• People may also be infected by inhalation of contaminated dust or aerosols, and as such, the CDC has labeled Brucella species as highly weaponizable. (wikipedia.org)
  • Brucella is a genus of Gram-negative bacteria, named after David Bruce (1855-1931). (wikipedia.org)
  • Bacteria of the genus Brucella are the causative agents of brucellosis, a worldwide zoonosis that affects a broad range of mammals, including livestock and humans. (mgc.ac.cn)
  • Bacteria of the genus Brucella are responsible for human and animal brucellosis worldwide and comprise the well-characterized, so-called classical species belonging to the core clade, with a host range limited to mammals, and the novel atypical strains mainly considered as non-zoonotic to date, but able to colonize non-traditional hosts such as amphibians. (bvsalud.org)
  • Transcriptional studies performed under anoxic conditions revealed a higher expression of genes participating in the last three denitrification steps in B. microti, as compared to B. suis, which correlates with the rapid and efficient consumption of nitrite in this atypical species and its rapid growth.IMPORTANCERespiration is a fundamental and complex process that bacteria use to produce energy. (bvsalud.org)
  • Bacteria of the genus Brucella are facultative intracellular parasites that cause brucellosis, a severe animal and human disease. (bvsalud.org)
  • 2002. The genome sequence of the facultative intracellular pathogen Brucella melitensis . (mgc.ac.cn)
  • 2002. The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. (mgc.ac.cn)
  • 2005. Whole-genome analyses of speciation events in pathogenic Brucellae . (mgc.ac.cn)
  • The genome of Brucella melitensis" by Vito G. DelVecchio, Vinayak Kapatral et al. (lsu.edu)
  • Despite marked phenotypical differences between the two groups, Brucella species display a high degree of genome identity, including genes encoding reductases involved in the denitrification pathway, a respiratory process able to reduce nitrate to nitrogen under anoxic conditions. (bvsalud.org)
  • To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. (lbl.gov)
  • The different species of Brucella are genetically very similar, although each has a slightly different host specificity. (wikipedia.org)
  • Hence, the National Center for Biotechnology Information taxonomy includes most Brucella species under B. melitensis. (wikipedia.org)
  • Two new brucella species, provisionally called B. pinnipediae and B. cetaceae , have been isolated from marine hosts within the past few years. (mgc.ac.cn)
  • 2011. Interactions of the human pathogenic Brucella species with their hosts. (mgc.ac.cn)
  • The rate of anaerobic growth of the atypical species Brucella microti was dependent on nitrate concentration, highlighting a more efficient denitrification pathway with rapid consumption of intermediate nitrite, whereas the classical species Brucella suis exhibited lower, nitrate concentration-independent growth coupled with nitrite accumulation. (bvsalud.org)
  • Our study further describes that efficient denitrification is not equally found within the Brucella genus, with atypical species showing a greater ability to denitrify, correlated with higher expression of the genes involved, as compared to classical species. (bvsalud.org)
  • The many names of brucellosis include (human disease/animal disease): Malta fever/Bang's disease Undulant fever/enzootic abortion Mediterranean fever/epizootic abortion Rock fever of Gibraltar/slinking of calves Gastric fever/ram epididymitis Contagious abortion/spontaneous abortion Sir David Bruce isolated B. melitensis from British soldiers who died from Malta fever in Malta. (wikipedia.org)
  • 2023. The gene regulatory network of Staphylococcus aureus ST239-SCCmecIII strain Bmb9393 and assessment of genes associated with the biofilm in diverse backgrounds. (openwetware.org)
  • 1] Almariri A, Mahmoud NH, Hammoud R.Efficacy evaluation of live Escherichia coli expression Brucella P39 protein combined with CpG oligodeoxynucleotides vaccine against Brucella melitensis 16M, in BALB/c mice[J]. Biologicals, 2012, 40(2):140. (aiijournal.com)
  • Based on all this information, we urge microbiologists, bacterial collections, genomic databases, journals, and public health boards to keep the Brucella and Ochrobactrum genera separate to avoid further bewilderment and harm. (bvsalud.org)
  • 5] Denoel PA, Vo TK, Weynants VE, et al.Identification of the major T-cell antigens present in the Brucella melitensis B115 protein preparation, Brucellergene OCB[J]. Journal of Medical Microbiology, 1997, 46(9):801-806. (aiijournal.com)
  • P39 protein is one of the most predominant antigenic proteins identified from Brucella by proteomics. (aiijournal.com)
  • Recently, a group of taxonomists merged the brucellae with the primarily free-living, phylogenetically related Ochrobactrum spp. (bvsalud.org)
  • Gene regulatory network inference and gene module regulating virulence in Fusarium oxysporum. (openwetware.org)
  • Its virulence depends on survival and replication properites in different cell types in which brucella controls the maturation of its vacuole to avoid innate immune responses and to reach its replicative niche associated with the endoplasmic reticulum. (mgc.ac.cn)
  • The macrophage capture effect of the modified protein was significantly stronger than prokaryotic protein,indicating that the glycosylation modification may affect the efficiency of the interaction between the target protein and the cell,which provides a reference for further exploring the effect of glycosylation on P39 protein and candidate antigen of Brucella glycosylated vaccine. (aiijournal.com)
  • Use of mass vaccination with a reduced dose of REV 1 vaccine for Brucella melitensis control in a population of small ruminants[J]. Tropical Animal Health & Production, 1999, 31(3):135. (aiijournal.com)
  • After exposure to Brucella, humans generally have a two- to four-week latency period before exhibiting symptoms, which include acute undulating fever (>90% of all cases), headache, arthralgia (>50%), night sweats, fatigue, and anorexia. (wikipedia.org)
  • A landscape of gene regulation in the parasitic amoebozoa Entamoeba spp. (openwetware.org)
  • Brucella can also target the male reproductive tract. (wikipedia.org)
  • Previous studies have demonstrated high prevalence lates and characterized them by molecular phylogenetic analysis of the citrate synthase gene, gltA . (cdc.gov)
  • Construction and Analysis of Gene Co-Expression Network in the Pathogenic Fungus Ustilago maydis. (openwetware.org)
  • 9. The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genes. (nih.gov)
  • Encoded on the large virulence plasmid in close proximity to the gene encoding the AAF. (mgc.ac.cn)
  • We looked into the probable differences of immune responses induced by different eukaryotic DNA plasmid vectors (pcDNA3.1 and pVAX1) harboring the same Omp31 gene of B. melitensis. (bvsalud.org)
  • Evaluation of B. melitensis 16M genome to get vaccine targets for cloning into eukaryotic expression plasmid. (cellbasedassayblog.com)
  • Brucella spp are intracellular bacteria that cause brucellosis, one of the most common zoonoses in the world. (unamur.be)
  • Protective responses of the immunized mice were evaluated by intraperitoneal challenge with pathogenic Brucella melitensis 16M and Brucella ovis PA76250. (bvsalud.org)
  • Although pcDNA-omp31 and pVAX-omp31 both elicited protective immunity, mice immunized with the latter showed a higher protection against both B. melitensis and B. ovis PA76250. (bvsalud.org)
  • 18. The Ton system, an ABC transporter, and a universally conserved GTPase are involved in iron utilization by Brucella melitensis 16M. (nih.gov)
  • First,the dominant antigen protein gene P39 was expressed in Pichia pastoris,and the expressed protein was purified and identified by Western blot. (aiijournal.com)
  • Effect of Glycosylation of Brucella P39 Antigen in Pichia pastoris on Macrophage Phagocytosis[J]. Biotechnology Bulletin, 2018, 34(9): 237-243. (aiijournal.com)
  • Using a panel of gene-deficient mice, we demonstrated that during a secondary recall response, both the Brucella-specific humoral response and CD4(+) Th1 cells must act together to confer protective immunity in the spleen to B. melitensis infection. (unamur.be)
  • Several studies demonstrated the usefulness of WGS data analysis through single-nucleotide polymorphism (SNP) calling from a reference sequence analysis for Brucella melitensis , whereas gene-by-gene comparison through core-genome multilocus sequence typing (cgMLST) has not been explored so far. (nih.gov)
  • Sequence analysis showed that ActR shared a high similarity with FtcR regulator of Brucella melitensis 16M known to be involved in flagellar regulation. (sciencegate.app)
  • BLASTX analysis of these unique sequences suggested that ∼131 kb (45% of the unique sequence) had matches to either known genes, or database ORFs of hypothetical or unknown function (dORFs). (microbiologyresearch.org)
  • The AGA58 chromosome composed of a single linear chromosome of 2,294,535 bp that is predicted to carry 2151 coding sequences, including 45 tRNA genes, 4 rRNA operons. (sciencegate.app)
  • Brucella is a genus of Gram-negative bacteria, named after David Bruce (1855-1931). (wikipedia.org)
  • A total of 32 genes and also open reading frames (ORFs) were referred to as being antigenic or immunogenic as indicated through the BLAST search. (cellbasedassayblog.com)
  • A major stable QTL for flag leaf width was narrowed down to 2.5 Mb region containing two predicated putative candidate genes, and its effects on yield-related traits was characterized. (researchsquare.com)
  • Six of toxigenic C. difficile organisms harbouring both toxin genes were also isolated by toxigenic culture. (bvsalud.org)
  • In this study, we characterize the cells and signaling pathways implicated in the generation of a protective immune memory response following priming by the injection of heat-killed or live Brucella melitensis 16M. (unamur.be)
  • It carries flagellar biosynthesis protein-encoding genes predicting motile behavior. (sciencegate.app)
  • In the event the annotation results matched a lot of these selection criteria, the gene coding for this purpose protein was subsequently cloned into the pcDNA3. (cellbasedassayblog.com)
  • 5] Denoel PA, Vo TK, Weynants VE, et al.Identification of the major T-cell antigens present in the Brucella melitensis B115 protein preparation, Brucellergene OCB[J]. Journal of Medical Microbiology, 1997, 46(9):801-806. (aiijournal.com)
  • This region contained 27 predicted genes, two of which were the most likely candidate genes for QFlw-5B . (researchsquare.com)
  • AGA58 predicted to carry bacteriocin genes for type A2 lantipeptide, Blp family class II bacteriocins showing antimicrobial potential of this bacterium which can be linked to antagonism tests that AGA58 can inhibit E. coli O157:H7, S. Typhimurium ATCC14028, and K. pneumonia ATCC13883. (sciencegate.app)
  • These family genes were amplified by PCR and cloned into pcDNA3. (cellbasedassayblog.com)
  • 13. Identification of OtpR regulated sRNAs in Brucella melitensis expressed under acidic stress and their roles in pathogenesis and metabolism. (nih.gov)
  • 17. OtpR regulated the growth, cell morphology of B. melitensis and tolerance to β-lactam agents. (nih.gov)