoisomerismSensationSubarachnoid SpaceAnalgesia, Patient-ControlledMorphineBrachial PlexusLabor, ObstetricDose-Response Relationship, DrugProcaineInjections, EpiduralAmbulatory Surgical ProceduresPregnancyPrilocaineEpinephrineSpecific GravitySciatic NerveThoracotomyHernia, Inguinal
EpiduralPlain BupivacaineHydrochloride InjectionHyperbaric bupivacaine plusFentanylDifferent concentrations of bupivacaine2016Intrathecal0.25SpinalFormulations of bupivacaineInguinal hernia repairLiposomalRegional anesthesiaInjectionLumbar0,125FormulationMepivacaineEpubAmideCardiotoxic2017ArthroscopicConcentration0.68Chemical NamePatientsMarcaineConclusionsDosesDoseGroupInfusionVentricularMedicationClinicallyBlockLocalMethodsSurgicalGroupsPregnant
Epidural10
  • There have been reports of cardiac arrest with difficult resuscitation or death during use of Bupivacaine Hydrochloride Injection for epidural anesthesia in obstetrical patients. (nih.gov)
  • Three mL of Bupivacaine Hydrochloride and Epinephrine Injection without antimicrobial preservative (0.5% bupivacaine with 1:200,000 epinephrine) is recommended for use as a test dose prior to caudal and lumbar epidural blocks when clinical conditions permit. (nih.gov)
  • Concentrated bupivacaine is not recommended for epidural freezing. (wikipedia.org)
  • Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. (wikipedia.org)
  • Bupivacaine has caused several deaths when the epidural anaesthetic has been administered intravenously accidentally. (wikipedia.org)
  • Bupivacaine Hydrochloride is available in sterile isotonic solutions with and without epinephrine (as bitartrate) 1:200,000 for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks. (nih.gov)
  • Bupivacaine hydrochloride, when administered properly, via the epidural route in doses 10 to 12 times the amount used in spinal anesthesia has been used for obstetrical analgesia and anesthesia without evidence of adverse effects on the fetus. (pfizermedicalinformation.com)
  • We also considered the possibility that a combination of epidural sufentanil and bupivacaine would demonstrate superior analgesia and fewer side effects when compared with either agent alone. (bmj.com)
  • Using a randomized, double-blind design, parturients were prospectively assigned to receive intermittent 10-ml doses of 3 μg/ml sufentanil in saline (Group S), 1.5 μg/ml sufentanil in 0.125% bupivacaine (Group SB), or 0.25% bupivacaine (Group B). Lumbar epidural catheters were placed during the first stage of labor, and a test dose (3 ml 2% lidocaine with 15 μg epinephrine) was given, followed by coded study solution. (bmj.com)
  • 5 ] However, it appears that with good breastfeeding support, epidural fentanyl plus bupivacaine has little overall effect on breastfeeding success. (nih.gov)
Plain Bupivacaine5
  • Liposomal formulations of bupivacaine (brand name EXPAREL) have not shown clinical benefit compared to plain bupivacaine when used in traditional perineural injections, although some industry-funded studies have suggested benefits when used in local infiltration. (wikipedia.org)
  • This retrospective study compares the effect of using LB versus plain bupivacaine on postoperative pain control, length of hospital stay and cost among patients undergoing vaginal reconstructive surgery. (canjurol.com)
  • Patients who underwent vaginal reconstructive surgery with levatorplasty and received an injection of 20 cc of either plain bupivacaine or LB for pudendal nerve block were included. (canjurol.com)
  • Between June 2016 and December 2021, 25 patients had received LB as a pudendal nerve block and 25 had received plain bupivacaine. (canjurol.com)
  • LB is not superior to plain bupivacaine for controlling pain following vaginal reconstructive surgery, and justification for the exponentially greater cost of LB is not supported. (canjurol.com)
Hydrochloride Injection9
  • These highlights do not include all the information needed to use BUPIVACAINE HYDROCHLORIDE INJECTION safely and effectively. (nih.gov)
  • The 0.75% (7.5 mg/mL) concentration of Bupivacaine Hydrochloride Injection is not recommended for obstetrical anesthesia and should be reserved for surgical procedures where a high degree of muscle relaxation and prolonged effect are necessary ( 5.1 ). (nih.gov)
  • Bupivacaine Hydrochloride Injection contains bupivacaine, an amide local anesthetic. (nih.gov)
  • Bupivacaine Hydrochloride Injection is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. (nih.gov)
  • Recommended concentrations and dosages of Bupivacaine Hydrochloride Injection/Bupivacaine Hydrochloride and Epinephrine Injection according to type of block. (nih.gov)
  • Bupivacaine Hydrochloride Injection, USP are available in multiple concentrations. (nih.gov)
  • Known hypersensitivity to bupivacaine or to any local anesthetic agent of the amide-type or to other components of Bupivacaine Hydrochloride Injection/Bupivacaine Hydrochloride and Epinephrine Injection. (nih.gov)
  • Monitor cardiovascular and respiratory vital signs and patient's state of consciousness after injection of Bupivacaine Hydrochloride Injection/Bupivacaine Hydrochloride and Epinephrine Injection. (nih.gov)
  • Intra-articular infusions of local anesthetics including Bupivacaine Hydrochloride Injection following arthroscopic and other surgical procedures is an unapproved use, and there have been post-marketing reports of chondrolysis in patients receiving such infusions. (nih.gov)
Hyperbaric bupivacaine plus1
Fentanyl5
  • The purpose of this study was to evaluate the onset and duration of sensory and motor block as well as adverse effects of adding exmedetomidine, fentanyl or magnesium to hyperbaric bupivacaine for spinal anesthesia. (statperson.com)
  • The cumulative maternal fentanyl dosages ranged from 50 to 400 mcg and the longest time from last dose to delivery was 3.1 hours (range 0 to 3.1 hours). (nih.gov)
  • Arm 2 (MD Group): Spinal Anesthesia with dose of 0.5% hyperbaric Bupivacaine chosen accorded to height and weight following a modified Harten's chart table + 25 micrograms of Fentanyl. (who.int)
  • the dose administered will be: 0.5% Hyperbaric Bupivacaine according to Harten's chart + 1 ml 0.5% Hyperbaric Bupivacaine + 25 micrograms Fentanyl, will be administered intrathecally immediately after placing the standard anesthesiology monitors (blood pressure cuff for blood pressure, pulse oximeter for heart rate and oxygen saturation) and before the operation room timeout for surgery. (who.int)
  • The aim of this study is to test the visibility of providing analgesia during mastectomy surgery using fentanyl (F) as an adjuvant to bupivacaine (B) through the lumbar IT route. (eg.net)
Different concentrations of bupivacaine2
  • The purpose of this study is to compare the efficacy of US-guided TAPB at two different concentrations of bupivacaine in pediatrics undergoing unilateral inguinal hernia repair. (istanbul.edu.tr)
  • Certain voltage- and time-dependencies of ICa,L were recorded using the whole-cell patch clamp method in the presence and absence of different concentrations of bupivacaine. (nih.gov)
20161
  • Med Princ Pract (2016) 25 (5): 417-422. (karger.com)
Intrathecal2
  • RCT: a Comparison between a fixed intrathecal dose of 0.5% Hyperbaric Bupivacaine, and tailored intrathecal dose of 0.5% Hyperbaric Bupivacaine based on a modified Harten's Chart in non pregnant patients. (who.int)
  • Patient were divided into three groups of 20 each randomly, Group A- intrathecal bupivacaine (0.5% heavy) 3ml (15mg) + 75mcg of intrathecal clonidine, Group B- intrathecal bupivacaine (0.5% heavy) 3ml (15mg) + 3 mcg/Kg of intravenous clonidine over 10min, Group C - (control group) - intrathecal bupivacaine (0.5% heavy) 3ml (15mg) + 0.5ml of normal saline, intrathecally in L3-L4 interspace with a 25G Quinke's needle. (oaji.net)
0.253
  • The aim of this study was to evaluate the effect of preoperative vs. postoperative plain 0.25 % bupivacaine TAP block on postoperative opioid use after colorectal surgery. (medscape.com)
  • A retrospective cohort study comparing postoperative opioid use in patients who received preoperative ( n = 240) vs. postoperative ( n = 22) plain 0.25 % bupivacaine TAP blocks. (medscape.com)
  • Plain 0.25 % bupivacaine TAP block administered postoperatively was associated with significantly lower need for postoperative PCA and discharge opioid medications. (medscape.com)
Spinal4
  • addition of dexmedetomidine prolonged the sensory and motor block significantly when used with hyperbaric bupivacaine for spinal anesthesia. (statperson.com)
  • Objective: To compare two different doses of hyperbaric bupivacaine in unilateral spinal anaesthesia among geriatric patients in hemiarthroplasty surgery. (fortuneonline.org)
  • an experienced anesthesiologist will give spinal anaesthesia (injecting the previously mentioned mixture intrathecally) using a 25 G pencil point needle, at level of L2-L3 or L3-L4. (who.int)
  • The researchers conducted a randomized clinical trial protocol to assess autonomic function at motor recovery in patients receiving spinal anesthesia with isobaric bupivacaine alone or clonidine-associated isobaric bupivacaine. (bvsalud.org)
Formulations of bupivacaine1
  • However, there is no information, data, or opinion in the public domain that would suggest any impact on chronic pain from these sustained-release formulations of bupivacaine. (justia.com)
Inguinal hernia repair2
  • The fixed-dose combination of bupivacaine with Type I collagen (brand name Xaracoll) is indicated for acute postsurgical analgesia (pain relief) for up to 24 hours in adults following open inguinal hernia repair. (wikipedia.org)
  • Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial. (istanbul.edu.tr)
Liposomal1
Regional anesthesia1
  • There have been reports of cardiac arrest and death during the use of bupivacaine for intravenous regional anesthesia (Bier Block). (nih.gov)
Injection3
  • Recent clinical reports and animal research suggest that these cardiovascular changes are more likely to occur after unintended intravascular injection of bupivacaine. (nih.gov)
  • L'anesthésie rachidienne continue pour la chirurgie de la fracture de la hanche chez le sujet âgé préserve plus l'hémodynamique per opératoire comparativement à l'anesthésie générale et à la rachianesthésie en injection unique. (latunisiemedicale.com)
  • steroid injection with methylprednisolone and bupi- vacaine to splinting with a thumb spica was found.3All patients in the steroid injection group (9/9)achieved complete relief of pain whereas none of the New reviews patients in the thumb spica group (0/9) had completerelief of pain, 1 to 6 days after intervention (number needed to treat to benefit [NNTB]=1.95% CI 0.8 to1.2). (medtheses.com)
Lumbar1
  • Patients and methods Forty-four patients were divided into two equal groups: one group was given general anesthesia only and the other group given lumbar IT 20 mg bupivacaine plus F 25 microgram (mcg) in lateral position followed by general anesthesia. (eg.net)
0,1251
  • After random allocation, 74 children aged 1-8 were randomized to receive US-guided TAPB by using 1 mg.kg − 1 bupivacaine as either 0,25% (0,4 ml.kg − 1 ) (Group 1) or 0,125% (0,8 ml.kg − 1 ) (Group 2) concentration. (istanbul.edu.tr)
Formulation1
  • An implantable formulation of bupivacaine (Xaracoll) was approved for medical use in the United States in August 2020. (wikipedia.org)
Mepivacaine1
Epub2
  • Epub 2015 Aug 25. (nih.gov)
  • Epub 2012 Dec 25 doi: 10.1007/s11748-012-0197-x. (nih.gov)
Amide1
  • Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. (wikipedia.org)
Cardiotoxic1
20171
  • The USA was the largest country in the market in 2017, accounting for nearly 25% market share. (powershow.com)
Arthroscopic1
  • Bupivacaine (Posimir) is indicated in adults for administration into the subacromial space under direct arthroscopic visualization to produce post-surgical analgesia for up to 72 hours following arthroscopic subacromial decompression. (wikipedia.org)
Concentration1
  • RESULTS: Bupivacaine, in a concentration-dependent manner (10-300 microM), tonically inhibited the peak amplitude of ICa,L. The inhibition was characterized by an increase in the time of recovery from inactivation and a negative-voltage shift of the steady-state inactivation curve. (nih.gov)
0.681
  • Furthermore, subjective pain was also similar between groups (0 vs. 1.6 ± 2.6, p = 0.68), (4.6 ± 2.3 vs. 4.9 ± 2.0 average POD 1 pain, p = 0.534) and (4.3 ± 2.1 for vs. 4.9 ± 2.1 average POD 2 pain, p = 0.373). (canjurol.com)
Chemical Name1
  • Molecular Formula:C62H98N16O22 Molecular Weight:1419.56 CAS: 137525-51-0 Chemical Name: BPC 157 MDL Number: MFCD06407962 Name : BPC-157 Synonyms:Booly protection compound 157, Gastric Juice Peptide. (yuanlongbiological.com)
Patients2
  • 38 articles, of which we collected 46 patients (25 women, 21 men), mean age of 52 years. (scielo.br)
  • Patients were divided into two groups: one group received Bupivacaine with clonidine, and the other group received only bupivacaine at a dose of 15 mg. (bvsalud.org)
Marcaine1
  • Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. (wikipedia.org)
Conclusions1
  • CONCLUSIONS: The inhibition of ICa,L appears, in part, to result from bupivacaine predisposing L-type Ca channels to the inactivated state. (nih.gov)
Doses2
  • Bupivacaine hydrochloride produced developmental toxicity when administered subcutaneously to pregnant rats and rabbits at doses 30-times the MHRD. (pfizermedicalinformation.com)
  • Bupivacaine hydrochloride was administered subcutaneously to rats at doses of 4.4, 13.3, and 40 mg/kg and to rabbits at doses of 1.3, 5.8, and 22.2 mg/kg during the period of organogenesis (implantation to closure of the hard palate). (pfizermedicalinformation.com)
Dose2
  • We revealed that the jicama fiber at the dose of 10% and 25% effectively precluded a marked increase in random and fasting blood glucose levels and sustained the glucose tolerance of HFD-fed mice. (japsonline.com)
  • After securing informed consent, each patient will be allocated to either group: Arm 1 (Controls group with fixed dose of 0.5% Hyperbaric Bupivacaine (FD Group)), and Arm2: (Cases group with modified dose of 0.5% Hyperbaric Bupivacaine (MD Group)), using the two sides of a coin, where Head is for Arm1 and Tails for Arm2. (who.int)
Group2
  • We carried out an experimental study using adult male mice fed with four different diets including normal diet, HFD, and HFD supplemented with 10% and 25% of jicama fiber ( n = 10 in each group) for 8 weeks. (japsonline.com)
  • The SLC group consisted of 25 males and 36 females with a mean age of 58.1 ± 7.2 years and a mean body mass index of 23.1 ± 3.2 kg/m 2 . (e-jmis.org)
Infusion1
Ventricular1
  • SO - Neurology 1997 Oct;49(4):1035-1041 UI - 98018928 PM - 9357896 PT - JOURNAL ARTICLE AU - Rossner KL AU - Freese KJ TI - Bupivacaine inhibition of L-type calcium current in ventricular cardiomyocytes of hamster. (nih.gov)
Medication1
  • Bupivacaine is available as a generic medication. (wikipedia.org)
Clinically1
  • Clinically significant adverse events result from systemic absorption of bupivacaine and primarily involve the central nervous and cardiovascular systems. (wikipedia.org)
Block1
  • For the time to reach T10 dermatome, Bromage 3 scale, and the regression of the sensory block to L1 dermatome and Bromage scale 0, ANOVA test was used to compare the means. (statperson.com)
Local2
  • Bupivacaine is related chemically and pharmacologically to the aminoacyl local anesthetics. (nih.gov)
  • According to another aspect of the above embodiments, the at least one local anesthetic is bupivacaine. (justia.com)
Methods1
  • Such cardiotoxicity might involve an inhibition of cardiac L-type Ca2+ current (ICa,L). This study was designed to define the mechanism of bupivacaine inhibition of ICa,L. METHODS: Cardiomyocytes were enzymatically dispersed from hamster ventricles. (nih.gov)
Surgical2
  • The da Vinci SP® Surgical System is approved for use in urologic procedures and uses a single, 25 mm multichannel trocar containing a high-definition, 3D robotic camera, and three instrument slots that deploy intracorporeally. (medscape.com)
  • Surgical management of traumatic rupture of aortic isthmus: a 25-year experience. (nih.gov)
Groups1
  • Linear polyphosphates These contain 'hybrid' ions intermediate between the pyrophosphate ion and the infinite linear metaphosphate ion, in which the terminal PO4 groups share one 0 and the intermediate groups two 0 atoms. (forextrading-madeeasy.com)
Pregnant1
  • In animal studies, embryo-fetal lethality was noted when bupivacaine was administered subcutaneously to pregnant rabbits during organogenesis and decreased pup survival was observed in a rat pre- and post-natal developmental study (dosing from implantation through weaning). (pfizermedicalinformation.com)