• Succimer facilitates urinary excretion of lead, and with sufficiently aggressive treatment, can reduce lead content in the brain. (wikipedia.org)
  • Succimer is an isomer of 2,3-dimercaptosuccinic acid. (wikipedia.org)
  • Succimer is a mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning. (drugbank.com)
  • Succimer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent. (drugbank.com)
  • 18F]PSMA-1007 PET is comparable to [99mTc]Tc-DMSA SPECT for renal cortical imaging. (lu.se)
  • MATERIALS AND METHODS: The DTC patients with iodine-negative metastases (n = 115) were enrolled in the study.Of them the whole body scintigraphy (WBS) was performed with technetium-99m-hexakis-2-methoxyisobutylisonitrile(99mTc-MIBI) (n = 30), WBS with technetium-99m dimercaptosuccinic acid (99mTc-DMSA) (n = 30), 18FDG PET (n = 30), andcomputer tomography (CT-scan) (n = 25). (bvsalud.org)
  • Dimercaptosuccinic acid[clarification needed] may be prepared by reacting acetylenedicarboxylic acid with sodium thiosulfate or thioacetic acid followed by hydrolysis. (wikipedia.org)
  • This colorless solid contains two carboxylic acid and two thiol groups, the latter being responsible for its mildly unpleasant odour. (wikipedia.org)
  • When radiolabeled with technetium-99m, it is used in many types of diagnostic testing. (wikipedia.org)
  • Attenuation compensation in 99mTc SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans. (umassmed.edu)
  • Dimercaptosuccinic acid is in the chelating agent family of medications. (wikipedia.org)
  • This graph shows the total number of publications written about "Technetium Tc 99m Exametazime" by people in this website by year, and whether "Technetium Tc 99m Exametazime" was a major or minor topic of these publications. (umassmed.edu)
  • A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. (drugbank.com)
  • Please note the following information prior to placing an order for ROTOP DMSA Kit for the Preparation of Technetium Tc99m Succimer Injection. (nih.gov)
  • To place an order for ROTOP DMSA Kit for the Preparation of Technetium Tc99m Succimer Injection (Theragnostics), please contact your local nuclear pharmacy, ex. (nih.gov)
  • Theragnostics has initiated temporary importation of DMSA Kit for the Preparation of Technetium Tc99m Succimer Injection into the U.S. market. (nih.gov)
  • At this time, no other entity except ROTOP Pharmaka GmbH, Germany through its US Agent, Theragnostics, and Theragnostics' distributor, Medi-Physics Inc., dba GE Healthcare, is authorized by the FDA to import or distribute the DMSA Kit for the Preparation of Technetium Tc99m Succimer Injection in the U.S. FDA has not approved ROTOP Pharmaka GmbH's Kit for DMSA Preparation of Technetium Tc99m Succimer Injection product in the U.S. (nih.gov)
  • There are some differences in the labeling between the FDA-approved DMSA Kit for the Preparation of Technetium Tc99m Succimer Injection (GE Healthcare) product and ROTOP DMSA Kit for the Preparation of Technetium Tc99m Succimer Injection (Theragnostics) product (please see the product comparison tables below). (nih.gov)
  • A lactating woman should pump and discard breastmilk for at least 24 hours after Technetium Tc 99m Succimer Injection administration. (nih.gov)
  • Use waterproof gloves, effective radiation shielding, and other appropriate safety measures when preparing and handling Technetium Tc 99m Succimer Injection. (nih.gov)
  • 4. Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptake. (nih.gov)
  • 10. Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: comparison with thallium-201 imaging. (nih.gov)
  • Prostate-specific membrane antigen (PSMA) is a well-validated prostate cancer marker but reported PSMA-targeted tracers derived from the Lys-urea-Glu pharmacophore including the clinically validated [99mTc]Tc-EDDA/HYNIC-iPSMA have high off-target uptake in kidneys, spleen, and salivary glands. (bvsalud.org)
  • Compared with the clinical tracer [99mTc]Tc-EDDA/HYNIC-iPSMA, the Lys-urea-Aad-derived [99mTc]Tc-EDDA-KL01127 had lower background uptake and superior tumor-to-background contrast ratios and is therefore promising for clinical translation to detect prostate cancer lesions with SPECT. (bvsalud.org)
  • This colorless solid contains two carboxylic acid and two thiol groups, the latter being responsible for its mildly unpleasant odour. (wikipedia.org)
  • Upon radiolabeling with technetium Tc 99m, it provides a clear, colorless solution containing up to 1,480 MBq (40 mCi) technetium Tc 99m succimer in approximately 5 mL volume at calibration time. (nih.gov)
  • 13. Prognostic value of dobutamine-atropine stress (99m)Tc-tetrofosmin myocardial perfusion SPECT in patients with known or suspected coronary artery disease. (nih.gov)
  • 1. The value of 99mTc-tetrofosmin brain SPECT in predicting survival in patients with glioblastoma multiforme. (nih.gov)
  • Dimercaptosuccinic acid can cross the blood-brain barrier of mice, but it is not known if this is also the case in humans. (wikipedia.org)
  • Imaging and ex vivo biodistribution studies in LNCaP tumor-bearing mice showed that [99mTc]Tc-EDDA/HYNIC-iPSMA and the three novel tracers successfully visualized LNCaP tumor xenografts in SPECT images and were excreted mainly via the renal pathway. (bvsalud.org)
  • Voiding cystography unveiled level 3 vesicoureteral regurgitate as well as technetium-99m dimercaptosuccinic acidity scintigraphy unveiled right to remaining surpassed renal ectopia together with fusion (L-shaped kidney). (5-htreceptor.com)
  • 14. Feasibility and image quality of dual-isotope SPECT using 18F-FDG and (99m)Tc-tetrofosmin after acipimox administration. (nih.gov)