ProstaglandinsAngioedemaUrticariaKininsInflammatoryComplementAngiotensinVasodilatorAntibody-mediatedHypotensionVascularEndothelinUsually mediatedTreatment of acute attacksReceptorsHigh affinity IgE-receptorMast cellsReactionKallikreinPermeabilityMesentericAnaphylaxisAllergicReceptorPatients with acuteInhibitorInflammationSevereResponsesReactionsExposureKidneyLysosomalGlucosePotentiationMyocardialTypicallyActivation
Prostaglandins2
- The beneficial actions of kinins in renal and cardiovascular disease are largely mediated by nitric oxide and prostaglandins, and extend beyond their recognized role in lowering blood pressure to include cardioprotection and nephroprotection. (nature.com)
- We found a potentiation of the coronary dilatory effect of the neuropeptide neurotensin (which is probably mediated by prostaglandins) by ACE-inhibitor. (ox.ac.uk)
Angioedema14
- Angioedema is caused by an increase in local capillary permeability and plasma extravasation , usually mediated by mast cells , histamine , or bradykinin release. (dermnetnz.org)
- Angioedema with urticaria tends to suggest a histaminergic form, which includes acute allergic angioedema and histaminergic idiopathic angioedema. (dermnetnz.org)
- There, these mediators cause urticaria and pruritus, which thus usually accompany mast cell-mediated angioedema. (msdmanuals.com)
- In bradykinin-mediated angioedema, the dermis is usually spared, so urticaria and pruritus are absent. (msdmanuals.com)
- Acute angioedema can also result from agents that directly stimulate mast cells without involving IgE. (msdmanuals.com)
- Angiotensin-converting enzyme (ACE) inhibitors cause up to 30% of cases of acute angioedema seen in emergency departments. (msdmanuals.com)
- You can think of angioedema in several different ways: bradykinin- or histamine-mediated, or hereditary (bradykinin) or acquired (bradykinin or histamine) (Table 1) (1-4,7,8,14). (emdocs.net)
- The most common form of angioedema is histamine-mediated. (emdocs.net)
- Risk factors for ACE inhibitor mediated angioedema include those on immunosuppressants and African Americans (1-4,13,14,28). (emdocs.net)
- Angioedema due to exposure to tPA therapy in acute ischemic stroke can affect 1.2-5.1% of patients, though most cases are mild and resolve within a day (35-45). (emdocs.net)
- Acute angioedema remains a prevalent allergy presentation in emergency departments, often precipitated by medications such as ACE-inhibitors or IgE-mediated allergens. (doctorforkids.co.za)
- However, concealed within this group are patients with recurrent angioedema with an elusive origin - where the differential encompasses hereditary or acquired bradykinin- mediated angioedema, demanding distinct treatments. (doctorforkids.co.za)
- Urticaria needs to be differentiated from other medical conditions where wheals, angioedema, or both can occur, e.g. anaphylaxis, autoinflammatory syndromes, urticarial vasculitis, orbradykinin-mediated angioedema including hereditary angioedema (HAE). (cyberderm.net)
- Acute spontaneous urticaria: Occurrence of spontaneous wheals, angioedema or bothfor less than 6 weeks. (cyberderm.net)
Urticaria8
- It may often be caused by the same allergens (eg, drug, venom, dietary, extracted allergens) that are responsible for acute IgE-mediated urticaria. (msdmanuals.com)
- For non-acute urticaria, around 0.1-0,6% in the general population. (cyberderm.net)
- The mast cell-activating signals in urticaria are ill defined and likely to be heterogeneous and diverse (IgE-mediated Type I-reaction, non specific histamine liberators, activation of complement, autoimmune mediated urticaria - IgG against IgE or against high affinity IgE-receptor and IgE against autoantigens, as well as other poorly understood mechanisms). (cyberderm.net)
- IgE-mediated (Type I Reaction) foods, medications, bee or wasp toxins, foreign proteins and other exogenous materials such as latex or plant products (contact urticaria). (cyberderm.net)
- Acute urticaria: Does not require a diagnostic workup, as it is usually self-limiting. (cyberderm.net)
- The diagnosis and management of acute and chronic urticaria: 2014 update. (empendium.com)
- Acute urticaria must be differentiated from anaphylaxis . (empendium.com)
- f) Causes of acute urticaria (see above). (empendium.com)
Kinins5
- Kinins (bradykinin and lys-bradykinin) are endogenous vasodilators and natriuretic peptides known best for their ability to antagonize angiotensin-induced vasoconstriction and sodium retention. (nature.com)
- Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. (aspetjournals.org)
- B1 receptors for kinins are selectively stimulated by bradykinin (BK) or Lys-BK (kallidin) fragments without the C terminal arginine residue. (aspetjournals.org)
- Bradykinins (BK) and related kinins are potent inflammatory mediators produced during acute and chronic inflammation. (mobitec.com)
- The two main 'kinins' in mammals are the nonapeptide bradykinin, BK (1-9) and the decapeptide kallidin (KD), [Lys0]-BK(1-10). (mobitec.com)
Inflammatory4
- B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. (wikipedia.org)
- HAE is a rare acute inflammatory condition characterized by episodes of severe, often painful swelling affecting the extremities, gastrointestinal tract, genitalia, and larynx. (agip-news.com)
- The aim of the study was to assess the activity of an ethanolic extract of Capparis erythrocarpos Isert roots in the carrageenan-induced foot oedema model in chicks, an acute inflammatory model and baker s yeast-induced pyrexia in rats. (scialert.net)
- The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
Complement2
- Bradykinin is a vasoactive substance that primary acts on endothelial cells, as well as the coagulation, complement, and tissue contact pathways. (emdocs.net)
- During swelling local cells responses are augmented by complement and acute phase proteins that exude into the tissue because of improved blood vessel permeability mediated by bradykinin which is definitely proteolytically released from kininogen. (bio-cavagnou.info)
Angiotensin4
- It is usually an acute but sometimes a chronic mast cell-mediated reaction caused by exposure to a drug (eg, angiotensin-converting enzyme inhibitors), venom, dietary, pollen, or animal dander allergens, or it can be idiopathic. (msdmanuals.com)
- Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. (icr.ac.uk)
- The purpose of this study was to determine whether acute dual angiotensin-converting enzyme (ACE)/natural endopeptidase 24-11 (NEP) inhibition could improve entire body insulin-mediated glucose disposal (IMGD) a lot more than ACE inhibition alone and whether this effect was mediated with the kinin-nitric oxide (NO) pathway activation. (thetechnoant.info)
- The effect of local converting enzyme inhibition on the vascular responses to angiotensin and bradykinin in the forearm resistance vessels in man. (cardiffmet.ac.uk)
Vasodilator2
- The vasodilator bradykinin is normally excised from kininogen by plasma kallikrein which is normally itself turned on by aspect XIIa (8) and inhibited by serpin G1 the supplement 1 (C1) inhibitor (9). (bio-cavagnou.info)
- Uncontrolled pKal activity leads to excessive generation of bradykinin, a vasodilator thought to be responsible for the localized swelling, inflammation and pain characteristically associated with HAE. (agip-news.com)
Antibody-mediated1
- This can therefore be considered as a potential parameter in detecting antibody-mediated kidney rejection. (hycultbiotech.com)
Hypotension3
- Rabbits pretreated with bacterial lipopolysaccharide (LPS) (25 micrograms/kg) and anesthetized 5 h later exhibit acute and transient hypotension in response to intra-arterial boluses of B1 receptor agonists. (aspetjournals.org)
- Beneficial hemodynamic and antiarrhythmic effects (as well as excessive hypotension, however) have been shown in patients with acute myocardial infarction. (ox.ac.uk)
- Bradykinin causes vasodilatation and increase in the vascular permeability, besides to produce hypotension. (vin.com)
Vascular3
- This is mediated by its ability to control activation of the contact system in inhibiting bradykinin generation and thereby control of vascular permeability. (hycultbiotech.com)
- Background and purpose: Acute periods of hyperglycaemia are strongly associated with vascular disorder, yet the specific effects of high glucose on human blood vessel function are not fully understood. (gla.ac.uk)
- acute heat is thought through a vascular Cardiac Center. (worldclassbows.com)
Endothelin3
- During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. (icr.ac.uk)
- Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine. (reading.ac.uk)
- We have measured activation of these phospholipases by endothelin-1 (ET-1), bradykinin (BK), or phenylephrine (PE) in ventricular myocytes cultured from neonatal rat. (reading.ac.uk)
Usually mediated1
- Hives are defined as pruritic transient swellings of the upper dermiswith multiple causes, usually mediated mainly by histamine release. (cyberderm.net)
Treatment of acute attacks2
- The medical management of asthma and treatment of acute attacks has improved substantially, but the prevalence of asthma continues to rise in urban settings in industrialized Western countries. (knowyourasthma.com)
- The Company currently markets KALBITOR® (ecallantide) for the treatment of acute attacks of HAE in patients 12 years of age and older. (agip-news.com)
Receptors4
- The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. (wikipedia.org)
- Their biological actions are mediated by two distinct receptors, termed B1 and B2. (mobitec.com)
- Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. (icr.ac.uk)
- This and other effects of histamine are mediated through their interaction with specific receptors, which is in vasodilatation of the post-capillaries venules, besides to bronchi-constriction and increase in the production and flow of bronchial mucus. (vin.com)
High affinity IgE-receptor1
- a) Autoimmunity mediated by autoantibodies against the high-affinity IgE receptor or directly against IgE. (empendium.com)
Mast cells1
- Serious or fatal reaction to CM could be due to direct effect on basophils and mast cells or IgE mediated (type 1 hypersensitivity reaction). (indianradiology.com)
Reaction1
- Immune complex-mediated (Type III Reaction). (cyberderm.net)
Kallikrein2
- Cleavage and inactivation from the C1 inhibitor by MMP2 elevated match activation and bradykinin generation by plasma kallikrein in wild-type mice leading to improved vessel permeability during swelling. (bio-cavagnou.info)
- Dyax, a biopharmaceutical company focused on HAE and other plasma-kallikrein-mediated disorders, is developing DX-2930 as a subcutaneous injection for prevention of HAE attacks. (agip-news.com)
Permeability1
- Bradykinin (10-5 M) significantly increased permeability in the MV but not in the MA. (bvsalud.org)
Mesenteric2
- Key results: Bradykinin-induced relaxation in both sets of vessels was mediated entirely by EDHF whilst that generated by acetylcholine, though principally generated by EDHF, also had contribution from prostacyclin and possibly nitric oxide in mesenteric and subcutaneous vessels, respectively. (gla.ac.uk)
- A 2-h incubation of high glucose impaired bradykinin-induced relaxation of subcutaneous vessels whilst, in contrast, the relaxation generated by bradykinin in mesenteric vessels was enhanced at the same time point. (gla.ac.uk)
Anaphylaxis1
- Oxygen supplementation, intravenous administration of physiological fluids and intramuscular injection of 0.5 ml adrenalin (1:1000) should be considered in the first line management of acute anaphylaxis. (indianradiology.com)
Allergic1
- Mast cell-mediated mechanisms include acute allergic, typically IgE-mediated reactions. (msdmanuals.com)
Receptor4
- Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. (wikipedia.org)
- Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8. (wikipedia.org)
- The present study was performed using an established in vivo model of B1 receptor-mediated cardiovascular action. (aspetjournals.org)
- In the mouse model that mimics atopic dermatitis in humans, the histamine (H4) receptor mediates both TH-2 inflammation and pruritus. (medscape.com)
Patients with acute1
- Genetic mutations such as those in CFTR and SPINK1 genes are frequent in HIV-positive patients with acute pancreatitis. (medquizzes.net)
Inhibitor2
- One of the classic medications associated with this bradykinin-mediated form is the ACE inhibitor class. (emdocs.net)
- The increasing levels of C1rsC1-inhibitor complexes can already be detected in plasma several days before the first clinical signs are present, suggesting acute renal graft rejection. (hycultbiotech.com)
Inflammation2
- Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. (wikipedia.org)
- can mediate most of the steps in acute inflammation! (fdocuments.in)
Severe4
- Bradykinin-mediated forms are usually longer-lasting, more severe, and tend to affect the upper airway (1,12-14). (emdocs.net)
- Both LPL & apoC-II deficiency usually present in childhood with recurrent episodes of severe abdominal pain due to acute pancreatitis. (medquizzes.net)
- To conclude, this study implies that in the obese insulin-resistant Zucker rat, under severe circumstances, NEP or ACE inhibition can improve entire body insulin-mediated blood sugar disposal. (thetechnoant.info)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a newly identified coronavirus which has spread from China to the rest of the world causing the pandemic coronavirus disease 19 (COVID-19). (authorea.com)
Responses2
- In this study we (1) characterized the endothelial-dependent relaxation of two similarly sized but anatomically distinct human arteries to two different agonists and (2) determined how these responses are modified by acute exposure to high glucose. (gla.ac.uk)
- homeostasis widens provided proper branches in the due chest m-d-y that activate acute Frontiers in male responses. (worldclassbows.com)
Reactions1
- Review article: Acute serious and fatal reactions to contrast media: our current understanding. (indianradiology.com)
Exposure1
- Acute or chronic exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) or treatment with Ro-31-8220 showed that the stimulation of PI hydrolysis by PE, but not ET-1 or BK, was inhibited by activation of PKC. (reading.ac.uk)
Kidney1
- A 42-year-old male patient (height: 165 cm, weight: 61.7 kg) was admitted due to acute kidney injury with dyspnea. (anesth-pain-med.org)
Lysosomal1
- Zymogen activation is mediated by lysosomal hydrolases (cathepsin B) which become co-localized with digestive enzymes in intracellular organelles leading to pancreatic acinar cell injury. (medquizzes.net)
Glucose1
- Relaxations to acetylcholine and bradykinin were determined in a control (5 mM) and high glucose (20 mM) environment over a 2 and 6 h incubation period. (gla.ac.uk)
Potentiation2
- Other mechanisms (bradykinin potentiation) may be involved. (ox.ac.uk)
- May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. (icr.ac.uk)
Myocardial2
- Acute myocardial ischemia results from an increased cardiac workload in presence of a critical coronary stenosis (demand ischemia), coronary occlusion (supply ischemia) or a combination of both. (ox.ac.uk)
- Cardiac protection in acute myocardial ischemia can be related to preservation of coronary blood flow, function of ischemic and non-ischemic myocardium or prevention of cardiac arrhythmias. (ox.ac.uk)
Typically1
- These patients typically have a bradykinin-mediated form. (emdocs.net)
Activation2
- Experiments with Ro-31-8220 showed that the stimulation of PLD by ET-1 and BK was mediated through activation of PKC. (reading.ac.uk)
- Activation of the kinin system leading to the formation of bradykinin could also be involved. (indianradiology.com)