MutationNeoplasmsGenes, NeoplasmGenes, BRCA1DNA Mutational AnalysisBreastGenes, BRCA2HeterozygoteBreast NeoplasmsGerm-Line MutationBRCA2 ProteinPoint MutationMutation, MissenseBRCA1 ProteinGenetic Predisposition to DiseaseCarcinoma, Ductal, BreastComputational BiologyReceptors, EstrogenHeterozygote DetectionProtein ConformationGenetic TestingOvarian NeoplasmsPedigreeCell Line, TumorReceptor, erbB-2MammographyTamoxifenReceptors, ProgesteroneBreast DiseasesGene Expression Regulation, NeoplasticPenetranceGenotypeRisk FactorsBreast Neoplasms, MaleJewsPrognosisMastectomyCase-Control StudiesFrameshift MutationNeoplasm ProteinsNeoplasm InvasivenessNeoplasm MetastasisTumor Markers, BiologicalFounder EffectSalpingectomyNeoplasm StagingEarly Detection of CancerRiskPhenotypeFamily HealthAllelesPolymerase Chain ReactionAntineoplastic Agents, HormonalAge of OnsetRisk AssessmentAntineoplastic AgentsGenetic CounselingImmunohistochemistryColorectal Neoplasms, Hereditary NonpolyposisBase SequenceCarcinoma, Intraductal, NoninfiltratingPolymorphism, GeneticAge FactorsPostmenopauseSurvival AnalysisCarcinomaCarrier ProteinsChemotherapy, AdjuvantCohort StudiesCarcinoma, LobularCarrier StateDNA, NeoplasmMolecular Sequence DataTumor Cells, CulturedGene Expression ProfilingRNA, MessengerFollow-Up StudiesHereditary Breast and Ovarian Cancer SyndromeExonsReverse Transcriptase Polymerase Chain ReactionDrug Resistance, NeoplasmMice, NudeIncidenceRetrospective StudiesMCF-7 CellsBreast FeedingPolymorphism, Single NucleotideAntineoplastic Combined Chemotherapy ProtocolsProspective StudiesDisease ProgressionEstrogen Receptor alphaOdds RatioDNA-Binding ProteinsPremenopauseDNA Mismatch RepairCell ProliferationEstrogensSurvival RateNeoplastic Syndromes, HereditaryDisease-Free Survival