Brain cells into adult. Medical search. Frequent questions

The Zika virus might not just harm the brain of the developing foetus - it could also affect parts of the adult brain, a new study in mice suggests. (cosmosmagazine.com)
To test this theory, the team monitored the brains of mice infected with Zika, using glowing biomarkers to track the virus and measure affected areas of the brain. (cosmosmagazine.com)
After a 3-day training period, mice that were treated greatly outperformed the control group and distinct hippocampal cell proliferation was observed. (miasdomain.com)
Using two types of specially engineered mice, they were able to specifically target and eliminate the stem cells that give rise to these new neurons in adults, while leaving other olfactory bulb cells intact. (nih.gov)
To further explore this idea, his team also eliminated the formation of adult-born neurons in mice that did not experience sensory deprivation. (nih.gov)
Introducing new stem cells into the brains of old mice slowed and reversed various measures of aging. (neurosciencenews.com)
To visualize and isolate mesencephalic precursor cells from a mixed population, we used transgenic mice and rats carrying green fluorescent protein (GFP) cDNA under the control of the nestin enhancer. (elsevierpure.com)
Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. (dkfz.de)
The researchers then confirmed the presence of the genes involved in this by studying brain slices from adult mice. (newscientist.com)
The researchers then used a type of fluorescent microscopy technique called two-photon imaging to study glutamate release by these cells in the brains of the mice. (newscientist.com)
Mice with the human cell transplants were smarter than normal mice, the researchers report. (nbcnews.com)
Researchers who transplanted human brain cells into newborn mice said the rodents grew up to be smarter than their normal littermates, learning how to associate a tone with an electric shock more quickly and finding escape hatches faster. (nbcnews.com)
Writing in the journal Cell Stem Cell, Nedergaard and Goldman said they were trying to find ways to cure mice of multiple sclerosis, which is caused when nerve cells lose their fatty coating of myelin and stop working properly. (nbcnews.com)
They used immature cells called glial progenitor cells taken from aborted fetuses, infused them into the brains of newborn mice, and watched what happened. (nbcnews.com)
The human glial cells not only survived in the brains of the mice - they thrived, Goldman says. (nbcnews.com)
The human glia cells essentially took over to the point where virtually all of the glial progenitor cells and a large proportion of the astrocytes in the mice were of human origin, and essentially developed and behaved as they would have in a person's brain," said Goldman. (nbcnews.com)
Again, the mice with human glial cells learned faster. (nbcnews.com)
To make sure it wasn't just the transplant of fresh cells that was improving learning, the researchers transplanted mouse progenitor glial cells into newborn mice. (nbcnews.com)
Goldman isn't worried that he is somehow making mice with human brains. (nbcnews.com)
There are many animals that carry human cells -- from the millions of lab mice injected with human tumor cells to study cancer, to sheep engineered to produce human liver cells. (nbcnews.com)
In their study - whose findings feature in Nature Neuroscience - the investigators worked with mice to find out more about how microglia, which are the immune cells that "service" the brain, perform their maintenance work during sleep. (medicalnewstoday.com)
After this, the investigators used precise micro-injections to transplant hippocampal cells that had been taken from newborn transgenic mice and cultured in an incubator into the hippocampi of about half the rats. (healthjockey.com)
The team knew Ly6C hi cells were present in a region of the brain's hippocampus called the dentate gyrus (DG) that builds new cells as mice learn new things. (icr.org)
When mice or men get an infection, these cells also help activate body defenses. (icr.org)
Mice that consumed probiotics or exercised on a running wheel reinvigorated their Ly6C hi cell population and hippocampus brain activity. (icr.org)
We found that an interneuron type that was previously associated with the mouse hippocampus-the 'ivy cell', which has neurogliaform characteristics-has become abundant across the neocortex of humans, macaques and marmosets but not mice or ferrets. (nature.com)
Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study published in JNeurosci . (sfn.org)
In mice, chemically activating the cells and placing animals in a stimulating environment with running wheels and toys reversed the alterations and restore some of the connectivity disrupted by dementia. (sfn.org)
The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells. (science20.com)
None of the mice formed tumors, which had been a major setback in prior attempts at stem cell transplantation. (science20.com)
We found that we could create new nerve cells from stem cells, transplant them effectively and make a positive difference in the behavior of the mice," said Dr. Lipton. (science20.com)
They then determined if the new cells could provide cognitive benefits to the stroke-afflicted mice. (science20.com)
The scientists found that when these cells were switched off, the mice stopped producing fear-related behaviors. (medicalnewstoday.com)
Conversely, when these cells were switched on, mice behaved anxiously, despite being in a safe area. (medicalnewstoday.com)
Background: The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. (harvard.edu)
Human neurons have been transplanted in rodents before, but generally in adult animals, usually mice. (co.ke)
In mice, a fatal brainstem tumor was cleared by injecting it with engineered T cells that recognized the cancer and targeted it for destruction. (stanford.edu)
In mice whose brainstems were implanted with human DIPG, engineered immune cells known as chimeric antigen receptor T cells - or CAR-T cells - were able to eliminate tumors, leaving very few residual cancer cells. (stanford.edu)
When the brains of the mice were examined via immunostaining after treatment, the animals had, on average, a few dozen cancer cells left, compared with tens of thousands of cancer cells in animals that received a control treatment. (stanford.edu)
However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials. (stanford.edu)
Crystal Mackall says she is encouraged that the work in mice showed that engineered immune cells called CAR-T cells were able to eradicate the tumors in mice. (stanford.edu)
Next, the team tested the GD2 CAR-T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered. (stanford.edu)
Adult male C57BL/6J or CX3CR1 -/- mice were exposed to our GWI model consisting of corticosterone (CORT) in the drinking water at levels associated with high physiological stress for 7 days followed by exposure to the nerve agent surrogate, diisopropyl fluorophosphate (DFP), on day 8 and a subsequent immune challenge with lipopolysaccharide (LPS) on day 10. (cdc.gov)

The fluorescent biomarker (in green) revealed that the adult mouse brain could be infected by Zika in a region called the subgranular zone of the hippocampus. (cosmosmagazine.com)
The hippocampus is the center of your brain in charge of consolidating short-term memories into long-term memories. (miasdomain.com)
The research team generated the atlas by analyzing gene expression in 690,000 individual cells isolated from nine brain regions, including the frontal and posterior cortex, hippocampus, cerebellum, thalamus, striatum, and substantia nigra. (broadinstitute.org)
The team specifically looked at cells in the brain's hippocampus region, because this is where the previous research claimed to have spotted non-neuronal synaptic transmission. (newscientist.com)
The researchers don't know how many of these cells can be found in the brain, or if they are mainly in the hippocampus. (newscientist.com)
That all changed in 1998, when a Swedish team showed that new brain cells form in the hippocampus, a structure involved in storing memories. (popsci.com)
Comprising of the hippocampus itself, this is known to be a major output structure connected to the cortex and the self-aware thinking part of the brain. (healthjockey.com)
It was observed under the microscope, that the transplanted cells had settled mainly in a sub-area of the hippocampus called the dentate gyrus. (healthjockey.com)
The study authors wrote, "Adult neurogenesis has been linked to hippocampus-dependent cognitive function, and it is required for memory resolution and for proper pattern separation in the DG of the hippocampus. (icr.org)
The hippocampus generates new brain cells throughout life and is implicated in neurodegenerative diseases. (sfn.org)
The scientists then traced these cells as they traveled from the hippocampus to the hypothalamus. (medicalnewstoday.com)
Toward determining the presence of constitutional aneuploidy in the human brain, we report here an analysis of the frequency of chromosome 21 gain and loss among neurons and non-neuronal cells isolated from the cerebral cortex and hippocampus of normal individuals ranging from 2 to 86 years of age. (jneurosci.org)
Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus. (lu.se)

All five showed evidence of recent, plentiful nerve cell division, or neurogenesis. (sciencelearn.org.nz)
In a process known as neurogenesis, adult-born neuroprogenitor cells are generated in the subventricular zone deep in the brain and migrate to the olfactory bulb where they assume their final positions. (nih.gov)
2016. Ly6C hi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis . (icr.org)
Neuroscientist Sandrine Thuret says that we can, and she offers research and practical advice on how we can help our brains better perform neurogenesis-improving mood, increasing memory formation and preventing the decline associated with aging along the way. (karmatube.org)
If adult neurogenesis is possible, and it is, then there is hope surely. (karmatube.org)
Sandrine Thuret is a neuroscientist studying adult neurogenesis - the process by which adult brains produce new nerve cells. (wglt.org)
She leads the Adult Neurogenesis and Mental Health Lab at King's College London. (wglt.org)
We show that silk organoids reproduce key molecular aspects of dopamine neurogenesis and reduce inter-organoid variability in terms of cell type composition and dopamine neuron formation. (lu.se)

Astrocytes are non-excitable cells in the CNS that can cause life-threatening astrocytoma tumors when they transform to cancerous cells. (mdpi.com)
Historically, chemotherapy played a small role in the treatment of brain tumors. (sciencedaily.com)
Research done in the last decade has shown that certain tumors of the brain and spinal cord, are sensitive to chemotherapy. (sciencedaily.com)
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
For many years now, the subventricular zone has been suspected to be the origin of specific malignant brain tumors called gliomas, the most deadly type of which is glioblastoma. (dkfz.de)
Nelson R. "Cell phones and brain tumors: no link, but is study flawed? (medscape.org)
In addition, the cells would sometimes become tumors. (science20.com)
Using MEF2C, the researchers created colonies of pure neuronal progenitor cells, a stage of development that occurs before becoming a nerve cell, with no tumors. (science20.com)
All industry funded and independent case-controlled studies looking at brain tumor risk from cell phone use show an increased risk (commonly a doubled risk) of brain tumors after 10 years of heavy cell phone use. (electromagnetichealth.org)
This tumor accounts for approximately 7-8% of all intracranial tumors and 30% of pediatric brain tumors. (medscape.com)
Medulloblastoma is the most common malignant pediatric tumor in the central nervous system (CNS), accounting for nearly 20% of all childhood brain cancers and ~40% of all childhood tumors in the posterior fossa. (medscape.com)
This set of tumors is considered the most common brain malignancy among pediatric population. (medscape.com)
Medulloblastoma accounts for 64.3% of all embryonal tumors in pediatric patients (0-19 years old), according to the Central Brain Tumor Registry of the United States (CBTRUS). (medscape.com)

Progenitor cells are partly along the path to from undefined to "adult" cells, and seem to have a better ability to flourish when transplanted. (nbcnews.com)
As a result, we were able to produce neuronal progenitor cells that differentiate into a virtually pure population of neurons and survive inside the brain. (science20.com)
The next step was to determine whether the transplanted neural progenitor cells became nerve cells that integrated into the existing network of nerve cells in the brain. (science20.com)

In these terms, the characterizing feature is the cell's transcriptome: those genes that are transcribed into RNA to make working proteins, which differ from cell to cell. (pennmedicine.org)
Using deep RNA sequencing, they found over 12,000 expressed genes in the cells, including hundreds of different types of RNAs specific to the different cell types. (pennmedicine.org)
They also identified long noncoding RNAs involved in regulation of many other genes that correlated with cell type. (pennmedicine.org)
Notably, we observed spatial cytosine methylation patterns on both genes and regulatory elements in cell types within and across brain regions. (bvsalud.org)
Brain -wide cell type comparison allowed us to build a regulatory model for each gene , linking transcription factors , DMRs, chromatin contacts, and downstream genes to establish regulatory networks. (bvsalud.org)
Thanks to human induced pluripotent stem cell (iPSC) and gene-editing technologies, it's possible to derive every kind of brain cell type, insert dementia -related genes and study them in culture. (jax.org)
Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
The new atlas, reported in Cell , provides a window into the brain's remarkable diversity of cells, a starting point for studying how genes and genetic variants contribute to neurological and psychiatric disorders, and insights into how different kinds of neurons achieve their highly specialized functions. (broadinstitute.org)
Genetic studies of psychiatric and neurological disorders are now implicating many specific genes, but we need to be able to make the scientific connections from genes to cell populations and circuits," said study senior author and Broad institute member Steven McCarroll , the director of genetics at the Stanley Center for Psychiatric Research and the Dorothy and Milton Flier Professor of Biomedical Science and Genetics at Harvard Medical School. (broadinstitute.org)
Historically, months of experiments were often required to figure out which cell populations express even one of these genes. (broadinstitute.org)
The researchers analysed data on the production by genes in mouse cells of RNA molecules, which are intermediates in protein production, to see if they could find the protein complexes required for synaptic transmission in cells other than neurons. (newscientist.com)
In the primate neocortex, dozens of genes showed spatial expression gradients among interneurons of the same type, which suggests that regional variation in cortical contexts shapes the RNA expression patterns of adult neocortical interneurons. (nature.com)
MEF2C is a transcription factor that turns on specific genes which then drive stem cells to become nerve cells. (science20.com)
MEF2C helps this process first by turning on the genes that, when expressed, make stem cells into nerve cells. (science20.com)
It then turns on other genes that keep those new nerve cells from dying. (science20.com)
The brainlike structures created from cells taken from autistic children showed increased activity in genes that control brain-cell growth and development. (sciencenews.org)
Too much activity in one of these genes led to an overproduction of a certain type of brain cell that suppresses the activity of other brain cells. (sciencenews.org)
For example, researchers at ETH Zurich in Switzerland published a study in Nature earlier this month describing how they are growing brain-like tissue from stem cells in the lab and then mapping the cell types in various brain regions and genes regulating their development. (co.ke)
These elements appear to influence the expression of both protein-coding genes and non-coding transcripts in the human brain through various mechanisms," says Raquel Garza. (lu.se)

This avenue of research is in line with the goals of the national BRAIN Initiative - including a cell census of neurons in the brain. (pennmedicine.org)
For decades, scientists thought that neurons in the brain were born only during the early development period and could not be replenished. (nih.gov)
In a major breakthrough, researchers have discovered how amyloid beta - the neurotoxin believed to be at the root of Alzheimer's disease (AD) - forms in axons and related structures that connect neurons in the brain, where it causes the most damage. (scitechdaily.com)
Amyloid beta formed in the brain's axons and nerve endings causes the worst damage in AD by impairing communication between nerve cells (or neurons) in the brain. (scitechdaily.com)

A published in Cell Stem Cell by US researchers found the virus targets stem cells in parts of a fully grown mouse brain responsible for learning and memory and stops them proliferating. (cosmosmagazine.com)
Now, a new study by researchers at Rockefeller University and La Jolla Institute in San Diego suggests the virus might also put adult brains at serious risk. (cosmosmagazine.com)
In a study published in Advanced Therapeutics , University of Minnesota Medical School researchers report on a "Goldilocks" balance which holds the key to awakening the body's immune response to fight off brain cancer. (scienceblog.com)
To determine how PID1 interacts with chemotherapy, the researchers engineered tumor cells to overexpress, or increase production, of PID1. (sciencedaily.com)
To test this, the researchers pretreated the tumor cells with an agent that selectively inhibits protein degradation, then exposed the cells to cisplatin. (sciencedaily.com)
iPSCs "can be turned into disease-relevant cells such as nerve cells, allowing researchers to study disease biology in the very types of cells that become affected. (jax.org)
Researchers unmask unique genetic signatures of more than 560 cell populations across nine brain regions, and lay the groundwork for deeper insights into the biology of brain disorders. (broadinstitute.org)
Researchers have generated a cellular atlas of the mouse brain, based on the gene expression profiles of nearly 700,000 individual cells covering nine major brain regions. (broadinstitute.org)
The researchers have coined these cells glutamatergic astrocytes. (newscientist.com)
Human brain cells in a mouse glow green because researchers have tagged them with a gene that looks green under fluorescent light. (nbcnews.com)
A team of researchers from the University of Rochester Medical Center in New York and the Massachusetts Institute of Technology in Cambridge has discovered more about how brain maintenance also occurs during sleep. (medicalnewstoday.com)
Compared to control subjects, the researchers observed strikingly similar alterations in newborn neurons from their mouse model and from human brain tissue of patients with frontotemporal dementia. (sfn.org)
Because of this high prevalence, researchers are forging ahead in an effort to uncover what goes on in the brain. (medicalnewstoday.com)
Researchers chemically reprogrammed human stem cells into small bundles of functional brain cells that mimic the developing brain. (sciencenews.org)
Researchers, whose study was funded partly by the National Institutes of Health, said they could do the same sorts of experiments using organoids made from the cells of people with disorders such as autism or schizophrenia - and potentially learn new things about how these conditions affect the brain, too. (co.ke)
At this free public event, our panel of researchers will showcase discoveries and tools that expand our foundational knowledge of the brain, the cell, and the immune system-and explore what this work means for understanding life and advancing health. (alleninstitute.org)
The next day, researchers perform pain testing and brain imaging and see how opioid receptors respond to pain medication. (medscape.com)
Researchers at Lund University have discovered that a specific group of genetic elements in our DNA influence the development of the human brain, their study was published in Science Advances. (lu.se)
Researchers at Lund University offer new insights in their latest study, published in Science Advances, detailing how a specific group of genetic elements have influenced the development of the human brain over time. (lu.se)
In Lund, researchers are investigating these repetitive regions of our DNA to understand the role transposable elements play in human brain development and evolution. (lu.se)
The cells come from aborted foetuses, if the women allow the tissue to be used by the researchers. (lu.se)
This cannot become a common method as long as the researchers have to use cells from aborted foetuses. (lu.se)

Adult rats, rabbits, and even birds can grow new neurons, but for 130 years, scientists failed to identify new brain-cell growth in adult humans. (popsci.com)
Apparently nerve-cell transplants were found to aid brain-damaged rats in fully recovering their lost ability to learn. (healthjockey.com)
A neuron-destroying chemical was first injected by the scientists into the subiculum area of approximately 48 adult rats. (healthjockey.com)
Armed with two well-established maze tests of spatial learning, it was found that the rats given cell transplants had recovered completely. (healthjockey.com)
The expression of brain-derived growth factor seems to have increased by nearly three times in the hippocampi of rats that had cell transplants. (healthjockey.com)
Scientists have transplanted human brain cells into the brains of baby rats, where the cells grew and formed connections. (co.ke)

Interruptions to the neuron development process in adult stem cells have been linked to Alzheimer's disease and cognitive deficits similar to the symptoms of depression. (cosmosmagazine.com)
Alzheimer's disease patients experience degeneration of this area of the brain first, making EGCG a potential element for future drug development. (miasdomain.com)
Iadecola, C. Neurovascular regulation in the normal brain and in Alzheimer's disease. (nature.com)
A promising new approach to finding effective treatments is to study human brain cells that carry mutations found in Alzheimer's patients. (jax.org)
Ph.D., professor and director of cellular engineering, has contracted with the National Institutes of Health to generate a collection of engineered iPSC brain cell lines for the Alzheimer's research community. (jax.org)
Conditions such as stroke, Alzheimer's, Parkinson's and Huntington's disease destroy brain cells, causing speech and memory loss and other debilitating consequences. (science20.com)
Amyloid in the brain is one of the proteins associated with Alzheimer's disease. (scitechdaily.com)
Among his many contributions to research on AD, Rudolph Tanzi, PhD, vice chair of Neurology and co-director of the McCance Center for Brain Health at MGH, led a team in 1986 that discovered the first Alzheimer's disease gene, known as APP, which provides instructions for making amyloid protein precursor (APP). (scitechdaily.com)
This role for MAMs was previously unknown, though earlier research indicated that they are increased in number and activity in the brains of people with Alzheimer's disease. (scitechdaily.com)
As with all adults, advancing age increases the chances a person with Down syndrome will develop Alzheimer's disease. (cdc.gov)
Chromosome 21 plays a key role in the relationship between Down syndrome and Alzheimer's disease as it carries a gene that produces one of the key proteins, amyloid protein, involved with changes in the brain associated with Alzheimer's. (cdc.gov)
Despite these brain changes, not everyone with Down syndrome develops Alzheimer's symptoms. (cdc.gov)
The presence of Alzheimer's disease in people with Down syndrome can lead to a rapid, progressive decline in brain health. (cdc.gov)

NIH scientists find that restocking new cells in the brain's center for smell maintains crucial circuitry. (nih.gov)
Making "scents" of new cells in the brain's odor-processing area Adult-born cells travel through the thin rostral migratory stream before settling into the olfactory bulb, the large structure in the upper right of the image. (nih.gov)
We replicated certain aspects of the brain's environment, but also left out key ingredients to help the cells avoid self-induced shock. (broadinstitute.org)
Their findings also support the growing theory that glia cells, one of the important components of the brain's so-called white matter, are far from being passive support cells and are in fact actively involved in brain function. (nbcnews.com)
We knew that Abeta is made in the axons of the brain's nerve cells, but we didn't know how," says Tanzi. (scitechdaily.com)
Those cells then multiplied to form organoids resembling the cerebral cortex, the human brain's outermost layer, which plays a key role in things like memory, thinking, learning, reasoning and emotions. (co.ke)
The significant elaboration of inflammatory cytokines related to the neuroinflammatory priming observed in our GWI mouse model indicates that this illness may be the result of long-term alterations in the brain's resident immune cells, namely microglia. (cdc.gov)

From this the team identified five known brain cell types after three weeks in culture: oligodendrocytes, microglia, neurons, endothelial cells, and astrocytes. (pennmedicine.org)
A ) In a normal uninjured brain resident microglia generally exist in a ramified M2 state. (biomedcentral.com)
Regulatory T-cells (Treg) are in constant communication with the resident ramified microglia ( B ) After TBI, ramified microglia change into activated microglia, which function mainly to phagocytose cellular debris created after injury. (biomedcentral.com)
The microglia are the immune cells that respond to any signs of infection or damage in the brain. (medicalnewstoday.com)
This work suggests that the enhanced remodeling of neural circuits and repair of lesions during sleep may be mediated in part by the ability of microglia to dynamically interact with the brain," explains first author Rianne Stowell, Ph.D. (medicalnewstoday.com)
Altogether, this research also shows that microglia are exquisitely sensitive to signals that modulate brain function and that microglial dynamics and functions are modulated by the behavioral state of the animal," Stowell adds. (medicalnewstoday.com)

This might play a role in 'reconstructive neurosurgery,' where we could use cellular replacements to mend damaged brain tissue, but this is not in human trials yet. (pennmedicine.org)
A month later, the canaries were killed and their brain tissue examined. (sciencelearn.org.nz)
The team wondered, could this regeneration be directed to heal damaged brain tissue? (sciencelearn.org.nz)
If these stem cells could be delivered to the damaged part of the brain, maybe they would divide and specialise, replenishing the damaged tissue and restoring people to good health. (sciencelearn.org.nz)
Infectivity titers of swab samples were calculated as the 50% tissue culture infectious dose/mL on Madin-Darby canine kidney (MDCK) cells (collection of cell lines in veterinary medicine, Friedrich-Loeffler-Institut, Südufer Insel Riems, RIE83). (cdc.gov)
In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
First, however, the team had to collect individual cells from the adult mouse brain in a way that reflects the cellular diversity of native, intact tissue. (broadinstitute.org)
Determining which cell types in CB-MNC enhance brain tissue repair, and the mechanisms by which they do so, will optimize decisions on dosing, route of administration, treatment frequency, and other critical clinical and regulatory parameters. (biorxiv.org)
Approaches that don't involve taking tissue out of the human brain are "promising avenues in trying to tackle these conditions. (co.ke)
Fresh-frozen samples of postmortem brain tissue from normal cerebral cortices and hippocampi were obtained from the Harvard Brain Bank (United States Public Health Service MH/NS 31862) and from the University of Miami/University of Maryland Brain and Tissue Bank (National Institute of Child Health and Human Development NO1-HD-8-3284). (jneurosci.org)
both fetal and adult brain tissue samples. (lu.se)

Together, these findings indicate that precursor cells harvested from the embryonic ventral mesencephalon can generate dopaminergic neurons able to restore function to the chemically denervated adult striatum. (elsevierpure.com)

Can we, as adults, grow new neurons? (karmatube.org)

Cookson, a cell biologist who studies the underlying pathways that lead to Parkinson's disease and related disorders, explains that a typical iPSC project would involve reverting a cell line from a patient with a given mutation back to the wild-type (or "normal") sequence, to compare the two. (jax.org)
Mesencephalic precursor cells may one day provide dopaminergic neurons for the treatment of Parkinson's disease. (elsevierpure.com)
Finally, nestin-GFP + cells were transplanted into the striatum of a rat model of Parkinson's disease. (elsevierpure.com)
These cells also appear to be in brain circuits involved in movement, which degenerate in Parkinson's disease, says Volterra. (newscientist.com)
After a voluntary ten-year break in the transplant of dopamine-producing cells to treat Parkinson's disease, new trials will now be carried out. (lu.se)
Parkinson's is the first to be tested because there is extensive knowledge of exactly which cells have been destroyed by the disease and where in the brain the new cells need to be placed. (lu.se)

Data show that older adults and people with underlying illness need the vaccine most. (technologyreview.com)
Older adults, people who are immunocompromised, and those with multiple underlying conditions that put them at risk for serious illness should get the updated vaccine. (technologyreview.com)
It is one of the most common nervous system problems in older adults. (medlineplus.gov)
But the symptoms can be hard to pin down, particularly in older adults. (medlineplus.gov)
Additionally, adults with Down syndrome experience "accelerated aging," meaning that in their 40s and 50s, they experience certain conditions that are more commonly seen in much older adults in the general population. (cdc.gov)
The cost for the first year of hearing loss treatment in older adults is projected to increase more than 500% from $8 billion in 2002 to an estimated $51 billion in 2030. (cdc.gov)

At the time, few scientists believed that an adult brain could produce new cells. (sciencelearn.org.nz)
Scientists questioned whether these changes were nerve cells and if they were functional. (sciencelearn.org.nz)
Scientists at the National Institutes of Health (NIH) report that newly formed brain cells in the mouse olfactory system - the area that processes smells - play a critical role in maintaining proper connections. (nih.gov)
When the scientists switched off Tlx, there were no more detectable stem cells in the brain and the formation of new neurons ceased. (dkfz.de)
Moreover, the scientists discovered that stem cells with increased Tlx production stimulate the formation of new vessels. (dkfz.de)
By creating a data resource like this - in which scientists can simply look these things up online - we hope to enable a stronger understanding of how brain illness arises in specific cell populations. (broadinstitute.org)
And while scientists have a general idea of the different types of cells that make up some brain regions, the detailed identities, molecular repertoires, and functional roles of cells at a brain-wide level have yet to be fully cataloged, further complicating efforts to link variant to cell to function. (broadinstitute.org)
For instance, scientists have learned that the brain consolidates newly formed memories during sleep. (medicalnewstoday.com)
Publishing in Cell Reports , German and U.S. scientists asked why the same cells showed up both in mouse brain and gut. (icr.org)
Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published today in The Journal of Neuroscience. (science20.com)
To investigate this region in more detail, the scientists measured the output of hundreds of cells in mice's hippocampi while they went about their daily business. (medicalnewstoday.com)
Though the study was small, using cells from only four autistic patients and eight family members, the results may indicate common factors underlying autism, the scientists say. (sciencenews.org)
Some scientists are studying human brain organoids outside of animals. (co.ke)
To make the brain organoids, Stanford University scientists transformed human skin cells into stem cells and then coaxed them to become several types of brain cells. (co.ke)
Scientists transplanted those organoids into rat pups 2 to 3 days old, a stage when brain connections are still forming. (co.ke)
To examine a practical use of this approach, scientists transplanted organoids into both sides of a rat's brain: one generated from a healthy person's cells and another from the cells of a person with Timothy syndrome, a rare genetic condition associated with heart problems and autism spectrum disorder. (co.ke)
To begin the research, the scientists screened human DIPG tumor cultures for surface molecules that could act as targets for CAR-T cells. (stanford.edu)

Anat Erdreich-Epstein, MD, PhD, a physician-scientist specializing in pediatric brain cancers at CHLA, published the first report on the role of PID1 in cancer -- establishing that it suppressed growth of medulloblastoma and glioma cells. (sciencedaily.com)
Tlx also plays an important role in glioblastoma, the most malignant of human brain cancers. (dkfz.de)
similar anti-GD2 CAR-T cells are now being tested in clinical trials in a few other cancers. (stanford.edu)

From these cell cultures, they identified more than five brain cell types and the potential proteins each cell could make. (pennmedicine.org)
The ultrasound effectively "blew up" the glass particles to rupture cancer cells, releasing proteins that attract white blood cells. (scienceblog.com)
According to Erdreich-Epstein, accounts in the literature suggest that cisplatin diminishes the amount of proteins that contribute to death of the cells, thereby leading to resistance to cisplatin and protection of the cells from death by cisplatin. (sciencedaily.com)

The protective activities were largely mediated by factors secreted by CB-MNC, as direct cell-to-cell contact between the injured brain slices and CB cells was not essential. (biorxiv.org)

Neurons in the olfactory bulb sort that information and relay the signals to the rest of the brain, at which point we become aware of the smells we are experiencing. (nih.gov)
Tests in lab dishes showed the mouse brains with human cells transmitted signals much more quickly than normal mouse brains. (nbcnews.com)
This research shows that the signals in our brain that modulate the sleep and awake state also act as a switch that turns the immune system off and on. (medicalnewstoday.com)
The Cell Reports authors wrote, "Therefore, we hypothesized the presence of a common mediator, which signals from the periphery to the brain, and that this messenger is affected by antibiosis and can be restored by exercise and probiotic treatment. (icr.org)
Performing intricate electrical studies, Dr. Lipton's investigative team showed that the new nerve cells, derived from the stem cells, could send and receive proper electrical signals to the rest of the brain. (science20.com)
A seizure occurs when one or more parts of the brain has a burst of abnormal electrical signals that interrupt normal brain signals. (hopkinsmedicine.org)

Based on our findings, getting infected with Zika as an adult may not be as innocuous as people think," says Joseph Gleeson, a neurologist at Rockefeller University in New York and an author of the paper. (cosmosmagazine.com)
Our findings may help us understand how cells change in response to the anti-convulsants the epilepsy patients were getting and how that might impact seizure treatment in the future," said Grady. (pennmedicine.org)
These findings suggest that CD14 + monocytes are a critical cell-type when treating HI with CB-MNC. (biorxiv.org)
The findings suggest that these cells are conserved [in people]," says team member Ludovic Telley , also at the University of Lausanne. (newscientist.com)
But the team at the University of Rochester say their findings also suggest that these brain cells, called glial cells, may very well be one of the important factors that make humans different from other animals. (nbcnews.com)
Down the road, Goldman hopes the findings might lead to procedures to transplant brain cells to treat diseases as diverse as multiple sclerosis, bipolar disease and even the brain shrinkage that causes memory loss in aging. (nbcnews.com)
The findings add to the evidence that mechanisms related to sleep play an essential role in ensuring that the brain receives necessary repairs and continues to function correctly. (medicalnewstoday.com)
These findings seem to confirm the potential of cell grafts to stimulate the release of growth factors for neurons in a process called neural plasticity. (healthjockey.com)

TBI, traumatic brain injury. (biomedcentral.com)

We also used positively selected subpopulations of CB-MNC and PB-MNC in this assay and demonstrated that purified CB-CD14 + cells, but not CB-PB CD14 + cells, efficiently protected neuronal cells from death and reduced glial activation following OGD. (biorxiv.org)
Sometimes they became glial cells, which lack many of the neurons' desirable properties. (science20.com)

This review discusses the similarities and differences between the morphology of astrocytes and astrocytoma cells, and the role that dysregulation in glutamate and calcium signaling plays in the aberrant morphology of astrocytoma cells. (mdpi.com)
Microscope images of brain cells collected for Drop-Seq analysis: neurons (pink), astrocytes (green), oligo- and polydendrocytes (blue). (broadinstitute.org)
These cells are a little bit like astrocytes and a little bit like neurons," says Volterra. (newscientist.com)

Nerve cells use a brain chemical called dopamine to help control muscle movement. (medlineplus.gov)
With Parkinson disease, the brain cells that make dopamine slowly die. (medlineplus.gov)
Without enough dopamine, the cells that control movement can't send proper messages to the muscles. (medlineplus.gov)
Here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. (lu.se)
Using single cell RNA sequencing, we identify the presence of three molecularly distinct subtypes of human dopamine neurons with high similarity to those in developing and adult human midbrain. (lu.se)
We couldn't just forget the good results we had seen here", says Håkan Widner, Professor of Neurology at Skåne University Hospital in Lund, who was part of the team that carried out the world's first transplant of dopamine-producing cells in 1987. (lu.se)
For the operation, a narrow cannula is inserted into exactly the right position in the brain, where the dopamine cells are placed. (lu.se)
A healthy individual has around one million dopamine cells in the brain. (lu.se)
We have high hopes and expectations for the transplant of dopamine cells. (lu.se)

Are the Roles of Adult Neural Stem Cells Determined Before Birth? (neurosciencenews.com)
According to a new study, adult neural stem cells appear to be programmed prior to birth to make specific types of neurons. (neurosciencenews.com)
Embryonic Origin of Postnatal Neural Stem Cells. (nih.gov)

Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in cerebral vascular smooth muscle cells (VSMCs) generates an Aβ non-clearing VSMC phenotype through transactivation of sterol regulatory element binding protein-2, which downregulates low density lipoprotein receptor-related protein-1, a key Aβ clearance receptor. (nature.com)
A receptor on the receiving cell detects the neurotransmitter, which causes the receiving cell to generate a new impulse. (msdmanuals.com)

Any abdominal ventral adult muscle precursor cell (FBbt:00003251) that is part of some abdominal segment 2 (FBbt:00000023). (virtualflybrain.org)
After sorting by fluorescence-activated cell sorting, the GFP + cells proliferated in vitro and expressed precursor cell markers but not neuronal markers. (elsevierpure.com)

Mononuclear cell (MNC) prepared from human umbilical cord blood (CB) are candidate therapeutics for treating hypoxic-ischemic (HI) brain injuries. (biorxiv.org)

MRIs and other tests did not show any evidence of tumor or other abnormal cells in the non-tumor tissues used for the study. (pennmedicine.org)
This study was supported by the National Institutes of Health Single Cell Analysis Program (U01 MH098953). (pennmedicine.org)
Our study establishes the first brain -wide, single- cell resolution DNA methylome and 3D multi-omic atlas, providing an unparalleled resource for comprehending the mouse brain 's cellular-spatial and regulatory genome diversity. (bvsalud.org)
This is a surprising new role for brain stem cells and changes the way we view them," said Leonardo Belluscio, Ph.D., a scientist at NIH's National Institute of Neurological Disorders and Stroke (NINDS) and lead author of the study. (nih.gov)
Our study was designed to answer these questions by experimental infection of adult mute swans ( Cygnus olor ). (cdc.gov)
A new Nature study reports hypothalamic neural stem cell decline accelerates as a result of aging. (neurosciencenews.com)
We haven't had a global framework for understanding, at the molecular, single-cell level, the cells that make up the core components of the brain," said Arpiar Saunders, a postdoctoral researcher in the McCarroll laboratory and co-first author of the study with Stanley Center associate member and Massachusetts General Hospital psychiatrist Evan Macosko. (broadinstitute.org)
In a 2014 study at the University of British Columbia in Canada, women who walked briskly for an hour twice weekly for six months-but not those who strength-trained or did no exercise-increased brain volume in the areas that control thinking and memory. (popsci.com)
The experiments are aimed at making models to study human brain diseases such as Huntington's and schizophrenia, as well as nerve diseases such as multiple sclerosis. (nbcnews.com)
According to Prof. Majewska and colleagues' new study, these cells are also active during sleep, attending to regular "wear and tear. (medicalnewstoday.com)
It's part of an effort to better study human brain development and diseases affecting this most complex of organs, which makes us who we are but has long been shrouded in mystery. (co.ke)
Many disorders such as autism and schizophrenia are likely uniquely human" but "the human brain certainly has not been very accessible," said said Dr. Sergiu Pasca, senior author of a study describing the work, published Wednesday in the journal Nature. (co.ke)
For example, in a study published in Fertility and Sterility (Vol. 89) in 2008 by A. Agarwal et al of the Cleveland Clinic, laboratory values of sperm count at an infertility clinic decreased as the duration of daily exposure to cell phones increased. (electromagnetichealth.org)
Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated. (stanford.edu)
However, despite significant advancements in the field, the use of brain organoids can be limited by issues of reproducibility and incomplete maturation which was also observed in this study. (lu.se)
This approach helped us to address these highly repetitive sequences, usually masked in standard bioinformatics pipelines, allowing us to accurately measure LINE-1 expression in each cell type found in our samples," explains Raquel Garza, co-first author of the study. (lu.se)

He adds that by engineering disease-causing mutations in a set of genetically diverse iPS cells, "the project is designed to ensure reproducibility of data across laboratories and to explore the effect of natural variation in dementia. (jax.org)
If the cultured cells were genetically modified to stop expressing the target sugar, the CAR-T cells no longer worked. (stanford.edu)

The long-term effects of Zika on adult brains are still unknown, and the team says more research is needed to ascertain whether the mouse model echoes the virus' effect on humans. (cosmosmagazine.com)
Single-cell DNA Methylome and 3D Multi-omic Atlas of the Adult Mouse Brain. (bvsalud.org)
To this end, we employed optimized single-nucleus methylome (snmC-seq3) and multi-omic (snm3C-seq1) sequencing technologies to generate 301,626 methylomes and 176,003 chromatin conformation/ methylome joint profiles from 117 dissected regions throughout the adult mouse brain . (bvsalud.org)
In the first set of mouse experiments, Dr. Belluscio's team first disrupted the organization of olfactory bulb circuits by temporarily plugging a nostril in the animals, to block olfactory sensory information from entering the brain. (nih.gov)
All told, the nine regions account for between 60 and 70 percent of the volume of the mouse brain. (broadinstitute.org)
To explore these mechanisms further, we exposed mouse brain organotypic slice cultures to oxygen and glucose deprivation (OGD) and then treated the brain slices with cells from CB or adult peripheral blood (PB). (biorxiv.org)
New research in mouse models suggests that specialized immune cells keep the brain in good working order by maintaining it during sleep. (medicalnewstoday.com)
1 They also asked why mouse brains stopped certain activities after antibiotics erased the helpful bacteria from mouse gut contents. (icr.org)
Here we use single-nucleus RNA sequencing to profile RNA expression in 188,776 individual interneurons across homologous brain regions from three primates (human, macaque and marmoset), a rodent (mouse) and a weasel (ferret). (nature.com)
The similarity between the mouse model and the human condition underscores the therapeutic potential of targeting these cells in dementia patients. (sfn.org)
María Llorens-Martín and colleagues at the Centro de Biología Molecular "Severo Ochoa" (CBMSO, CSIC-UAM) used a mouse model of frontotemporal dementia to investigate the effects of the disease on dentate granule cells. (sfn.org)
Seven to eight weeks after the tumor was established, each mouse received one intravenous injection of GD2 CAR-T cells or, as a control treatment, an injection of CAR-T cells that react to a different target. (stanford.edu)

PHILADELPHIA - Studying brain disorders in people and developing drugs to treat them has been slowed by the inability to investigate single living cells from adult patients. (pennmedicine.org)
Green tea's effects on the human brain are of particular importance because mental disorders are becoming increasingly prevalent. (miasdomain.com)
Mental disorders generally have a lot to do with an abnormal regeneration of brain cells. (miasdomain.com)
Zlokovic, B. V. The blood-brain barrier in health and chronic neurodegenerative disorders. (nature.com)
Cytosine DNA methylation is essential in brain development and has been implicated in various neurological disorders . (bvsalud.org)
Anxiety disorders are "the most common mental illness" in the United States, affecting an estimated 40 million adults . (medicalnewstoday.com)
It is important to understand which brain circuits are controlling the anxiety response, and what goes wrong with those circuits in people with anxiety disorders. (medicalnewstoday.com)
Now that these cells have been described, they could provide a new direction for treating anxiety disorders. (medicalnewstoday.com)
As a postdoctoral fellow at the University of Washington, she studied potassium channel variants identified in neurodevelopmental disorders and worked on developing a novel cell-type specific CRISPR/Cas9 gene editing technology. (alleninstitute.org)
Gokhan has extensive experience in human disease modeling using vertebrate embryos and human induced pluripotent stem cells to understand blood disorders, obesity and diabetes, and neurological diseases. (alleninstitute.org)
in adults, goiter (with its complications) and fertility disorders. (who.int)

He and his colleagues also found similar protein signatures of synaptic transmission in non-neuronal cells in humans by looking at existing datasets. (newscientist.com)
Prior to this research, creating pure neuronal cells from ES cells had been problematic as the cells did not always differentiate into neurons. (science20.com)
Even when the neuronal cells were created successfully, they often died in the brain following transplant-a process called programmed cell death or apoptosis. (science20.com)
Chromosome 21 aneuploid cells constitute ∼4% of the estimated one trillion cells in the human brain and include non-neuronal cells and postmitotic neurons identified by the neuronspecific nuclear protein marker. (jneurosci.org)
Together, these data demonstrate that human brain cells (both neurons and non-neuronal cells) can be aneuploid and that the resulting genetic mosaicism is a normal feature of the human CNS. (jneurosci.org)

CNS involvement is primarily limited to the anterior horn cells of the spinal cord and brain stem nuclei, although intellectual performance remains normal. (medscape.com)

Neuroscientist Sandrine Thuret explains how we can encourage the production of more nerve cells. (wglt.org)

The research builds upon the team's previous work creating brain "organoids," tiny structures resembling human organs that have also been made to represent others such as livers, kidneys, prostates, or key parts of them. (co.ke)
The organoids grew so that they eventually occupied a third of the hemisphere of the rat's brain where they were implanted. (co.ke)
Neurons from the organoids formed working connections with circuits in the brain. (co.ke)
Pasca, a psychiatry professor at the Stanford School of Medicine, said this is the first time these organoids have been placed into early rat brains, creating "the most advanced human brain circuitry ever built from human skin cells and a demonstration that implanted human neurons can influence an animal's behavior. (co.ke)
Ethicists also wonder about the possibility of brain organoids in the future attaining something like human consciousness, which experts say is extremely unlikely now. (co.ke)
Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. (lu.se)

Anderson P. "Long-term cell phone use linked to brain tumor risk. (medscape.org)

In CAR-T therapies now used in humans, some of the patient's own immune cells are removed, engineered to attack a surface antigen on the cancer cells, and returned to the patient's body, where they target the cancer cells for destruction. (stanford.edu)

This constellation of cells constitute our immune system," said senior author Clark C. Chen, MD, PhD, Lyle French Chair in Neurosurgery and Head of the Department of Neurosurgery at the University of Minnesota Medical School. (scienceblog.com)
The prize was awarded to the discovery of a drug that activates the patient's immune response against cancer cells. (scienceblog.com)
This meant that during states of arousal and wakefulness, the immune cells could not respond appropriately and perform maintenance on brain cell connections. (medicalnewstoday.com)
Ly6C hi cells belong to the immune system where they help immune surveillance. (icr.org)
Cell surface antigens are large molecules sticking out from a cell that help the immune system determine whether the cell is harmless or harmful. (stanford.edu)

According to Dr. Belluscio, it is generally assumed that the circuits of the adult brain are quite stable and that introducing new neurons alters the existing circuitry, causing it to re-organize. (nih.gov)
Her work uses ethologically grounded behaviors to understand population dynamics and cell-type specific mechanisms for perception, cognition, and flexible behavior in distributed circuits across the brain. (alleninstitute.org)

Using clonogenic sphere formation assays, we showed that this sorted population was enriched in multipotent precursor cells that could differentiate into both neurons and glia. (elsevierpure.com)

Cord blood (CB) mononuclear cells (MNC) are being tested in clinical trials to treat hypoxic-ischemic (HI) brain injuries. (biorxiv.org)

They discovered that LINE-1 elements play an important role in shaping the structural and functional complexity of our brains as we age. (lu.se)

The specific compound that adds the most antioxidant properties to green tea is called epigallocatechin-3-gallate (EGCG) and strong evidence shows EGCG aiding in the regeneration of hippocampal cells. (miasdomain.com)

Johan Jakobsson, a professor at Lund University and research group leader at MultiPark and Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)

However, understanding which variants matter in which cell types, and how they relate to healthy and disease states, remain among the greatest challenges in neuroscience and neuropsychiatric research. (broadinstitute.org)
The team was led by Stuart A. Lipton, M.D., Ph.D., professor and director of the Del E. Webb Neuroscience, Aging, and Stem Cell Research Center at Burnham. (science20.com)

Nottebohm initially suggested that this swelling and shrinking of the song nuclei must be caused by the cells in this area changing size. (sciencelearn.org.nz)

Unlike embryonic stem cells, iPSCs are derived from adult human cells. (jax.org)

Anything that interrupts the normal connections between nerve cells in the brain can cause a seizure. (hopkinsmedicine.org)

To determine if a specific subpopulation of CB-MNC are responsible for these protective activities, we depleted CB-MNC of various cell types and found that only removal of CB CD14 + monocytes abolished neuroprotection. (biorxiv.org)

These cells are special, and somehow very susceptible to the infection. (cosmosmagazine.com)
H1N1pdm09 virus infection in the past has caused severe illness in some children and young- and middle-aged adults. (cdc.gov)

They may also excite regeneration or reorganization of a part of the brain, and restore cognitive function as part of this process. (healthjockey.com)
Activation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. (harvard.edu)

In 1998, inspired by Nottebohm's work, Fred Gage and his team at the Salk Institute found that adult human brains were also able to make new nerve cells. (sciencelearn.org.nz)

Reference: "Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes" by Raja Bhattacharyya, Sophia E. Black, Madhura S. Lotlikar, Rebecca H. Fenn, Mehdi Jorfi, Dora M. Kovacs and Rudolph E. Tanzi, 18 May 2021, Cell Reports . (scitechdaily.com)
The build-up of amyloid protein in the brain disrupts the way brain cells communicate to each other. (cdc.gov)
Amyloid accumulation is seen in almost all adults over 40 with Down syndrome. (cdc.gov)

By isolating and reprogramming brain cells with dementia-causing genetic mutations, a team at JAX offers a powerful new research tool. (jax.org)

However, the process of making iPSCs from patients with these diseases, and the subsequent genetic engineering of the cell lines, is "difficult, expensive and time consuming," says Ward. (jax.org)
An important European review of the EMF science, called The Reflex Report , prepared by 12 scientific institutes in 7 countries, confirmed long-term genetic damage in the blood and brains of users of mobile phones and other sources of electromagnetic fields. (electromagnetichealth.org)

The more synapses, the faster and better the brain works. (nbcnews.com)
Each time a new memory is created or a new skill is learned, stronger connections - or synapses - are built between brain cells. (cdc.gov)
Young people's brains build synapses faster than adult brains. (cdc.gov)

We will transplant three to four million cells in each operation", explains Håkan Widner. (lu.se)
One problem that remains even if the treatment produces the desired results is the lack of cells to transplant. (lu.se)

The susceptibility of the developing fetal brain to damage induced by the lack of iodine, and the fact that pregnant women come second (after lactating women) as regards iodine intake requirements, mean that, in order to provide optimal protection of the developing fetus against low iodine intake, monitoring efforts should focus on pregnant women. (who.int)

Prior to joining the Allen institute, he received his PhD in Cell and Developmental Biology from Oregon Health and Science University and did postdoctoral research at the University of Chicago. (alleninstitute.org)

Using iterative clustering and integrating with companion whole- brain transcriptome and chromatin accessibility datasets, we constructed a methylation -based cell type taxonomy that contains 4,673 cell groups and 261 cross-modality-annotated subclasses. (bvsalud.org)

Neuromyths have gotten folded into popular culture," says Nicholas Spitzer, co-director of the Kavli Institute for Brain and Mind at the University of California at San Diego. (popsci.com)

Anatomy50

Organisms21

Diseases36

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology12

Phenomena and Processes52

Disciplines and Occupations2

Humanities1

Information Science8

Health Care4

Mice44

Hippocampus13

Neurogenesis8

Tumors13

Progenitor cells3

Genes19

Neurons in the brain4

Researchers22

Rats6

Alzheimer's13

Brain's7

Microglia6

Tissue12

Chemically1

Grow new neurons1

Parkinson's6

Older adults6

Scientists17

Cancers3

Proteins3

Injured brain slices1

Signals6

Findings8

Traumatic brain1

Glial2

Astrocytes3

Dopamine9

Neural stem3

Receptor2

Precursor cell2

Umbilical cord1

Study16

Genetically2

Mouse12

Disorders11

Neuronal cells5

Spinal cord1

Sandrine Thuret1

Organoids6

Tumor risk1

Humans1

Immune5

Circuits2

Multipotent1

Hypoxic-ischemic1

Functional1

Hippocampal cells1

Lund Stem Cell Center1

Neuroscience2

Nuclei1

Embryonic1

Nerve cells in the brain1

Monocytes1

Infection2

Regeneration2

19981

Amyloid3

Dementia1

Genetic2

Synapses3

Transplant2

Fetal1

Biology1

Datasets1

University of Ca1