• University of Granada researchers (from the Institute for Neuroscience of the Department of Pharmacology of the Faculty of Medicine), conducted this research in collaboration with the Clinical Trial Service of the University Hospital San Cecilio, Granada, the department of Physiology and Pharmacology of the University of Salamanca, the department of Pharmacology of the University of Jordan and the Service of Endocrinology of the Hospital Carloss III, Madrid. (sciencedaily.com)
  • WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively. (wikipedia.org)
  • Researchers in Spain have analyzed the effects of melatonin on obesity, dyslipidemia and high blood pressure in young diabetic obese rats. (sciencedaily.com)
  • University of Granada researchers have analyzed in young Zucker diabetic obese rats the effects of melatonin on obesity, dyslipidemia and high blood pressure associated with obesity. (sciencedaily.com)
  • Thus, the brain sites and receptors involved have been identified, and a possible physiological role of endogenous serotonin in controlling natural patterns of eating and nutrient selection has been defined. (springer.com)
  • In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
  • Journal of Clinical Endocrinology and Metabolism. (nebraska.edu)
  • Her lab also studies how the normal function of the brain changes in response to alterations in body weight including obesity (excess body weight) and anorexia/cachexia (insufficient body weight), and how these changes in the brain contribute to the development of commonly associated diseases like diabetes. (exeter.ac.uk)
  • The long term goal of Kate's research is to impact human health by improving our knowledge of how the brain controls food intake and body weight, which will help in the development of new therapies for obesity and anorexia/cachexia. (exeter.ac.uk)
  • Journal of Molecular and Cellular Cardiology. (ku.dk)
  • Recent pharmacological studies have more precisely characterised the nature of the inhibitory effect of brain serotonin (5-hydroxytryptamine) on feeding behaviour. (springer.com)
  • Epididymal hypospermia and spermatogenic epithelial degeneration had been observed after four weeks at 1250 mg/kg in rats, but not in doses up to 500 mg/kg. (ehd.org)
  • Wistar rats) [155], failed to influence food intake during a 1 h ad libitum feeding period, moderate to high doses of CBD (4.4 mg·kg −1 , i.p. [58]. (researchgate.net)
  • The prostaglandin E2 (PGE2) level, brain-derived neurotrophic factor (BDNF), interleukin-10 (IL-10), and IL-1β gene expression were evaluated in the cortex. (researchgate.net)
  • In particular her research is focused on how different cell types in the brain (neurons, microglia, astrocytes and endothelial cells) coordinate and interact to regulate these processes. (exeter.ac.uk)
  • Angiotensin -( 1 - 7 ) ANP Arterial Pressure Brain endothelial cells. (silverchair.com)
  • Resveratrol is gaining a reputation among neurohackers for controlling brain inflammation , boosting dopamine , helping reverse cognitive decline and fighting brain cell aging . (nootropicsexpert.com)
  • The international journal of cardiovascular imaging. (regionh.dk)
  • In addition to the brain-type CB 1 receptor, a second cannabinoid receptor was identified in lymphoid tissue and was named CB 2 [ 6 ]. (degruyter.com)
  • Telemetric oxygen-sensitive carbon paste electrodes were implanted in Sprague-Dawley rats (250-300 g), either in renal medulla (n = 9) or cortex (n = 7). (kahasciences.com)
  • Interestingly, there is growing evidence that CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain early microbiome-host interactions during fetus development Curr Envir Health Rpt (2018) 5:512-521 513 and early infancy are critical factors that will determine life- early onset of type 2 diabetes [33], and, in the latter case, the long health or disease states [9-11]. (sagepub.com)
  • Journal of Diabetes and its Complications, 28 (2). (edu.au)
  • Even more studies in animals have shown that Resveratrol can reduce depression, treat addictions, protect against memory loss, is anti-anxiety, reduces plaques in Alzheimer's disease , improves learning, memory and mood, protects the brain from stroke and shields from hearing loss. (nootropicsexpert.com)
  • The evaluation of the biogenic amine steady state level is currently considered a useful tool to predict the effect of a drug on the activity in the brain, particularly in in vivo studies [44,45]. (researchgate.net)
  • Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain liver diseases. (medlineplus.gov)
  • Rasmussen CLM, Hede E, Routhe LJ, Körbelin J, Helgudottir SS, Thomsen LB, Schwaninger M, Burkhart A, Moos T. A novel strategy for delivering Niemann-Pick type C2 proteins across the blood-brain barrier using the brain endothelial-specific AAV-BR1 virus . (uni-luebeck.de)
  • 2011). Bradley C. and other authors have shown in Zucker rat models that ALA has protective effects against hypercholesterolemia and the accumulation of hepatic fat in conditions of overeating and in case of genetic predisposition. (jmedicalcasereports.org)
  • Figure 2: Complex relationships between insulin signalling in the brain and elsewhere in the body in health and disease. (nature.com)
  • 1986. A review of unique male rat hydrocarbon nephropathy. (cdc.gov)
  • Ce mélange de café unique promet la riche saveur du café noir dépourvu de goût de champignon tout en offrant simultanément les bienfaits thérapeutiques des champignons médicinaux, connus pour leurs propriétés protectrices, anti-inflammatoires, antioxydantes et stimulantes du système immunitaire (Li et al. (leanfactor.com)
  • Pflügers Archiv: European Journal of Physiology. (ku.dk)
  • Editor's Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. (mdpi.com)
  • KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes. (ku.dk)