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  • vitro
  • The combination of eribulin and radiation enhanced DNA damage in vitro. (bioportfolio.com)
  • In this study we have redesigned our previously reported anticancer nanocomposite formulation with improved drug loading based on iron oxide magnetite nanoparticles coated with polyethylene glycol and loaded with anticancer drug gallic acid (Fe 3 O 4 -PEG-GA). The in vitro release profile and percentage drug loading were found to be better than our previously reported formulation. (mdpi.com)
  • The designed formulation (Fe 3 O 4 -PEG-GA) showed better anticancer activity than free gallic acid (GA). The results of the in vitro studies are highly encouraging to conduct the in vivo studies. (mdpi.com)
  • Lung Cancer
  • The NCI research team investigated HIV protease inhibitors because these drugs are known to inhibit the activation of Akt, a protein that has been implicated in the development of many types of cancer, including non-small cell lung cancer. (nih.gov)
  • apoptosis
  • When the DNA in a cell becomes damaged by agents such as toxic chemicals, radiation, or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the damaged cell will self-destruct (undergo apoptosis). (nih.gov)
  • Results: Among the various combinations of chemotherapeutic agents and radiation doses, concurrent chemoradiation therapy (CCRT) led to the highest rate of apoptosis and synergism. (aacrjournals.org)
  • In this paper, we investigated the role of Bax and Bcl-2 in the novel epothilone B analogue BMS-247550 (EpoB)-induced apoptosis of human breast cancer cells. (aacrjournals.org)
  • A number of cell lines with mutations in genes that are relevant to apoptosis are resistant to radiation ( 4 - 7 , 9 - 11 ). (pubmedcentralcanada.ca)
  • chemotherapeutic agents
  • After processing of various combinations according to the radiation dose and concentrations of chemotherapeutic agents, the level of cell survival was quantified by a MTT assay. (aacrjournals.org)
  • Current cancer treatments rely on radiation and chemotherapeutic agents that work by killing rapidly dividing cells in the body. (mdpi.com)
  • HER2
  • We determined sensitivity to neratinib in a panel of 36 breast cancer cell lines, including HER2 positive, luminal and basal-like cell lines (Figure 1A left panel, Supplementary Table 1). (amazonaws.com)
  • As the HER2 positive cell lines were significantly more sensitive to neratinib, we investigated the effect of neratinib on HER2 signalling in two HER2 positive breast cell lines. (amazonaws.com)
  • Figure 1: Neratinib is most effective in HER2 positive breast cell lines and reduces HER2 phosphorylation. (amazonaws.com)
  • introduced aldehyde dehydrogenase-1 (ALDH1) as an additional marker for the breast CSCs, and recently, our laboratory showed that HER2 is a novel breast CSC marker responsible for their resistance to radiation therapy (Duru et al. (springer.com)
  • inhibitor
  • b4) treating the patient such that the inhibitor is overcome and drug acts on the cells characteristic of the disease. (google.de)
  • 8 . A method as in claim 7 , wherein the inhibitor comprises a coating that encapsulates the drug, and wherein treating the patient so that the inhibitor is overcome comprises applying a magnetic field such that the delivery packages generate heat, motion, or a combination thereof sufficient to disrupt the inhibitory function of the coating. (google.de)
  • These data point to the potential of combining radiotherapy with an anti-miR-21 as a potent G2/M check point inhibitor in overcoming radiation resistance of tumours. (biomedcentral.com)
  • survival
  • Past statistics have shown the average survival rate of inflammatory breast cancer to be approximately 18 months. (imaginis.com)
  • A previous study revealed a significant difference in distant disease-free survival following IBTR depending on the subtype of breast cancer tissues present, as determined by immunohistochemical staining ( 6 ). (spandidos-publications.com)
  • The miR-21 expression levels were quantified (qRT-PCR) in a panel of 86 cases of invasive breast carcinomas in relation to metastasis free survival. (biomedcentral.com)
  • Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma. (bioportfolio.com)
  • Zoledronic acid and aromatase inhibitors are not expected to cure the breast carcinomas with bone metastasis, although they are effective in restraining further progression of the cancer and can significantly improve overall survival [ 2 ] and disease-free survival [ 3 ], respectively. (biomedcentral.com)
  • To determine, in the context of this phase I/II trial, the anti-tumor activity of combining vorinostat with radiation, followed by maintenance vorinostat for twelve courses, in children with newly diagnosed DIPG, as measured by 12-month event-free survival (EFS) and overall survival (OS). (clinicaltrials.gov)
  • The survival of HT29 and DU145 were increased by 30 and 100% respectively when these cells were exposed to γ radiation in the absence of glucose compared to that in the presence of glucose. (pubmedcentralcanada.ca)
  • effective
  • At the time, it was the newest and most effective kind of radiation therapy used to treat tumours. (cancer.ca)
  • A: That is exactly right - we are using drug-eluting technologies to deliver effective anti-cancer therapy by inserting the ABCD adjacent to the tumour site. (medindia.net)
  • Several protease inhibitors that are used in combination with other drugs to treat Human Immunodeficiency Virus (HIV) infection may also be effective against certain types of cancer, according to researchers from the National Cancer Institute (NCI), part of the National Institutes of Health. (nih.gov)
  • Development of an effective and side effects lacking anticancer therapy is the trending research direction in healthcare pharmacy. (frontiersin.org)
  • Of ten analyzed chemotherapeutics, vinblastine was the most effective compound, with docetaxel and doxorubicine being less effective in combination with radiation. (aacrjournals.org)
  • This suggests that combining vinblastine and radiation may be an effective radiation sensitizing strategy. (aacrjournals.org)
  • vorinostat
  • To estimate the maximum tolerated dose (MTD) or recommend a phase 2 dose of vorinostat given concurrently with radiation in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). (clinicaltrials.gov)
  • To define and describe the toxicities of vorinostat given concurrently with radiation in children with newly diagnosed DIPG. (clinicaltrials.gov)
  • To determine the toxicities of vorinostat for 12 additional courses after completion of vorinostat and radiation. (clinicaltrials.gov)
  • progression
  • 2012 ). The continuous and urgent need to define specific biomarkers to precisely identify breast CSCs for the early detection of tumor progression and the prevention of metastasis accelerated the research in this area extensively. (springer.com)