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  • 1989
  • 1989) "Immunodetection of DNA with Biotinylated RNA Probes: A Study of Reactivity of a Monoclonal Antibody to DNA-RNA Hybrids. (patentgenius.com)
  • This brief report describes the sequential modifications and improvements made in the development of various assays for laboratory diagnosis of hepatitis C virus (HCV) infection after its characterization in 1989. (indmedica.com)
  • proteins
  • Loss of labile chloride ligands results in nucleophilic substitution reactions with DNA and proteins, generation of oxidative stress, inflammation, increased cytosolic free calcium, and ultimately cell death ( Pabla and Dong, 2008 ). (aspetjournals.org)
  • Chomczynski, Piotr, (1993) "A Reagent For the Single-Step Simultaneous Isolation of RNA, DNA and Proteins from Cell and Tissue Samples. (patentgenius.com)
  • sensitivity
  • The branching of the DNA allows for very dense decorating of the DNA with the enzyme, which is important for the high sensitivity of the assay. (primidi.com)
  • The first assay developed was the 'first generation ELISA ', followed by assays with further improvement in the sensitivity and specificity, labeled subsequently as ELISA -2 and ELISA -3. (indmedica.com)
  • technology
  • As with conventional methods there are many limitations to nucleic acid amplification technology. (bmj.com)
  • Advanced DNA and RNA sequencing technology has created large pools of data that are being studied to better understand the meaning and consequences of variation in genomic DNA and its transcription products. (thermofisher.com)
  • transcription
  • A number of signaling pathways, most notably those controlled by the nuclear factor E2-related factor 2 (Nrf2) transcription factor, are activated to counteract accumulating reactive oxygen species and electrophiles ( Aleksunes and Manautou, 2007 ). (aspetjournals.org)
  • Tissue Samples
  • With Affymetrix' ViewRNA ISH portfolio for tissue samples, researchers can rapidly design assays for virtually any mRNA transcript or long noncoding RNA in any tissue type. (technologynetworks.com)
  • methods
  • Disclosed herein are biomarkers related to WNT signal transduction pathway, as well as methods and kits comprising the same. (patents.com)
  • results
  • Results from microarrays and RNA sequencing are often validated using real-time PCR with Applied Biosystems™ TaqMan® Assays. (thermofisher.com)
  • type
  • Lastly, the Nrf2 activator, CDDO-Im [2-cyano-3,12-dioxooleana-1,9-dien-28-oic imidazolide], increased Nrf2 signaling in kidneys from wild-type mice and protected them from cisplatin toxicity. (aspetjournals.org)
  • Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monocloncal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5A resolution. (springer.com)
  • This bead type also makes automating the assay more difficult. (thermofisher.com)
  • measure
  • The QuantiGene Plex and QuantiGene Singleplex RNA assays are designed to quantitatively measure RNA directly from cell or tissue homogenates and even directly from blood without RNA purification or enzymatic manipulation, thereby avoiding inefficiencies inherent to these processes. (thermofisher.com)
  • culture
  • Increased levels of IL-17A have been detected in the synovial fluid of patients with RA [ 8 - 10 ], and blockade of IL-17A signaling can inhibit osteoclast formation induced by conditioned culture media of RA synovial tissues. (biomedcentral.com)
  • portfolio
  • We continue to support customers of our pre-existing (non-ProcartaPlex) portfolio of Invitrogen assays for the Luminex platform. (thermofisher.com)
  • cell
  • HBV is a DNA virus that primarily infected hepatocytes which mediated by HBV receptors located on the hepatocyte cell membrane. (paperity.org)