• Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease that is characterized by the alveolar and interstitial accumulation of a periodic acid-Schiff (PAS) stain-positive phospholipoprotein that is derived from surfactant. (medscape.com)
  • Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
  • Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are prevalent and commonly co-occur as overlap syndrome. (e-jsm.org)
  • Chronic obstructive pulmonary disease (COPD) is common in smoking adult populations and distinctive of airflow limitation not entirely reversible and inflammatory response leading to small airway narrowing and parenchymal destruction of the lungs [ 1 ]. (e-jsm.org)
  • CONCLUSION: Our study shows that PCT is generally uncommon, but when it occurs, it occurs more frequently on the right side and in female patients with end-stage pulmonary disease. (bvsalud.org)
  • Chronic obstructive pulmonary disease may be a predisposing factor for developing PCT. (bvsalud.org)
  • Respiratory health consequences after aerosolized exposures to high-concentrations of particulates and chemicals can be grouped into 4 major categories: 1) upper respiratory disease (chronic rhinosinusitis and reactive upper airways dysfunction syndrome), 2) lower respiratory diseases (reactive [lower] airways dysfunction syndrome, irritant-induced asthma, and chronic obstructive airways diseases), 3) parenchymal or interstitial lung diseases (sarcoidosis, pulmonary fibrosis, and bronchiolitis obliterans, and 4) cancers of the lung and pleura. (elsevierpure.com)
  • Lung transplantation,using RATG induction therapy, remains an important modality for end-stage pulmonary disease. (pdfdrugs.com)
  • they include frequent visits for pulmonary disease progression, medication management, and evaluation by a multidisciplinary team of providers. (stanford.edu)
  • Pulmonary complications, including infections, are highly prevalent in patients after hematopoietic cell transplant with chronic graft-versus-host disease. (stanford.edu)
  • These comorbid diseases can make the diagnosis of early lung graft-versus-host disease (bronchiolitis obliterans syndrome) challenging. (stanford.edu)
  • This is an important new area and it is quite reassuring that leading respiratory journals are now recognising the potential importance of EMT in pathogenesis of chronic obstructive pulmonary disease (COPD) and its deadly consequences. (biomedcentral.com)
  • Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease (COPD) is airflow limitation caused by an inflammatory response to inhaled toxins, often cigarette smoke. (merckmanuals.com)
  • During the study, 2,519 adult patients were of chronic obstructive pulmonary disease ( 7 ). (cdc.gov)
  • Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data. (escholarship.org)
  • Genetic variation has a substantial contribution to chronic obstructive pulmonary disease (COPD) and lung function measurements. (escholarship.org)
  • Lung transplantation is an established treatment option for well-selected patients with end-stage pulmonary disease, when other therapeutic options are no longer available. (klinikrespirasimalang.com)
  • Obliterative Bronchiolitis (OB) is the pathological correlate of Bronchiolitis Obliterans Syndrome (BOS) a progressive disease that results in the fibrotic obliteration and blockage of the airways. (ndltd.org)
  • Background Hospital admissions with acute exacerbations of chronic obstructive pulmonary disease are common and associated with high mortality rates, frequent readmission and worse quality of life. (ndltd.org)
  • Lung transplantation is a potentially curative therapy for patients with end-stage pulmonary disease. (nature.com)
  • Previous diagnosis of an obstructive lung disease, and peribronchial distribution of the nodules on CT increased the likelihood of DIPNECH vs. other diagnoses. (biomedcentral.com)
  • Other types of respiratory diseases potentially impacted by workplace exposures include chronic obstructive pulmonary disease (or COPD), hypersensitivity pneumonitis, silicosis, lung cancer, and bronchiolitis obliterans. (cdc.gov)
  • Patients with asthma and conditions such as chronic obstructive pulmonary disease (COPD) are treated in the general clinics. (mse.nhs.uk)
  • COPD includes chronic bronchitis and chronic obstructive airways disease. (mse.nhs.uk)
  • It has been approved in Europe to treat asthma and chronic obstructive pulmonary disease. (pharmakb.com)
  • The conditions most commonly evaluated for transplantation include chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis, pulmonary hypertension, and sarcoidosis. (ochsnerjournal.org)
  • Bronchiolitis occurs in a variety of clinical settings and may be associated with large airway disease and parenchymal disease. (pneumon.org)
  • HRCT of obliterative bronchiolitis and other small airways disease. (pneumon.org)
  • Cervical vertebrae 1,2, …?Ca: Calcium?Ca: Cancer?Ca: Carcinoma?Ca: Cardiac arrest?Ca: Coronary artery?CA-125: A tumor marker for ovarian cancer?CAB: Cellulose acetate butyrate?CABG: Coronary artery bypass graft?CACI: Computer-Assisted Continuous Infusion?CAD: Coronary artery disease?CAG: ?CAH: Chronic active hepatitis?CAH: Congenital adrenal hyperplasia?calid. (kuwaitpharmacy.com)
  • Brief Summary Monitoring patients with chronic, inflammatory airways disease particularly in the early stages is hampered by the relative insensitivity of current outcome measures to detect subtle changes. (cardiff.ac.uk)
  • Other major histopathologic forms of idiopathic interstitial pneumonias include the following: desquamative interstitial pneumonia (DIP), respiratory bronchiolitis interstitial lung disease (RBILD), acute interstitial pneumonitis (AIP), also known as Hamman-Rich syndrome, nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP) (see Bronchiolitis Obliterans Organizing Pneumonia ), and lymphocytic interstitial pneumonia (LIP) (see Lymphocytic Interstitial Pneumonia ). (medscape.com)
  • Of patients referred to a pulmonary disease specialist, an estimated 10-15% have a DPLD. (medscape.com)
  • Patients with an overlap syndrome have a worse prognosis than those with COPD or OSA alone. (e-jsm.org)
  • As COPD and OSA are common, COPD-OSA syndrome has been postulated [ 3 ]. (e-jsm.org)
  • COPD-OSA overlap syndrome was suspected. (e-jsm.org)
  • Because COPD, cor pulmonale, and pulmonary hypertension were diagnosed, medical treatments including oxygen therapy were started. (e-jsm.org)
  • Prolonged exposure can lead to chronic inflammatory lung diseases such as asthma, chronic obstructive pulmonary disorder, idiopathic pulmonary fibrosis, and bronchiolitis obliterans syndrome. (lu.se)
  • Here, we identified miR-323a-3p to be downregulated in the epithelium of lungs with bronchiolitis obliterans syndrome (BOS) after lung transplantation, idiopathic pulmonary fibrosis (IPF), and murine bleomycin-induced fibrosis. (escholarship.org)
  • Patchy fibrosis with greater involvement of the lower lobes and subpleural regions is readily apparent in idiopathic pulmonary fibrosis. (medscape.com)
  • Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are collectively referred to as interstitial lung diseases (ILDs) or diffuse parenchymal lung diseases. (atsjournals.org)
  • Idiopathic pulmonary fibrosis (or cryptogenic fibrosing alveolitis) (IPF or CFA) is one of several idiopathic interstitial pneumonias. (atsjournals.org)
  • The purpose of this consensus statement is to provide assistance to clinicians in the diagnosis and management of idiopathic pulmonary fibrosis (IPF). (atsjournals.org)
  • 2 Dr Joel Cooper from the Toronto Lung Group followed by performing the first successful single lung transplant in a patient with idiopathic pulmonary fibrosis in 1983. (ochsnerjournal.org)
  • DPLD may be idiopathic, a classic illustration of which is idiopathic interstitial fibrosis (IPF), which is discussed in another article (see Pulmonary Fibrosis, Idiopathic ). (medscape.com)
  • This article presents a broad overview, with an emphasis on those etiologies that result in pulmonary fibrosis not discussed elsewhere in this series. (medscape.com)
  • It is thought to begin with acute injury to the pulmonary parenchyma, leading to chronic interstitial inflammation, then to fibroblast activation and proliferation, and finally progressing to the common endpoint of pulmonary fibrosis and tissue destruction. (medscape.com)
  • Previously documented respiratory health effects include symptoms such as wheeze, cough, and dyspnea, bronchial hyperresponsiveness, reduced spirometric parameters, and chronic lung diseases including asthma and obliterative bronchiolitis (OB) (3, 510). (cdc.gov)
  • Obliterative bronchiolitis: varying presentations and clinicopathological correlation. (pneumon.org)
  • Here, we report a middle-aged man with overlap syndrome who had multiple comorbidities such as cor pulmonale, pulmonary hypertension, and one lung ventilation, managed with continuous positive airway pressure (CPAP) and oxygen therapy. (e-jsm.org)
  • Pulmonary hypertension is increased pressure in the pulmonary circulation. (msdmanuals.com)
  • Severe pulmonary hypertension leads to right ventricular overload and failure. (msdmanuals.com)
  • Many conditions and drugs cause pulmonary hypertension. (msdmanuals.com)
  • In the first group (pulmonary arterial hypertension [PAH]), the primary disorder affects the small pulmonary arterioles. (msdmanuals.com)
  • The largest pulmonary arteries have small yellow atherosclerotic plaques in pulmonary arterial hypertension. (medscape.com)
  • 1 The 1980s saw the development of lung transplantation, starting in 1981 when Dr Bruce Reitz at Stanford University performed a heart-lung transplant on a patient with pulmonary arterial hypertension. (ochsnerjournal.org)
  • It is observed in obstructive lung diseases such as asthma, bronchiolitis obliterans syndrome and chronic obstructive pulmonary diseases such as emphysema and chronic bronchitis. (wikipedia.org)
  • The objective of my research is to contribute to an increased understanding of the mechanisms behind inflammatory pulmonary diseases. (lu.se)
  • My goal is also to find new markers for early diagnosis and new targets for the treatment of chronic inflammatory lung diseases. (lu.se)
  • Similarly, loss of CD28 was associated with an increased percentage of T and NK-like T-cells producing IFN-gamma or TNF-alpha in patients with chronic obstructive pulmonary diseases (44). (cgp60474.com)
  • A quantitative method to differentiate among these pulmonary diseases can address diagnostic challenges and facilitate earlier and more targeted therapy.We conducted a single center study of 66 patients with computed tomography chest scans analyzed with a quantitative imaging tool known as parametric response mapping. (stanford.edu)
  • A support vector machine algorithm differentiated bronchiolitis obliterans syndrome with specificity of 88%, sensitivity of 83%, accuracy of 86% and an area under the receiver operating characteristic curve of 0.85.Our machine learning models offer a quantitative approach for the identification of bronchiolitis obliterans syndrome versus other lung diseases, including late pulmonary complications after hematopoietic cell transplant. (stanford.edu)
  • Maladaptive epithelial repair from chronic injury is a common feature in fibrotic diseases, which in turn activates a pathogenic fibroblast response that produces excessive matrix deposition. (escholarship.org)
  • 4 These diseases are not only the major causes of death but are also associated with chronic lung allograft dysfunction (CLAD). (nature.com)
  • Panel members are experts in adult pulmonary diseases. (atsjournals.org)
  • Bronchiolitis is a generic term applied to a variety of inflammatory diseases that affect the bronchioles, sparing a considerable portion of the other parenchymal structures, in which both inflammatory cells and mesenchymal tissue are present. (pneumon.org)
  • The Journal publishes all types of articles in the field of treatment and management of diseases related Pulmonary and respiratory issues. (peertechzpublications.org)
  • It's providing a path for discovering new methods or mechanisms for chronic diseases and other healthcare professionals to find-out most recent advances in all the related areas of treatment and management of diseases related to Pulmonary tract and Respiratory system. (peertechzpublications.org)
  • Any obstruction or inflammation of these airways, as seen in conditions like asthma or chronic bronchitis, can lead to breathing difficulties and impaired gas exchange, affecting overall lung function. (labtestsguide.com)
  • in farmers, in whom chronic bronchitis is far more common, occurs independently of smoking status, is linked to thermophilic actinomycete exposure, and leads to findings similar to those of hypersensitivity pneumonitis on diagnostic testing. (merckmanuals.com)
  • ARDS), and bronchiolitis obliterans or bronchitis but is caused by inhalation of toxic nitrogen oxides produced by freshly fermented corn or alfalfa silage. (merckmanuals.com)
  • This review describes several respiratory consequences of occupational and environmental disasters and uses the World Trade Center disaster to illustrate in detail the consequences of chronic upper and lower respiratory inflammation. (elsevierpure.com)
  • The Pulmonary Physiology Department carries out a wide range of diagnostic tests to assess lungs function, cardio-respiratory function and muscle strength. (mse.nhs.uk)
  • Meanwhile, gut-associated bacteria were significantly enriched in the patents with pulmonary inflammation. (nature.com)
  • With more and more exposure, the immune system reacts against the allergic reaction, causing chronic inflammation . (symptoma.com)
  • Minimal lung inflammation is normally seen in the inhalation fevers (e.g., organic dust toxic syndrome, metal fume fever and polymer fume fever ). (symptoma.com)
  • Occupational exposure to butter flavoring vapors (BFV) is airway injury including necrosis and inflammation of the associated with significant pulmonary injury. (cdc.gov)
  • Pulmonary Embolism (PE) Pulmonary embolism (PE) is the occlusion of pulmonary arteries by thrombi that originate elsewhere, typically in the large veins of the legs or pelvis. (msdmanuals.com)
  • Risk factors for pulmonary embolism are. (msdmanuals.com)
  • Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
  • Chest CT showed compensatory hyperexpansion, multifocal cystic bronchiectasis, and bronchiolitis obliterans in the right lung. (e-jsm.org)
  • Long-term (chronic) cough with large amounts of foul smelling sputum is the main symptom of bronchiectasis. (medlineplus.gov)
  • Various disorders can manifest the CT pattern of bilateral pulmonary nodules together with mosaic attenuation, and this combination is nonspecific for DIPNECH, which was found in only 10% of our cohort. (biomedcentral.com)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Bronchiolitis in association with connective tissue disorders. (pneumon.org)
  • In Interstitial Pulmonary and Bronchiolar Disorders. (pneumon.org)
  • Capsule?CAPD: Continuous ambulatory peritoneal dialysis?Caps: Capsules?CAPS: Cryopyrin-Associated Periodic Syndromes disorders?CAPTIA Syph G: ?CAPTIA Syph M: ?CAST: Cardiac arrhythmia suppression trials?CAT: Computerized axial tomography?Cataplasm. (kuwaitpharmacy.com)
  • Clusters 2 and 3 represented obstructive physiology (encompassing 81% of patients with bronchiolitis obliterans syndrome) in increasing severity (percent air trapping 15.6% and 43.0%, respectively). (stanford.edu)
  • Several different phenotypes of CLAD have been identified, based on the physiology of the lung function decline, such as obstructive (bronchiolitis obliterans syndrome, BOS), restrictive (restrictive allograft syndrome) or a combination (mixed phenotype), along with the presence or absence of persistent opacities on chest imaging [2, 3]. (klinikrespirasimalang.com)
  • Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is characterized by multifocal proliferation of pulmonary neuroendocrine cells. (biomedcentral.com)
  • Hypersensitivity pneumonitis is a syndrome of cough, dyspnea, and fatigue caused by sensitization and subsequent hypersensitivity to environmental (frequently occupational or domestic) antigens. (merckmanuals.com)
  • Frontal chest radiograph from a patient with pulmonary alveolar proteinosis. (medscape.com)
  • Obstructive sleep apnea (OSA), which is characterized by repetitive partial or complete obstruction of the upper airway, is also prevalent in adults. (e-jsm.org)
  • Obstructive Sleep Apnea (OSA) Obstructive sleep apnea (OSA) consists of multiple episodes of partial or complete closure of the upper airway that occur during sleep and lead to breathing cessation (defined as a period of. (msdmanuals.com)
  • RESULTS: Pulmonary carcinoid tumorlet was incidentally discovered in the explanted lungs from 15 patients (1.1%) out of 1367 lung transplants performed during the study period. (bvsalud.org)
  • It is often associated with chronic pulmonary inflammatory processes. (bvsalud.org)
  • Since OB is difficult to diagnose, a committee sponsored by now accepted as appropriate treatment for end-stage the International Society for Heart and Lung Transplan- tation (ISHLT) proposed a clinical description of OB, One-year survival for lung transplant recipients has termed bronchiolitis obliterans syndrome This risen from 47% in 1988 to 75% in 2001. (pdfdrugs.com)
  • Parametric response mapping results were correlated with pulmonary function tests and clinical characteristics. (stanford.edu)
  • Currently many clinical trials are in progress aimed at the identification of the most appropriate treatment for each specific type of bronchiolitis. (pneumon.org)
  • Detailed Description This is a Phase III randomized, controlled clinical trial of L-CsA for the treatment of bronchiolitis obliterans syndrome in adults diagnosed with BOS following double lung transplant. (cardiff.ac.uk)
  • Pulmonary function tests (PFTs) may show a restrictive lung function defect or a lowtrending diffusing capacity for CO without necessarily the presence of clinical symptoms or definite changes on imaging including HRCT. (pneumotox.com)
  • Moreover, clinical bronchiolitis obliterans also min. (cdc.gov)
  • TEM, and CD16+CD56+ CD8+ T-cells in peripheral blood, probably associated with the chronic infection with HPV (44). (cgp60474.com)
  • Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. (nature.com)
  • Severe allograft rejection (AR) and pulmonary infection (PI) are the most common complications within 1 year after the transplant. (nature.com)
  • Organic dust toxic syndrome (pulmonary mycotoxicosis, grain fever), for example, is a syndrome consisting of fever, chills, myalgias, and dyspnea that does not require prior sensitization and is thought to be caused by inhalation of toxins produced by fungi or other contaminants of organic dust. (merckmanuals.com)
  • ODTS is also called Toxic Organic Dust Syndrome (TODS), grain fever , or pulmonary mycotoxicosis. (symptoma.com)
  • Diagnosis is made by finding elevated pulmonary artery pressure (estimated by echocardiography and confirmed by right heart catheterization). (msdmanuals.com)
  • Although the post-transplant survival has much improved in recent years, the development of chronic lung allograft dysfunction (CLAD), which affects 40-50% of all patients by 5 years post-transplant, remains the major cause of morbidity and mortality [1]. (klinikrespirasimalang.com)
  • BACKGROUND: Pulmonary carcinoid tumorlet (PCT) is defined as small proliferation of neuroendocrine cells that invade the adjacent basement membrane. (bvsalud.org)
  • Bronchiolitis: pathologic considerations. (pneumon.org)
  • Thus, e.g., inhibition of metabolic changes including air trapping, bronchial wall thickening, and clearance pathways leads to a diminished scrubbing capacity constrictive bronchiolitis (Akpinar-Elci et al. (cdc.gov)
  • Here we report a middle-aged man with overlap syndrome who had multiple comorbidities, managed with continuous positive airway pressure and oxygen therapy. (e-jsm.org)
  • Brief Summary The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in double lung transplant recipients. (cardiff.ac.uk)