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  • Hypoxia
  • This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). (curehunter.com)
  • The Na + -Ca 2+ exchanger 1 (NCX1) is reduced in stroke by the RE1-silencing transcription factor (REST), whereas it is increased in ischemic brain preconditioning (PC) by hypoxia-inducible factor 1 (HIF-1). (jneurosci.org)
  • In the 2-hour middle cerebral artery occlusion model with 3-hour recirculation, we have identified 28 known ischemia-hypoxia response genes that are upregulated and 6 that are downregulated, together with 35 upregulated and 41 downregulated genes newly connected with ischemia. (pptaglobal.org)
  • We believe this new template may be important because it's showing different mechanisms of action-different ways to interact with neurons, possibly with a good therapeutic effect for such diseases as epilepsy, hypoxia-ischemia and several neurodegenerative disorders," said Alban Pereira, a postdoctoral researcher in Scripps' CMBB. (acronymfinder.com)
  • 00 Hardcover RC388 Twenty-eight international academics, researchers, and practitioners contribute nine chapters on recent and significant research on brain hypoxia-ischemia . (acronymfinder.com)
  • Effects of the 21-amino steroid tirilazad mesylate (U-74006F) on brain damage and edema after perinatal hypoxia-ischemia in the rat. (acronymfinder.com)
  • 2018
  • Pune, India -- ( SBWIRE ) -- 02/01/2018 -- MarketResearchFuture.com adds "Brain Ischemia Market -2018 Global Analysis, Growth, Trends and Opportunities Research Report Forecasting to 2023" reports to its database. (sbwire.com)
  • carotid
  • Eklöf B, Siesjö BK: Cerebral blood flow in ischemia caused by carotid artery ligation in the rat. (springer.com)
  • To address this issue, we have used a novel biosensor technology to examine the purine levels in sequential arterial blood samples taken before, during and after the mild and reversible brain ischaemia that is imposed during the cross-clamp phase of awake carotid endarterectomy. (springer.com)
  • pathway
  • Using in vivo and neuronal OGD models, it was recently established that mTORC1 (mammalian Target of Rapamycin Complex-1), a protein complex downstream of PI3K-Akt pathway, is one of the players deregulated after ischemia and OGD. (frontiersin.org)
  • therapeutic
  • Therapeutic window of globular adiponectin against cerebral ischemia in diabetic mice: the role of dynamic alteration of adiponectin/adiponectin receptor expression. (curehunter.com)
  • Another highly protective agent is human albumin, administered in doses of 1.25 to 2.5 g/kg-a therapy that reduces infarct volume in this ischemia model by 60% to 65%, markedly diminishes brain swelling, and has a therapeutic window extending to 4 hours. (pptaglobal.org)
  • strokes
  • Treatments for brain ischemia include alteplase to minimize the effects of ischemic strokes and anticonvulsants for the prevention of seizures, states the Columbia University Medical Center. (reference.com)
  • insult
  • We found that TIGAR was highly expressed in brain neurons and was rapidly upregulated in response to ischemia/reperfusion insult in a TP53-independent manner. (jneurosci.org)
  • This timed, controlled, ischaemic insult to the brain provides an ideal model in which to investigate how rapidly purines are released into the blood following the onset of ischaemia, and how quickly they return to baseline following resolution of the ischemic insult. (springer.com)
  • Research
  • is a direct appreciation by Market Research Future of the market potential of the Brain Ischemia Market. (sbwire.com)
  • The report of global brain ischemia market research report by Market Research Future comprises of extensive primary research along with detail analysis of qualitative as well as quantitative aspects by various industry experts and key opinion leaders to gain a deeper insight of the market and industry performance. (sbwire.com)
  • The world Brain ischemia market research report is a condition in which there is an insufficient blood flow to the brain which results in poor oxygen supply to the brain. (sbwire.com)
  • World Brain ischemia market research report is segmented on the basis of diagnosis which are segmented into MRI, CT, ultrasound, angiography and other. (sbwire.com)
  • functional
  • Whether EE-related gene transcription and/or translation reported in this thesis are linked with EE-induced functional benefits to brain ischemia, further studies need be conducted. (lu.se)
  • Disorders
  • Cerebral palsy is a term used for disorders that consist of difficulty controlling movement due to damage to the developing brain, according to WebMD. (reference.com)
  • global brain
  • Major driving factor for global brain ischemia market are increasing number of patient suffering from diabetes, obesity hypertension and other related diseases as well as increasing aging population. (sbwire.com)
  • clinically
  • At present, there are no clinically effective pharmacologic interventions to halt brain damage following I/R. The major Aim of this dissertation will be to investigate possible mechanisms involved in neuron death following brain I/R, which may potentially lead to the development of effective therapies. (wayne.edu)
  • metabolism
  • I will discuss clinical outcomes, the major mechanisms, and especially focus on TA following brain I/R. The most current ideas on TA link it to intracellular stress responses and the formation of subcellular particles involved in mRNA metabolism such as stress granules and mRNA granules. (wayne.edu)
  • blood
  • Although the severity of brain damage depends mainly on the degree and duration of the decrease of cerebral blood flow /CBF/, and hence the depletion of macroerg phosphates, mitochondria seem quite resistant to ischemia /Ikrényi et al. (springer.com)
  • Vagotomy almost abolished the decrease in gastric mucosal blood flow during cerebral ischemia. (springer.com)
  • The human brain requires a constant flow of blood to sustain itself. (millerandzois.com)
  • Blood supplies the brain with oxygen and nutrients. (millerandzois.com)
  • When the supply and/or circulation of blood to the brain is interrupted, the brain is deprived of essential oxygen and brain cells began to die. (millerandzois.com)
  • Infant brain ischemia can occur when blood and oxygen flood to the baby are cut off or interrupted during pregnancy or during labor and delivery. (millerandzois.com)
  • Reduced blood flow to the fetus can in turn result in infant brain ischemia. (millerandzois.com)
  • Abnormally fast contractions and a rapid labor can create conditions that temporarily restrict blood flow to the baby's brain. (millerandzois.com)
  • The standard of accepted medical care requires the delivery team to properly monitor for the complications that can interrupt blood flow to the baby's brain during pregnancy or delivery. (millerandzois.com)
  • In this case the blood flow to the baby's brain was apparently interrupted by umbilical cord compression during labor. (millerandzois.com)
  • We performed a prospective observational study to test whether purine levels in arterial blood might correlate with brain ischaemia. (springer.com)
  • While purine nucleosides can enter the brain from blood [ 19 ], it is by no means certain that the efflux of purines into the extracellular space could be sufficient to result in an increase in their concentration in blood. (springer.com)
  • The loss of blood flow to the brain is termed ischemia and the subsequent resumption of blood flow is termed reperfusion. (wayne.edu)