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  • fetal
  • Putting fetal brain tissue grafts in the mature central nervous system (CNS) differs from peripheral nerve (PN) grafting in at least the following two ways. (utah.edu)
  • The fetal grafted tissue must develop its own set of connections with the right structures in the host brain, and these connections must be orderly arranged. (utah.edu)
  • Furthermore, the fetal graft may produce trophic factors or signaling cues, which are present in the brain only at early developmental stages, and should reactivate neurotropic processes in a 'dormant' host neuron populations. (utah.edu)
  • Unfortunately, there is abundant literature suggesting that environmental constraints from the mature host brain alter the restorative capacities of fetal grafts in various ways. (utah.edu)
  • Insightful chapters, including one on the concept of "self-identity," bring the religious, legal, historical, and more recent topics, such as brain tissue grafting and fetal transplants, into a unified structure. (powells.com)
  • There was no evidence of any significant difference in the lumped constant between transplant and host tissue which might compromise the validity of the 2-deoxyglucose technique when used together with intracerebral implantation of fetal neuronal cell suspensions. (muscimol.xyz)
  • mice
  • In preliminary experiments, the transplantation of mouse neural stem cells, which survived in the brain for the four week period of the trial, provided protective effects in delaying disease progression in an HD mouse model and increased production of protective molecules in the brains of these mice. (ca.gov)
  • Cell types in the brains of mice and humans are almost indistinguishable in structure and function, but their numbers vary over more than three orders of magnitude. (nervenet.org)
  • Donor
  • Questions have been raised about the rights of both recipient and donor, as well as the social, religious, and ethical propriety of transplantation itself. (powells.com)
  • With the increasing diversity of stem cell sources emerging for donor cells in transplantation therapy, many laboratory-to-clinic translational factors must first be considered, dynamics such as the source of the cells, ease of extraction, immunogenicity, capacity for proliferation, and cell yield. (mdpi.com)
  • Autologous stem cells are acquired from the host in which the cells are intended for use, while allogenic cells are procured from an unrelated donor prior to transplantation. (mdpi.com)
  • tumors
  • However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. (mdpi.com)
  • adult
  • Here, we used an inducible transgenic mouse model to track the stages of differentiation of adult endogenous NSCs and observed distinct NSC behaviors in three brain regions (subventricular zone, subgranular zone, and tanycyte layer) after long-term alcohol consumption. (jove.com)
  • Disorders
  • Injury to the brain areas concerned with vision can cause a variety of disorders ranging from visual field defects to much more complex deficits like visual agnosia. (utah.edu)
  • Journal concerned with all aspects of language impairment and related disorders resulting from brain damage. (dmoztools.net)
  • differences
  • The 3-O-[14C]methylglucose tracer was distributed homogeneously throughout the host brain areas analysed, with no side-to-side differences, despite a marked unilateral depletion of acetylcholinesterase activity ipsilateral to the lesion site. (muscimol.xyz)
  • Genes that modulate absolute numbers of neurons are key determinants of development, individual behavior, species differences in brain structure, and rates of brain evolution. (nervenet.org)
  • response
  • While it is known that alcohol alters NSCs, little is known about how NSC response to alcohol is related to sex, brain region, and stage of differentiation. (jove.com)
  • death
  • Huntington's disease (HD) is a devastating degenerative brain disease with a 1 in 10,000 prevalence that inevitably leads to death. (ca.gov)
  • Information on organ donation and brain death, and links to key local, regional and national sites. (dmoztools.net)
  • effects
  • The effects of the lesion and the presence of transplanted tissue in neocortex were visualized by acetylcholinesterase histochemistry. (muscimol.xyz)
  • cause
  • A non-profit organization dedicated to furthering the cause of organ and tissue donation around the world. (dmoztools.net)
  • individual
  • Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species. (bioportfolio.com)