Brain a small gtp binding protein. Medical search. Frequent questions

Small G-proteins, monomeric GTPases, or the RAS (Rat sarcoma) superfamily are a large family of small guanine nucleotide-binding proteins with molecular weights ranging from 20 to 30 kDa [ 1 , 2 ]. (oncotarget.com)
Small GTPases function as binary molecular switches, transmitting extracellular signals to an intracellular environment [ 4 ]. (oncotarget.com)
In cellular signaling, the monomeric small GTPases (small G proteins) are known to play an important role in diverse molecular processes. (encyclopedia.pub)
RAS family proteins are membrane-associated, small GTPases that have the function of transmitting a multitude of cellular signals [ 7 ] . (encyclopedia.pub)
It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. (embl-heidelberg.de)
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. (utsouthwestern.edu)
GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. (embl-heidelberg.de)
Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. (embl-heidelberg.de)
Background: Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. (researchsquare.com)
The superfamily of G proteins includes three main classes: Ras-like GTPases, G α subunits of heterotrimeric G proteins, and the translation elongation factors. (biomedcentral.com)
Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. (biomedcentral.com)
Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
Rho GTPases are small (20-30 kDa) GTP-binding proteins of the Ras superfamily. (biomedcentral.com)
Interestingly, small GTPases related to Rac are found even in organisms that lack Ras, such as plants. (biomedcentral.com)
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)

There is a superfamily of ras p21/ras p21-like small GTP-binding proteins (small G proteins) with GTPase activity. (nii.ac.jp)
The conversion from the GDP-bound to GTP-bound form and the reverse conversion are induced by GDP/GTP exchange and GTPase reactions, respectively. (nii.ac.jp)
We have purified and characterized several GDP/GTP exchange proteins (GDP dissociation stimulator (GDS) and GDP dissociation inhibitor (GDI)) and GTPase activating Proteins (GAP) for small G proteins. (nii.ac.jp)
The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. (embl.de)
RHEB is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. (signalchem.com)
RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form. (signalchem.com)
Drosophila RHEB is a direct target of Tsc2 GTPase-activating protein (GAP) activity both in vivo and in vitro. (signalchem.com)
The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins. (embl-heidelberg.de)
This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl-heidelberg.de)
By enhancing their GTPase activity, GAP proteins inactivate small Rho and Ras proteins, so inactivation of rhoGAP proteins might cause constitutive activation of their GTPase targets. (embl-heidelberg.de)
In particular, we propose that Arg 85 and Asn 194 are involved in binding G proteins and enhancing GTPase activity. (embl-heidelberg.de)
This phosphorylation occurs in the active site of the plexin GTPase-activating protein (GAP) domain, which in turn inhibits endogenous GAP activity toward Ras/Rap family small GTP-binding proteins by recruiting the phospho-serine/threonine-binding protein 14-3-3ε. (stanford.edu)
PKA modulates iron trafficking in the striatum via small GTPase, Rhes. (neurotree.org)
Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity. (neurotree.org)
Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. (researchsquare.com)
The zebrafish Rab11a, Rab11ba and Rab11bb proteins are highly conserved during evolution, especially the GTPase domain, suggesting their important functions. (researchsquare.com)
Mutational analysis revealed that only the C1 and DH domains are essential for Vav3 GEF activity with the C1 region being involved in binding with the GTPase substrate. (cytoskeleton.com)
They all share a common GTPase cycle, being turned on by binding GTP and off by hydrolyzing GTP to GDP. (biomedcentral.com)
Additional regulatory proteins are often required to induce the conformational changes that occur during this cycle: guanine nucleotide exchange factors, which catalyze release of bound GDP and promote its replacement by GTP, and GTPase-activating proteins, which accelerate GTP hydrolysis. (biomedcentral.com)
Many, but not all, of these effectors contain a conserved 18 amino-acid binding motif that has been termed CRIB (Cdc42-Rac interactive binding), PBD (p21-binding domain) or GBD (GTPase-binding domain) [ 4 ]. (biomedcentral.com)
The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. (nih.gov)
High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. (nih.gov)
Belongs to the small GTPase superfamily. (lu.se)

Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. (embl-heidelberg.de)
It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)
Guanine nucleotide exchange factors ("GEFs") stimulate the dissociation of the GTP hydrolytic product, GDP, from small GTP-binding proteins, to promote the binding of a new GTP molecule. (justia.com)

15. The role of G-protein coupled receptor kinases in the regulation of muscarinic cholinergic receptors. (elsevier.com)
A disruption in the interplay between kinases and phosphatases regulating dopamine receptors and its downstream partners has been implicated in brain diseases also linked to defects in dopamine neurotransmission. (ohri.ca)
Our major endeavors employ recombinant DNA technologies, RNA interference, biochemical and cell biological approaches to probe the underlying molecular relationships between dopamine receptor structure, G protein and effector regulation, kinases, phosphatases and drug action. (ohri.ca)
Like the other Vav proteins, Vav3 is phosphorylated (activated) following ligand binding to a variety of receptor tyrosine kinases (TKs), including EGF receptor, PDGF receptor, insulin receptor, and insulin-like growth factor I receptor. (cytoskeleton.com)
RAF protein kinases (ARAF, BRAF and CRAF) are key components of the RAS-RAF-MEK-ERK signaling cascade. (carnabio.com)
This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)

An upstream signal such as from a receptor tyrosine kinase allows RAS to convert to the active GTP-bound form. (carnabio.com)

We have found that the C-terminal systeine residues of smg p21B, rhoA p21, and smg p25A are geranylgeranylated, and that these prenylation are essential for each small G protein to bind to membranes. (nii.ac.jp)
We have partially purified and characterized geranyl-geranyl transferase for rhoA p21 … More from bovine brain. (nii.ac.jp)
1999 ) provided evidence that p75 NTR can regulate axon extension by signaling through the RhoA pathway, such that the unbound state of p75 NTR activates RhoA, whereas neurotrophin binding to p75 NTR terminates this mode of RhoA activation. (jneurosci.org)
Additionally, we found that neurotrophin binding to p75 NTR reduces RhoA activity. (jneurosci.org)
Ectopic expression of RhoE was found to induce membrane ruffle formation, increased migration and invasion both in vitro and in vivo and altered the relative levels of GTP-bound Rac1 and RhoA. (bmj.com)
Vav3 GTP Exchange Factor (GEF) of Rac1, RhoA and Cdc42. (cytoskeleton.com)

We evaluated the protein expression level of RhoE in gliomas tissues, cell lines and brain tumor initiating stem cells (BTSCs). (bmj.com)
The binding of the two proteins keeps immune cells from killing tumor cells. (nih.gov)
One type of immunotherapy interferes with this binding process and can restore the natural ability of the immune system to kill the tumor cells. (nih.gov)
Through comparative proteomic profiling of brain tumor tissue versus normal tissue, molecular alterations leading to tumorigenesis can be detected. (cns.org)
G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma. (nih.gov)

This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. (nih.gov)

Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. (embl-heidelberg.de)
Rab/Ypt proteins are small GTP-binding proteins of the Ras superfamily and are key players in intracellular vesicular trafficking regulation [1, 2]. (researchsquare.com)
G proteins constitute a large superfamily of regulatory proteins that show a high similarity in primary structure and organization of the functional center [ 1 - 3 ]. (biomedcentral.com)

Small G proteins have two interconvertible forms, GDP-bound inactive and GTP-bound active forms. (nii.ac.jp)
The RAS family proteins act as binary molecular switches that cycle between active guanosine triphosphate (GTP)-bound and inactive guanosine diphosphate (GDP)-bound states [ 9 ] . (encyclopedia.pub)
Such transition between active and inactive forms allows for them to serve as molecular switches and to make G proteins suitable for the regulation of a wide range of cellular processes such as signal transduction, cytoskeletal reorganizations, vesicular transport and protein synthesis [ 4 ]. (biomedcentral.com)

The protein normally encoded by the OPHN1 gene belongs to what scientists call the Rho subfamily of GTP-binding proteins. (scienceblog.com)

Publications] Sasaki,T.: 'A mammalian inhibitory GDP/GTP exchange protein(GDI)for smg p25A is active on the yeast SEC4 protein. (nii.ac.jp)
3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)

The communication or cross-talk between dopamine receptors and its effectors is mediated by the stimulation of molecular switches known as heterotrimeric G proteins on which dopamine receptors initiate a repetitive exchange cycle between two guanosine nucleotides: guanosine diphosphate or GDP-bound G proteins (switch off) guanosine triphosphate or GTP-bound G proteins (switch on). (ohri.ca)

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. (wikipedia.org)
10. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, and Dolly JO (1994) Primary structure of a β subunit of α-dendrotoxin-sensitive K + channels from bovine brain. (aspetjournals.org)

Mitogen-activated protein kinase 8-interacting protein 3 gene (MAPK8IP3) encodes the c-Jun-amino-terminal kinase-interacting protein 3 (JIP3) and is involved in retrograde axonal transport. (bvsalud.org)
That has been a major objective of studies in Van Aelst's lab, where previous experiments have shown that "knocking-down" expression of the gene that encodes the production of the OPHN1 protein (the gene is designated by the italic OPHN1) causes a potentially important change in neuronal structure. (scienceblog.com)
BRAF encodes the B-Raf protein, which is involved in signal transduction inside cells. (news-medical.net)
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. (embl-heidelberg.de)
In the case of the latter, these advances mark a watershed because scientists can now focus on discrete neural pathways in an effort to understand how the brain encodes these fundamental social behaviors. (stanford.edu)
This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. (maayanlab.cloud)
This gene encodes a member of the regulator of G-protein signaling family. (nih.gov)

Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)

The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl.de)
Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl-heidelberg.de)
and proteins that interact with members of the Arp2/3 complex and hence the actin cytoskeleton (Table 1 ). (biomedcentral.com)
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. (maayanlab.cloud)

Evidence is accumulating that small G proteins are involved in the regulation of cell growth and differentiation. (nii.ac.jp)
Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling. (embl.de)
The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl.de)
However, GEF activity of Dbl toward Rho as measured by in vitro GDP binding assays remained unaffected following Gbetagamma binding, suggesting that additional signals may be required for the regulation of Dbl. (embl.de)
While dopamine receptors mediate their effects on cells through the classical regulation of G proteins, they can also control cell activity in a G protein-independent manner via direct protein-protein interactions with effectors and other intracellular partners. (ohri.ca)
Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes. (neurotree.org)
Currently, little information is still available about its expression profile and regulation during flatfish metamorphosis. (biomedcentral.com)

Neurotrophins bind two classes of receptors, the receptor tyrosine kinase family of Trk (A, B, and C) receptors and the p75 neurotrophin receptor (NTR). (jneurosci.org)
Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl.de)
16. Activation, cellular redistribution and enhanced degradation of the G proteins Gq and G11 by endogenously expressed and transfected phospholipase C-coupled muscarinic m1 acetylcholine receptors. (elsevier.com)
RAS family proteins mediate extracellular signals, transduced through their receptors, with multiple signaling pathways, and consequently regulate a wide array of cellular processes [ 8 ] . (encyclopedia.pub)
Research in our laboratory focuses on the elucidation of the molecular and regulatory mechanisms controlling the functionality of a class of proteins called receptors located on the cell surface and to which the brain chemical dopamine attaches and induces their activation. (ohri.ca)
The dopamine receptors (D1R, D2R, D3R, D4R and D5R) are plasma membrane proteins sharing structural and functional similarities with one of the largest family of receptors found in living organisms. (ohri.ca)
Indeed, dopamine receptors belong to the large family of G protein-coupled receptors or GPCRs. (ohri.ca)
Odorant receptors (ORs) are G protein-coupled receptors (GPCRs) that are essential for detecting and distinguishing among odorants. (bmbreports.org)
The SH3-SH2-SH3 C-terminal domains bind directly with the auto-phosphorylated cytoplasmic tails of the receptor TKs while the B- and T-cell receptors activate cytosolic TKs. (cytoskeleton.com)

2. Zhang, Y. et al: Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. (signalchem.com)
RAS family proteins include 23 genes coding for at least 25 proteins that are divided into eight paralog groups based on sequence identity, structure, and function: RAS, RAS-like (RAL), RAS-related protein (R-RAS), RAS-like protein in tissues (RIT), RAS-related protein Rap (RAP), RAS homolog enriched in brain (RHEB), Dexamethasone-induced RAS-related protein (RASD), and GTP-binding protein Di-RAS (DIRAS) [ 5 ] . (encyclopedia.pub)

13. Rhodes KJ, Keilbaugh SA, Barrezueta NX, Lopez KL, and Trimmer JS (1995) Association and colocalization of K + channel α-and β-subunit polypeptides in rat brain. (aspetjournals.org)
Nitrogen permease regulator-like 2 (NPRL2) is a requisite subunit of GAP activity toward Rags 1 (GATOR1), an evolutionarily conserved complex that is comprised of three proteins called NPRL2, NPRL3, and DEP domain containing 5 (DEPDC5). (eneuro.org)

Lipocalin 2 (lcn2) is a member of the lipocalin family that binds to small hydrophobic molecules. (jneurosci.org)
GPCRs specializing in the recognition and attachment of dopamine instruct to cells specific chemical information through the recruitment of different effectors such as adenylyl cyclases (enzymes that synthesize a second messenger named cyclic AMP inside cells), ion channels and pumps (allowing cells to control the entry and exit of small charged molecules). (ohri.ca)
But collecting EVs, breaking them open, and pooling their contents for assessment means that molecules occurring in small quantities (like PD-L1) can get lost in the mix. (nih.gov)
Proteins as the functional molecules in the cells are the main effectors of normal cellular and disease processes. (cns.org)
small molecule perturbations changing expression of CDC42EP3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. (maayanlab.cloud)
In doing so, this GEF-facilitated exchange of GDP for GTP is associated with structural changes in the GTP-binding protein which influence the degree to which the GTP-binding protein can interact with other molecules. (justia.com)
When GTP is bound, for instance, Ras proteins can interact with effectors and other molecules to affect cell proliferation, differentiation and apoptosis. (justia.com)

Endosomal/lysosomal proteins were particularly highly enriched in amyloid plaques. (researchsquare.com)
Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)

Phosphatidylinositol transfer proteins (PITPs) can bind specifically and transfer a single phosphatidylinositol (PI) molecule between phospholipid membranes in an ATP-independent manner in vitro. (embl.de)

All mutations that we know of in the OPHN1 gene lead to OPHN1 proteins that do not function," Van Aelst says. (scienceblog.com)
Tuberous sclerosis complex (TSC) and Sturge-Weber syndrome (SWS) are prototypical neurocutaneous disorders in which genetic mutations in pathways regulating cell growth cause developmental dysfunction of the brain, skin, and other organs. (uspharmacist.com)
TSC is characterized by autosomal-dominant mutations in the TSC1 or TSC2 genes (encoding for the protein Hamartin on chromosome 9q34 and Tuberin on chromosome 16q13 respectively) leading to overactivation of the mTOR (mechanistic target of rapamycin) pathway with increased cell proliferation and a range of other consequences. (uspharmacist.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Members of this family of proteins act as effectors of CDC42 function. (maayanlab.cloud)

Additionally, the absence of NPRL2 expression increases mTORC1-dependent signal transduction and significantly alters amino acid homeostasis in the brain. (eneuro.org)
Loss of NPRL2 increases mTORC1 signal transduction, significantly alters amino acid homeostasis in the brain, and causes sudden unexpected death of epileptics (SUDEP). (eneuro.org)

RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)

In this research project, we have investigated the C-terminal structures of small G proteins, purified the regulatory proteins for small G proteins, and made monoclonal antibodies against small G proteins and their regulatory proteins. (nii.ac.jp)
Among these regulatory proteins, we have cloned the cDNAs of smg p21 GDS, smg p25A GDI, and rho GDI, and made monoclonal antibodies against them. (nii.ac.jp)

The analysis of Cdc42 and Rac function in evolutionarily distant organisms is useful as a tool to uncover the basic activities of these proteins. (biomedcentral.com)
By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)

These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. (wikipedia.org)
The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. (wikipedia.org)
We obtained a clone of 2817 bp with an open reading frame of 1731 bp encoding for a protein of 576 amino acids that is 96.7% identical and 97.9% similar to its human counterpart. (nih.gov)
An amino-terminal portion conserved among a subset of Dbl family proteins is sufficient for the binding of Gbetagamma. (embl.de)
The B-Raf protein has 766 amino acids in three conserved domains. (news-medical.net)
Zebrafish rab11a was clustered in the Rab11a group, and rab11ba and rab11bb in the Rab11b group (Fig.1B) in the phylogenic tree constructed according to amino acid sequences of all the Rab11 proteins above. (researchsquare.com)
This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. (nih.gov)

The product of this gene belongs to the family of Ras-related proteins. (wikipedia.org)
The small-G-protein family consists of numerous proteins with varying degrees of homology, one of which is a guanosine nucleotide-binding protein (RAS) [ 4 ] . (encyclopedia.pub)
RAS family proteins play a vital role in the modulation of cell survival, proliferation, and differentiation by signaling through a set of molecular pathways [ 10 ] . (encyclopedia.pub)
Those molecular functions of RAS family proteins exhibit an essential role that co-occurs in the repeated pattern of physiological change during the ovarian cycle. (encyclopedia.pub)
The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. (embl-heidelberg.de)
Residues conserved across the rhoGAP family are largely confined to one face of this bundle, which may be an interaction site for target G proteins. (embl-heidelberg.de)
The eukaryotic translation elongation factor 1 alpha, currently termed eEF1A, is a member of the G protein family, and one of the four subunits that compose the eukaryotic elongation factor 1 [ 5 , 6 ]. (biomedcentral.com)

Fluorescent immunohistochemistry was used to validate the enrichment of four proteins in amyloid plaques (moesin, ezrin, ARL8B and SMOC1) and to compare the amount of total Aβ, Aβ40, Aβ42, phosphorylated Aβ, pyroglutamate Aβ species and oligomeric species in EOAD and DS. (researchsquare.com)
Previous studies have typically used immunohistochemistry to identify amyloid plaque proteins. (researchsquare.com)

In this process, astrocytes proliferate to fill gaps and undergo a typical morphological change: a large cytoplasmic mass, long and branched processes, and increased expression of intermediate filaments such as glial fibrillary acidic protein (GFAP). (jneurosci.org)
Cold Spring Harbor, NY - A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated the mechanism by which a signaling protein found throughout the brain controls the maturation and strength of excitatory synapses, the tiny gaps across which the majority of neurons communicate. (scienceblog.com)

To improve these predictions, a research team led by Eduardo Reátegui, The Ohio State University, Columbus, engineered a new technology to measure exRNA and proteins found within and on the surface of extracellular vesicles (EVs ) [1]. (nih.gov)

Activator of protein kinase A (cyclic AMP agonist). (biolog.de)

That mutation has been found in papillary thyroid carcinoma, colorectal cancer, melanoma, and non-small cell lung cancer. (news-medical.net)

tissues with high or low expression of CDC42EP3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. (maayanlab.cloud)
Thus, existing techniques and current knowledge have not used nor addressed the interactions of GEF-H1 with other proteins as a means by which cell proliferation can be controlled or the detection and treatment of cancerous, tumorigenic cells and tissues be developed. (justia.com)
Found in all the examined tissues except in brain. (lu.se)

Polyisoprenylated cysteinyl amide inhibitors (PCAIs) are agents that mimic the essential posttranslational modifications of G-proteins. (oncotarget.com)
Protein phosphorylation is one of the widely used posttranslational modifications that alter protein function in vivo. (stanford.edu)

Mounting evidence suggests that stress, along with the associated hormonal and neurochemical mediators (particularly glucocorticoids), induces changes in glutamate release, transmission and metabolism in cortical and limbic brain areas, thereby influencing cognitive and emotional processing and behaviour. (nature.com)
Acyl-CoA-binding domain containing 3 modulates NAD + metabolism through activating poly(ADP-ribose) polymerase 1 Biochemical Journal . (neurotree.org)

Tran LM, Bang SH , Yoon J, Kim YH, Min J. Effect of GTP-binding protein (YPT1 protein) on the enhanced yeast vacuolar activity. (neurotree.org)

In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)

Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
In ALK fusion proteins, the kinase domain of ALK is fused to the oligomerization domain of partner proteins²⁾ (Fig.1). (carnabio.com)

The paralog group of RAS proteins is composed of four isoforms (H-RAS, N-RAS, K-RAS4A, and K-RAS4B) that are encoded by three genes, H-RAS , N-RAS , and K-RAS [ 6 ] . (encyclopedia.pub)
Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
whereas in the cells isolated from high grade tumors, five isoforms of vimentin, transgelin, Mn-SOD, pyruvate kinase (PKM), GTP-binding nuclear protein Ran and 40S ribosomal protein SA were detected to be overexpressed. (cns.org)

3 The name tuberous sclerosis comes from the characteristic tuber or potato-like nodules in the brain, which calcify with age and become hard or sclerotic. (uspharmacist.com)

The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits. (embl.de)
Association of the proto-oncogene product dbl with G protein betagamma subunits. (embl.de)
Here, we show the association of Dbl with G protein betagamma subunits (Gbetagamma) in transient co-expression and cell-free systems. (embl.de)

This study tested this hypothesis by determining the effect of the PCAIs on the levels of RAS and related monomeric G-proteins. (oncotarget.com)
These findings implicate the potential role of PCAIs as anticancer agents through their direct interaction with monomeric G-proteins. (oncotarget.com)

cellular components containing CDC42EP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. (maayanlab.cloud)

Small knob-like features, called dendritic spines, that protrude from a neuron's branch-like dendrites, typically receive signals across synapses from the axons of other neurons. (scienceblog.com)

These revolutionary methods include the expensive CAR-T cell therapies, but also include direct targeting of immune pathways with small. (carnabio.com)

Two transcript variants encoding the same protein have been identified for this gene. (wikipedia.org)

Although Rab11a subcellular localization has been demonstrated by transgenic zebrafish [10], and molecular function of Rab11 proteins in primary cilia membrane assembly in Kupffer Vesicle has been studied [6], the developmental expression profile of Rab11 proteins in zebrafish remains elusive. (researchsquare.com)
cellular components containing CDC42EP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. (maayanlab.cloud)
cellular components co-occuring with CDC42EP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. (maayanlab.cloud)

It catalyzes phosphorylation of serine and threonine on target proteins, converting adenosine triphosphate (ATP) to adenosine diphosphate (ADP). (news-medical.net)

The structure also identified a hydrophobic binding pocket for lipid binding. (embl.de)

Publications] Araki,S.: 'Role of the Cーterminal region of smg p25A in its interaction with membranes and the GDP/GTP exchange protein. (nii.ac.jp)

The rat G-protein-coupled receptor kinase 6 (GRK6) cDNA was cloned from rat brain tissue by a combination of reverse-transcription polymerase chain reactions (RT-PCR), based on homology to the cloned human GRK6, and rapid amplification of cDNA ends (RACE-PCR). (nih.gov)
Depending on age, gender, duration and the type of the stressors experienced, stress may either have beneficial effects on cognitive and emotional functions or induce noxious and maladaptive changes in brain tissue, which have been linked to the development of neuropsychiatric disorders. (nature.com)
Amyloid plaques and neighbouring non-plaque tissue were microdissected from human brain sections using laser capture microdissection and label-free LC-MS was used to quantify the proteins present. (researchsquare.com)

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). (embl.de)
Lipid-binding domain. (embl.de)
The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. (embl.de)
Taxonomic distribution of proteins containing SEC14 domain. (embl.de)
The complete taxonomic breakdown of all proteins with SEC14 domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing SEC14 domain in the selected taxonomic class. (embl.de)
These proteins share a core structure, the conserved G-box (GDP/GTP) binding domain, of approximately 170 residues [ 3 ]. (oncotarget.com)
Conserved region 1 (CR1) is a Ras-GTP-binding self-regulatory domain. (news-medical.net)
Taxonomic distribution of proteins containing RhoGEF domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with RhoGEF domain is also avaliable . (embl-heidelberg.de)
Taxonomic distribution of proteins containing RhoGAP domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with RhoGAP domain is also avaliable . (embl-heidelberg.de)
Maturation and activity of sterol regulatory element binding protein 1 is inhibited by acyl-CoA binding domain containing 3. (neurotree.org)

Pathogenic variants in ATP-dependent chromatin remodeling proteins are a recurrent cause of neurodevelopmental disorders (NDDs). (bvsalud.org)
Heterozygous de novo pathogenic variants in MAPK8IP3 result in a neurodevelopmental disorder with or without brain abnormalities and possible axonal peripheral neuropathy. (bvsalud.org)
Multiple alternatively spliced variants, encoding the same protein, have been identified. (cancerindex.org)

Anatomy6

Organisms3

Diseases5

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes16

Information Science3

GTPases15

GTPase23

Guanine nucleot3

Kinases6

Active GTP-bound form1

RhoA6

Tumor5

Hydrolysis1

Superfamily3

Inactive3

Subfamily1

Mammalian3

Molecular switches1

Bovine brain2

Encodes7

Effector domain1

Actin cytoskeleton5

Regulation7

Receptors9

Rheb2

Subunit2

Molecules7

Lysosomal proteins2

Molecule1

Mutations4

Effectors1

Signal transduction2

Downstream1

Antibodies2

Cdc422

Amino7

Family7

Immunohistochemistry2

GAPs2

Extracellular1

Activator1

Melanoma1

Tissues3

Posttranslational modifications2

Metabolism2

Yeast1

Activation1

Kinase domain2

Isoforms3

Tuberous1

Subunits3

Monomeric2

Assays1

Signals1

Pathways1

Transcript1

Localization3

Threonine1

Hydrophobic1

Interaction1

Tissue3

Domain13

Variants3