BRCA1 ProteinGenes, BRCA1BRCA2 ProteinGenes, BRCA2MutationGerm-Line MutationBreast NeoplasmsPoint MutationMutation, MissenseHeterozygoteOvarian NeoplasmsGenetic TestingGenetic Predisposition to DiseaseDNA Mutational AnalysisRad51 RecombinaseFrameshift MutationNeoplasm ProteinsPedigreeTranscription FactorsDNA RepairBase SequenceJewsExonsMolecular Sequence DataPolymorphism, Single-Stranded ConformationalDNA DamagePolymerase Chain ReactionFounder EffectDNA-Binding ProteinsCell LineGenes, p53PhenotypeGenotypeNuclear ProteinsAllelesAmino Acid SequencePromoter Regions, GeneticTumor Cells, CulturedTranscription, GeneticNeoplastic Syndromes, HereditaryDNA, NeoplasmSequence DeletionMutation RateBreast Neoplasms, MaleGenetic CounselingSequence Analysis, DNAHeterozygote DetectionCodon, NonsenseFamily HealthTumor Suppressor Protein p53HomozygoteAmino Acid SubstitutionTransfectionGene Expression RegulationRNA, MessengerGene Expression Regulation, ViralGene DeletionDNA PrimersDNATumor Suppressor ProteinsProtein Structure, TertiaryUbiquitin-Protein LigasesHeLa CellsGene Expression Regulation, NeoplasticProtein BindingTranscriptional ActivationMutagenesisMutagenesis, Site-DirectedCell Line, TumorBinding SitesLoss of HeterozygosityCarrier ProteinsPenetranceGene FrequencyPolymorphism, GeneticChromosome MappingPlasmidsCloning, MolecularRecombination, GeneticTrans-ActivatorsGenes, RecessiveCodonGene Expression ProfilingModels, GeneticGenomic InstabilityCell Transformation, NeoplasticSalpingectomyGenes, DominantReverse Transcriptase Polymerase Chain ReactionCell Cycle ProteinsGene Products, taxSequence Homology, Amino AcidViral ProteinsCase-Control StudiesOligonucleotide Array Sequence AnalysisOncogenesHomologous RecombinationCells, CulturedSequence AlignmentCell Nucleus