Brenner tumor. Medical search. Frequent questions

Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour. (wikipedia.org)
Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. (wikipedia.org)
Brenner tumor of the ovary - ultrasound features and clinical management of a rare ovarian tumor mimicking ovarian cancer. (nih.gov)
Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature. (nih.gov)
4. Pure and mixed Brenner tumors of the ovary: clinicopathologic and histogenetic observations. (nih.gov)
7. Coexisting Brenner tumor and struma ovarii in the right ovary: case report and review of the literature. (nih.gov)
8. Malignant Brenner tumor of the ovary with transformation to trabecular carcinoid: an immunocytochemical and electron microscopic study. (nih.gov)
9. Brenner tumor of the ovary. (nih.gov)
13. [Brenner tumor of the ovary--a clinicopathological report of 5 cases]. (nih.gov)
14. [Malignant Brenner's tumor of the ovary: description of a case]. (nih.gov)
Epithelial tumors start from the cells that cover the outer surface of the ovary. (cancer.org)
Stromal tumors start from structural tissue cells that hold the ovary together and produce the female hormones estrogen and progesterone. (cancer.org)
Some of these tumors are benign (non-cancerous) and never spread beyond the ovary. (cancer.org)
The malignant serous adenocarcinoma is the most common malignant tumour of the ovary, accounting for 40% of all ovarian malignancies including non-surface epithelial stromal tumours. (wikidot.com)
Borderline malignant tumors are intermediate in features between benign and malignant tumors of the ovary, and they are also known as semi-malignant. (12healthy.com)
Epithelial Malignant tumors peak at 50 to 70 years of age, and non-epithelial malignancies of ovary occur before 40 years of age. (12healthy.com)
Gross image of tumor obliterating normal ovary removed at 27 weeks gestation. (mdwiki.org)

This disclosure provides adoptive cell therapy embodiments that allow therapeutic efficacy in individuals with cancer, including solid tumors. (justia.com)
For the dose-escalation cohort: measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) criteria is desirable but not required. (astrazenecaclinicaltrials.com)
Anthracyclines are important antitumor agents used in the treatment of solid tumors, lymphomas, and acute lymphoblastic as well as myelocytic leukemias. (nih.gov)
In the hematogenous route, circulating tumor cells (CTCs), which have shed from solid tumors and intravasated, can circulate throughout the body and attach at distant organs to grow metastatic lesions. (oncotarget.com)
It is a cell surface glycoprotein that regulates cellular reactions to the microenvironment and plays a role in various solid tumors, especially in tumor cell proliferation [ 16 , 17 ]. (jmchemsci.com)

The coffee bean nuclei are the nuclear grooves exceptionally pathognomonic to the sex cord stromal tumour, the ovarian granulosa cell tumour, with the fluid-filled spaces Call-Exner bodies between the granulosa cells. (wikipedia.org)
The most common subtypes are granulosa-theca tumors and Sertoli-Leydig cell tumors . (webmd.com)
Caution is required with both systemic and topical menopausal hormone therapy in women with serous and granulosa cell tumors because of their hormone dependence, and non-hormonal options are recommended as initial therapy. (bmj.com)

Histopathology revealed a low-grade borderline serous tumour arising from a serous cystadenoma. (radiologyacrossborders.org)
Mucinous ovarian tumors (MOT) consist of mucinous cystadenoma (MCA), mucinous borderline tumor (MBOT), and MOC, but the diagnosis still needs further study. (jmchemsci.com)
There is a broad histological spectrum in these tumors, from benign cystadenoma, borderline to malignant carcinoma [ 10 ]. (jmchemsci.com)
Differentiating between mucinous borderline tumor (MBOT) and mucinous cystadenoma (MCA) is sometimes difficult, especially if epithelial proliferation is found [ 11 ]. (jmchemsci.com)

If your epithelial tumor is cancer, it's called a carcinoma . (webmd.com)
A rare tumor, nasopharyngeal carcinoma (NPC) develops from the epithelium of the nasopharynx. (medscape.com)
Patients with the following histologic epithelial ovarian cancer cell types are eligible: Serous adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma, transitional cell carcinoma, malignant Brenner's Tumor, or adenocarcinoma not otherwise specified (NOS). (astrazenecaclinicaltrials.com)
Other local therapies, such as radiofrequency ablation (RFA), percutaneous ethanol injection therapy, and transarterial chemoembolization (TACE), are used as alternatives in medically-inoperable patients with hepatocellular carcinoma (HCC) and metastatic liver tumors ( 1 - 6 ). (iiarjournals.org)

Brenner tumours are an uncommon subtype of the surface epithelial-stromal tumour group of ovarian neoplasms. (wikipedia.org)
The World Health Organization classification groups them into benign, borderline, and malignant on the basis of proliferation and invasiveness, and borderline Brenner tumor is defined as "displaying epithelial proliferation beyond that seen in benign Brenner's tumor, but lacking stromal invasion. (nih.gov)
A tumor composed of solid and cystic nests of neoplastic urothelial-type cells in an abundant stromal component that is dense and fibroblastic in nature. (nih.gov)
Gonadal-stromal cell tumors constitute 3-5% of all tumors. (medscape.com)
Stromal Overgrowth in a Brenner Tumor or Ovarian Fibroma With Minor Sex Cord Elements? (medscape.com)
Benign tumors are divided into germ cell tumors such as dermoid cyst (mature cystic teratoma), mature solid teratoma, epithelial tumors, which include adenomas (serous, mucinous, endometrioid) and Brenner tumor, as well as benign sex cord-stromal tumors such as Sertoli-Leydig cell tumor, and fibromas. (12healthy.com)

Using an immunohistochemical technique specific for the tumor marker, they localized CA-125 expression in the omentum and peritoneal surfaces rather than in the fibroma. (medscape.com)
Differentials include fibroma, thecoma, Brenner tumour and metastasis (if bilateral). (radiologyacrossborders.org)

Is Imprint Cytology Useful to Diagnose Malignancy for Brenner Tumors? (karger.com)
Tumor marker serum levels of CA-125 can be elevated in Meigs syndrome, but the degree of elevation does not correlate with malignancy. (medscape.com)
Brenner tumor of borderline malignancy. (nih.gov)
Alternatively, noninvasive or minimally invasive imaging technologies have been used to evaluate the malignancy of brain tumors. (ajnr.org)
The tumors were evaluated using the risk of malignancy index (RMI), International Ovarian Tumors Analysis (IOTA) group simple rules, expert opinion, IOTA logistic regression model 2 (LR2) and 3D vascular indices, and were postoperatively compared to histopathological results. (biomedcentral.com)

CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. (nih.gov)
Nobuhiro Takeshima Objective: This study retrospectively investigated the usefulness of intraoperative diagnosis based on imprint cytology and frozen sections for ovarian germ cell tumor. (karger.com)
However, liver tumors are often unresectable at diagnosis and hepatectomy is invasive. (iiarjournals.org)
Furthermore, it has been shown that many high-grade tumors do not show contrast enhancement in the postcontrast images, 7 , 8 which may yield a false-negative diagnosis. (ajnr.org)

We reviewed the literature on borderline Brenner tumor and have summarized the clinical and pathologic findings, as well as the treatment, differential diagnoses, and recent advances in histogenesis and molecular pathogenesis. (nih.gov)
It includes benign Brenner tumor, borderline Brenner tumor, and malignant Brenner tumor. (nih.gov)
11. Borderline Brenner Tumor: A Review of the Literature. (nih.gov)

The last two subtypes -- endodermal sinus tumor, also known as "yolk sac tumor," and Choriocarcinoma -- grow and spread rapidly, but they are very rare. (webmd.com)

6. Bilateral ovarian serous cystadenofibromas coexisting with an incidental unilateral Brenner tumor and Walthard cell rests in bilateral Fallopian tubes: an unusual case with diagnostic implications and histogenesis. (nih.gov)
Depending on tumor type and stage, treatments include hysterectomy with or without bilateral salpingo-oophorectomy, radiotherapy, and chemotherapy. (bmj.com)
She was receiving tamoxifen therapy for breast cancer and had bilateral ovarian Brenner tumors. (nyu.edu)

Epithelial ovarian tumors start in the outer surface of the ovaries. (cancer.org)
Your ovaries have three main types of cells, and a tumor can develop in any of them. (webmd.com)
Most cases of ovarian cancer involve tumors that start in the layer of tissue that covers your ovaries. (webmd.com)
A smooth, solid or cystic fibroepithelial ( FIBROEPITHELIAL NEOPLASMS ) tumor, usually found in the OVARIES but can also be found in the adnexal region and the KIDNEYS . (nih.gov)
Serous adenocarcinoma is the most common malignant tumor of the ovaries. (12healthy.com)

Psychotic manifestations are usually not seen in primary brain tumor patients. (nerdyseal.com)

This type of tumor is very rare and generally found in girls younger than 18. (webmd.com)

Treatment options include surgical removal of the tumor mass with a maximal reduction of the peritoneal cancer mass in case of local tumor extension. (medscape.com)
Even though the association of benign ovarian tumors and pleural effusion was reported before, it was Meigs and Cass who reported the resolution of ascites and pleural effusion after the removal of the tumor. (capsulehealth.one)

[8] Pathology reveals well circumscribed solid tumor nodules within a dense desmoplastic stroma . (mdwiki.org)

This clinical trial is a Phase 1-2, open-label, sequential-group, dose-escalation and cohort-expansion study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of Zotatifin (eFT226) in subjects with selected advanced solid tumor malignancies. (stanford.edu)

When looked at in the lab, some ovarian epithelial tumors don't clearly appear to be cancerous and are known as borderline epithelial ovarian cancer . (cancer.org)
The limited evidence available suggests that menopausal hormone therapy, either systemic or topical, does not appear to be associated with harm and does not decrease overall or disease-free survival in women with non-serous epithelial ovarian cancer and germ cell tumors. (bmj.com)

17. Unusual presentation of benign cystic brenner tumor with exuberant psammomatous calcifications. (nih.gov)

These include tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), ionizing and ultraviolet radiation, anti-cancer drugs, growth-factor withdrawal, infection by human immunodeficiency virus (HIV) or bacteria. (biomedcentral.com)
Growing evidence suggests that proinflammatory cytokines (PICs), such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα), are induced in the spinal cord under various injury conditions and contribute to pain hypersensitivity. (jneurosci.org)

Wilms tumor (WT) is a type of kidney cancer that occurs in children. (nih.gov)
Wilms tumor and other childhood kidney tumors treatment (PDQ) - health professional version. (nih.gov)
Research has indicated that there is a chimeric relationship between DSRCT and Wilms' tumor and Ewing sarcoma . (mdwiki.org)
DSRCT shares characteristics with other small-round blue cell cancers including Ewing's sarcoma, acute leukemia, small cell mesothelioma, neuroblastoma, primitive neuroectodermal tumor , rhabdomyosarcoma , and Wilms' tumor. (mdwiki.org)

Because this is a rare tumor, not many family physicians or oncologists are familiar with this disease. (mdwiki.org)

2 The most widely used stage reporting classification is the Tumor, Node, Metastasis (TNM) staging system, as depicted in the most recent edition of the American Joint Committee on Cancer (AJCC) staging manual. (allenpress.com)
My research is on the translational application of next-generation sequencing technologies to breast cancer care: (1) the value of hereditary cancer genetic panel testing in clinical practice, (2) the mechanisms by which inherited genetic variants lead to breast cancer development, and (3) the analysis of somatic tumor sequencing data to inform understanding of breast tumorigenesis, metastasis, and development of resistance in response to therapeutics. (stanford.edu)

Emerging notion in carcinogenesis ascribes tumor initiation and aggressiveness to cancer stem cells (CSCs). (bgu.ac.il)
The carcinogenesis and tumor progression involve the regulation of proliferation and invasion. (jmchemsci.com)

Amplification of the gene encoding estrogen receptor- α occurs in about 20% of breast cancers and is an important mechanism for estrogen receptor overexpression in this tumor type. (medscape.com)
To study a potential role of estrogen receptor- α gene amplification for estrogen receptor overexpression in ovarian cancer, a tumor tissue microarray containing 428 ovarian cancers was analyzed by fluorescence in situ hybridization for estrogen receptor- α gene amplification and immunohistochemistry for estrogen receptor expression. (medscape.com)
Estrogen receptor gene amplification was found in 5 of 243 (2%) of tumors. (medscape.com)
All five amplified tumors were estrogen receptor positive, with 3 of 5 tumors showing highest (Allred score, 7-8) estrogen receptor levels. (medscape.com)

Ovarian tumors are divided into the following histologic subgroups, and Meigs syndrome can be observed with any of the benign tumors. (medscape.com)
12. Ovarian Brenner tumors and Walthard nests: a histologic and immunohistochemical study. (nih.gov)
15. Brenner tumors: histologic types and associated lesions in the genital tract. (nih.gov)
Comment: Histologic sections show a lymph node with deposits of tumor cells in diffuse sheets and few with a trabecular pattern. (pathologyoutlines.com)

Stage-related diagnostic challenges in standardized colorectal cancer reporting have been highlighted by review articles, survey-based publications, and clinical outcome studies, with much of the focus centered on controversies and problems regarding the classification of pT3 versus pT4a tumors, in particular those tumors that approach within 1 mm of the visceral peritoneum. (allenpress.com)
More recently, quantitative perfusion imaging by using dynamic susceptibility contrast (DSC) MR imaging has been applied to predict glioma grade, and several studies have shown that perfusion parameters can be used as biomarkers for tumor grade 9 - 13 and, in 1 study, for clinical outcome (survival time). (ajnr.org)
Even after receiving multimodality therapy, the clinical result for most ovarian cancer patients remains poor since they are discovered at an advanced stage with intraperitoneal tumor progression and metastases [ 4 , 5 ]. (jmchemsci.com)

These "benign" epithelial tumors include serous adenomas, mucinous adenomas and Brenner tumors. (webmd.com)

Brenner tumors arise from ovarian epithelium, accounting for approximately 5% of benign ovarian epithelial tumors. (nih.gov)
Rare triad of benign ovarian tumor, ascites and pleural effusion that resolves after resection of the tumor. (capsulehealth.one)

For the dose-expansion cohort of subjects with relapsed or refractory ovarian cancer, subjects must have an archival tumor sample that demonstrates EphA2 expression by immunohistochemical stain. (astrazenecaclinicaltrials.com)

experimental_protocol_type C177560 experimental_protocol_type A C177537 GDC Value Terminology C179450 Primary Tumor Field The anatomic site(s) surrounding and including a primary tumor. (nih.gov)
treatment_anatomic_site C70729 treatment_anatomic_site A C177537 GDC Value Terminology C179451 Primary Tumor Site The anatomic location of a primary tumor. (nih.gov)
3 For colorectal cancer, the primary tumor (pT) category is based on depth of tumor invasion through the colon wall, with pT2 comprising "tumor that invades the muscularis propria," pT3 defined as "tumor that invades through the muscularis propria into pericolorectal tissue," and pT4a designating "tumor that invades through the visceral peritoneum. (allenpress.com)

To address the clinicopathologic characteristics and prognosis of pT2 int tumors. (allenpress.com)
Cerebral glioma is the most common type of primary brain tumor, and the prognosis for this disease remains very poor. (ajnr.org)

Malignant (cancerous) or borderline (low malignant potential) ovarian tumors can spread (metastasize) to other parts of the body and can be fatal. (cancer.org)
These tumors can be benign (not cancer), borderline (low malignant potential), or malignant (cancer). (cancer.org)
These tumors were previously called tumors of low malignant potential (LMP tumors) . (cancer.org)

This study investigated the diagnostic value of circulating tumor cells (CTCs) in peripheral blood from patients with suspected ovarian tumors. (oncotarget.com)
We hypothesize that a combined measure of cerebral blood volume and vascular permeability using vascular-space occupancy (VASO) MR imaging, a recently developed imaging technique, is of diagnostic value for predicting tumor grade. (ajnr.org)
Both VASO Tumor and VASO Ratio were found to be significant predictors of tumor grade, giving diagnostic accuracies of 66.7% and 71.8%, respectively. (ajnr.org)
However, subjective assessment by an experienced ultrasound examiner has been considered to be the best diagnostic method for ovarian tumors [ 2 , 3 ]. (biomedcentral.com)
Multiple diagnostic difficulties can arise with mucinous ovarian tumors (MOT). (jmchemsci.com)
DSRCT is associated with a unique chromosomal translocation t(11;22)(p13:q12) [4] resulting in an EWS - WT1 fusion transcript [5] that is diagnostic of this tumor. (mdwiki.org)

These tumors, which originate from the coelomic epithelium, constitute 80-85% of all ovarian tumors. (medscape.com)

experimental_strategy A C177537 GDC Value Terminology C179443 Macroscopically Positive Parametrial Margin The presence of macroscopically visible residual tumor in surgical margins in the parametrial region. (nih.gov)
Surgical resection is the standard therapy for solitary primary or metastatic liver tumors. (iiarjournals.org)
Following surgical removal of the brain tumor, psychotic manifestations disappeared. (nerdyseal.com)
The surgical treatment of ovarian cancer should be reserved for gynecological oncologists, while benign tumors can be operated on less radically by general gynecologists, or even managed conservatively. (biomedcentral.com)

Worldwide, ovarian cancer is the fifth most frequent malignant tumor in women and the most common cause of death among cancers of the reproductive system. (medscape.com)
In specific embodiments, the disclosure concerns adoptive cell therapy cancer treatment in which tumor-1 infiltrating lymphocytes and/or engineered T cells are modified to increase their efficacy as a cancer treatment. (justia.com)
Just because your doctor finds an epithelial tumor doesn't automatically mean you have cancer . (webmd.com)
Most epithelial tumors turn out not to be cancer . (webmd.com)
Sometimes, your doctor looks at an epithelial tumor under a microscope and can't clearly tell whether it's cancer. (webmd.com)
one group says it was a Brenner Tumor and another say it is edometrioid cancer. (cancer.org)
Dr. Brenner, principal investigator for the studies, presented the results this week at the European Cancer Congress meeting in Vienna, Austria. (sciencedaily.com)
This drug outsmarts the cancer," Dr. Brenner said. (sciencedaily.com)
I am very proud of the work of Dr. Brenner and his team who are setting the stage for breakthrough advances in the treatment of brain cancer here at the CTRC," said Ian Thompson Jr., M.D., CTRC director. (sciencedaily.com)
We are also especially thankful that Dr. Brenner is helping lead the large team of scientists and physicians who are developing next-generation cancer treatments at our cancer center. (sciencedaily.com)
Here, we sought to exploit the merits of a well-characterized GEM model of pancreatic cancer to determine whether proteomics technologies allow identification of protein changes associated with tumor development and whether such changes are relevant to human pancreatic cancer. (nih.gov)
Analysis of proteins chosen on the basis of increased levels in plasma from tumor-bearing mice and corroborating protein or RNA expression in tissue documented concordance in the blood from 30 newly diagnosed patients with pancreatic cancer relative to 30 control specimens. (nih.gov)
There is no evidence to contraindicate the use of systemic or topical menopausal hormone therapy by women with cervical, vaginal, or vulvar cancer, as these tumors are not considered to be hormone dependent. (bmj.com)
Management of menopausal symptoms and the prevention and treatment of osteoporosis in women with gynecological cancer needs to be individualized, with or without menopausal hormone therapy, according to tumor type and stage, and the woman's age. (bmj.com)
Frankly Speaking About Brain Tumors An excellent brain tumor guide from the National Brain Tumor Foundation and Cancer Support Community. (virtualtrials.org)
CD44 is a cancer stem cell (CSC) marker that mainly plays a role in tumor cell proliferation. (jmchemsci.com)
Regulation of proliferation involves tumor suppressor genes, protooncogenes, and cancer stem cells (CSC) [ 14 , 15 ]. (jmchemsci.com)
The tumor appears to arise from the primitive cells of childhood, and is considered a childhood cancer. (mdwiki.org)

DSRCT in young patients can be mistaken for other abdominal tumors including rhabdomyosarcoma , neuroblastoma , and mesenteric carcinoid . (mdwiki.org)

Micrograph of a Walthard cell nest, the entity Brenner tumours are thought to arise from. (wikipedia.org)

Brenner tumours very rarely can occur in other locations, including the testes. (wikipedia.org)
Borderline and malignant Brenner tumours are possible but each are rare. (wikipedia.org)
The same crystals were also noted under high-power view in Brenner tumours. (wikipedia.org)

Mutations in p53 are highly frequent in CRC, and are known to facilitate tumor development and aggressiveness. (bgu.ac.il)

Desmoplastic small-round-cell tumor (DSRCT) is a type of soft tissue sarcoma , a cancerous soft tissue tumor that typically occurs as masses in the abdomen . (mdwiki.org)

Diseases5

Chemicals and Drugs2

Information Science1

Ovary17

Solid tumors5

Granulosa3

Cystadenoma4

Carcinoma4

Stromal6

Fibroma2

Malignancy5

Diagnosis4

Borderline Brenner tumor3

Yolk sac t1

Bilateral3

Ovaries5

Brain tumor patients1

Type of tumor1

Removal of the tumor2

Pathology1

Malignancies1

Epithelial ovarian cancer2

Cystic1

Necrosis2

Wilms Tumor4

Rare tumor1

Metastasis2

Carcinogenesis2

Estrogen4

Histologic4

Clinical3

Adenomas1

Benign ovarian2

Immunohistochemical1

Primary tumor3

Prognosis2

Malignant potential3

Diagnostic6

Epithelium1

Surgical4

Cancer18

Carcinoid1

Arise1

Tumours3

Aggressiveness1

Cancerous1