• Common inbred strains include BALB/c, C3H, C57BL/6 and DBA. (uwm.edu)
  • Reproductive performance consisting of mean litter size, number of pups that wean (wean: born ratio) and mean reproductive index of three inbred mice strains, which are BALB/cMlac, C57BL/6Mlac and DBA/2Mlac, were investigated to provide some basic information on the breeding and maintaining of a foundation colony. (mahidol.ac.th)
  • Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
  • Furthermore, the absolute amounts of Compact disc4+Compact disc25+ and Compact disc4+Compact disc25+FoxP3+ cells in spleens of infected BALB/c mice were greater than those from infected C57BL/6 mice (Figure 1E & F). the pathogenesis of experimental disease, their exact part remains questionable. (rawveronica.com)
  • We wanted to determine whether Tregs donate to specific phenotypic results in BALB/c and C57BL/6 mice and if just how they function regarding control of parasitemia and creation of disease-exacerbating proinflammatory cytokines. (rawveronica.com)
  • Strategy/Results BALB/c and C57BL/6 mice had been contaminated intraperitoneally (i.p) with 103 clone TC13 and both kinetics of Tregs development and intracellular cytokine information in the spleens and livers were monitored directly by movement cytometry. (rawveronica.com)
  • CFD1 As opposed to a transient and non significant upsurge in the percentages and total numbers of Compact disc4+Compact disc25+Foxp3+ T cells (Tregs) in C57BL/6 mouse spleens and livers, a substantial upsurge in the percentage and total amounts of Tregs was seen in spleens of contaminated BALB/c mice. (rawveronica.com)
  • Ablation or raising the amount of Compact disc25+ cells in the fairly resistant C57BL/6 mice by anti-CD25 mAb treatment or by adoptive transfer of Compact disc25+ T cells, respectively, ameliorates or exacerbates parasitemia and creation of proinflammatory cytokines. (rawveronica.com)
  • Summary Collectively, our outcomes display that regulatory T cells donate to susceptibility in experimental murine trypanosomiasis in both highly vulnerable BALB/c and fairly resistant C57BL/6 mice. (rawveronica.com)
  • Writer Overview BALB/c mice are susceptible even though C57BL/6 is relatively resistant to experimental disease highly. (rawveronica.com)
  • For instance, BALB/c mice are extremely susceptible as the C57BL/6 mice are fairly resistant to disease with as assessed by the capability to control parasitemia and success period [3], [4]. (rawveronica.com)
  • For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
  • Past studies have mapped four susceptibility loci (Pas1-4) for pulmonary adenoma in which A/J and C57BL/6J (B6) mice have different alleles that affect incidence and multiplicity of tumours. (bmj.com)
  • 6 Inbred mouse strains vary in their susceptibility to cancer and two extreme strains are A/J (susceptible) and C57BL/6J (B6, resistant). (bmj.com)
  • Mouse pulmoary adenoma susceptibility loci (Pas) as mapped in crosses of strains A/J and C57BL/6. (bmj.com)
  • We hypothesized that oral doxycycline would alter the composition of the GM (as evidenced by changes in the fecal microbiota [FM]) in female C57BL/6NCrl mice, and that the GM would return to baseline when the drug was temporarily discontinued. (biomedcentral.com)
  • On day 0, 20 female C57BL/6NCrl mice were divided into experimental (DOX, n = 10) and control ( n = 10) groups. (biomedcentral.com)
  • There are over 400 documented inbred strains of mice. (uwm.edu)
  • The objective of this study was to determine if there is variation in susceptibility of different strains of mice to MLA and to identify factors responsible for the variation that could be used as a model for cattle. (usda.gov)
  • The results of this study confirm previous reports that there is a fairly large animal to animal variability to larkspur toxicity, and that this variation is found across numerous strains of mice. (usda.gov)
  • The acute toxicity of methyllycaconitine (MLA) in ten different inbred strains of mice was compared. (usda.gov)
  • Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
  • Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
  • Methods Using unilateral and bilateral implantation models of syngeneic breast tumors (E0771, MM3MG-HER2, and JC-HER3) in mice, we assessed whether HS201-PDT could induce local and systemic antitumor immunity. (bmj.com)
  • Although tumor immunosurveillance was first hypothesized more than four decades ago, the observed absence of spontaneous tumors in several immune-compromised mouse strains initially dampened enthusiasm for this idea. (silverchair.com)
  • Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
  • L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
  • Occurrence of mammary tumors, reticular neoplasms, and pulmonary tumors in strain BALB-cAnDe breeding female mice. (jax.org)
  • E) Immunohistological analysis of Vegf expression in tumors harvested from MSTO-211H -bearing nude mice either treated with anti-tumor drug or not. (modelorg.com)
  • 1991 - Became the first commercial provider of the C.B-17 SCID mouse model. (wikipedia.org)
  • The severe-combined immunodeficient (SCID) mice have been exploited as a model for onchocerciasis and are permissive to mf of O. lienalis [ 12 ]. (biomedcentral.com)
  • Balb/c nude mice, NOD/SCID or other immunodeficient mice. (modelorg.com)
  • 1994 - Contracted with National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and transgenic mice. (wikipedia.org)
  • transgenic mice generated by using BAC clone, cTG: conditional transgenic mice, KO: knockout mice, KI: knock-in mice, cKO: conditional knockout mice, CRIPR/Cas9: Endonuclease-mediated mice. (riken.jp)
  • Anti-Id B cells from BCR knock-in mice, together with Id-specific CD4(+) T cells from previously established TCR-transgenic mice, enabled us to study Id-specific T cell-B cell collaboration by dilution of transferred cells into syngeneic BALB/c recipients. (ozgene.com)
  • Doxycycline is a common effector for control of gene expression using the tet-inducible system in transgenic mice. (biomedcentral.com)
  • They produce selectively bred and genetically engineered mice and rats for research use. (wikipedia.org)
  • The use of animals selectively bred to prefer or to avoid alcohol has been highly instrumental in advancing the understanding of the neurobiological basis of ethanol preference. (aspetjournals.org)
  • Both the protein expression differences and the potential identification of genetic markers discovered in mice will provide the basis for future experiments to identify genetic factors that correlate with susceptibility to larkspur toxicity in cattle. (usda.gov)
  • Likewise, different strains of inbred mice display varying amount of susceptibility to experimental disease. (rawveronica.com)
  • There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
  • There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
  • The majority of genomic studies used to identify susceptibility pathways involved in disease pathologies have been performed in the mouse. (biomedcentral.com)
  • Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
  • 1, 2 Moreover, susceptibility is largely intrinsic to the lung itself as shown by the classical experiments involving lung explants from sensitive and resistant mice. (bmj.com)
  • 4, 5 Four QTLs identified as pulmonary adenoma susceptibility (Pas) loci 1-4 have been mapped, respectively, to mouse chromosomes 6, 17, 19, and 9. (bmj.com)
  • Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
  • [4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
  • The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi − and CBi/L inbred mice lines. (biomedcentral.com)
  • The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. (biomedcentral.com)
  • In longevity experiments, 16 female 11-mon-old BALB/c mice and both genders of 12-mon-old ICR mice were daily fed with BPSP supplemented diets at doses of 0, 0.1 and 0.5 g BPSP/kg bw for 750 and 762 days, respectively. (scirp.org)
  • It is of merit to demonstrate that peanut kernels as a potent producer could be bio-elicited to biosynthesize a broad spectrum of bioactive stilbenes to prepare BPSP which is effective to extend mouse longevity as science-evidenced by the two long-term animal experiments. (scirp.org)
  • Therefore increased interindividual gut microbiota similarity may be seen as a way to reduce group sizes in mouse experiments. (ku.dk)
  • Our CRO portfolio includes Animal supply (breeding and trading of animas for experiments), Discovery (Pharmacology & Microbiology Efficacy) and Regulatory research (Toxicology, Mutagenicity & Analytical Chemistry). (cadilapharma.com)
  • The facility is registered with CPCSEA for the breeding and supply of animals for in-house experiments and trading. (cadilapharma.com)
  • In a few experiments, mice had been injected with anti-CD25 mAb prior or post disease or adoptively (by intravenous path) given extremely enriched na?ve Compact disc25+ T lymphocytes ahead of infection as well as the inflammatory cytokine/chemokine amounts and success were monitored. (rawveronica.com)
  • We would like to ask all the users to confirm the quality and characteristics of our mouse resources as soon as possible, before starting your full scale experiments. (riken.jp)
  • This suggests that the GM of mouse models should be considered as a variable in animal experiments. (biomedcentral.com)
  • However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
  • Selective inbreeding of this mutant led us to the establishment of a colony of inbred hydronephrosis mice. (mahidol.ac.th)
  • Taconic received the NCr nude Spontaneous mutant model from NCI in 1993 after several years of random breeding. (vivobio.com)
  • Alcohol consumption and preference, as well as food and water consumption, total caloric intake, and weight were assessed in adult female and male Clock Δ19/Δ19 mutant mice or wild-type (WT) litter-mates, housed under a 12-hour:12-hour light:dark (L:D) cycle or a shortened 10-hour:10-hour L:D cycle. (mdpi.com)
  • One naturally occurring genetic defect in mice results in an animal with no hair that is called a nude. (uwm.edu)
  • A-B) Human colon cancer cells genetically engineered to express firefly luciferase gene were injected via carotid artery into nude mice. (modelorg.com)
  • Right) Subcutaneous tumor formed by HepG2 cells on nude mice. (modelorg.com)
  • Nude mice were subcutaneously inoculated with A549 cells that constitutively express EGFP. (modelorg.com)
  • Twenty Mlac:WR breeding pairs were randomized to determine the percentage of hydronephrosis in the original National Laboratory Animal Center colony. (mahidol.ac.th)
  • Breeding pairs that produced hydronephrosis offspring were removed from the colony and replaced with offspring from other healthy breeding pairs within the same group in the next generation. (mahidol.ac.th)
  • Taconic Biosciences is a private biotechnology company specializing in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services. (wikipedia.org)
  • Genetically modified mouse strains derived from embryonic stem (ES) cells have become essential tools for functional genomics and biomedical research. (liveconscience.com)
  • Since the early 1990s we have specifically used the aggregation method to generate multiple genetically revised mouse stresses from 129S1129X1 (L1) [30] and 129S6B6F1 (G4) [31] Sera cells. (liveconscience.com)
  • Increased gut microbiota similarity in closely related mice in inbred mouse colonies is, therefore, more likely to be caused by other factors, such as imprinting or different intrauterine conditions, rather than by residual heterozygosity. (ku.dk)
  • Breeding & trading of animals: Below mentioned animal colonies are maintained by in-breeding, out-breeding, or random breeding systems as per the species characteristics. (cadilapharma.com)
  • The mice were derived by hysterectomy to achieve Germfree status prior to introduction into Restricted Flora™ IBU colonies. (vivobio.com)
  • A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)
  • To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
  • Identification of the genes predisposing to mouse lung cancer could have considerable implications for diagnosis, treatment, or chemoprevention of lung cancer in humans. (bmj.com)
  • Previously, classical genetic studies involving cross breeding of mouse strains with differing susceptibilities have identified chromosomal areas associated with predisposition to developing spontaneous and chemically induced lung adenomas. (bmj.com)
  • Some cattle breeds indigenous to Western Africa (like the Ndama) are fairly resistant to trypanosomiasis, whereas the Western breeds, from the Zebu background are highly susceptible particularly. (rawveronica.com)
  • Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)
  • More laboratory mice are used in research every year than any other animal species. (uwm.edu)
  • 1969 - Began offering rats, including Sprague Dawley, one of the most popular breeds of laboratory rat 1969 - Taconic was the first breeder to receive full accreditation from the American Association for the Accreditation of Laboratory Animals 1970 - Contracted to provide the National Institutes of Health with Sprague Dawley rats. (wikipedia.org)
  • Insect larvae such as tobacco hornworm can accelerate and economize preclinical research by complementing classic laboratory animals such as rats and mice. (uni-giessen.de)
  • The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
  • A significant incidence of late onset adenocarcinoma observed in both IFN-γ- and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance. (silverchair.com)
  • A mouse model of primary liver cancer can be established in about 6 months after intraperitoneal injection of DEN. (modelorg.com)
  • Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). (silverchair.com)
  • The purpose of the study was to analyze spontaneous behavior of young and old females of the original CBRB inbred strain with signs of parkinsonism after 80 weeks of age and females of the standard BALB/cJ strain of the same ages using express-test. (labanimalsjournal.ru)
  • Based on the data obtained, strain differences and age-related changes in the spontaneous behavior of female mice of the CBRB and BALB/cJ strains were revealed. (labanimalsjournal.ru)
  • The express modification of the cylinder test enabled to confirm not only the previously discovered motor traits of female CBRB mice, but also certain non-motor changes in spontaneous behavior that are similar to characteristics of patients with Parkinson's disease. (labanimalsjournal.ru)
  • The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
  • Acute death seen in contaminated BALB/c mice is definitely from the extreme production of pro-inflammatory cytokines usually. (rawveronica.com)
  • Two strains may be bred together to produce a mixture of the genes of each strain. (uwm.edu)
  • 1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)
  • Germline transmission breeding and subsequent backcrosses to C57BT/6 (M6) to generate congenic stresses delay practical studies and increase costs, while at the same time genes closely linked to the unique targeted locus remain from the unique Sera cell genome and may confound study results [4]. (liveconscience.com)
  • Collectively, these considerations led the large level mouse mutagenesis projects structured under the umbrella Aliskiren hemifumarate of the World Knockout Mouse Consortium (IKMC) to select M6-produced Sera cells as the parental lines in which to mutate all Aliskiren hemifumarate protein coding genes of Aliskiren hemifumarate mouse [5], [6]. (liveconscience.com)
  • In humans, the wide variety of carcinogens and varying degrees of exposure make identifying the predisposing genes difficult, but in a mouse model, such confounding variables can be controlled. (bmj.com)
  • Kalinin M.A. - participation in the performance of behavioral tests, in the maintenance of the collection, and experimental mice. (labanimalsjournal.ru)
  • Inbred strains are the result of at least 20 generations of brother-sister mating. (uwm.edu)
  • BALB/cCrl mice were, however, found to have a mean heterozygosity of only 0.8% in their genome, and selection of breeders with a high similarity in the gut microbiota for three generations did not change the overall gut microbiota similarity, which was 66% in the P generation and 66%, 64% and 63% in the F1, F2 and F3 generations, respectively. (ku.dk)
  • After inbreeding for 20 generations, a surprisingly high incidence of hydronephrosis was encountered and we finally obtained a strain of mice with a very high incidence of severe hydronephrosis affected on both sides of kidney and in both sexes as the process of inbreeding has been increased. (mahidol.ac.th)
  • From then on, a regular system of inbreeding involving full-sib (FS) mating was applied and maintained for more than 30 generations giving rise to CBi/L FS, CBi − FS and CBi FS lines. (biomedcentral.com)
  • PCR tests for the genetic background of inbred and wild-derived strains by using microsatellite or single nucleotide polymorphism (SNP) markers. (riken.jp)
  • Genetic differentiation among autochthonous and cosmopolitan goat breeds based on information from microsatellite markers - a preliminary study. (krakow.pl)
  • These mice have both BALB/c inbred and NIH(S) outbred stock in their genetic background. (vivobio.com)
  • Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)
  • Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
  • CBi is an inbred mouse strain derived from an outbred population generated by crossing BALB/c, Rockland, NIH and Swiss mice. (biomedcentral.com)
  • The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi − and CBi/L, is a good murine model to study the process of tumor immunoediting. (biomedcentral.com)
  • Genotype I of T. gondii is most virulent for mice, inducing extensive parasite dissemination and sudden murine death. (springer.com)
  • The investment in training should be outweighed by the benefits observed with more reliable behavioral and physiological responses in the mice. (uwm.edu)
  • Solovieva A.S. , Aronov D.A. , Shubernetskaya O.S. , Kalinin M.A. , Moiseeva Е.V. Express-modification of cylinder test for assessing the behavioral parameters of young and old cbrb and BALB/CJ mice. (labanimalsjournal.ru)
  • Inflammatory diseases in mouse models are under strong impact from the gut microbiota. (ku.dk)
  • We therefore hypothesized that selective breeding of mice aiming at a high similarity in the gut microbiota would increase the interindividual similarity of the gut microbiota. (ku.dk)
  • This study aims to demonstrate the effect of oral doxycycline on fecal microbiota of mice. (biomedcentral.com)
  • Breeder selection for breeding was carried out by using the progeny selection method, which selects offspring based on their characteristics, in combination with the breeding principle of maximum avoidance of inbreeding and the rotational mating system. (mahidol.ac.th)
  • The results from selection and breeding revealed that the incidence of hydronephrosis was 7.5% in the F0, decreasing to 1.07%-1.72% in the F2-F4, and 0.00% in the F5. (mahidol.ac.th)
  • Deposited mice are housed separately based on the microbial test results at deposition, and then, all the mice are cleaned-up by a rederivation procedure. (riken.jp)
  • A combination of HS201-PDT with anti-PD-L1 antibody demonstrated the greatest antigen-specific immune response, tumor growth suppression, prolonged mouse survival time and abscopal effect. (bmj.com)
  • We had been interested in dealing with the following queries: Perform Tregs donate to the specific phenotypic outcomes seen in disease in mice. (rawveronica.com)
  • The 129 strain of mice had twice the amount of alpha 7 nAChR subunit expression as the A/J strain, which was in direct proportion to the approximate two fold difference in LD50. (usda.gov)
  • First successful transplantations of ovaries between female mice are performed by William Russell at JAX. (jax.org)
  • In this study, we disrupted circadian rhythms in female and male mice using both environmental (i.e., shifting diurnal cycles) and genetic (i.e. (mdpi.com)
  • FXGs were previously identified in mouse, rat, and human brains in a conserved subset of neuronal circuits but with species-dependent developmental profiles. (biorxiv.org)
  • Previously, a low incidence of mild hydronephrosis was observed mostly in male mice and found only on the right kidney. (mahidol.ac.th)
  • L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
  • Recently, RI strains have also been used to map QTLs that that are responsible for biometric variation in the architecture of the mouse CNS (Belknap et al. (nervenet.org)
  • Small mammals like mice or rats are indispensable for preclinical research. (uni-giessen.de)
  • Gene-targeted mice have greatly aided our understanding of the key effector molecules in tumor immunity. (silverchair.com)
  • Production of gene-targeted mice for specific effector molecules has greatly aided this endeavor ( 4 - 14 ). (silverchair.com)
  • To address this issue, we generated a double knock-in mouse that expresses V regions of a somatically mutated anti-Id mAb with intermediate affinity (affinity constant [Ka] = 0.77 × 10(7) M(-1)) for the myeloma protein M315. (ozgene.com)
  • Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)
  • references 5 , 14 , and 16 ), key molecules of both the innate and adaptive immune systems, contribute to tumor prevention in mice treated with the chemical carcinogen, methylcholanthrene (MCA), or in mice deficient for p53 expression. (silverchair.com)
  • Based on the resultant survival curves and average lifespans of both mouse models, basal diets supplemented with BPSP are effective to extend mouse longevity by a dose dependent manner. (scirp.org)
  • Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). (modelorg.com)
  • In CDX models, cancer cells are inoculated into immuno-deficient mice via various routes. (modelorg.com)
  • Fig 4: Evaluation of efficacy and toxicity of anti-tumor drug candidates D1 and D2 on A549 (A&B)- and MSTO-211H (C&D)-bearing mouse models. (modelorg.com)
  • The state-of-the-art facility is spread over more than 11500 square feet which include animal breeding, experimentation rooms and support laboratories. (cadilapharma.com)
  • In mice, FXGs are found in the olfactory bulb throughout life but in other forebrain regions are only found in juvenile animals during periods of robust experiencedependent circuit refinement. (biorxiv.org)
  • In contrast, FXGs are found in rats throughout life in both hippocampal and olfactory bulb circuits while recapitulating the developmental downregulation in other forebrain regions seen in mice. (biorxiv.org)
  • Simple Summary Domestic dogs have a wide variety of colorations, and previous research has found that, in certain breeds, coat color can be linked to behavior. (researchgate.net)
  • The Syrian hamsters were found to be the more permissive to O. ochengi mf as fully viable mf were recovered from them on day 30, compared to BALB/c mice where such mf were recovered on day 15, but not 30. (biomedcentral.com)
  • A variety of sponsor embryos and methods possess been used to generate germline chimeras from M6 Sera cells such as BALB/c and C57BT/6-blastocyst injections. (liveconscience.com)
  • Aggregation of cleavage stage embryos with Sera cells [29] gives an accessible method for generating Sera cell chimeric mice. (liveconscience.com)
  • Use of such natural variations in marker assisted breeding could lead to the development of higher yielding soybean varieties. (trentu.ca)
  • The company has three service laboratories and six breeding facilities in the U.S. and Europe, and is headquartered in Rensselaer, New York. (wikipedia.org)
  • Nevertheless, the over creation of IFN- and also other proinflammatory cytokines, (especially IL-1, IL-6, IL-12 and TNF) plays a part in disease and loss of life in the extremely vulnerable BALB/c mice [8]. (rawveronica.com)
  • Initially sought as pets, the Granby mice become important in research. (jax.org)
  • The anti-Id mice have normal peripheral B cell populations, and allelic exclusion is efficient. (ozgene.com)
  • When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi − the tumor growths briefly and then begins a rejection process in 100% of the animals. (biomedcentral.com)
  • Improved methods for the generation of germline transmitting chimeric mice from M6 Sera cell lines will make the IKMC and additional M6 Sera cell resources more accessible to the broader biomedical Aliskiren hemifumarate study community. (liveconscience.com)
  • Cancer cell line-derived xenograft (CDX) model is a well-established mouse model type commonly used for cancer research and anti-tumor drug development, due to its user-friendly techniques and outstanding repeatability. (modelorg.com)
  • Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
  • These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)
  • Data were collected from studies that were deemed eligible for analysis based on set inclusion criteria, and findings were assessed in relation to strain of mouse, type of injury and organ of investigation. (biomedcentral.com)