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  • protein
  • The translocation with bradykinin occurred even after pretreatment with an islet-activating protein, wortmannin, and phorbol 12,13-dibutyrate. (diabetesjournals.org)
  • Burch, R.M., and Axelrod, J., 1987, Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: Evidence for G protein regulation of phospholipase A2, Proc. (springer.com)
  • significantly
  • Notably, bradykinin sensitization of TRPV1 in peptidergic nociceptors was significantly blocked by inhibiting Ca 2+ -dependent neuronal exocytosis. (frontiersin.org)
  • However, in a study presented earlier, we showed that bradykinin significantly increased the stimulation-evoked norepinephrine release in the hypothalamus of spontaneously hypertensive rats via the dihydropyridine-sensitive calcium channels. (ahajournals.org)
  • nonapeptide
  • 13 Because cardiac anaphylaxis is associated with marked ischemia caused by an array of coronary-vasoconstricting agents 1 and ischemia increases bradykinin outflow from the heart, 10 we questioned whether bradykinin production is increased during cardiac anaphylaxis and, if so, whether this nonapeptide may function as a mitigating factor against threatening vasoconstricting mediators. (ahajournals.org)
  • Bradykinin is a nonapeptide that is generated in plasma and tissues in response to injury and infection. (springer.com)
  • Gene
  • In addition, silencing αCGRP gene expression, but not substance P, drastically reduced bradykinin-induced TRPV1 sensitization in peptidergic nociceptors. (frontiersin.org)
  • 1965
  • COLLIER H.O.J., JAMES G.W.L. and PIPER P.J. (1965) - Intensifica tion by adrenalectomy or by 8-adrenergic blockade of the bronchoconstrictor action of bradykinin in the guinea-pig. (springer.com)
  • constriction
  • Initial secretion of bradykinin post-natally causes constriction and eventual atrophy of the ductus arteriosus , forming the ligamentum arteriosum between the pulmonary trunk and aortic arch. (wikipedia.org)
  • ileum
  • Homozygous null mutants are indistinguishable from normal littermates, but bradykinin response is eliminated in ileum, uterus, and cervical ganglia. (jax.org)
  • Hypertensive
  • 5 Therefore, we would like to know whether bradykinin might have synergistic or antagonistic effects on the Ang-(1-7)-induced BRS alterations in hypertensive (mRen2)27 rats in the study by Dr Nautiyal et al. (ahajournals.org)
  • Synergistic effects of Bay K 8644 and bradykinin on norepinephrine release in the hypothalamus of spontaneously hypertensive rats. (ahajournals.org)
  • Roles
  • These compounds hold great promise as novel analgesic/ anti-inflammatory agents and permit, for the first time, assessment of the physiological and pathophysiological roles of bradykinin. (springer.com)
  • doses
  • Since there was no tachyphylaxis to even threshold doses of bradykinin, the conclusion is drawn that it affects directly the coronary bed through its typical vasodilating action. (ahajournals.org)
  • glucose
  • Some studies have suggested that bradykinin is locally released from contracting muscles and may be responsible for GLUT4 translocation and the increase of glucose transport in skeletal muscles. (diabetesjournals.org)
  • Bradykinin is probably one of the factors responsible for exercise-stimulated glucose uptake in skeletal muscles. (diabetesjournals.org)
  • permeability
  • Bradykinin caused platelet adhesion on the apparently unbroken endothelium of the femoral vein, decreased peripheral vascular resistance of the microcirculation and increased permeability of venules of the vasa vasorum of the abdominal aorta in dogs. (ebscohost.com)
  • edema
  • Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema , formerly known as hereditary angio-neurotic edema. (wikipedia.org)