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  • glioma
  • Neuronal stem cells (NSCs), neuronal cells, precursors and differentiated glioma cells are considered as the sources of STCs. (exp-oncology.com.ua)
  • This is a safety (Phase 1) trial using mebendazole for recurrent pediatric brain cancers that include medulloblastoma and high grade glioma, that are no longing responding to standard therapies. (clinicaltrials.gov)
  • Because of these factors, our understanding of the biology of adult brainstem glioma is incomplete. (frontiersin.org)
  • In this article, we review the current state of knowledge for brainstem glioma in adults and identify key areas for which additional information is required. (frontiersin.org)
  • Pediatric diffuse intrinsic pontine glioma (DIPG) - the most frequent malignant primary brain tumor of childhood - on the other hand, has been found to have substantially different biological underpinnings. (frontiersin.org)
  • At the nexus of these two diagnoses is brainstem glioma in adults. (frontiersin.org)
  • Unfortunately, it is perhaps more apt to describe adult brainstem glioma as the valley shrouded in shadow between the two growing mountains of knowledge that represent adult glioma and pediatric DIPG, as few studies have investigated this particular diagnosis. (frontiersin.org)
  • The anatomical basis of adult brainstem glioma does not lend itself to easy study, as the brainstem is packed full of brainstem nuclei and white matter tracts that are essential for basic functions. (frontiersin.org)
  • Within the umbrella of adult brainstem glioma, there is a subset of tumors that is similar in appearance and potentially similar in etiology to childhood DIPG, but with slightly older onset, generally affecting young adults. (frontiersin.org)
  • In this article, we will review the current state of knowledge (and lack of knowledge) for adult brainstem glioma and highlight prospects for advances in therapy. (frontiersin.org)
  • In contrast to pediatric DIPG, which accounts for approximately 20% of pediatric primary brain neoplasms, adult brainstem glioma constitutes less than 2% of adult gliomas, with a slight male preponderance ( 3 , 4 ). (frontiersin.org)
  • The purpose of the Dendritic Cell Immunotherapy study for patients with glioblastoma and/or brainstem glioma is to determine whether in patients with malignant brain tumors, dendritic cells injected peripherally can reactivate the immune system against the brain tumor. (clinicaltrials.gov)
  • This multi-institutional study will prospectively collect tumor and constitutional tissue samples from patients with diffuse brainstem glioma and other types of brainstem gliomas either during therapy or at autopsy to perform an extensive analysis of genetic and molecular abnormalities in these tumors. (clinicaltrials.gov)
  • Since very little is known about the biology of diffuse brainstem glioma, the goal of this protocol is to undertake a systematic analysis of DNA abnormalities, and of RNA and protein expression in prospectively collected fresh-frozen and fixed tumor samples and correspondent normal tissue from patients affected with this tumor. (clinicaltrials.gov)
  • Perform genome-wide analysis of DNA gains and losses and RNA expression in tumor samples and normal tissue from patients with diffuse brain stem glioma. (clinicaltrials.gov)
  • The purpose of this study is to prospectively collect specimens from pediatric patients with diffuse intrinsic pontine glioma or brainstem glioma, either during therapy or at autopsy, in order to characterize the molecular abnormalities of this tumor. (clinicaltrials.gov)
  • High grade diffuse intrinsic pontine glioma (DIPG) accounts for approximately 80% of pediatric brainstem tumors and 10% of pediatric brain tumors, and is the most lethal form of brainstem gliomas in children. (clinicaltrials.gov)
  • The aim of this trial is to collect specimens from pediatric patients with diffuse intrinsic pontine glioma including serum, cerebrospinal fluid, urine, brain tumor and other constitutional tissue, during therapy and/or at autopsy. (clinicaltrials.gov)
  • Cerebrospinal fluid, serum, urine, brainstem tumor and constitutional tissue from patients with diffuse intrinsic pontine glioma or brainstem glioma will be collected. (clinicaltrials.gov)
  • Cancer stem-like cells (CSCs) have been extensively studied in most malignancies, including glioma. (frontiersin.org)
  • This review article covers the current knowledge regarding normal and aberrant cellular quiescence control whilst also exploring how different molecular mechanisms and properties of the neighboring cells can influence the molecular processes behind glioma stem cell quiescence. (frontiersin.org)
  • cancers
  • In this study, the proteins that are manufactured and known to be associated with brain cancers will be mixed with the dendritic cells obtained during leukopheresis (a procedure in which the dendritic cells are separated from the patients' blood). (clinicaltrials.gov)
  • embryonal
  • Given the above situation, we plan to explore the possible efficacy of high-dose chemotherapy and autologous stem cell rescue in patients with high-risk embryonal tumors, relapsed brain tumors and in infants and young children with brain tumors.High-dose chemotherapy and autologous stem cell rescue has improved the survival of children with high-risk solid tumors. (clinicaltrials.gov)
  • situ
  • Confirm genomic gains or losses identified by means of fluorescence in situ hybridization (FISH) performed on tissue microarray using non-neoplastic brain tissue from each patient as control when available. (clinicaltrials.gov)
  • Surgery
  • PROTOCOL OUTLINE: Patients undergo surgery to remove the first side or second side tumor, during which the multichannel auditory brain stem implant is implanted. (clinicaltrials.gov)
  • head and neck
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • liver
  • The most commonly used method is the determination of CD133 molecule (prominin-1) as a marker for many STCs identified to date in the tumors of brain, lung, liver, prostate, etc. [4, (exp-oncology.com.ua)
  • occur
  • Although usually a brain tumor, AT/RT can occur anywhere in the central nervous system (CNS) including the spinal cord. (icd.codes)
  • Although brain tumors occur in dogs of all breeds, either sex and any age, the incidence increases over 5 years of age, and with certain breeds. (vin.com)
  • Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Neurofibromatosis
  • An auditory brainstem implant is a device designed to restore some hearing in an individual with neurofibromatosis type 2 (NF-2) rendered deaf by the surgical removal of neurofibromas involving both auditory nerves. (unicare.com)