Breast erbb 2 overexpression receptor erbb 2. Medical search. Frequent questions

Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using HER2/ErbB2 (29D8) Rabbit mAb. (cellsignal.com)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using HER2/ErbB2 (29D8) RmAb in the presence of control peptide (left) or HER2/ErbB2 Blocking Peptide #1059 (right). (cellsignal.com)
The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named HER2 in humans and neu in rodents ErbB-3, also named HER3 ErbB-4, also named HER4 v-ErbBs are homologous to EGFR, but lack sequences within the ligand binding ectodomain. (wikipedia.org)
Receptor tyrosine-protein kinase erbB-2, also known as HER2/Neu (human epidermal growth factor receptor 2), is a member of the human epidermal growth factor receptor family. (meridianbioscience.com)
Overexpression of HER2/Neu plays an essential role in the development and progression of specific subtypes of breast cancer. (meridianbioscience.com)
Approximately 15%-20% of all newly diagnosed breast cancers are HER2-positive, and HER2 testing identifies patients who would benefit from HER2-targeted therapies, such as trastuzumab (Herceptin), lapatinib (Tykerb), pertuzumab (Perjeta), and T-DM1 (Kadcylapatients). (meridianbioscience.com)
Triple-negative breast cancer (TNBC) is any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) and Her2/neu [ 1 ]. (oncotarget.com)
Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)
The degree of HER2 overexpression and amplification varies with the location of the carcinoma, with higher expression in the gastroesophageal and proximal parts compared to the distal parts of the stomach. (wjgnet.com)
Further, HER2 overexpression and amplification also seems to be related to the Lauren histological classification, with higher levels found in the intestinal phenotype compared to the diffuse and mixed types. (wjgnet.com)
The prognostic properties of HER2 overexpression and amplification are still under debate, but a large number of studies seem to indicate that HER2 is a negative prognostic factor. (wjgnet.com)
Patients with a strong overexpression of the HER2 protein (IHC3+) specifically benefited from the treatment, with a median overall survival of 17.9 mo. (wjgnet.com)
Mechanisms of pathway activation other than mutation have been discovered in recent years, and include overexpression mediated by gene amplification or by amplification of a dinucleotide repeat in the EGFR promoter, mutation of an extracellular region on EGFR generating a mutant protein termed EGFRvIII, and enhanced signaling due to heterodimerization with other members of the EGFR family, particularly overexpression of HER2/HER3. (aacrjournals.org)
This membrane deformation will not need receptor signalling actions, but outcomes from the high degrees of HER2 in the cell surface area. (president2010.info)
HER2 is certainly a CAY10471 Racemate known person in the ErbB/HER receptor tyrosine kinase family members1,2,3. (president2010.info)
HER2 BC cells using a 3+ immunohistochemistry (IHC) rating display high basal degrees of receptor kinase activity and phosphorylation, and these induce CAY10471 Racemate constitutive activation from the mitogen-activated proteins phosphatidylinositol and kinase 3-kinase/Akt pathways8. (president2010.info)
These features of HER2 overexpression had been acquired from several ensemble experiments, where receptor actions are averaged more than an extremely large numbers of cells typically. (president2010.info)
These observations claim that a non-canonical aftereffect of HER2 overexpression is available that plays a part in the disruption of epithelial features exhibited in HER2 3+ BC cells14, Mouse monoclonal to EphA5 which is certainly implicated in early-stage cancers development15,16. (president2010.info)
A lot of area points of specific HER2s had been obtained by monitoring one receptors (for 100?s in a 10.72?Hz acquisition price) labelled with anti-HER2 Fab:QD (H2Fab:QD) conjugates using total inner reflection fluorescence microscopy (TIRFM)13. (president2010.info)
We initial likened the receptor distribution patterns inside the same cell type where HER2 appearance levels had been artificially changed. (president2010.info)
Although neither kinase-dead human epidermal growth factor receptor (HER)3 nor orphan HER2 can be activated by HER-related ligands on their own, the formation of HER2/HER3 heterodimers creates the most mitogenic and transforming receptor complex within the HER (erbB) family of transmembrane receptor tyrosine kinases. (biomedcentral.com)
in particular, HER3 signalling buffered against incomplete inhibition of HER2 kinase activity has been suggested to be the mechanism that allows HER2 over-expressing breast cancer cells to escape HER TKIs. (biomedcentral.com)
It remains to be elucidated whether reactivation of HER3 signalling can also account for the poor efficacy of HER TKIs in treating breast carcinomas that contain low overall levels of HER2 receptors. (biomedcentral.com)
However, it appears that regardless of the mechanism that triggers the formation of oncogenic HER2/HER3 heterodimers (HER2 over-expression or overall low HER2 but high levels of the HER3 ligand heregulin), HER3 transphosphorylation is a common response of breast cancer cells upon treatment with current inhibitors of the HER receptor tyrosine kinase network. (biomedcentral.com)
Failure to reverse breast cancer progression despite apparent inhibition of HER1 and HER2 kinase functions in cell-based assays as well as in patient tissues and tumours is an enigma that is not yet resolved [ 6 ]. (biomedcentral.com)
In TGF-beta-treated MCF10A mammary epithelial cells overexpressing HER2 and by chromatin immunoprecipitation, we identified novel Smad targets including protein tyrosine phosphatase receptor type kappa (PTPRK). (nih.gov)
HER2 overexpression down-regulated its expression. (nih.gov)
Endogenous RPTPkappa associated with EGF receptor and HER2, resulting in suppression of basal and ErbB ligand-induced proliferation and receptor phosphorylation. (nih.gov)
One such target of these novel therapies has been the human epidermal growth factor receptor 2 ( HER2 ) gene. (degruyter.com)
Receptor tyrosine-protein kinase ERBB-2 (HER2 - human epidermal growth factor receptor 2) is considered as a marker of aggressiveness in the case of breast cancer in primary tumours as well as in corresponding metastases. (biomedres.us)
HER2 positive breast cancer is identified by the overexpression of human epidermal growth factor receptor-2 (HER2) protein in tumor tissue and results in an increased rate of cell proliferation. (her2support.org)
3 Baselga J, Norton L, Albanell J, Kim Y M, Mendelsohn J. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. (thieme-connect.de)
Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors of human epidermal growth factor receptor-2 (HER2) or epidermal growth factor receptor (EGFR) such as trastuzumab and lapatinib. (jcancer.org)
HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. (biovisi.com)
HER2 is an oncogene and overexpression of unaltered HER2 coding sequences in NIH 3T3 cells results in cellular transformation and tumorigenesis. (biovisi.com)
HER2 is amplified in about 30% of primary human breast malignancies and overexpression of HER2 is associated with the most aggressive tumors that show uncontrolled proliferation, resistance to apoptosis and increased motility. (biovisi.com)
In particular, HER2 and HER3 are over-expressed in 23277-43-2 IC50 a number of tumors, and their expression levels are associated with abnormal growth and poor clinical prognosis. (researchhunt.com)
Overexpression of EGFR, HER2 and HER3 is associated with decreased survival in cancer, while HER4 overexpression is correlated with increased survival [8], [9]. (researchhunt.com)
While this has led to the development of a range of therapeutics targeting the HER2 receptor [15], the use of these drugs can often lead to resistance through a diverse set of mechanisms [16]. (researchhunt.com)
1 The human epidermal growth factor receptor 2 (HER2 or ErbB2) is a tyrosine kinase receptor that belongs to the EGFR (ErbB) family and is sometimes implicated in breast, lung, and other cancers. (mdforlives.com)
An estimated 2-6% of NSCLC cases have a mutation in the HER2 oncogene, and others have overexpression or amplification of HER2. (mdforlives.com)
Human epidermal growth factor receptor 2 (HER2) bound to a targeted therapeutic agent. (mdforlives.com)
Other examples are trastuzumab deruxtecan (T-Dxd) and ado-trastuzumab emtansine (T-DM1), which are HER2-targeted antibody-drug conjugates in trials for NSCLC that involves HER2 overexpression or mutation. (mdforlives.com)
Antibody-drug conjugates are finding success in Phase 2 clinical trials for the treatment of NSCLC that involves HER2 overexpression or HER2 mutation. (mdforlives.com)
Omdat bij 70% van de alvleesklierkankerpatiënten de HER2-Neu expressie oververtegenwoordigd is en juist Herceptin bij borstkankerpatiënten met deze receptor uitstekende resultaten laat zien zijn deze trials opgezet. (kanker-actueel.nl)
Herceptin has been successfully used in combination with other chemotherapeutic agents in breast cancer, a cancer in which only 30% of patients harbor elevated HER2/neu levels. (kanker-actueel.nl)
ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. (utrgv.edu)
The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
The HER2 receptor does not bind to any known ligands, however, its dimerization arm is innately positioned in an open conformation. (plos.org)
Introduction Epidermal development element receptor (EGFR) was the 1st discovered from the ErbB category of receptor tyrosine kinases with a total of four users: Erbb1/EGFR, ErbB2/Her2, ErbB3 and ErbB4. (bio-biz-navi.com)
In this study, we aimed to determine the pattern of immunohistochemical profiles of IDC using oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 receptor (HER2) and proliferative index (Ki-67) biomarkers in our tertiary healthcare facility in Uyo, Akwa Ibom State, Nigeria given the dearth of its data in our environment. (bvsalud.org)
OBJECTIVES: To evaluate the expression of COX-2 and HER2 and determine their correlation with clinicopathologic parameters in surgically resected histologically diagnosed cases of colorectal cancer. (bvsalud.org)

The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. (wikipedia.org)
c- erb B-2 (HER-2/ neu ) is a 185 kDa receptor tyrosine kinase belonging to the epidermal growth factor receptor family, which also includes EGFR (HER-1), c- erb B-3 (HER-3), and c- erb B-4 (HER-4). (ihcworld.com)
The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). (activemotif.com)
The discovery of epidermal growth factor receptor (EGFR) mutations in never-smokers has been the most relevant finding ever in non-small cell lung cancer. (aacrjournals.org)
Similarly, the tyrosine kinase inhibitors have limited activity in a variety of tumor types with EGFR overexpression. (aacrjournals.org)
In our prior research of epidermal development aspect receptor (EGFR) dimerization dynamics at a single-molecule level, we demonstrated that receptor activation by ligand binding is certainly spatially asymmetric on cells overexpressing EGFR (ref. 13). (president2010.info)
HER-2/neu , also known as c-erbB-2/neu , is an oncogene located in chromosome 17 which encodes HER-2/neu, a transmembrane protein belonging to the EGFR family. (degruyter.com)
The epidermal growth factor receptor (EGFR) tyrosine kinase (TK) plays an important role in the pathogenesis of NSCLC. (bmj.com)
Alterations in receptor tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor 1, include overexpression, amplification or mutations. (bmj.com)
It has been proposed that oncogenes (EGFR (ERBB), MET) and tumor suppressors (PTEN, TP53) may also be capable of altering the vesicular release of tissue factor (TF) from cells [4-6]. (biomedres.us)
For NSCLC, much of the work in the last decade has been focussed on mutations of the epidermal growth factor receptor (EGFR) and on the abnormal fusion of the anaplastic lymphoma kinase (ALK) being inhibited successfully with EGFR tyrosine kinase inhibitors (TKI) and crizotinib respectively. (amegroups.org)
HER-2 (ErbB2) is a 185-kDa transmembrane tyrosine kinase with extensive homology to the epidermal growth factor receptor (EGFR). (touchoncology.com)
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. (thermofisher.com)
EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)
EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. (thermofisher.com)
Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. (thermofisher.com)
Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. (thermofisher.com)
Moreover, MCT-1 overexpression induces EMT signaling cascade via activation of EGFR and Src pathway by which promote tumor progression and metastasis. (nhri.org.tw)
Epidermal growth factor receptor ( EGFR , ErbB ) gene mutations are one of the most well-researched targets for lung cancer treatment. (mdforlives.com)
1,2 EGFR tyrosine kinase inhibitors (EGFR TKI) are used as first-line treatments in advanced NSCLC cases where EGFR mutations are present. (mdforlives.com)
1,2 Patritumab deruxtecan (HER3-DXd/U3-1402) is a HER3-targeted antibody-drug conjugate that showed anti-tumor activity and acceptable safety in patients with advanced NSCLC who are on EGFR TKI. (mdforlives.com)
2,13 Monoclonal antibodies against programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are effective treatment options for a relatively small percentage of patients with NSCLC, but they are not recommended for patients with EGFR-mutated NSCLC. (mdforlives.com)
The epidermal growth factor receptor (EGFR) is among the most well-studied signaling pathways in cancer progression. (bio-biz-navi.com)
Furthermore, this hypothesis presents the chance of making use of EGFR agonism like a potential restorative approach for the treating metastatic breast malignancy. (bio-biz-navi.com)
2 Since its finding, EGFR continues to be characterized like a mediator of a multitude of signal transduction occasions that control cell proliferation, migration and success. (bio-biz-navi.com)
Overexpression of EGFR transforms NIH3T3 fibroblasts within an EGF-dependent way. (bio-biz-navi.com)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)

The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)

The epidermal growth factor receptor (ERBB1) and related family member HER-2/ neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. (aacrjournals.org)
Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
In particular, the overexpression of ERBB2 enhances the properties of tumour cells associated with increased cancer metastasis (invasiveness, angiogenicity, enhanced survival). (biomedres.us)
The enhancement in metastatic properties was also found to occur via activation of ERBB2 receptor signaling pathways [2]. (biomedres.us)
These reports led us to consider as a working hypothesis whether the overexpression of ERBB2 is able to establish a procoagulant disorder in cancer. (biomedres.us)
To investigate a possible modulatory role of ERBB2 in the procoagulant status of breast cancer cells, a line of ERBB2 overexpressing human breast cancer MCF-7 cells (MCF-7 ERBB2+) and human normal mammary MCF-12a cells (MCF-12a ERBB2+) respectively, were established by transfection with an ERBB2 plasmid (Addgene, Cambridge, USA) in our lab. (biomedres.us)
It was observed that overexpression of ERBB2 was able to modulate the level of several coagulation proteins, including protein C, Factor-X and TF, and the activities of TF and thrombomodulin, as well as the rate of clotting and thrombin activity. (biomedres.us)
In line with this conclusion it was also observed that the expression of coagulation proteins corresponded with the level of expression of ERBB2 in three 'native' breast cancer cell lines (human enriched breast cancer stem cell (CSC), MDA-MB231 and MCF-7). (biomedres.us)
The finding is the first time shown pro-tumour gene ERBB2 enable to modulate coagulation protein expression and clotting kinetics in breast cancer cells, it is via the PI3k/Akt pathways, which further supports the proposal that the state of the coagulation system in cancer is directly influenced by oncogenic transformation. (biomedres.us)
ErbB2 belongs to the ErbB family of receptor tyrosine kinases, which has been implicated in a variety of human cancers , including cancers of the breast. (her2support.org)
ERBB2 gene amplification detected by fluorescent differential polymerase chain reaction in paraffin-embedded breast carcinoma tissues. (thieme-connect.de)
7 Borg A, Baldetorp B, Ferno M, Killander D, Olsson H, Sigurdsson H. ERBB2 amplification in breast cancer with a high rate of proliferation. (thieme-connect.de)
EXPERIMENTAL DESIGN: Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (novartis.com)
Lack of interaction between ErbB2 and insulin receptor substrate signa" by Sarah M. Farabaugh, Bonita T. Chan et al. (utrgv.edu)
Signaling crosstalk between ErbB2 and IRSs was examined in vitro by knockdown or overexpression followed by western blot analysis for downstream signaling intermediates and growth assays. (utrgv.edu)
Substantiating this, overexpression or knockdown of IRS1 or IRS2 in MMTV-ErbB2 mammary cancer cell lines had little effect upon ErbB2 signaling. (utrgv.edu)
Despite previous evidence suggesting that ErbB receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS pathway in these models to promote mammary tumorigenesis. (utrgv.edu)
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. (musc.edu)

Amplification of the HER-2 gene with overexpression of the protein occurs in 20-30% of breast cancers, and tumor progression in mammary cancer is associated with elevated levels of tyrosine-phosphorylated neu and erbB-3. (ihcworld.com)
Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. (activemotif.com)
Gene amplification and overexpression of the proteins in breast malignancies (BCs) anticipate poor disease final result due to raised metastatic potentials4,5,6,7. (president2010.info)
Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification. (musc.edu)
HER-2/neu amplification predicts poor survival in node-positive breast cancer. (thieme-connect.de)
14 King C R, Kraus M H, Aaronson S A. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. (thieme-connect.de)
The amplification of the HER-2 oncogene occurs in ~25% of breast cancer patients and is associated with diminished disease-free and overall survival. (touchoncology.com)
Furthermore, loss-function p53 alongside MCT-1 overexpression promote pleiotropic mitotic catastrophes, including centrosome amplification, chromosome missegregation, and cytokinesis failure. (nhri.org.tw)
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. (musc.edu)
Comprehensive profiling of 8p11-12 amplification in breast cancer. (musc.edu)
Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers. (musc.edu)

ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors. (wikipedia.org)
Breast cancer is the commonest cancer in Malaysian women with an incidence of 39.5 per 100,000 population and consisting of 31% of all female cancers, as reported in the Second Report of the National Cancer Registry, Malaysia ( 1 ). (ispub.com)
EphB4 is a membrane-bound receptor tyrosine kinase (RTK) commonly over-produced by many epithelial cancers but with low to no expression in most normal adult tissues. (oncotarget.com)
Dr. Hsu has confirmed the clinical relevance of the MCT-1 activation in different types of aggressive breast cancers and lung carcinoma. (nhri.org.tw)
Lung cancer kills more people worldwide than breast, prostate, colorectal, and brain cancers combined. (mdforlives.com)
This family of RTKs has been highly implicated in the formation and progression of various cancers via aberrant overexpression, kinase activation, and mutation [1] , [2] . (plos.org)
Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon. (musc.edu)
ER protein determinations were performed using two-thirds of all breast cancers are ER at the time of diagnosis, the standard methods in the routine clinical laboratory (9). (lu.se)
Opinions differ as to whether those breast cancers supplemented by 10% fetal bovine serum, penicillin, and streptomycin. (lu.se)

Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. (cdc.gov)
Breast cancer is one of the most common primary tumors to develop associated brain metastases ( 1 , 2 ), and while recent progress in cancer therapy has improved control of primary breast tumors, methods to effectively treat brain metastases from breast cancer remain inadequate. (jcancer.org)
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. (lookformedical.com)
An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)
[ 2 ] Targeted disruption of TP53 in the mouse leads to the development of various tumors (see image below). (medscape.com)

The histological type of breast cancer comprised 137 infiltrating ductal carcinoma (not otherwise specified), 4 invasive lobular carcinoma, 3 papillary, 2 mucinous, one each of medullary, tubular and inflammatory carcinoma, 27 ductal carcinoma in situ and 1 Non Hodgkin lymphoma. (ispub.com)
The size of infiltrating ductal carcinoma (IDC) tumours at presentation is tabulated in table 1 and the histological grade of IDC, in table 2. (ispub.com)
Cases of invasive breast carcinoma with the phosphorylated receptor have displayed aggressive clinicopathological features and adverse prognoses. (ihcworld.com)
Activation of HER-2 is frequent in ductal carcinoma in situ suggesting that HER-2 signaling plays a critical role in the early stages of breast tumorigenesis. (ihcworld.com)
Over-expression of the c-erbB-2 oncogene occurs in a proportion of human adenocarcinomas and in breast carcinoma is associated with poorer prognosis. (nih.gov)
Precursors and preinvasive lesions of the breast include atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and lobular neoplasia (LN). There is a significant debate regarding the classification, diagnosis, prognosis and management of these lesions. (biomedcentral.com)
2 Barnes D M, Lammie G A, Millis R R, Gullick W L, Allen D S, Altman D G. An immunohistochemical evaluation of c-erbB-2 expression in human breast carcinoma. (thieme-connect.de)
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST . (lookformedical.com)
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma. (lookformedical.com)
It is often an area of ill-defined thickening in the breast , in contrast to the dominant lump characteristic of ductal carcinoma . (lookformedical.com)
In addition, 14 of the patients were the normal mammary gland and are also important in the development premenopausal (5 ER and 9 ER ) and 33 were postmenopausal (18 ER and progression of breast carcinoma. (lu.se)

The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. (wikipedia.org)

The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)

Cloning and characterization of T cell receptors (TCRs) from responding T cells resulted in the identification of the two HLA-A*0201-restricted T cell epitopes CXorf61 66-74 and CXorf61 79-87 . (oncotarget.com)

The HER-2/neu onkogene may play a role in the prognosis and management of patients with breast cancer. (thieme-connect.de)
Prospective studies correlating HER-2/neu overexpression with prognosis might provide additional data. (thieme-connect.de)
5 Beckmann M W, Niederacher D, Schnurch H G, Bender H G. The erbB gene family: significance for tumor development, prognosis and new therapeutic modalities. (thieme-connect.de)
12 Göhring U J, Aslan-Schadwinkel Y, Scharl A. Expression of the p185neu oncoprotein indicates an unfavorable prognosis in small, node negative breast cancer without systemic adjuvant treatment (T1N0). (thieme-connect.de)
While the importance 23277-43-2 IC50 of HER expression levels has been established for clinical prognosis and drug resistance, the mechanistic link between receptor expression, HER activation and downstream consequences is not as clear yet. (researchhunt.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)

OBJECTIVES: This study aimed to compare the time required and concerns raised by various perspectives of participants regarding administering subcutaneous and intravenous trastuzumab for patients with breast cancer (BC). (bvsalud.org)
11 Gilewski T, Seidman A, Norton L, Hudis C. An immunotherapeutic approach to treatment of breast cancer: focus on trastuzumab plus paclitaxel. (thieme-connect.de)
Such examples include trastuzumab for HER-2 over-expressing breast cancer and vemurafenib for BRAF-mutant melanoma ( 9 , 10 ). (amegroups.org)
While it has been recognised for some time that overexpression of HER-2 is a poor prognostic factor in breast cancer, it was the advent of trastuzumab, a humanised monoclonal antibody directed against the extracellular domain of HER-2, that has allowed clinicians to better understand the natural history of HER-2-positive metastatic breast cancer. (touchoncology.com)
The use of trastuzumab when given with chemotherapy improves response rates and progression-free and overall survival of patients with HER-2-positive metastatic breast cancer. (touchoncology.com)

Many other genetic targets are under active research in lung cancer, including Kirsten rat sarcoma viral oncogene homolog (KRAS), c-mesenchymal-epithelial transition receptor (c-Met), anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and neurotrophic tyrosine receptor kinase (NTRK). (mdforlives.com)

Notably, the ErbB1 and ErbB4 are the two most studied and intact among the family of ErbB proteins, Which forms functional intracellular tyrosine kinases. (wikipedia.org)
Novel therapeutic agents, in particular those that specifically target members of the human epidermal growth factor receptor (HER (ErbB1)) pathway, have shown encouraging therapeutic efficacy. (bmj.com)

The ability ('+') or inability ('-') of each growth factor to activate each of the ErbB receptors is shown in the table below: The dimerization occurs after ligand bind to the extracellular domain of the ErbB monomers and monomer-monomer interaction establishes activating the activation loop in a kinase domain, that activates the further process of transphosphorylation of the specific tyrosine kinases in the kinase domain of ErbB's intracellular part. (wikipedia.org)
Unique in the approach to abolishing function of this gene coded receptor, it was the first target of new monoclonal antibody therapy targeting the extracellular receptor and now also a target of small molecule drugs against the intracellular tyrosine kinase domain. (degruyter.com)
These receptors convert signals received from the extracellular environment into cell decisions such as growth and survival C a process termed signal transduction. (researchhunt.com)
A monoclonal antibody which specifically targets this identified extracellular epitope of EphB4 significantly reduced breast cancer xenograft growth in vivo confirming that EphB4 is a useful target for ligand-mimicking antibody-based anti-cancer therapies. (oncotarget.com)
1 ErbB users type homo- and heterodimeric cell-surface receptors with original extracellular domains yielding ligand-binding specificity. (bio-biz-navi.com)

About 5% of breast carcinomas are positive for phospho-c- erb B-2/HER-2/ neu oncoprotein. (ihcworld.com)
IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (AENPEYLGLDVPV) corresponding to amino acids 1243-1255 of human c-erbB-2/HER-2/neu oncoprotein. (australbiologicals.com)
C-erbB-2 oncoprotein is a 185 kDa type I membrane tyrosine kinase receptor and belongs to the EGF receptor family. (australbiologicals.com)
Likewise, the highest concentrations of this oncoprotein are found in patients with breast cancer, but lower concentrations may be found in other malignancies, particularly ovarian, prostate and lung cancer (mainly adenocarcinomas). (degruyter.com)

erbB-2 overexpression in human mammary epithelial cells confers growth factor independence. (musc.edu)
Similar results were obtained in human mammary epithelial cells (MCF10A) and breast cancer cell lines. (utrgv.edu)
Cooperative interactions of HER-2 and HPV-16 oncoproteins in the malignant transformation of human mammary epithelial cells. (musc.edu)

Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. (activemotif.com)
Also, the growth-inhibitory effects of HER1/2 tyrosine kinase inhibitors (TKIs) were previously found to be attenuated in the presence of heregulin, which is a high-affinity combinatorial ligand for HER3. (biomedcentral.com)
Despite significant promiscuity between other Eph family members and the ephrin ligands, the single physiologically-relevant ligand of the EphB4 receptor is ephrin-B2 [ 2 ]. (oncotarget.com)
Both the receptor and the ligand are membrane-bound but usually expressed on neighbouring cells. (oncotarget.com)
Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member. (lookformedical.com)

Transphosphorylation of kinase-dead HER3 and breast cancer progression: a new standpoint or an old concept revisited? (biomedcentral.com)
Because kinase-inactive HER3 is not presently an amenable target for forthcoming HER TKIs, molecular approaches that can efficiently block heregulin-triggered HER3 transactivation or nucleocytoplasmic trafficking of heregulin might offer novel strategies with which to manage HER-driven breast cancer disease. (biomedcentral.com)
The current study aimed to map the putative transactivation domains (TADs) of the HER3 receptor. (plos.org)
To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)
Further, the overexpression of HER3 enhanced cyclin D1 mRNA expression, while HER3 deleted of its identified TADs was hindered at doing so. (plos.org)
Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)

Duitse onderzoekers publiceren in oktober a.s. het abstract van een aantal laboratoriumstudies en dierstudies die ze gedaan hebben met Herceptin als basis aangevuld met gemcitabine en/of docetaxel bij inoperabele en gevorderde alvleesklierkanker . (kanker-actueel.nl)

There were 177 cases (1 male) of breast cancer cases diagnosed at Hospital Pulau Pinang in 2003 and 2004 as reviewed from histopathology records. (ispub.com)
The disease is associated with high morbidity and mortality especially as we tend to see more advanced stages of breast cancer in our part of the world ( 2 , 3 ). (ispub.com)
However data on breast cancer in Malaysia is still scarce and studies seem to be concentrated in the highly urban area around the capital city of Kuala Lumpur. (ispub.com)
The aim of this study was to determine the pattern of breast cancer in Hospital Pulau Pinang and to compare it with other studies conducted in Kuala Lumpur. (ispub.com)
The histopathology records of all newly diagnosed breast cancer cases in Hospital Pulau Pinang in 2003 and 2004 were retrospectively reviewed. (ispub.com)
Triple-negative breast cancer (TNBC) is a high medical need disease with limited treatment options. (oncotarget.com)
In CXorf61-negative breast cancer cell lines CXorf61 expression is activated by treatment with the hypomethylating agent 5-aza-2′-deoxycytidine. (oncotarget.com)
Triple negative is sometimes used as a surrogate term for basal-like breast cancer, which is a distinct, morphologically and molecularly defined entity. (oncotarget.com)
Given the importance of erbB-2 in human breast cancer, the finding of erbB-2 overexpression in canine OSA may be important in further understanding the pathogenesis and possible therapies of OSA. (cdc.gov)
Because of this, ErbB-2 is one of the major drug targets for breast cancer and other cancer treatments. (activemotif.com)
erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line. (musc.edu)
The notion that breast cancer disease can be viewed as a biological process that is driven by overactive human epidermal growth factor receptor (HER)1/2 receptor tyrosine kinases (RTKs) has led to development of various anti-HER tyrosine kinase agents. (biomedcentral.com)
Breast cancer is the most common malignancy affecting women and there remains a need for effective adjuvant therapies for this disease, for which plant sterols may play a distinctive role. (mdpi.com)
While many factors are involved in the etiology of cancer, it has been clearly established that diet significantly impacts risk of this disease [ 1 , 2 , 3 ]. (mdpi.com)
Our study evaluated the effects of iMBSR intervention on mental health, self-efficacy, and body image in women with breast cancer in Taiwan. (bvsalud.org)
Materials and methods: Sixty-seven women with breast cancer were allocated to a 6-week iMBSR (n = 41) program or a waitlist control group (n = 26), without heterogeneity between group characteristics. (bvsalud.org)
Conclusion: Our preliminary study supports iMBSR as a program that can improve mental health, body image, and self-efficacy in women with breast cancer. (bvsalud.org)
LL) chemotherapy for recurrent advanced or metastatic breast cancer (A/MBC) patients. (bvsalud.org)
2 The pathogenesis of lung cancer involves the accumulation of several molecular abnormalities over time. (bmj.com)
Therefore, in recent years, this protein has become an important biomarker and target of therapy for around a third of breast cancer patients [3]. (biomedres.us)
With respect to the aforementioned molecules, this article reviews their pathophysiological importance, and puts the stress on whether they confer additional risk for invasive breast cancer or not. (biomedcentral.com)
Molecular markers nowadays seem to have the potential to improve our ability to care for patients with, or at risk for, breast cancer. (biomedcentral.com)
With respect to the molecules implicated, this article focuses especially on whether they confer additional risk for invasive breast cancer or not. (biomedcentral.com)
Breast cancer is the most frequent gynecological tumor. (thieme-connect.de)
Expression analyses of epidermal growth factor receptor and HER-2/neu: no advantage of prediction of recurrence or survival in breast cancer patients. (thieme-connect.de)
Breast Cancer Medicine Service. (thieme-connect.de)
c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes. (thieme-connect.de)
Conversely, treatment for small cell lung cancer remains chemotherapy-based and whilst there are promising results with novel cytotoxics, its platinum-etoposide backbone holds strong ( 2 ). (amegroups.org)
TAK-285 was as effective as lapatinib in antitumor activity in a mouse subcutaneous BT-474 breast cancer xenograft model. (jcancer.org)
TAK-285 was examined in a model of breast cancer brain metastasis using direct intracranial injection of BT-474-derived luciferase-expressing cells and showed greater inhibition of brain tumor growth compared to animals treated with lapatinib. (jcancer.org)
Key drug efflux transporters operational in preserving the BBB are the P-glycoprotein (Pgp) transporter, which belongs to the ATP-binding cassette (ABC) transporter family, and the breast cancer resistance protein (BCRP) ABCG2 ( 4 , 5 ). (jcancer.org)
The incidence of central nervous system (CNS) metastatic disease in breast cancer patients depends on the stage at initial diagnosis. (touchoncology.com)
1-3 However, there are no prospective screening studies of serial computed tomography (CT) or magnetic resonance imaging (MRI) to evaluate the rate of occult CNS metastasis in patients with breast cancer over time. (touchoncology.com)
reported an incidence of 14.8% of occult CNS involvement in heavily pre-treated breast cancer patients, 5 and autopsy studies have found clinically unsuspected brain metastasis in 30% of patients with advanced breast cancer. (touchoncology.com)
The median time to diagnosis of CNS metastatic disease is two years after the initial diagnosis of breast cancer, and it is unusual for it to be the only site of metastatic disease. (touchoncology.com)
It soon became clear that patients with HER-2-overexpressing metastatic breast cancer were at high risk of developing CNS involvement. (touchoncology.com)
The HER/ErbB family of receptor tyrosine kinases drives critical responses in normal physiology and cancer, and the expression levels of the various HER receptors are critical determinants of clinical outcomes. (researchhunt.com)
Author Summary A family of cell surface molecules called the HER receptor family plays important roles in normal physiology and cancer. (researchhunt.com)
The HER receptor expression profile is a critical determinant of cell behavior [6], [7], and outcomes in cancer pathology. (researchhunt.com)
Dr. Hsu lab have proved that MCT-1 oncogene is highly expressed in lung adenocarcinoma and in triple negative breast cancer. (nhri.org.tw)
25 april 2013: In BMC - British Journal of Cancer verscheen vorig jaar een publicatie van een fase 2 studie waarbij gesteld werd dat verder onderzoek naar herceptin bij alvleesklierkanker niet zinnig wordt veronderstelt. (kanker-actueel.nl)
Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important. (lookformedical.com)
ErbB receptors can bind and phosphorylate insulin receptor substrates (IRS) and this may be critical for ErbBmediated anti-estrogen resistance in breast cancer. (utrgv.edu)
Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
Molecular cytogenetic analysis of 11 new breast cancer cell lines. (musc.edu)
Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. (musc.edu)
p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal. (musc.edu)
Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. (musc.edu)
Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cells. (musc.edu)
Identifying and validating causal genetic alterations in human breast cancer. (musc.edu)
Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines. (musc.edu)
Transforming properties of 8p11-12 amplified genes in human breast cancer. (musc.edu)
Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells. (musc.edu)
Identification and functional analysis of 9p24 amplified genes in human breast cancer. (musc.edu)
KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer. (musc.edu)
Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death. (musc.edu)
Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. (musc.edu)
Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression. (musc.edu)
Induced Invasion in Basal Breast Cancer. (musc.edu)
MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer. (musc.edu)
Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. (musc.edu)
Objective To compare the financial and time cost of breast cancer biomarker analysis by immunohistochemistry with that by the Xpert® STRAT4 assay. (bvsalud.org)
Methods We estimated costs (personnel, location, consumables and indirect) and time involved in breast cancer diagnosis at the Butaro Cancer Centre of Excellence, Rwanda, using time-driven activity-based costing. (bvsalud.org)
Findings We estimated that breast cancer diagnosis in Rwanda costs 138.29 United States dollars (US$) per patient when conducting biomarker analysis by immunohistochemistry. (bvsalud.org)
Conclusion Breast cancer biomarker analysis with STRAT4 has the potential to reduce the required human and capital resources in subSaharan African laboratories, leading to improved treatment selection and better clinical outcomes. (bvsalud.org)
Endocr Relat Cancer 15(2):485-497. (who.int)

The intracellular/cytoplasmic region of the ErbB receptor consists mainly of three subdomains: A juxtamembrane with approximately 40 residues, a kinase domain containing approximately 260 residues and a C-terminal domain of 220-350 amino acid residues that become activated via phosphorylation of its tyrosine residues that mediates interactions of other ErbB proteins and downstream signaling molecules. (wikipedia.org)
The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB-2), 1M6B (ErbB-3) and 2AHX (ErbB-4): The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher-order oligomers upon activation by a subset of potential growth factor ligands. (wikipedia.org)

DCIS is defined as a proliferation of malignant epithelial cells within the breast parenchymal structures with no evidence of invasion across the basement membrane [ 1 ]. (biomedcentral.com)
The exact biological mechanism(s) by which the BBB limits drug exposure is not clear, but in addition to epithelial tight junctions, enhanced efflux of chemotherapeutic agents out of the CNS space by endothelial cell membrane transporters in brain blood vessels plays a primary role ( 2 ). (jcancer.org)
To explore whether the downregulation of AP-2alpha and AP-2gamma is of functional significance for lactogenic differentiation, we analyzed the expression of the AP-2 family members during the lactogenic differentiation of HC11 mammary epithelial cells in vitro. (biomedcentral.com)

Any neoplasms of the male breast . (lookformedical.com)
The most frequent application is the diagnosis of neoplasms of the female breast . (lookformedical.com)

The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. (lookformedical.com)
We performed a cost-minimization analysis to compare the cost of biomarker analysis for estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 status with immunohistochemistry versus STRAT4. (bvsalud.org)

Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)

Results of estrogen receptor and c-erbB-2 status using immunohistochemistry were documented. (ispub.com)
METHODS: Fifty-three paraffin-embedded tissue blocks of colorectal resections and corresponding patient information were retrieved from the archives of the Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital.A 4-micron slide section was obtained from each specimen and immunohistochemistry for COX-2 and HER-2 expression was performed. (bvsalud.org)

ErbB-2 overexpression is also observed in ovarian, gastric, salivary and non-small cell lung carcinomas. (activemotif.com)
Sensitivity of HER-2/neu antibodies in archival tissue samples of invasive breast carcinomas. (thieme-connect.de)

For the activation of kinase domain in the ErbB dimer, asymmetric kinase domain dimer of the two monomers is required with the intact asymmetric (N-C lobe) interface at the site of adjoining monomers. (wikipedia.org)
Activation of the tyrosine kinase domain leads to the activation of the whole range of downstream signaling pathways like PLCγ, ERK 1/2, p38 MAPK, PI3-K/Akt and more with the cell. (wikipedia.org)
Therefore, we utilized quantum dot (QD)-structured single-receptor monitoring and analysis strategies in live cells to research whether a spatial control exists that may impact the activation of overexpressed HER2s in BC cells. (president2010.info)
The model enables us to quantitatively link HER expression levels to receptor dimerization and activation. (researchhunt.com)
This process leads to the activation of each receptors' tyrosine kinase and the subsequent phosphorylation of tyrosine residues located on their C-terminal tails. (plos.org)

The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. (cdc.gov)
The overexpression of the erbB-2 proto-oncogene is associated with an aggressive human adenocarcinomas, mainly breast and ovarian tumours. (australbiologicals.com)

Recently, several novel agents targeting growth factor receptors, angiogenic pathways, adhesion molecules and mediators of intracellular signal transduction have been clinically explored. (docksci.com)
Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)

The total-ErbB-2 antibody supplied in the FACE ErbB-2 Kits recognizes ErbB-2 protein regardless of its phosphorylation site. (activemotif.com)

Translational research advances now allow such mutations to be inhibited by either receptor monoclonal antibodies (mAb) or small molecule tyrosine kinase inhibitors (TKI). (amegroups.org)
These mutations in receptors or protein kinases can stimulate a complex cascade of cross signalling pathways such as the RAS-RAF-MEK-ERK or MAPK, PI3K-AKT-mTOR or JAK-STAT pathways ( Figure 2 ) ( 3 , 4 , 7 , 18 , 20 ). (amegroups.org)
This protocol demonstrates how to (1) isolate CD34+ progenitor cells from human bone marrow aspirate, (2) prepare single-cell amplicon libraries, and (3) analyze the libraries to assign somatic mutations to individual cells. (rna-seqblog.com)

Each FACE ErbB-2 Kit provides 96 rxns each of 2 antibodies that enable you to monitor and compare the levels of both phosphorylated and total ErbB-2. (activemotif.com)

10% and seems to be related to overexpression in tissue as well as to the most important prognostic factors: tumor size and nodal involvement. (degruyter.com)
This finding could indicate that HER-2/neu expression is a new independent prognostic factor. (thieme-connect.de)

Downstream signaling from these receptors proceeds TSPAN10 via tyrosine phosphorylation. (bio-biz-navi.com)

In this study we used real-time reverse transcriptase polymerase chain reaction to evaluate erbB-2 expression in seven canine OSA cell lines and 10 canine OSA tissue samples. (cdc.gov)
All 12 cases of mammary Paget's disease showed membrane staining of intra-epidermal cells, indicating c-erbB-2 over-expression. (nih.gov)
In this report we analyzed AP-2 transcription factor expression in HC11 cells subjected to lactogenic differentiation conditions. (biomedcentral.com)
The prostaglandin-endoperoxide synthase 2 gene (PTGS2), which encodes cyclooxygenase-2, was found to upregulate the expression of TGF-β2 ( 14 ). (spandidos-publications.com)
These results are consistent with another study concerning the gene expression profiling of breast CAFs, which were detected using a complementary DNA microarray ( 15 ). (spandidos-publications.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
In a bid to gain some insight into the molecular characteristics of CRC in our environment, we set out to investigate the expression of COX-2 and HER-2 among Nigerian subjects. (bvsalud.org)

Presently, DCIS constitutes 15-20% of screen-detected malignancies of the breast [ 14 , 15 ], and it is known that such a diagnosis confers an 8-10-fold elevated risk for the development of IBC [ 16 ]. (biomedcentral.com)

2 There is only limited knowledge of the factors that predict for the development of CNS metastasis, but the main ones reported include young age, African ethnicity, oestrogen receptor (OR)-negativity, HER 2 -positivity, high tumour grade and BRCA 1 phenotype. (touchoncology.com)

Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. (aacrjournals.org)
The clinical utility of HER-2/neu in patients with advanced disease is mainly for therapeutic monitoring. (degruyter.com)

Chi square was used to test the association between ethnic group, tumour size (categorized as ≤2 cm, >2 cm and ≤5 cm, and >5 cm), histological grade, estrogen receptor (ER) status, c-erbB-2 status and lymph node metastases. (ispub.com)
HER-2/neu sensitivity (proportion of patients with abnormal values) in patients with metastasis is around 40%-45%, with a clear relationship to tissue overexpression and to site (higher in visceral metastases) and number of metastases. (degruyter.com)
Table 1 A listing of medical studies looking into EGFRi therapies for the treating breast malignancy metastasis, cells produced from pulmonary metastases are inherently resistant to EGFRi and go through robust development inhibition in response to EGF. (bio-biz-navi.com)

Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)

all nine tumours were c-erbB-2 positive and in eight the in situ component was of comedo or solid type. (nih.gov)

Our studies were designed to evaluate the effect of ERBB inhibition on tumor cell motility and intravasation in vivo using clinically relevant small-molecule inhibitors. (aacrjournals.org)
These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)

Anatomy22

Organisms8

Diseases31

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology2

Phenomena and Processes58

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science5

Health Care14

HER252

EGFR27

Epidermal growth factor r1

ErbB218

Amplification11

Cancers10

Tumors5

Carcinoma11

Erythroblastic leukemia viral oncogene1

Transmembrane receptor tyrosin1

Cell receptors1

Prognosis6

Trastuzumab5

Viral oncogene1

ErbB12

Extracellular5

Oncoprotein4

Human mammary3

Ligand6

Her36

Abstract1

Cancer66

Proteins2

Epithelial3

Neoplasms2

Progesterone receptor2

Ligands1

Immunohistochemistry2

Carcinomas2

Activation5

Proto-oncogene2

Signal Transduction2

Phosphorylation site1

Mutations3

Antibodies1

Prognostic2

Downstream1

Expression7

Malignancies1

Oestrogen receptor1

Clinical2

Metastases3

Pathways1

Tumours1

Tumor cell2