DNA DamageBRCA1 ProteinGenes, BRCA1BRCA2 ProteinGenes, BRCA2DNA RepairTumor Suppressor Protein p53Ataxia Telangiectasia Mutated ProteinsCell Cycle ProteinsUltraviolet RaysCheckpoint Kinase 2DNA-Binding ProteinsGamma RaysProtein-Serine-Threonine KinasesTumor Suppressor ProteinsCell CycleG2 PhaseRadiation, IonizingNuclear ProteinsDNA Breaks, Double-StrandedMutationApoptosisComet AssayRad51 RecombinasePhosphorylationCell Line, TumorDNA ReplicationProto-Oncogene Proteins c-mdm2Genomic InstabilityMitomycinCyclin-Dependent Kinase Inhibitor p21Protein KinasesHeLa CellsCell LineS PhaseSOS Response (Genetics)Radiation ToleranceDNAGenes, p53MitosisPoly(ADP-ribose) PolymerasesHistonesHCT116 CellsDNA-Activated Protein KinaseRNA, Small InterferingCell SurvivalDose-Response Relationship, RadiationProtein BindingFibroblastscdc25 PhosphatasesSignal TransductionG1 PhaseUbiquitinationCell NucleusIntracellular Signaling Peptides and ProteinsUbiquitin-Protein LigasesCyclinsTumor Cells, CulturedMethylnitronitrosoguanidineTranscription, GeneticCyclin BMolecular Sequence DataBreast NeoplasmsMethyl MethanesulfonateCDC2 Protein KinaseSaccharomyces cerevisiae ProteinsProliferating Cell Nuclear AntigenSerineGene Expression RegulationDeoxyguanosineCells, CulturedRecombination, GeneticGerm-Line MutationRNA InterferenceTranscription FactorsProto-Oncogene ProteinsBase SequenceTransfectionCisplatinModels, BiologicalOxidative StressOvarian NeoplasmsApoptosis Regulatory ProteinsAntineoplastic AgentsTranscriptional ActivationProtein Structure, TertiaryCell DivisionVaccines, DNAPromoter Regions, GeneticDoxorubicinBlotting, WesternTime FactorsCyclin-Dependent Kinase 2Amino Acid SequenceRepressor ProteinsMicroscopy, FluorescenceRNA, MessengerGene Expression Regulation, NeoplasticEnzyme InhibitorsMutagens