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Trypanosoma brucei bruceiTrypanosomiasis, AfricanTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseEukaryotic CellsProtozoan ProteinsVariant Surface Glycoproteins, TrypanosomaRNA, ProtozoanMolecular Sequence DataEukaryotaTrypanocidal AgentsAmino Acid SequenceTrypanosomiasisPhylogenyTrypanosomaGenes, ProtozoanEvolution, MolecularBase SequenceSequence Homology, Amino AcidDNA, KinetoplastTsetse FliesSequence AlignmentGenome, ProtozoanDNA, ProtozoanSaccharomyces cerevisiaeProkaryotic CellsRNA, GuideRNA EditingRNA InterferenceSaccharomyces cerevisiae ProteinsTrypanosomatinaRNA, Spliced LeaderLife Cycle StagesCloning, MolecularArchaeaConserved SequenceProtein Structure, TertiaryFlagellaTrypanosomiasis, BovineGlycosylphosphatidylinositol Diacylglycerol-LyaseMutationProtein BindingMitochondriaTranscription, GeneticModels, MolecularTrypanosoma congolenseTrypanosoma cruziDiminazeneGlycosylphosphatidylinositolsRNA, MessengerBiological EvolutionSubstrate SpecificityPentamidineGenomeRNA, RibosomalSpecies SpecificityFungal ProteinsSchizosaccharomycesGene Transfer, HorizontalCell NucleusArabidopsisModels, GeneticSequence Analysis, DNAArchaeal ProteinsTrypanosoma vivaxBinding SitesNucleic Acid ConformationMultigene FamilyModels, BiologicalRhodophytaDNAPlantsOrganellesDiplomonadidaRNARecombinant ProteinsEscherichia coliProtein TransportSequence Homology, Nucleic AcidRNA-Binding ProteinsBacteriaComputational BiologyLeishmaniaDNA ReplicationKineticsGiardia lambliaFungiRNA, TransferGene Expression RegulationRNA, Ribosomal, 18SCrithidia fasciculataRNA Processing, Post-TranscriptionalTrans-SplicingArabidopsis ProteinsMitochondrial ProteinsDNA PrimersDNA-Binding ProteinsChlorophytaAntiprotozoal AgentsRNA Splicing
TrypanosomaLeishmaniaProteinsProkaryotes and eukaryotesUnicellularMitochondrialTrypanosomesGenesMitochondriaProteinBacteriaYeastSleeping sicknessEvolutionaryOrganismsSpeciesLacksEnzymeOrganelleFoundSequenceFragmentChromosomesDuplicationMortalityStructuralResultsLostFormHumanShowsRoundDistributionPotentialFullyLight
Trypanosoma17
  • This putative activity was addressed by focusing on a protein composed solely of MORN repeats - Trypanosoma brucei MORN1. (biorxiv.org)
  • High- and low-resolution structures of the MORN1 protein from Trypanosoma brucei and homologous proteins from the parasites Toxoplasma gondii and Plasmodium falciparum were obtained using a combination of macromolecular crystallography, small-angle X-ray scattering, and electron microscopy. (biorxiv.org)
  • Reference: Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymes. (neb.com)
  • Upon searching the nearly completed genome data base of the related parasite Trypanosoma brucei, we discovered genes for two pol beta-like proteins. (neb.com)
  • Interestingly, the single mitochondrion of parasitic protist Trypanosoma brucei is able to undergo remarkable functional and structural changes reflecting available carbon sources. (nusl.cz)
  • Trypanosoma brucei is a parasite most frequently occurring in Sub-Saharan Africa that causes sleeping sickness in humans and various similar illnesses in animals. (nusl.cz)
  • ClustalW and bl2seq sequence analysis showed that LaTRF shared sequence identity with the Trypanosoma brucei TRF (TbTRF) protein and had the same degree of sequence similarities with the dimerization (TRFH) and the canonical DNA-binding Myb-like domains of both mammalian TRFs. (biomedcentral.com)
  • Background Tc38 of Trypanosoma cruzi has been isolated as a single stranded DNA binding protein with high specificity for the poly [dT-dG] sequence. (healthandwellnesssource.org)
  • In dieser Arbeit wurde der Effekt der Prostaglandine auf die Blutform von Trypanosoma brucei untersucht. (uni-tuebingen.de)
  • We propose that Trypanosoma brucei , a severe human pathogen, during its development in the tsetse fly midgut faces the same conditions and follows the same strategy as Vickermania by employing an analogous adaptation, the flagellar connector. (biomedcentral.com)
  • Trypanosoma cruzi , the etiological agent of Chagas disease, presents high variability in both chromosomes size and copy number among strains, though the underlying mechanisms are unknown. (biomedcentral.com)
  • Trypanosoma cruzi and Trypanosoma brucei , which are responsible for more than 50,000 deaths annually [ 17 ]. (biomedcentral.com)
  • These single-celled marvels are Trypanosoma brucei , the African trypanosome, and if they were to get into your bloodstream, they would trigger muscle aches, chills, confusion and - if not caught in time - death. (clemson.world)
  • The trypanosomes are a group of protozoa that include the pathogen Trypanosoma brucei , which causes nagana in cattle and sleeping sickness in humans throughout great areas of Africa ( Figure 15.12 ). (openstax.org)
  • Figure 15.12 Trypanosoma brucei is the causative agent of sleeping sickness in humans. (openstax.org)
  • We use the protozoan parasite Trypanosoma brucei as a model to study Golgi duplication, and the implication was that the results of such studies are only worthy of a wider audience once they have been demonstrated in humans, or at least one of the other crown eukaryotes, that is, yeast, flies, worms, fish, or mice. (rupress.org)
  • [20] Estevez A. M., Thiemann O. H., Alfonzo J. D., Simpson L. T7 RNA polymerase-driven transcription in mitochondria of Leishmania tarentolae and Trypanosoma brucei Mol. (org.ua)
Leishmania4
  • The nuclear localization of LaTRF, its association and co-localization with parasite telomeres and its high identity with TbTRF protein, support the hypothesis that LaTRF is a Leishmania telomeric protein. (biomedcentral.com)
  • It entails several kDNA replication specific proteins that have been primarily characterized in T. brucei Leishmania and Crithidia fasciculata [2]. (healthandwellnesssource.org)
  • Leishmania is a unicellular eukaryote and member of the Trypanosomatidae family. (ac.ir)
  • Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. (inrae.fr)
Proteins4
  • MORN (membrane occupation and recognition nexus) repeat proteins have a wide taxonomic distribution, being found in both prokaryotes and eukaryotes. (biorxiv.org)
  • metabolism of this heme-free eukaryote, we searched for heme- There are only a few examples of facultatively anaerobic or containing proteins in its de novo sequenced genome and exam-ined several cellular processes for which heme has so far been con- pathogenic bacteria that do not require heme (10-12), but no sidered indispensable. (medicinelakex1.com)
  • The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)
  • Given the near-ubiquity of only 6 proteins across ciliated eukaryotes, we propose that the MKS complex represents a dynamic complex built around these 6 proteins and implicated in Y-link formation and ciliary permeability. (biomedcentral.com)
Prokaryotes and eukaryotes1
  • A dual-intein autoprocessing domain that directs synchronized protein co-expression in both prokaryotes and eukaryotes. (ac.ir)
Unicellular3
  • This article is focused on the main pathways used by viruses to achieve infection and lysis of unicellular eukaryotes described as pathogenic for multicellular organisms. (bvsalud.org)
  • Thus, a comparative panel of viral lysis of exogenous pathogenic unicellular eukaryotes such as Acanthamoeba sp. (bvsalud.org)
  • Overview of Intestinal Protozoan and Microsporidia Infections Protozoa is a loose term for certain nucleated, unicellular organisms (eukaryotes) that lack a cell wall and are neither animals, plants, nor fungi. (msdmanuals.com)
Mitochondrial2
  • 7) The Mitocox primers, specific for mitochondrial cytochrome C oxidase of insects, worked for both prokaryotes as well as all of the eukaryotes in the survey. (suny.edu)
  • The mitochondrial gene content is highly variable across eukaryotes. (biomedcentral.com)
Trypanosomes3
  • Moreover, it was proposed that trypanosomes belong among the most ancient eukaryotes and as such, their mitochondria raised high attention of biologists. (nusl.cz)
  • Unlike bacteria and viruses, trypanosomes are eukaryotes, which means that their cells are built and organized much like those of animals. (clemson.world)
  • Trypanosomes, and virtually all other eukaryotes, have organelles called mitochondria that supply the cell with chemical energy. (openstax.org)
Genes2
  • Multiple sequence alignments of MAT genes from a wide diversity of eukaryotes demonstrated a paralogue of MAT, named MATX, with distinctive features that are absent in all other eukaryotic MATs. (biomedcentral.com)
  • [4] Remacle C., Cardol P., Coosemans N., Gaisne M., Bonnefoy N. High-efficiency biolistic transformation of Chlamydomonas mitochondria can be used to insert mutations in complex I genes Proc. (org.ua)
Mitochondria1
  • Mitochondria are organelles that express their own DNA and are believed to be the remnants of a symbiotic relationship between a eukaryote and an engulfed prokaryote. (openstax.org)
Protein1
  • Recently a 38 kDa protein (p38) of T. brucei [10] was proposed to participate in kDNA replication and maintenance. (healthandwellnesssource.org)
Bacteria1
Yeast1
  • Sequence comparisons indicate that the enzyme belongs to the C group of serine carboxypeptidases, within the S10 serine peptidase family, and shows the higher similarity to plant and yeast enzymes. (inrae.fr)
Sleeping sickness1
  • Transmitted via the bite of an infected tsetse fly, T. brucei causes sleeping sickness and threatens millions of people, mostly in sub-Saharan Africa. (clemson.world)
Evolutionary2
  • Probably as a consequence of its evolutionary range from higher eukaryotes this protozoan shows several unique features. (healthandwellnesssource.org)
  • The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. (elifesciences.org)
Organisms1
  • In all other eukaryotes, clear consensus sequences for origins are elusive, perhaps indicating there are no cis elements to initiate replication in most of these cells and organisms. (biomedcentral.com)
Species1
  • almost all CDCA7 harboring eukaryote species also have HELLS and DNMT1 (or another maintenance methyltransferase, DNMT5). (elifesciences.org)
Lacks1
  • We found that P. serpens lacks most of the eukaryote that can survive without heme has been identified. (medicinelakex1.com)
Enzyme1
  • Methionine adenosyltransferase (MAT) is a ubiquitous essential enzyme that, in eukaryotes, occurs in two relatively divergent paralogues: MAT and MATX. (biomedcentral.com)
Organelle1
  • The vault is this large cytoplasmic organelle found in eukaryotes, but whose function has not fully been elucidated. (wikipedia.org)
Found2
  • Taken together, considerably greater flexibility in initiator-directed origin usage is found in eukaryotes than in prokaryotes. (biomedcentral.com)
  • The recombinant MATX from Euglena gracilis has been found to function as a homo-dimer with activities comparable to MATs from other eukaryotes [ 9 ]. (biomedcentral.com)
Sequence2
  • The minicircle replication origins include the universal minicircle sequence (UMS GGGGTTGGTGTA) that is present in varying copy numbers and well conserved among different kinetoplastids [15 16 The exact sequence of the maxicircle replication origin is not yet known although it has been mapped to the variable region of T. brucei and C. fasciculata [17]. (healthandwellnesssource.org)
  • The hallmark of the family is a domain of approximately 260 amino acids that has a high degree of sequence similarity in all sirtuins. (biomedcentral.com)
Fragment1
  • Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transposition. (mbl.edu)
Chromosomes1
Duplication1
  • The origin of the MATX paralogue is unclear, and it cannot be excluded that it arose by a gene duplication event before the most recent common ancestor of eukaryotes. (biomedcentral.com)
Mortality1
  • Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. (bvsalud.org)
Structural1
  • Triangle network motifs predict complexes by complementing high-error interactomes with structural information. (leibniz-fli.de)
Results1
  • The validation results show that the prediction performance was organism-independent and could reproduce the annotation of other automated systems as well as high-quality manual annotations. (biomedcentral.com)
Lost2
  • A few eukaryotes that lost this pathway are synthesis of ergosterol, its precursor, lanosterol, is instead incorpo- known to scavenge heme from external sources. (medicinelakex1.com)
  • 5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. (elifesciences.org)
Form1
  • The few dozens of maxicircles carry information equivalent to that of the mtDNA from higher eukaryotes while the several thousand varied minicircles carry info for RNA editing in the form of guidebook RNA (gRNAs) that direct extensive modification of the maxicircle mRNA transcripts [1]. (healthandwellnesssource.org)
Human1
  • T. brucei splits its life cycle between two hosts: a mammal such as a human or a cow, and a tsetse fly. (clemson.world)
Shows1
  • The changed inquiry by the Access to Medicine Basement shows which brawny pharmaceutical companies are marketing the most leading medicines and vaccines for the highest-burden illness in developing countries. (yawatax.com)
Round1
  • EU approved biosimilar medicines are available for patients in over 60 countries 'round the world, and recognised as high supremacy, safe and useful medicines. (yawatax.com)
Distribution2
  • MATX has a punctate distribution across the tree of eukaryotes and, except for a few cases, is mutually exclusive with MAT. (biomedcentral.com)
  • Like MAT/MATX, the EF-1α/EFL paralogues have a patchy distribution across the tree of eukaryotes and rarely occur together in the same organism. (biomedcentral.com)
Potential2
  • Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
  • Finding potential ways to attack eukaryotes, then, requires a delicate touch. (clemson.world)
Fully1
  • In eukaryotes, many metabolic pathways are partially or fully compartmentalized in subcellular organelles. (biorxiv.org)
Light1
  • Others use the concept in a narrower sense, to refer to the individualized portions of chromatin during cell division, visible under light microscopy due to high condensation. (wikipedia.org)