OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Brucella canisBrucella abortusBrucellaBrucellosisBrucella melitensisBrucella VaccineDog DiseasesBrucellosis, BovineAgglutination TestsToxocara canisDogsAntibodies, BacterialBrucella ovisEhrlichia canisAbortion, Veterinary
SuisBrucellosisBacteriaBiovarCattleGenusInfectionPathogenicIntracellularRB51IsolatesHumansATCCStrainsStrainAntibodyBacterialSpecies of BrucellaAerobicDogsExposureSerologyAssayAntibodiesVirulence factorsChromosomeBiochemicalDiagnosisBacteriumBisonHostsDetectionEndemicCanineSeroprevalenceSpecificityDisease
Suis20
  • B melitensis, B abortus, and B suis have been completely sequenced, and these sequencing data will help improve our understanding of the pathogenesis and the manifestations of this complex disease. (medscape.com)
  • CDC utilizes a test called the Brucella microagglutination test (BMAT), a modified version of the serum (tube) agglutination test (SAT), that can detect antibodies to Brucella species - abortus , melitensis or suis . (cdc.gov)
  • small Gram-negative coccobacilli that can infect cattle (infection with B. abortus), goats and sheep (B. melitensis), pigs (B. suis), and dogs (B. canis). (cdc.gov)
  • Brucella is a genus of Gram-negative coccobacilli, and it groups together several species including Brucella abortus , Brucella melitensis, Brucella canis and Brucella suis. (osmosis.org)
  • So, B. abortus is transmitted by cattle, B. melitensis is transmitted by small ruminants such as goats and sheep, B. canis is transmitted by dogs and B. suis is transmitted by swine and rodents. (osmosis.org)
  • Brucella species of greatest one-health relevance in the US include those infecting dogs ( Brucella canis ), swine ( Brucella suis ), and cattle and domestic bison ( Brucella abortus ). (avma.org)
  • While brucellosis has been eradicated from domestic livestock in the US, its detection in US companion animals ( B canis ) and US wildlife reservoirs ( B suis and B abortus ) and enzootic presence internationally pose a threat to human and animal health, warranting its spotlight on the one-health stage. (avma.org)
  • Brucella are gram-negative coccobacilli that commonly infect cows (Brucella abortus), pigs (Brucella suis), goats (Brucella melitensis), and dogs (Brucella canis), along with wild animals such as deer, elk, and moose. (loinc.org)
  • The main pathogenic species of Brucella are Brucella melitensis, Brucella suis and Brucella abortus. (loinc.org)
  • Brucella suis infections in pigs causes chronic inflammatory lesions in the reproductive organs or orchitis and may affect joints and/or other organs. (loinc.org)
  • Brucella suis are differentiated into five strains. (loinc.org)
  • Human infections are caused most frequently by B. melitensis, B. suis, and B. abortus, while B. canis causes only rare infections. (loinc.org)
  • 本病主要由流產布氏桿菌（B. abortus）、馬爾他布氏桿菌（B. melitensis）、豬布氏桿菌（B. suis (gov.tw)
  • The separation of B. canis from B. suis bv 3, however, failed. (biomedcentral.com)
  • Brucella melitensis -ek, Brucella abortus -ek, Brucella suis -ek eta Brucella canis -ek, hain zuzen. (wikipedia.org)
  • The causative organisms of human brucellosis are B. abortus (from cattle), B. melitensis (from sheep and goats), and B. suis (from hogs). (msdmanuals.com)
  • Generally, B. melitensis and B. suis are more pathogenic than other Brucella species. (msdmanuals.com)
  • The genus Brucella consists of six classic species, designated on the basis of host preference, antigenic and biochemical characteristics as Brucella melitensis (goats and sheep), Brucella abortus (cattle), Brucella suis (pigs), Brucella canis (dogs), Brucella ovis (sheep) and Brucella neotomae (wood rats). (mgc.ac.cn)
  • 2002. The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. (mgc.ac.cn)
  • 2005. Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis . (mgc.ac.cn)
Brucellosis17
  • Interest in brucellosis has been increasing because of the growing phenomena of international tourism and migration, in addition to the potential use of Brucella as a biological weapon. (medscape.com)
  • Brucella abortus is a Gram-negative bacterium in the family Brucellaceae and is one of the causative agents of brucellosis. (wikipedia.org)
  • Brucellosis: Brucella Abortus" (PDF). (wikipedia.org)
  • None of the exposed persons reported having previously had brucellosis or being unintentionally inoculated with Brucella vaccine. (cdc.gov)
  • Editorial Note: Brucellosis, also known as 'undulant fever' or 'Bangs disease,' is a systemic infection caused by Brucella sp. (cdc.gov)
  • Brucellosis is in infectious disease caused by bacteria in the genus Brucella . (medicinenet.com)
  • Diagnosis and treatment of brucellosis is challenging due to the limitations of diagnostic assays and the tendency of Brucella spp to produce nonspecific, insidious clinical signs and evade antimicrobial therapy, making prevention essential. (avma.org)
  • Although various potential intermediate hosts have harbored brucellosis in the extra-Mediterranean world, dairy cattle infected with B abortus have been particularly important hosts in North America. (medscape.com)
  • Outbreaks of epizootic bovine abortion due to B abortus should alert health care providers to the possibility of human brucellosis. (medscape.com)
  • When humans come in contact with an infected animal or animal products that are contaminated with Brucella, brucellosis may result. (loinc.org)
  • Brucellosis in dogs is usually overlooked and yet there is extensive contact between humans and their pets.Objective: This study investigated brucellosis in children and dogs using a confirmatory serological testing series that screens for three Brucella sp.Methods: Residual blood samples from malaria smear-negative febrile children were collected and tested for Brucella sp and malaria parasite. (bvsalud.org)
  • Canine brucellosis is a zoonosis whose etiologic agent is Brucella canis, although other Brucella species can infect dogs, including B. melitensis, B. abortus, and B. (proteomebinders.org)
  • Although brucellosis is mainly a bacterial disease of animals, several species of Brucella bacteria are known to cause disease in humans. (medscape.com)
  • Approximately 70%-75% of US brucellosis cases reported annually to CDC are due to the bacterial species B melitensis and B abortus . (medscape.com)
  • Brucellosis is caused by Brucella species, which are gram-negative bacteria. (msdmanuals.com)
  • Brucellosis is a widespread zoonosis of great economic importance caused by facultative intracellular Gram-negative bacteria belonging to the genus Brucella . (biomedcentral.com)
  • Bacteria of the genus Brucella are the causative agents of brucellosis, a worldwide zoonosis that affects a broad range of mammals, including livestock and humans. (mgc.ac.cn)
Bacteria11
  • Cattle and other livestock are the major host species for the bacteria B. abortus. (wikipedia.org)
  • Now, Brucella it's a non-motile bacteria that doesn't form spores. (osmosis.org)
  • Now, Brucella is a very slow growing bacteria, so colonies usually grow in the solid medium after 6 to 8 weeks of incubation. (osmosis.org)
  • Brucella bacteria can enter the human body through mucous membranes, breaks in the skin, the respiratory tract, gastrointestinal tract, and even the conjunctiva . (medicinenet.com)
  • If animals like sheep, goats, buffalo, cows, or camels are infected with Brucella , the milk they produce is contaminated with the bacteria. (medicinenet.com)
  • Although this risk is generally associated with people who work in laboratories studying Brucella organisms, it is possible that people working in meat-processing areas could be exposed to the bacteria by inhalation of droplets from contaminated meat (cattle, sheep). (medicinenet.com)
  • Brucellae are Gram-negative, facultative intracellular bacteria that can infect many species of animals and man. (hindawi.com)
  • Murine peritoneal macrophages and guinea pig peritoneal macrophages were used to study infections caused by Brucella species ( Brucella canis and Brucella abortus ) with effective elimination of intracellular bacteria (Fountain et al, 1985). (toku-e.com)
  • Quick detection of B. abortus and B. melitensis can provide the most effective strategies for control of these bacteria. (ophrp.org)
  • A commercial biotyping system (Taxa Profile™, Merlin Diagnostika) testing the metabolization of various substrates by bacteria was used to determine if a set of phenotypic features will allow the identification of members of the genus Brucella and their differentiation into species and biovars. (biomedcentral.com)
  • Based on specific and stable reactions a 96-well " Brucella identification and typing" plate (Micronaut™) was designed and re-tested in 113 Brucella isolates and a couple of closely related bacteria. (biomedcentral.com)
Biovar3
  • isolates were B. melitensis biovar 1 and B. abortus biovar 3. (ophrp.org)
  • Species and biovar classification of brucellae is historically based on natural host preference and phenotypic traits, i.e. (biomedcentral.com)
  • Brucella abortus biovar 1 str. (up.ac.za)
Cattle6
  • B. abortus causes abortion and infertility in adult cattle and is a zoonosis which is present worldwide. (wikipedia.org)
  • B. abortus can last a lot longer in animals if they are not watched closely and if the cattle are not treated for it. (wikipedia.org)
  • A species of the genus BRUCELLA whose natural hosts are cattle and other bovidae. (harvard.edu)
  • Natural hosts of B. abortus are cattle and other bovidae. (loinc.org)
  • A qualified nurse and includes those that cause infection seroprevalence of Brucella was reported approached them and explained the in cattle ( B. abortus ), goats and sheep ( B. to be 8% among high-risk individuals objectives of the study. (who.int)
  • Finally, people can become infected with Brucella RB51, a strain of B abortus that is used to vaccinate cattle in the United States and other parts of the world. (medscape.com)
Genus6
  • Brucella abortus is a species of the genus Brucella. (loinc.org)
  • Ten species are recognized within the genus Brucella . (hindawi.com)
  • B canis is zoonotic, although cases of human infection are rare and less severe than those caused by the smooth species of the genus. (msdvetmanual.com)
  • socioeconomic standard, and Al Hus- isms belonging to the genus Brucella is Associated pathological changes were sein Hospital, the fifth largest public one of the five common bacterial zoon- preterm labour chorioamnionitis, pla- hospital, located in the city of Salt [19]. (who.int)
  • The comprehensive testing of metabolic activity allows cluster analysis within the genus Brucella . (biomedcentral.com)
  • The aim of our study was to develop a miniaturised semi-automated system for the reliable identification of members of the genus Brucella and the differentiation of its species based on comprehensive metabolic activity testing. (biomedcentral.com)
Infection12
  • On May 26-27, 1997, nine persons (a farmer, four veterinary clinicians, and four veterinary students) in Manhattan, Kansas, participated in an attempted vaginal delivery, a cesarean delivery, and a necropsy on a stillborn calf that died because of Brucella abortus infection. (cdc.gov)
  • The infection was confirmed by isolation of B. abortus from placental and fetal lung tissue cultures. (cdc.gov)
  • The vaccine had caused active B. abortus infection because the 14-month-old heifer delivering the calf was not known to be pregnant when she was vaccinated with RB51 at approximately 8 months of age, which was within the specified age range for vaccination. (cdc.gov)
  • Evidence that intrauterine infection was caused by the RB51 vaccine strain, and not by field strains of B. abortus or by S19, included immunohistochemical staining specific for RB51 (negative for S19), RB51-specific titer of greater than 1:10,000 on experimental dot-blot assay measuring antibody to RB51, and RB51-specific DNA sequences identified by polymerase chain reaction (PCR). (cdc.gov)
  • Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization. (harvard.edu)
  • B Lymphocytes provide an infection niche for intracellular bacterium Brucella abortus. (harvard.edu)
  • [ 7 ] Surprisingly, infection with Brucella species accounts for as many as 10% of laboratory-acquired infections, 24% of laboratory-acquired bacterial infections, and 11% of occupational-exposure deaths in the United States. (medscape.com)
  • A common route of Brucella infection is eating or drinking infected dairy products that have not been pasteurized. (loinc.org)
  • ABSTRACT Results differ as to whether Brucella infection during pregnancy increases a woman's risk of miscarriage. (who.int)
  • Brucella canis infection also has been reported as a cause of uveitis, meningitis, diskospondylitis, glomerulonephritis and pyogranulomatous dermatitis in the dog. (dvm360.com)
  • However, B canis and Brucella RB51 won't show up on serology, so culture is needed to confirm the infection. (medscape.com)
  • Regarding the second group of animals, the IS 711 real-time PCR detected infection in 26% of animals, while Brucella spp. (biomedcentral.com)
Pathogenic3
  • Strains of highly pathogenic Brucella have been considered to be used as a biological weapon because the organisms can be aerosolized and then easily inhaled. (medicinenet.com)
  • 2005. Whole-genome analyses of speciation events in pathogenic Brucellae . (mgc.ac.cn)
  • 2011. Interactions of the human pathogenic Brucella species with their hosts. (mgc.ac.cn)
Intracellular4
  • Brucella organisms, which are small aerobic intracellular coccobacilli, localize in the reproductive organs of host animals, causing abortions and sterility. (medscape.com)
  • Brucellae are aerobic gram-negative coccobacilli that possess a unique ability to invade both phagocytic and nonphagocytic cells and to survive in the intracellular environment by finding ways to avoid the immune system. (medscape.com)
  • Description: Brucella Canis (strain ATCC 23365 / NCTC 10854) Probable intracellular septation protein A (BCAN_A1979), recombinant protein. (postgenomeconsortium.com)
  • 2002. The genome sequence of the facultative intracellular pathogen Brucella melitensis . (mgc.ac.cn)
RB512
  • Serology is not currently available to monitor persons for RB51 vaccine exposure or for Brucella canis exposure. (cdc.gov)
  • The National Animal Disease Center, U.S. Department of Agriculture (USDA), identified the B. abortus isolate from the calf as the RB51 vaccine strain. (cdc.gov)
Isolates1
  • Due to their typical metabolic profiles a differentiation of Brucella isolates to the species level could be achieved. (biomedcentral.com)
Humans4
  • There are many different ways B. abortus can spread from the different animals and even to humans. (wikipedia.org)
  • Brucella is a gram-negative coccobacilli that can infect humans and animals. (osmosis.org)
  • The challenges of B canis diagnosis in humans and dogs is addressed in more detail in the companion Currents in One Health by Guarino et al, AJVR , April 2023. (avma.org)
  • Although less common in humans, B canis is found in dogs all over the world, including the United States, and generally causes mild illness in people. (medscape.com)
ATCC3
Strains3
  • The biotyping system developed for the identification of Brucella and differentiation of its species and biovars may replace or at least complement time-consuming tube testing especially in case of atypical strains. (biomedcentral.com)
  • A biotyping assay useful for Brucella identification and species differentiation must consequently be able to identify the rising number of upcoming new species as well as single atypical strains which do not fit within the pre-existing scheme [ 10 , 11 ]. (biomedcentral.com)
  • 2008. Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes. (mgc.ac.cn)
Strain1
  • Brucella species and biovars revealed characteristic metabolic profiles and each strain showed an individual pattern. (biomedcentral.com)
Antibody3
  • Most clinical diagnostic laboratories are able to run serologic tests, which detect an antibody response to most of the Brucella species. (medscape.com)
  • Human IgG antibody Laboratories manufactures the canine brucella test saliva reagents distributed by Genprice. (postgenomeconsortium.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human Brucella Antibody (IgG) in samples from serum, plasma, cell culture supernates, tissue homogenates. (postgenomeconsortium.com)
Bacterial2
  • Using commercially available rapid bacterial identification systems such as the API 20 NE ® (BioMerieux, Nürtingen, Germany) which include a restricted number of biochemical tests Brucella spp. (biomedcentral.com)
  • The source of antigenic cross-reactions is the O-chain of the smooth lipopolysaccharide (S-LPS) present on the surface of the bacterial cell, which shows great similarity in smooth Brucella spp. (biomedcentral.com)
Species of Brucella2
  • Because the diagnostic test and treatment vary, it is important to identify whether a patient is infected with Brucella , and if so, which [species of] Brucella is causing disease. (medscape.com)
  • Each species of Brucella has distinct risk factors. (medscape.com)
Aerobic2
  • The prokaryotic B. abortus is non-spore-forming, non-motile and aerobic. (wikipedia.org)
  • Brucella are aerobic, gram-negative coccobacilli. (medicinenet.com)
Dogs3
Exposure1
  • Serology for laboratory workers exposed to Brucella are drawn at 0, 6, 12, 18 and 24 weeks post exposure. (cdc.gov)
Serology1
  • CDC recommends that Brucella serology testing only be performed using tests approved by the Food and Drug Administration (FDA), or validated under the Clinical Laboratory Improvement Amendments (CLIA) and shown to reliably detect the presence of Brucella antibodies. (cdc.gov)
Assay3
  • IS 711 -based real-time PCR assay as a tool for detection of Brucella spp. (biomedcentral.com)
  • In the present study, we describe the evaluation of the recently established real-time PCR assay based on the Brucella -specific insertion sequence IS 711 with blood samples from 199 wild boars (first group of animals) and tissue samples from 53 wild boars (second group of animals) collected in Switzerland. (biomedcentral.com)
  • The results presented here indicate that IS 711 real-time PCR assay is a specific and sensitive tool for detection of Brucella spp. (biomedcentral.com)
Antibodies5
  • There is no serological test available to detect antibodies to B. canis . (cdc.gov)
  • The immune response to Brucella is characterized by an initial production of IgM antibodies followed afterward by the production of IgG antibodies. (cdc.gov)
  • For example, Leal-Klevezas and colleagues stated that detectable amounts of antibodies are not recorded in the first 12-16 days after artificial inoculation of goats with Brucella abortus [ 19 ]. (biomedcentral.com)
  • The basis of the Genprice Gentaur test is direct agglutination of the killed stained antigen by Brucella canis antibodies. (genomeboy.com)
  • The Anigen Rapid B.Brucella Ab Test Kit is a chromatographic immunoassay for the qualitative detection of antibodies against Brucella abortus in bovine whole blood, plasma, serum or milk. (genomeboy.com)
Virulence factors1
Chromosome2
Biochemical1
  • Biochemical tests and bacteriophage typing as the golden standard indicated that all Brucella spp. (ophrp.org)
Diagnosis2
  • Definitive diagnosis requires culture of Brucella canis from blood, lymph node aspirates, or infected tissues or discharges. (dvm360.com)
  • The rapid slide agglutination test (RSAT) for the diagnosis of Brucella canis was described by George and Carmichael (Proc. (genomeboy.com)
Bacterium1
  • Brucella melitensis is a gram-negative coccobacillus bacterium from the Brucellaceae family. (loinc.org)
Bison2
  • B. abortus also affects bison. (wikipedia.org)
  • Commonly infected animals that are hunted that may contain Brucella are caribou, moose, wild hogs (feral hogs), elk, and bison. (medicinenet.com)
Hosts1
  • Two new brucella species, provisionally called B. pinnipediae and B. cetaceae , have been isolated from marine hosts within the past few years. (mgc.ac.cn)
Detection1
  • The classical bacteriological detection process used to identify Brucella spp. (ophrp.org)
Endemic1
Canine2
  • The Canine Brucella Test Saliva reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (postgenomeconsortium.com)
  • To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact canine brucella test. (postgenomeconsortium.com)
Seroprevalence2
Specificity1
  • The sensitivity and specificity of the URS-PCR method make it suitable for detecting B. abortus and B. melitensis . (ophrp.org)
Disease1
  • Brucella abortus enters phagocytes that invade human and animal innate defenses which in turn, cause chronic disease in the host. (wikipedia.org)