Budding yeast rad17 gene. Medical search. Frequent questions

Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene.Rad9 has been shown to induce G2 arrest in the cell cycle in response to DNA damage in yeast cells. (wikipedia.org)
This gene product is highly similar to S. pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. (wikipedia.org)
This complex is recruited by checkpoint protein Rad17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. (wikipedia.org)
The 9-1-1 complex requires Rad17-RFC, which is independently recruited to the damage site as a cofactor, in order to bind to DNA. (wikipedia.org)

Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene.Rad9 has been shown to induce G2 arrest in the cell cycle in response to DNA damage in yeast cells. (wikipedia.org)
This gene product is highly similar to S. pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. (wikipedia.org)
This complex is recruited by checkpoint protein Rad17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. (wikipedia.org)
Nearly 48% of protein-coding genes have non-synonymous amino acid changes between haplotypes, and centromeric regions showed the highest diversity. (bvsalud.org)
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. (utsouthwestern.edu)
The encoded protein has similarity to yeast Sec23p component of COPII. (utsouthwestern.edu)
COPII is the coat protein complex responsible for vesicle budding from the ER. (utsouthwestern.edu)
To study more complex relationships involving multiple biological interaction types, we assembled an integrated Saccharomyces cerevisiae network in which nodes represent genes (or their protein products) and differently colored links represent the aforementioned five biological interaction types. (biomedcentral.com)

Rad9 was originally found in budding yeast cells but a human homolog has also been found and studies have suggested that the molecular mechanisms of the S and G2 checkpoints are conserved in eukaryotes. (wikipedia.org)

In addition, two genes can relate to each other by transcriptional regulation, sequence homology, or expression correlation. (biomedcentral.com)
gff-version 3 ##genome build Waern_2013 S288C 2010 reference sequence, genome version 64.1.1 (budding yeast) # # Waern, K. & Snyder, M. (2013) Extensive transcript diversity and novel upstream open reading frame regulation in yeast. (yeastss.org)

for example, if a combination of mutations in two genes causes a more severe fitness defect (or death) than either mutation alone, the two genes have a synthetic sick or lethal (SSL) genetic interaction. (biomedcentral.com)
Genetic interactions describe synergistic or antagonistic consequences of mutations in two or more genes. (biomedcentral.com)

Multiple alternatively spliced transcript variants have been identified in this gene. (utsouthwestern.edu)

Thus, what is found in yeast cells are likely to be similar in human cells. (wikipedia.org)

The 9-1-1 complex requires Rad17-RFC, which is independently recruited to the damage site as a cofactor, in order to bind to DNA. (wikipedia.org)

The function of this gene product has been implicated in cargo selection and concentration. (utsouthwestern.edu)

Furthermore, MYC supports the expression of DNA replication and nucleotide biosynthesis genes along with ribosomal RNA. (bvsalud.org)