• A strong intergene correlation was observed among expression levels of all 9 genes except nuclear factor of activated T cells (eg, among ERCC1, RRM1 , and BRCA1 ). (medscape.com)
  • Our findings indicate that, although BRCA1 is closely related to ERCC1, RRM1 , and other genes like MZF1 , it stands out as the most significant prognostic marker of relapse. (medscape.com)
  • The present study investigated whether germline mutation status and mRNA expression of two BER genes, MUTHY and OGG1 , were correlated with BRCA1 in 59 patients with BC/OC and 50 matched population controls. (nih.gov)
  • Genetic testing of breast cancer susceptibility genes, BRCA1 and BRCA2, has become common practice for patients with a strong family history of the disease. (otago.ac.nz)
  • However, since this report focuses on testing for mutations in the genes BRCA1 ( br east ca ncer gene 1) and BRCA2 ( br east ca ncer gene 2) that predispose women to both breast and ovarian cancer, ovarian cancer will also be reviewed. (cdc.gov)
  • 28. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). (nih.gov)
  • 32. Characterisation of unclassified variants in the BRCA1/2 genes with a putative effect on splicing. (nih.gov)
  • The BRCA1 and BRCA2 genes code for tumor suppressor proteins. (news-medical.net)
  • These wide ranging consequences of the loss of BRCA1 function are explained by the proteins numerous interactions with several molecules, including the products of tumor suppressor genes and cancer-causing genes or oncogenes. (news-medical.net)
  • A strong correlation between the overexpression of DNA helicase genes and HRD was find both in BRCA1/2 -mutated breast cancer as well as in BRCA1/2 wild-type breast cancers. (hindawi.com)
  • During his time at Myriad, Dr Tavtigian contributed to the identification and/or complete cloning of the key cancer susceptibility genes BRCA1, BRCA2, and PTEN. (utah.edu)
  • Here, continuing work started towards the end of his time at IARC, he has calibrated computational methods for evaluating VUS in cancer susceptibility genes, most notably BRCA1, BRCA2, MLH1, and MSH2, that are applicable to clinical VUS classification. (utah.edu)
  • Clinical mutation screening of high-risk cancer susceptibility genes such as BRCA1, BRCA2, MLH1, and MSH2 will often find clearly pathogenic mutations, providing very useful information for the clinical management of high-risk patients and their close relatives. (utah.edu)
  • Currently, the method is applicable to UVs in the breast cancer susceptibility genes BRCA1 and BRCA2 as well as the colorectal cancer genes MLH1 and MSH2. (utah.edu)
  • Ruthenium treatment upregulated the marker genes involved in apoptosis and cell cycle progression while it downregulated BRCA1 mRNA and replication of HCC1937 cells. (biomedcentral.com)
  • In addition, Qu treatment significantly increased the mRNA levels of all these genes, when compared to cells treated with vehicle only (control cells) (*p (cancerindex.org)
  • The VEGF profile also correlates using the manifestation profile of three specific genes (HIF-1overexpression can be more regular in BRCA1-related breasts cancer in comparison to that in sporadic tumor in a little group of 30 instances [40]. (rockstarsagainstliveearth.com)
  • Hans-Guido Wendel, M.D., Memorial Sloan-Kettering Cancer Center, will test whether proteins that translate the mRNAs expressed from oncogenic genes respond to small molecules as potential cancer treatments. (cancer.org)
  • HRR consists after various REP of DNA clostridial octanoyl mRNA( DSB) genes, which is Archived specific lipoproteins. (erik-mill.de)
  • Two other genes, BRCA1 and BRCA2, were mutated in 22% of the tumors. (nih.gov)
  • Methods to test for the likelihood of a patient with mutations in BRCA1 and BRCA2 developing cancer were covered by patents owned or controlled by Myriad Genetics. (wikipedia.org)
  • The cancer susceptibility syndromes most associated with this pattern are hereditary breast and ovarian cancer due to BRCA1/2 mutations, Li-Fraumeni syndrome due to p53 mutations, and Cowden syndrome due to PTEN mutations. (cdc.gov)
  • For instance, mutations in BRCA1/2 are associated with a 36 to 87 percent lifetime risk for breast cancer, and a 9 to 66 percent lifetime risk of ovarian cancer. (cdc.gov)
  • 25. Investigating the effect of 28 BRCA1 and BRCA2 mutations on their related transcribed mRNA. (nih.gov)
  • 30. Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing. (nih.gov)
  • Mutations or alterations that affect the BRCA1 gene are linked to familial breast and ovarian cancer syndromes. (news-medical.net)
  • Nearly 10% of all ovarian cancers are caused by mutations in either the BRCA1 or BRCA2 gene and nearly 45% of breast cancers may be caused by mutations in the BRCA1 gene. (news-medical.net)
  • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. (cdc.gov)
  • Approximately 10% of HGSC develop via BRCA1/BRCA2 mutations and the lifetime risk of ovarian cancer in BRCA mutated patients is around 50% 7 . (turkjpath.org)
  • This study will address this important issue through collaborative links with the international scientific consortia, ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles) and CIMBA (Consortium of Investigators of Modifiers of BRCA1/2). (otago.ac.nz)
  • BRCAness phenotype in breast cancer has been shown to be highly correlated with the response to platinum-based chemotherapy and PARP inhibitors in BRCA1 and BRCA2 germline wild-type triple negative breast cancer (TNBC) [ 9 , 10 ]. (hindawi.com)
  • A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - An NRG Oncology/Gynecologic Oncology Group study. (cdc.gov)
  • 24. Molecular characterization and clinical interpretation of BRCA1/BRCA2 variants in families from Murcia (south-eastern Spain) with hereditary breast and ovarian cancer: clinical-pathological features in BRCA carriers and non-carriers. (nih.gov)
  • 26. A high proportion of DNA variants of BRCA1 and BRCA2 is associated with aberrant splicing in breast/ovarian cancer patients. (nih.gov)
  • 27. The identification of pathogenic variants in BRCA1/2 negative, high risk, hereditary breast and/or ovarian cancer patients: High frequency of FANCM pathogenic variants. (nih.gov)
  • 29. BRCA1 Gene Mutation Screening for the Hereditary Breast and/or Ovarian Cancer Syndrome in Breast Cancer Cases: a First High Resolution DNA Melting Analysis in Indonesia. (nih.gov)
  • 35. Identifying sequence variants contributing to hereditary breast and ovarian cancer in BRCA1 and BRCA2 negative breast and ovarian cancer patients. (nih.gov)
  • Sleep disturbances in asymptomatic BRCA1/2 mutation carriers: women at high risk for breast-ovarian cancer. (cdc.gov)
  • The mRNA expression of MMP-9,-11 and -14 was significantly upregulated in Stage IV compared to normal/benign ovarian tissues. (frontiersin.org)
  • Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants. (cdc.gov)
  • Patients whose tumors had high BRCA1 expression had significantly poorer survival and should be candidates for adjuvant chemotherapy. (medscape.com)
  • Multimolecular characteristics and role of BRCA1 interacting protein C-terminal helicase 1 (BRIP1) in human tumors: a pan-cancer analysis. (nih.gov)
  • This observation may explain the way the BRCA1 tumors enhance hypoxic drive. (rockstarsagainstliveearth.com)
  • A module that is central to DDR is BRCA1, which includes BRCA1-associated ring domain protein (BARD1), BRCA2, partner and localizer of BRCA2 (PALPB2), ATM, and E2F transcription factor 1. (medscape.com)
  • These four helices combine to form a heterodimerization interface and stabilize the BRCA1-BARD1 heterodimer complex. (wikipedia.org)
  • The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. (wikipedia.org)
  • BRCA1 polypeptides, in particular, Lys-48-linked polyubiquitin chains are dispersed throughout the resting cell nucleus, but at the start of DNA replication, they gather in restrained groups that also contain BRCA2 and BARD1. (wikipedia.org)
  • During normal cellular activities, the BRCA1 protein associates with its binding partner, BARD1 (BRCA1-Associated Ring Domain protein), to assist with genomic repair events and RNA synthesis 9 . (nature.com)
  • Consistent with this observation, RNA Polymerase II (RNAP II) - the machinery responsible for mRNA production in all human cells - BRCA1 and BARD1 contained in nuclear extracts co-eluted from Nickel-nitrilotriacetic acid (Ni-NTA) agarose beads ( Fig. 1a , Step 2 ). (nature.com)
  • a ) Breast cancer cells were lysed and the nuclear material was separated from the other cellular contents ( Step 1, 30 min ) and enriched ( Step 2, 60 min ) in RNAP II (RPB1 subunit, ~260 kDa), BRCA1 (~220 kDa) and BARD1 (~87 kDa) as identified by western blot analysis. (nature.com)
  • Changes in the conformation and binding constants of ruthenium-BRCA1 adducts were observed, causing inactivation of the RING heterodimer BRCA1/BARD1-mediated E3 ubiquitin ligase activity. (biomedcentral.com)
  • The BARD1 protein acts as tumor suppressor with BRCA1. (lncrnablog.com)
  • In cancer, mRNAs encoding the tumor suppressor full length BARD1 are often down-regulated while the expression of oncogenic truncated isoforms is boosted. (lncrnablog.com)
  • In addition we discovered a novel lncRNA, BARD1 9′L, which is transcribed from an alternative promoter in intron 9 of the BARD1 gene and shares part of the 3′UTR with the protein coding BARD1 mRNAs. (lncrnablog.com)
  • We demonstrate with the example of two microRNAs, miR-203 and miR-101, that they down-regulate the expression of FL BARD1 and cancer-associated BARD1 mRNAs, and that BARD1 9′L counteracts the effect of miR-203 and miR-101, As BARD1 9′L is abnormally over-expressed in human cancers, we suggest it might be a tumor promoting factor and treatment target. (lncrnablog.com)
  • Genotyping and mRNA profiling reveal actionable molecular targets in biliary tract cancers. (cdc.gov)
  • Our results could provide an alternative approach to finding effective therapeutic ruthenium-based agents with promising anticancer activity, and demonstrated that the BRCA1 RING domain protein was a promising therapeutic target for breast cancers. (biomedcentral.com)
  • since when do we need a flu vaccine based on mrna? (godlikeproductions.com)
  • But this is the first phase-IIb randomised clinical trial to test the investigational mRNA vaccine in patients. (godlikeproductions.com)
  • An experimental personalized mRNA vaccine in combination with the immunotherapy Keytruda reduced the risk of recurrence or death from melanoma in patients who had already had surgery, Moderna and Merck said Tuesday. (godlikeproductions.com)
  • They will be designed to be shipped to remote locations, where they can churn out its vaccine candidate and other mRNA-based therapies depending on the recipe fed into the machine. (godlikeproductions.com)
  • The funding and resources that are flowing into mRNA vaccine research will help the cancer vaccine field. (godlikeproductions.com)
  • Additionally, there is inhibition of DNA repair, contamination with SV-40 oncogene promoters, as additional mechanisms to explain the occurrence or acceleration of cancer in mRNA vaccine recipients. (whatreallyhappened.com)
  • 'The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses' is a 2021 paper ( 1 ) from scientists at the Radboud Centre for infectious diseases in the Netherlands. (canceractive.com)
  • In November 2021, a small paper was published by Goldman et al: "Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following Pfizer mRNA vaccine booster shot" ( click here ). (truth11.com)
  • Furthermore, the C-terminus of BRCA1 interacts with the RNA polymerase II holoenzyme to act as transcriptional activator. (news-medical.net)
  • We report that B[a]P does not compromise the stability of BRCA-1 mRNA, but represses transcriptional activity of a 1.69-kb BRCA-1 (pGL3-BRCA-1) promoter fragment that contains both exon-1A and exon-1B transcription start sites. (nih.gov)
  • These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression. (nih.gov)
  • The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). (nih.gov)
  • The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. (wikipedia.org)
  • Although BRCA1 plays a critical role in these processes, the precise manner in which BRCA1 interacts with other proteins remains unclear. (nature.com)
  • The first 109 amino acids of BRCA1 contain a protease-resistant domain that interacts with E2F1 and BAP1. (news-medical.net)
  • The C-terminal end of BRCA1 interacts directly or indirectly with p53, RNA Polymerase II, RNA helicaseA, p300 and CBP (CREB binding protein), BRCA2, histone-deacetylase complex, RB and CtIP. (news-medical.net)
  • BRCA1 interacts with several proteins that regulate the cell cycle. (news-medical.net)
  • The fact that high levels of ERCC1 or RRM1 transcripts conferred a higher risk of relapse [ 8 ] provides further evidence for the role of the loss of let-7 in the upregulation of ERCC1 and RRM1, as well as BRCA1, [ 24 ] and for the upregulation of BRCA1 and RRM1 in the SV40 T/t antigen signature. (medscape.com)
  • [ 26 ] Nevertheless, the clinical evidence indicates that the overexpression of ERCC1, RRM1, and especially BRCA1 mRNA confers poor survival in early NSCLC. (medscape.com)
  • The BRCA1 protein contains the following domains: Zinc finger, C3HC4 type (RING finger) BRCA1 C Terminus (BRCT) domain This protein also contains nuclear localization signals and nuclear export signal motifs. (wikipedia.org)
  • the Znf C3HC4- RING domain, the BRCA1 serine domain and two BRCT domains. (wikipedia.org)
  • Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. (nih.gov)
  • To better define BRCA1 interactions in a hereditary breast cancer system, we interrogated the nuclear contents of primary ductal carcinoma cells that express wild type BRCA1 (HCC70 line) ( Fig. 1a , Step 1 ). (nature.com)
  • Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. (nih.gov)
  • For ectopic expression of BRCA1, cells were transfected with pBabe-empty, pBabe-HA-BRCA1, or pBabe-Myc-BRCA1 as previously described [31]. (cahrr.org)
  • Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 (/ˌbrækəˈwʌn/) gene. (wikipedia.org)
  • To accomplish this task, we developed a new molecular toolkit using patient-derived cancer cells that produce the breast cancer susceptibility protein, BRCA1. (nature.com)
  • BRCA1 and BRCA2 are unrelated proteins, but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. (wikipedia.org)
  • The coronavirus pandemic has thrown a spotlight on messenger RNA (mRNA)-the molecule that carries a cell's instructions for making proteins. (godlikeproductions.com)
  • Proteins that interact with BRCA1 are termed BRCA1-interacting proteins (BIPs). (news-medical.net)
  • Needlessly to say, ACTA2 manifestation was considerably higher in CAFs than in NAFs (manifestation more than doubled in CAFs in comparison to NAFs (((mRNAs had been expressed in tumor cells and combined fibroblasts, whereas mRNA was indicated almost specifically in fibroblasts (Fig. (palomid529.com)
  • Boxplot showing relative Pdgfr mRNA levels in ((tumor cells that invade into surrounding muscle are strongly positive for Pdgfr (tumor B in top panel) and that most Pdgfr-positive cells in tumor cells at the tumor invasion front are indicated. (cahrr.org)
  • In addition, exon 11 of BRCA1 possesses two nuclear-localization signals for targeting BRCA1 to the nucleus. (news-medical.net)
  • KLK7 mRNA expression level has been quantified by RT-PCR in breast cancer tissues and reported to be a better prognostic marker for the unfavorable prognosis of breast carcinoma. (biomedcentral.com)
  • When only patients with stage I disease were examined, median survival was significantly different according to expression levels of ERCC1 , myeloid zinc finger 1 ( MZF1), TWIST , and BRCA1 . (medscape.com)
  • At the cellular level, TIMP-2 mRNA expression was significantly higher in CN compared to CR epithelial cells in patients. (frontiersin.org)
  • The amount of microvessels that are positive for vasohibin-1 SGC 707 (a poor feedback regulator of angiogenesis) and vasohibin-1 mRNA amounts in 17 breasts ductal carcinomas (DCIS) can be significantly lower in comparison to those of 22 intrusive ductal carcinomas [42]. (rockstarsagainstliveearth.com)
  • Retrieved on December 10, 2023 from https://www.news-medical.net/health/BRCA1-Interactions.aspx. (news-medical.net)
  • To address this concern, we have explored the cellular responses of BRCA1-defective and triple-negative breast cancer cells, and in vitro BRCA1 interactions induced by the ruthenium(II) complexes containing the bidentate ligand, 5-chloro-2-(phenylazo)pyridine. (biomedcentral.com)
  • There are six known isoforms of BRCA1, with isoforms 1 and 2 comprising 1863 amino acids each. (wikipedia.org)
  • We and others have reported that BRCA1 deficiency in human and mouse mammary epithelial cells (MECs) activates the p16 and p18, inducing premature senescence [11, 31C34]. (cahrr.org)
  • Importantly, the S2 segment has not been found in the body after the infection, however, it is readily produced in large quantities after mRNA COVID-19 vaccination as published by Patterson et al in 2022. (whatreallyhappened.com)
  • From 1 January 2022 , a new item (63399) was listed on the Medicare Benefits Schedule (MBS) for cardiac magnetic resonance imaging (MRI) to assist in diagnosing myocarditis associated with mRNA COVID-19 vaccination. (mbsonline.gov.au)
  • reporting two cases of aggressive lymphoma that developed within a week following Pfizer COVID-19 mRNA vaccination ( click here ). (truth11.com)
  • 33. Intronic variants in BRCA1 and BRCA2 that affect RNA splicing can be reliably selected by splice-site prediction programs. (nih.gov)
  • Triple-negative MDA-MB-231, BRCA1-defective HCC1937 and BRCA1-competent MCF-7 breast cancer cell lines were treated with ruthenium(II) complexes. (biomedcentral.com)
  • Now, some investigators believe the success of the mRNA COVID-19 vaccines could help accelerate clinical research on mRNA vaccines to treat cancer. (godlikeproductions.com)
  • (3) molecular structures of complexes containing BRCA1 are heavily under-investigated despite their clinical significance. (nature.com)
  • An increased induction of apoptotic cells as well as an upregulation of p53 mRNA was observed in all tested breast cancer cells. (biomedcentral.com)
  • Competing endogenous RNAs (ceRNAs) represent one recently emerged type of functional lncRNAs that share microRNA recognition sequences with mRNAs and may compete for microRNA binding and thus affect regulation and function of target mRNAs. (lncrnablog.com)
  • They found that BRCA1, a multifunctional protein involved in DNA repair and epigenetic regulation, played a critical role in the regulation of CSC-like characteristics. (stemcellsciencenews.com)
  • In chemotherapy-naive patients with early-stage, resected NSCLC, BRCA1 mRNA expression was the only independent prognostic variable. (medscape.com)
  • In addition, to evaluate the relationship between MUTYH , OGG1 and BRCA1 , their possible mutual modulation and correlation among mutational spectrum, gene expression and demographic characteristics were evaluated. (nih.gov)
  • 21. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. (nih.gov)
  • To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. (nih.gov)
  • The expression of mRNA was decided utilizing an Illumina array in 64 major UM from Leiden. (aabioetica.org)
  • . In a second cohort of 15 instances from Leiden, mRNA expression was studied by Fluidigm qPCR, whereas a 3rd cohort consisted of 80 UM from TCGA. (aabioetica.org)
  • The prognostic significance of HOXA9 promoter methylation alone and in combination with four protein-coding gene (XPO1, BRCA1, HIF1α, DLC1), and miR-21 expression was assessed by Cox regression and Kaplan-Meier in two independently collected cohorts of Stage I lung adenocarcinoma. (nih.gov)
  • The mRNA expression of TIMPs and MMPs was quantified by real time PCR (qRT-PCR). (frontiersin.org)
  • LncRNAs could act as epigenetic regulators of gene expression affecting transcription, mRNA stability and transport, and translation, although, precise functions have been attributed to only few of them. (lncrnablog.com)
  • We have studied human tissue Kallikrein 7 (KLK7) mRNA expression profile in breast cancer patients of our region. (biomedcentral.com)
  • The N-terminal end of BRCA1 contains a zinc-finger domain that can interact with DNA directly or indirectly. (news-medical.net)
  • 2) CDS status was determined by comparing the clone sequence with NCBI RefSeq mRNA. (riken.jp)
  • The clone could differ from the NCBI mRNA reference sequence. (riken.jp)
  • 1) Refference sequence either NCBI mRNA or DDBJ DNA identified by the 5' terminal sequence. (riken.jp)
  • In fact, scientists at both Pfizer-BioNTech and Moderna drew on their experience developing mRNA cancer vaccines to create their coronavirus vaccines. (godlikeproductions.com)
  • Scientists are starting to provide a clearer understanding of why people who have mRNA vaccines and booster shots (Pfizer and Moderna) are subject to more viral infections (for example, Shingles). (canceractive.com)
  • Intriguingly, in vitro studies have shown that BRCA1 can regulate differential sensitivity to different classes of chemotherapy agents. (medscape.com)
  • The N -terminal BRCA1 RING protein was used for conformational and functional studies using circular dichroism and in vitro ubiquitination. (biomedcentral.com)
  • This was a 66 yo man who had 2 Pfizer COVID-19 mRNA vaccines and developed an aggressive lymphoma 6 months later (left image). (truth11.com)
  • Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. (nih.gov)
  • Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. (nih.gov)
  • Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. (electrichealth.org)
  • BACH1 is a widely used alternative name for BRCA1 interacting protein C-terminal helicase 1 (BRIP1), which can be confused with the official symbol for BTB domain and CNC homolog 1 (BACH1). (nih.gov)
  • Spectrum of BRCA1 interacting helicase 1 aberrations and potential prognostic and therapeutic implication: a pan cancer analysis. (nih.gov)
  • Studies have shown that the C-terminus of BRCA1 which incorporates amino acids 1528 to 1863 forms a complex with RNA polymerase II, an enzyme that makes mRNA precursors as well as many noncoding RNAs. (news-medical.net)
  • Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. (nih.gov)
  • Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. (nih.gov)
  • These domains encode approximately 27% of BRCA1 protein. (wikipedia.org)
  • Bioinformatic analysis revealed that the alternatively spliced mRNA (KF963192) will potentially encode a truncated and non-functional protein. (biomedcentral.com)
  • However, RNA-sequencing confirmed the Ep + CSC specific up-regulation of only HSPA8 , HNRNPC , MPST and GAPDH mRNAs among these. (stemcellsciencenews.com)
  • Researchers examined the role of the tumor suppressor BRCA1 and hypoxia in the regulation of cancer cell stemness using genetically matched breast cancer cell lines. (stemcellsciencenews.com)
  • RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. (nih.gov)
  • BRCA1 is a human tumor suppressor gene (also known as a caretaker gene) and is responsible for repairing DNA. (wikipedia.org)
  • The human BRCA1 gene is located on the long (q) arm of chromosome 17 at region 2 band 1, from base pair 41,196,312 to base pair 41,277,500 (Build GRCh37/hg19) (map). (wikipedia.org)
  • BRCA1 combines with other tumor suppressors, DNA damage sensors and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). (wikipedia.org)
  • BRCA1 orthologs have been identified in most vertebrates for which complete genome data are available. (wikipedia.org)
  • BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. (nih.gov)
  • A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. (nih.gov)