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  • bryostatin
  • Scientists have long known bryostatins, particularly a type of the compound called bryostatin 1, have anti-cancer properties, including activity against pancreatic and renal cancer, leukemia, non-Hodgkin's lymphoma and melanoma that involves flipping a switch that makes the cancer cells behave like normal cells. (ohsu.edu)
  • By sequencing the genes from two closely related strains of the Endobugula sertula bacterium found in different Bugula neritina bryozoan species - one living in deep waters, the other in shallow waters - they isolated a gene cluster "proposed to code for the biosynthetic machinery to make a common precursor" of the 20 known bryostatins, called bryostatin 0, according to the study. (ohsu.edu)
  • Angewandte Chemie DOI: 10.1002/anie.200900109 Bryostatins Catalysis in the Total Synthesis of Bryostatin 16** Aubry K. Miller* bryostatins · homogeneous catalysis · lactones · macrocycles · total synthesis M acrocyclic secondary metabolites, perhaps best exemplified by the polyketide macrolactones, hold a special place in the history of natural product total synthesis. (docme.ru)
  • The target molecule of Trosts synthesis, bryostatin 16 (1), belongs to a family of related macrolactones known collectively as the bryostatins. (docme.ru)
  • Haygood
  • The larvae are covered with a skin of bryostatins," said Haygood, whose research was described recently in the Journal of Natural Products. (ohsu.edu)
  • So Haygood and her team, including colleagues at the Scripps Institution of Oceanography and the University of Michigan, came up with a method that may someday lead to the commercial production of bryostatins themselves. (ohsu.edu)
  • Haygood said the next step is moving the bacterial genes into a host organism that can process them properly and go on to produce bryostatins, partial bryostatins or new relatives of bryostatins in the laboratory and, ultimately, on an industrial scale. (ohsu.edu)