Breast toxicity epirubicin. Medical search. Frequent questions

Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. (wikipedia.org)
Epirubicin monotherapy was shown to be therapeutically equivalent to doxorubicin monotherapy in patients who had to receive previous chemotherapy for advanced breast cancer. (wikipedia.org)
Equimolar doses of epirubicin and doxorubicin have been shown to be therapeutically equivalent in patients with metastatic breast cancer. (wikipedia.org)
The mechanism of action of epirubicin is similar to that of doxorubicin and other anthracycline drugs. (wikipedia.org)
The observed clinical differences between epirubicin and doxorubicin can be explained by the pharmacokinetic differences based on the different affinity to DNA and lipophilicity, as there is no indication that different mechanisms are involved in their activity. (wikipedia.org)
Doxorubicin is an essential component of the treatment of aggressive lymphoma, childhood solid tumors, bone and soft tissue sarcomas, and breast cancer and additional indications are emerging. (bgu.ac.il)
Epirubicin has a spectrum very similar to doxorubicin but lesser toxicity. (bgu.ac.il)
In the use of chemotherapy drugs, anthracyclines, such as doxorubicin and epirubicin, are generally used in combination with drugs such as cyclophosphamide, epirubicin, and fluorouracil. (encyclopedia.pub)
The anthracyclines are commonly used antibiotic cytotoxics, and include epirubicin and doxorubicin . (wikidot.com)

Additionally the administration of more dose intensive epirubicin-containing regimens to patients with metastatic breast cancer has been associated with improved response rates, but not increased overall survival. (wikipedia.org)
In thisopen-label phase I study, irinotecan was administered IV at a fixeddose of 250 mg/m2 on day 1 in combination with capecitabine at a fixeddose of 1,500 mg/m2 for days 2 to 7 and epirubicin starting at a dose of40 mg/m2 and escalating by 10 mg/m2 in cohorts of three patients forthose with metastatic adenocarcinomas. (cancernetwork.com)
Bevacizumab, a humanized monoclonal antibody that inhibits angiogenesis, had been approved for use in combination therapy for metastatic breast cancer. (medscape.com)
Fulvestrant (Faslodex) was approved by the FDA for hormone receptor (HR)-positive, HER2-negative locally-advanced or metastatic breast cancer in postmenopausal women not previously treated with endocrine therapy. (medscape.com)
Palbociclib and ribociclib are cyclin-dependent kinases (CDK) 4, 6 inhibitors indicated in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. (medscape.com)
There is a potential rationale if the cancer is triple negative," Ruth O'Regan, MD, of the University of Wisconsin Carbone Cancer Center, told MedPage Today , but cautioned that overall, EGFR inhibitors have not been shown to be effective in metastatic triple-negative breast cancer. (medpagetoday.com)
The combination of EXE/EVE as first- or second-line therapy for ER+ve/HER2−ve metastatic breast cancer is more efficacious than several chemotherapy regimens that were reported in the literature. (unicatt.it)
For secondary (also called metastatic or advanced) breast cancer, chemotherapy can often be prescribed as a single drug. (owise.uk)
High-dose therapy followed by peripheral blood stem cell (PBSC) support was performed in 29 patients with primary high-risk (Group I) or chemoresponsive metastatic (Group II) breast cancer patients. (johnshopkins.edu)
[ 2 ] Abemaciclib, palbociclib, and ribociclib are approved for initial and second-line therapy of HR-positive advanced and metastatic breast cancer. (medscape.com)
Deaths from metastatic breast cancer continue to be a leading cause of global cancer mortality among women. (amegroups.org)
The pace of advances in the treatment of hormone-receptor positive metastatic breast cancer (HR + MBC) has introduced nuance and complexity in choosing between available agents as patients and physicians explore options across lines of therapy. (amegroups.org)
Combining sequential treatment options, evolving treatment options, and advanced genetic and genomic testing along with shared decision making between patients and physicians, this review aims to outline the key factors that ultimately drive the decisions for treatment in hormone-positive metastatic breast cancer. (amegroups.org)
Over the last decade, the improvements in survival achieved with new therapies for metastatic breast cancer (MBC) have been groundbreaking. (amegroups.org)
Systemic adjuvant chemotherapy with anthracycline- and taxane-containing regimens has become the standard first line treatment for early and metastatic breast cancer [ 5 ], with large phase III randomized trials showing extremely high long-term disease-free survival and overall survival rates (resp. (hindawi.com)
In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)

Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands. (wikipedia.org)
Systemic toxicities of anthracyclines (myelosuppression, mucositis, nausea/vomiting) are seen in patients with non-intact bladders. (worthingtoncaron.com)
Epirubicin is an antineoplastic drug that belongs to the class anthracyclines. (mrmed.in)

Epirubicin is an anthracycline drug used for chemotherapy. (wikipedia.org)
With the introduction of anthracycline-based regimens, 5-year survival rates have significantly improved in patients with early-stage breast cancer. (carcinogenesis.com)
New areas of research in relation to anthracycline antibiotics include introduction of new the analogs, insight into mechanisms of resistance, the reversal of multidrug resistance in vitro, the protection of cardiac toxicity, and the study of other important biochemical reactions relevant to cytotoxicity. (bgu.ac.il)
We investigate the incidence of hematological toxicities and their relation to the haplotype ATP-binding cassette B1 (ABCB1) which were polymorphisms of C1236T , C3435T , G2677T, and glutathione S-transferase P1 ( GSTP1 ) A313G genes in Indonesian breast cancer patients who received anthracycline during chemotherapy. (omjournal.org)
Anthracycline-induced cardiac toxicity may be manifested by early (or acute) or late (delayed) events. (recallguide.org)
These results overall suggest that the use of scalp cooling is effective in preventing alopecia in the majority of early breast cancer patients receiving neoadjuvant or adjuvant CT, especially for patients undergoing a taxane-based non-anthracycline regimen. (plkinhibitors.com)

In comparison to this the Epirubicin therapy contains fluorouracil/epirubicin/cyclophosphamide (FEC). (wikipedia.org)
Three large randomized studies have directly compared the epirubicin-containing regimen fluorouracil/epirubicin/cyclophosphamide (FEC) with CMF in the adjuvant setting. (wikipedia.org)
85% for historical regimens (ie, cyclophosphamide/methotrexate/fluorouracil) are known to affect breast cancer survival. (jnccn.org)
In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
This study sought to retrospectively characterize outcomes for patients with node-negative and node-positive breast cancer receiving adjuvant trastuzumab in combination with docetaxel/cyclophosphamide (DCH), docetaxel/carboplatin/trastuzumab (TCH), or fluorouracil/epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (FEC-DH) chemotherapy in Alberta, Canada, from 2007 through 2014. (jnccn.org)
She received neoadjuvant chemotherapy with 5-fluorouracil, epirubicin, and cyclophosphamide followed by paclitaxel. (iiarjournals.org)
The effects of fluorouracil, epirubicin, and cyclophosphamide (FEC60) on the intestinal barrier function and gut peptides in breast cancer patients: an observational study. (naturalmedicinejournal.com)
All participants received the same chemotherapy FEC-60 (fluorouracil 600 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 600 mg/m2 every 21 days for 6 cycles). (naturalmedicinejournal.com)
As with other cytotoxic agents, Epirubicin Hydrochloride Injection at the recommended dose in combination with cyclophosphamide and fluorouracil can produce severe leukopenia and neutropenia. (recallguide.org)

It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere. (wikipedia.org)
Epirubicin [Ellence] has a unique AE. (freezingblue.com)

The chemotherapy regimens in the trial included four cycles of adriamycin or epirubicin , followed by taxane therapy. (medscape.com)
However, she noted, the results should not be applied to patient populations outside of breast cancer or treatment regimens outside this study. (medscape.com)
Safety profile of docetaxel regimens includes toxicities, particularly a high risk of neutropenia and febrile neutropenia. (hindawi.com)

With the addition of granulocytecolony-stimulating factor (G-CSF [Neupogen]) to the regimen,patients received epirubicin at clinically relevant doses after dose-escalation.Results of the topoisomerase activity will be reported with thefinal results of this phase I study. (cancernetwork.com)
This combination regimen in patients with upper gastrointestinalmalignancies and breast cancer will be investigated as partof phase II studies, once the dose-limiting toxicity is determined. (cancernetwork.com)
With the addition of granulocyte colony-stimulating factor (G-CSF [Neupogen]) to the regimen, patients received epirubicin at clinically relevant doses after dose-escalation. (cancernetwork.com)
In patients receiving adjuvant aromatase inhibitor therapy for breast cancer who are at high risk for fracture, the monoclonal antibody denosumab or either of the bisphosphonates zoledronic acid and pamidronate may be added to the treatment regimen to increase bone mass. (medscape.com)
Adding panitumumab to a carboplatin-containing neoadjuvant chemotherapy regimen yielded a higher rate of pathologic complete response (pCR) in patients with triple-negative inflammatory breast cancer (IBC), a small study found. (medpagetoday.com)
After this the investigators adopted a 3 weeks on, 1 week off approach that resulted in less intense hematological toxicity compared with the weekly regimen. (medpagetoday.com)
For breast cancer subtypes with HER2 overexpression, trastuzumab is generally added to the neoadjuvant chemotherapy regimen, and satisfactory results have been obtained in clinical use [ 5 ] . (encyclopedia.pub)
For primary (early-stage) breast cancer, a chemotherapy regimen combining two to three drugs is usually recommended. (owise.uk)
We suggest that the FE 120 C plus G-CSF is an effective and innovative regimen for PBSC mobilization in breast cancer patients, and high-dose CTCb therapy with PBSC support is a safe and well-tolerated treatment modality. (johnshopkins.edu)
The regimen is being evaluated in a randomized trial of the International Breast Cancer Study Group. (tau.ac.il)

Approval of ribociclib was based on interim analysis results from the pivotal phase 3 MONALEESA-2 trial in postmenopausal women who received no prior systemic therapy for their advanced breast cancer. (medscape.com)
In recent years, breast cancer has been considered a systemic disease, and neoadjuvant chemotherapy has also been included as an important part of the treatment of breast cancer. (encyclopedia.pub)
As reviewed in the present paper, the investigated targeted drug delivery systems have proven to be more effective than free drugs by enhancing efficacy and reducing the systemic toxicity of therapy. (brieflands.com)

Purpose: To evaluate the activity and toxicity of the combination of paclitaxel given by three-hour infusion, and carboplatin as first- line chemotherapy in patients with advanced breast cancer (ABC). (ucy.ac.cy)
Because paclitaxel has very little aqueous solubility, a Cremophor /ethanol vehicle is used, but its toxicity limits the amount of paclitaxel that can be clinically administered [ 10 - 12 ]. (oncotarget.com)

The dose-limiting toxicity has not yetbeen reached. (cancernetwork.com)
The dose-limiting toxicity has not yet been reached. (cancernetwork.com)
Delayed myelosuppression is the dose-limiting toxicity. (worthingtoncaron.com)
Definitive SRS has historically been performed in a single fraction, with dose limited by tumor size in order to minimize toxicity ( 2 ). (iiarjournals.org)
Because tumor control is related to dose, multi-fraction approaches have been proposed for larger lesions to reduce recurrence without increasing toxicity. (iiarjournals.org)
A dose-dependent, reversible leukopenia and/or neutropenia is the predominant manifestation of hematologic toxicity associated with epirubicin and represents the most common acute dose-limiting toxicity of this drug. (recallguide.org)
This toxicity appears to be dependent on the cumulative dose of Epirubicin Hydrochloride Injection and represents the cumulative dose-limiting toxicity of the drug. (recallguide.org)
Purpose: To determine the safety and efficacy of multiple cycles of dose-intensive, nonablative chemotherapy in women with poor-prognosis breast cancer. (tau.ac.il)
For which cytotoxic drugs is renal damage the dose-limiting toxicity? (freezingblue.com)

Epirubicin is also capable of generating cytotoxic free radicals, which are very reactive against DNA, cell membranes and mitochondria. (wikipedia.org)
Epirubicin Hydrochloride Injection should be administered only under the supervision of qualified physicians experienced in the use of cytotoxic therapy. (recallguide.org)
Before beginning treatment with epirubicin, patients should recover from acute toxicities (such as stomatitis, neutropenia, thrombocytopenia, and generalized infections) of prior cytotoxic treatment. (recallguide.org)
Epirubicin inhibits DNA, RNA, and protein synthesis by exerting cytotoxic activity. (mrmed.in)

Subsequently, lapatinib, an orally bioavailable small molecule dual HER2- and EGFR/HER1-specific tyrosine kinase inhibitor, received Food and Drug Administration (FDA) approval in combination with capecitabine for patients with advanced HER2+ breast cancer. (carcinogenesis.com)
In December 2013, Hoffmann-La Roche, manufacturer of capecitabine (Xeloda), an oral agent for the treatment of breast and colorectal cancers, reported that in rare cases, patients using the drug may develop potentially fatal cutaneous disease, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. (medscape.com)

Hematological toxicity induced by chemotherapy is known to be caused by multiple factors, including genetic factors such as polymorphisms. (omjournal.org)
Data on patient characteristics and the incidence of hematological toxicity after each of the three cycles of chemotherapy were obtained from the medical records. (omjournal.org)
Indonesia breast cancer patients who underwent three cycles of chemotherapy demonstrated susceptibility to hematological toxicity by developing side effects such as anemia and neutropenia. (omjournal.org)
However, no relationship was found between hematological toxicity and ABCB1 and GSTP1 polymorphisms. (omjournal.org)
While chemotherapy has improved recovery rates, it also produces adverse reactions such as hematological toxicity. (omjournal.org)
5 When hematological toxicity occurs, the physician may decide to delay the chemotherapy. (omjournal.org)

The FDA also approved 1 year of extended adjuvant neratinib after chemotherapy and a year of trastuzumab for HER2-positive breast cancer on the basis of the ExteNET trial. (carcinogenesis.com)
This subtype accounts for approximately 20%-30% of invasive breast cancers, and until the discovery of effective anti-HER2 therapies ( first of which is trastuzumab), was associated with reduced disease-free survival (DFS), increased risk of metastases, and shorter overall survival (OS). (carcinogenesis.com)
Comparative real-world outcomes for patients with HER2-positive (HER2+) breast cancer receiving adjuvant trastuzumab outside of clinical trials are lacking. (jnccn.org)
Herzuma (trastuzumab-pkrb) is a HER2 /neu receptor antagonist indicated for the treatment of HER2-overexpressing breast cancer . (rxlist.com)
Administration of trastuzumab products can result in serious and fatal infusion reactions and pulmonary toxicity. (rxlist.com)
Neratinib: A tyrosine kinase inhibitor approved for the extended adjuvant treatment of patients with early-stage Her2Neu-positive breast cancer, following adjuvant trastuzumab-based therapy. (medscape.com)

In a retrospective survey, including 9144 patients, mostly with solid tumors in advanced stages, the probability of developing CHF increased with increasing cumulative doses of Epirubicin Hydrochloride Injection (Figure 5). (recallguide.org)

The long-circulating and higher tumor accumulation of E/PCF-NPs resulted in complete ablation of breast tumor tissue through the enhanced photothermal effect by NIR laser irradiation-mediated cell apoptosis. (dovepress.com)
It can be used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. (wikipedia.org)
The emergence of taxanes and their significant anti-tumor activity against advanced breast cancer have further improved the efficacy of neoadjuvant chemotherapy. (encyclopedia.pub)
Although this has historically been performed in a single fraction, multi-fraction approaches such as fraction radiosurgery (FSRS) and staged radiosurgery (SSRS) have been recently examined as alternative approaches for larger lesions to permit better tumor control without increased toxicity. (iiarjournals.org)
The study enrolled 60 breast cancer patients who had undergone surgical resection of the tumor and lymph nodes and received adjuvant chemotherapy. (naturalmedicinejournal.com)
The challenge is to increase chemotherapeutic concentrations within the tumor environment while decreasing the general toxicity. (oncotarget.com)

Neoadjuvant Chemotherapy of Breast Cancer" Encyclopedia , https://encyclopedia.pub/entry/14321 (accessed November 28, 2023). (encyclopedia.pub)
With the increasing development of medicine today, the clinical application of neoadjuvant chemotherapy has brought new hope to the treatment of breast cancer. (encyclopedia.pub)
Based on the relevant research on the existing drug resistance mechanism, the current treatment plan for reversing the resistance of breast cancer to neoadjuvant chemotherapy is explored, and the potential drug targets are analyzed, aiming to provide a new idea and strategy to reverse the resistance of neoadjuvant chemotherapy drugs in breast cancer. (encyclopedia.pub)
At present, there is no uniform standard for neoadjuvant chemotherapy for breast cancer. (encyclopedia.pub)
Although the efficacy of neoadjuvant chemotherapy has been confirmed, clinical trial data show that the effects of neoadjuvant chemotherapy for different breast cancer patients are very different, and it is easy to develop drug resistance, which is not conducive to subsequent treatment [ 6 ] . (encyclopedia.pub)
European Journal of Cancer 39 (2003) 1061-1067 www.ejconline.com Extended neoadjuvant chemotherapy in locally advanced breast cancer combined with GM. (coek.info)
To this end, the number of activated DC (i.e. positive for the marker S100) in tumour-draining lymph nodes (TDLN) was determined and compared between LABC patients receiving neoadjuvant chemotherapy with GM-CSF (n=52) or without GM-CSF (n=11), and a control group of chemonaı¨ve breast cancer patients (n=10). (coek.info)
1. Introduction In an attempt to improve the overall survival (OS) of patients with locally advanced breast cancer (LABC), we previously performed a phase II study with neoadjuvant chemotherapy followed by local therapy [1]. (coek.info)

Early cardiac toxicity of epirubicin consists mainly of sinus tachycardia and/or ECG abnormalities such as non-specific ST-T wave changes, but tachyarrhythmias, including premature ventricular contractions and ventricular tachycardia, bradycardia, as well as atrioventricular and bundle-branch block have also been reported. (recallguide.org)
Delayed cardiac toxicity results from a characteristic cardiomyopathy that is manifested by reduced LVEF and/or signs and symptoms of congestive heart failure (CHF) such as tachycardia, dyspnea, pulmonary edema, dependent edema, hepatomegaly, ascites, pleural effusion, gallop rhythm. (recallguide.org)
Over the last years, the hpv mouth symptoms pictures of the cardiac toxicity of anticancer treatment has markedly increased due to improvements in patient survival, aging of the population including cancer patients and the introduction of new anticancer drugs with unique toxicities. (leacurinaturiste.ro)

Adjuvant treatment for breast cancer involves radiation therapy and a variety of chemotherapeutic and biologic agents. (medscape.com)
In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)

Treatment is aimed at reducing the risk of future recurrence, thereby reducing breast cancer−related morbidity and mortality. (medscape.com)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)

The combination of Epirubicin and tamoxifen lead to an increase survival in node-positive postmenopausal women with hormone receptor-positive breast tumours. (wikipedia.org)

Nine patients died on study (one of which was deemed to be treatment related), and three patients ceased treatment due to toxicity or distant metastasis. (medpagetoday.com)
In clinical treatment of breast cancer, surgery is usually combined with chemotherapy. (encyclopedia.pub)
With the development of biology and immunology, the approach to breast cancer treatment is constantly updated. (encyclopedia.pub)
It aims to transform inoperable breast cancer into operable breast cancer, convert breast cancer that requires breast removal into breast-sparing breast cancer and provide drug basis in the follow-up treatment to improve the prognosis of patients [ 4 ] . (encyclopedia.pub)
Breast Cancer Research and Treatment , 152 , 95-117. (unicatt.it)
Chemotherapy (often called chemo) is a common treatment for breast cancer. (owise.uk)
No major treatment-related toxicities were noted. (johnshopkins.edu)
Breast Cancer Research and Treatment , 49 (3), 237-244. (johnshopkins.edu)
These effects do not usually predict subsequent development of delayed cardiotoxicity, are rarely of clinical importance, and are generally not considered an indication for the suspension of epirubicin treatment. (recallguide.org)
If it occurs, delayed cardiotoxicity usually develops late in the course of therapy with Epirubicin Hydrochloride Injection or within 2 to 3 months after completion of treatment, but later events (several months to years after treatment termination) have been reported. (recallguide.org)
The major toxicity was severe, reversible myelosuppression that was more prolonged with successive cycles, and this did not differ between patients given treatment every 28 days and those treated every 21 days. (tau.ac.il)
KEYTRUDA is indicated for the treatment of patients with high-risk early-stage triple-negative breast cancer (TNBC) in combination with chemotherapy as neoadjuvant treatment, and then continued as a single agent as adjuvant treatment after surgery. (keytrudahcp.com)
For more information, see Breast Cancer , HER2 Breast Cancer , and Breast Cancer Treatment Protocols . (medscape.com)
During a Targeted Oncology Case-Based Peer Perspectives event, Sara M. Tolaney, MD, MPH, discussed therapies available for the treatment of a 42-year-old woman with HER2-positive breast cancer. (targetedonc.com)
Treatment with actinomycin D can cause reactivation of radiation toxicity, often of the skin. (wikidot.com)
They are perhaps best known for breast cancer treatment. (wikidot.com)
All prior treatment-related toxicities must have resolved to ≤ Grade 2 prior to enrollment. (sparkcures.com)
There is clinical and experimental evidence suggesting that antiprogestins might be used for the treatment of selected breast cancer patients. (oncotarget.com)
Despite efforts to develop novel therapeutic anticancer agents to block specific signaling pathways, chemotherapy is still the gold standard for advanced breast cancer treatment. (oncotarget.com)
We describe existing clinical trials of antiangiogenic agents and the challenges facing the clinical development and optimal use of these agents for the treatment of breast cancer. (biomedcentral.com)
This review focusses on clinical aspects of treatment of breast cancer with monoclonal antibodies, and tyrosine kinase and mammalian target of rapamycin (mTOR) inhibitors. (biomedcentral.com)
Before initiating the treatment, inform your physician if you have kidney or liver problems, recent vaccination, or if you have any acute toxicities such as acute inflammation of the mouth, low white blood cell count, platelet count, or any infections. (mrmed.in)
Female subjects who are breast feeding should discontinue nursing prior to the first day of study treatment and until 6 months after the last study treatment. (who.int)

This survey, addressed to breast cancer surgeons in Spain, has the objective of assessing current clinical trends on axillary staging of cN + patients treated with NAC. (unav.edu)
There are large differences between the clinical responses of individual breast cancer patients in chemotherapy induced hematological toxicities. (omjournal.org)
At present, several antiangiogenic therapies are in clinical trials testing their promise in breast cancer. (biomedcentral.com)
Proceedings from conferences of the American Society of Clinical Oncology (ASCO), the American Association of Cancer Research (2005 to 2009), and the San Antonio Breast Cancer Symposium (2005 to 2009) were searched for relevant abstracts. (biomedcentral.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)

There are some malignant disease associations like synchronous or metachronous ovarian, colonic and endometrial tumours with Breast cancer. (org.pk)
12 Kindler syndrome is associated with some malignant tumours like skin, larynx, oropharynx, bladder etc. 11 Kindlin 1 is a regulator of TGF-beta and through this mechanism it plays a role in pulmonary metastasis of breast cancer and lung cancer. (org.pk)
In situ hybridization studies have demonstrated expression of VEGF mRNA in many human tumours, including breast cancer. (biomedcentral.com)

incr risk of fatal pulmonary toxicity. (freezingblue.com)

This retrospective cohort study was conducted on 138 breast cancer patients who underwent three cycles of chemotherapy in H. Adam Malik Hospital, Medan, Indonesia, who satisfied the inclusion criteria. (omjournal.org)

The median survival rates markedly better than those achieved with epirubicin monotherapy. (wikipedia.org)

For patients with triple-negative breast cancer (TNBC) treated with KEYTRUDA in the neoadjuvant setting, monitor blood cortisol at baseline, prior to surgery, and as clinically indicated. (keytrudahcp.com)

Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas. (wikipedia.org)

New statistics show that breast cancer still ranks first among female cancers. (encyclopedia.pub)

The combination of irinotecan (Camptosar), epirubicin, andcapecitabine (Xeloda) has shown an acceptable toxicity profile. (cancernetwork.com)

The goal of this study was to compare the efficacy and toxicity of chemotherapy to exemestane plus everolimus (EXE/EVE) through a network meta-analysis (NMA) of randomized controlled trials. (unicatt.it)
We propose that antiprogestins have the potential to enhance the efficacy of chemotherapy in breast tumors with a high PRA/PRB ratio. (oncotarget.com)

The aim of Epirubicin as adjuvanted therapy is to eradicate micro metastasis and prolong disease free survival. (wikipedia.org)
It is designed to treat micrometastatic disease (or breast cancer cells that have escaped the breast and regional lymph nodes but which have not yet had an established identifiable metastasis). (medscape.com)
IBC is a rare type of breast cancer, occurring in roughly 3% to 5% of all cases, and is characterized by aggressive progression and metastasis. (medpagetoday.com)

BACKGROUND: Adjuvant chemotherapy for patients with early breast cancer improves outcomes but its toxicity affects patients' quality of life (QOL). (icr.ac.uk)
MADRID - Short-term fasting during chemotherapy enhances health-related quality of life in patients with early breast cancer , with no untoward effects, according to late-breaking research presented on day 1 of the European Society for Medical Oncology (ESMO) Congress 2023. (medscape.com)
The randomized controlled trial assessed the feasibility and impact of short-term fasting on health-related quality of life compared with a plant-based, low-sugar diet (active comparator) in 106 women with early breast cancer. (medscape.com)
In February 1998 she joined the CRCTU as a Trial Coordinator coordinating a national, multicentre, phase III, trial called SECRAB which was designed to determine the optimal sequence of chemotherapy and radiotherapy in patients with early breast cancer. (birmingham.ac.uk)
The CDK4/6 inhibitor abemaciclib (Verzenio) has been approved for use in hormone receptor (HR)-positive, Her2Neu-negative early breast cancer, for patients who have high-risk, node-positive disease and whose tumors have a Ki-67 score of ≥20%, as determined by a US Food and Drug Administration (FDA)-approved test. (medscape.com)
Chemotherapy-induced alopecia (CIA) affects the majority of patients receiving chemotherapy (CT) for early breast cancer. (plkinhibitors.com)
Consecutive early breast cancer patients admitted to Istituto Oncologico Veneto who were recommended to receive neoadjuvant or adjuvant CT, were eligible to undergo scalp cooling during the CT administration within this study. (plkinhibitors.com)
To assess the feasibility of QOL assessment in a cohort of Tunisian cancer patients, the EORTC QLQ-C30 questionnaire was administered to 23 women treated with adjuvant chemotherapy for early breast cancer on an outpatient basis at baseline and during the 3rd cycle of chemotherapy. (who.int)

There are multiple chemotherapy drugs to treat breast cancer. (owise.uk)

Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types. (icr.ac.uk)
BACKGROUND: This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). (icr.ac.uk)
Interim Toxicity Analysis From the Randomized HERMES Trial of 2- and 5-Fraction Magnetic Resonance Imaging-Guided Adaptive Prostate Radiation Therapy. (icr.ac.uk)

epirubicin decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
epirubicin decreases effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic antagonism. (medscape.com)

These improvements in outcome are very welcome, yet they do have associated substantial toxicities, especially a moderate-to-high risk of neutropenia or febrile neutropenia (FN) [ 8 ]. (hindawi.com)

In this article, we review the current data on the therapeutic management of HER2-positive early-stage breast cancer in the adjuvant and neoadjuvant setting. (carcinogenesis.com)
One type of breast cancer is identified by the human epidermal growth factor receptor 2 (HER2) gene amplification. (carcinogenesis.com)
The approval of palbociclib for ER+/HER2- advanced breast cancer in combination with fulvestrant in women (regardless of menopausal status) with disease progression following endocrine therapy was based on the PALOMA-3 trial (n=521). (medscape.com)
Women with stage I-III, hormone receptor-positive/negative, HER2-negative breast cancer treated with adjuvant FEC-D chemotherapy from 2007 through 2014 in Alberta, Canada, were included. (jnccn.org)
Neoadjuvant therapy may be recommended to people with HER2-positive, triple negative, breast cancer (BRCA) gene-positive, high risk or inflammatory breast cancer. (owise.uk)

What are the precautions of epirubicin? (mrmed.in)

Trial one and two contained premenopausal node-positive women with breast cancer, Trial three pre- and postmenopausal women with node-positive or negative breast cancer. (wikipedia.org)

The combined chemo-photothermal therapy using E/PCF-NPs for triple-negative breast cancer was evaluated. (dovepress.com)
Summing up, Koppold said that short-term fasting represents a "promising" supportive therapy during breast cancer chemotherapy to enhance quality of life. (medscape.com)
Total and differential WBC, red blood cell (RBC), and platelet counts should be assessed before and during each cycle of therapy with Epirubicin Hydrochloride Injection. (recallguide.org)
Epirubicin is given as a cycle therapy. (mrmed.in)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)

Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. (encyclopedia.pub)
Breast cancer is currently a cancer with an extremely high incidence in women, and its mortality rank first among female tumors [ 1 ] . (encyclopedia.pub)
Patients and Methods: Women with stage II breast cancer and 10 or more involved nodes or four or more involved nodes and estrogen receptor- negative tumors and women with stage III disease received three cycles of epirubicin 200 mg/m 2 and cyclophosphamide 4 g/m 2 , with progenitor cell and filgrastim support every 28 days (n = 79) or 21 days (n = 20). (tau.ac.il)

assess the feasibility of QOL evaluation in a The QLQ-C30 was assessed by the same cohort of Tunisian women with early breast physician (A.M.) at 2 points of time: just cancer receiving adjuvant chemotherapy. (who.int)

Do not take this injection if you are allergic to Epirubicin or any other ingredients of this medicine, pregnant or breastfeeding, or have severe liver and bladder problems.Store Epirubicin in the refrigerator (2°C to 8°C). Do not freeze. (mrmed.in)

The study adds to other evidence suggesting that fasting around chemotherapy cycles may reduce toxicity and adverse effects associated with chemotherapy. (medscape.com)

The combination carries the risk of serious side effects such as cardio, gastrointestinal, and hematological toxicities. (omjournal.org)

Anatomy5

Diseases29

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology2

Phenomena and Processes14

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science1

Health Care12

Doxorubicin9

Metastatic16

Anthracyclines3

Anthracycline6

Fluorouracil9

Ellence2

Regimens3

Regimen10

Systemic3

Paclitaxel2

Dose9

Cytotoxic4

Capecitabine2

Hematological toxicity6

Trastuzumab6

Doses1

Tumor6

Neoadjuvant chemotherapy8

Cardiac3

Chemotherapeutic2

Recurrence2

Tamoxifen1

Treatment23

Clinical6

Tumours3

Pulmonary1

Cycles of chemotherapy1

Monotherapy1

Clinically1

Ovarian1

Cancers1

Xeloda1

Efficacy2

Metastasis3

Early breast cancer8

Drugs1

Radiation3

Decreases2

Neutropenia1

HER25

PRECAUTIONS1

Postmenopausal women1

Therapy5

Tumors3

Cancer receivin1

Severe1

Adverse effects1

Combination1