• The purified SAP2 was shown to cleave human kininogens, preferably the low molecular mass form (LK) and optimally in an acidic environment (pH 3.5-4.0), and to produce two kinins, Met-Lys-bradykinin and its derivative, {[}Hydroxyproline(3)]-Met-Lys-bradykinin, both of which are capable of interacting with cellular bradykinin receptors of the B2 subtype. (uni-muenchen.de)
  • Additionally, albeit with a lower yield, des-Arg(9)-Met-Lys-bradykinin, an effective agonist of B1-subtype receptors, was released. (uni-muenchen.de)
  • Bradykinin-related peptides, universal mediators of inflammation collectively referred to as the kinins, are often produced in excessive amounts during microbial infections. (uni-muenchen.de)
  • Bradykinin dilates blood vessels via the release of prostacyclin , nitric oxide , and Endothelium-Derived Hyperpolarizing Factor . (wikipedia.org)
  • BACKGROUND: This study investigates bradykinin and nitric oxide as potential mediators of AT2-receptor-stimulated duodenal mucosal alkaline secretion. (gu.se)
  • We postulate that bradykinin plays a protective role in cardiac anaphylaxis by accumulating at the luminal surface of the coronary endothelium and promoting, in an autocrine mode, a B 2 -receptor-mediated production of nitric oxide and prostacyclin in concentrations sufficient to elicit a paracrine effect on coronary vascular smooth muscle, thus opposing the vasoconstricting effects of other anaphylactic mediators. (ahajournals.org)
  • Previously we described ENAP-1, a 90-kDa protein that is tyrosine-phosphorylated in endothelial cells in response to bradykinin (BK) stimulation and is associated with endothelial nitric oxide synthase (eNOS). (elsevier.com)
  • In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. (nel.edu)
  • While mast cell -mediated angioedema can be successfully treated with antihistamines and glucocorticosteroids and with omalizumab as a prophylactic treatment [ 6 ], Bk-AE requires interventions that target the synthesis or receptor activity of bradykinin. (biomedcentral.com)
  • We show here that genetic ablation ( B2 -/- mice) or pharmacological blockade of the bradykinin B2 receptor increases UUO-induced interstitial fibrosis in mice, whereas transgenic rats expressing increased endogenous bradykinin show reduced UUO-induced interstitial fibrosis. (jci.org)
  • In sample of plasma from each patient, concentrations of endogenous bradykinin produced by kinin-forming activitation in plasma during a period of 60 minutes were measured in vitro using a physical chemical technique. (ssc.ca)
  • Bradykinin is an inflammatory mediator . (wikipedia.org)
  • Furthermore, bradykinin is a likely mediator of immediate hypersensitivity, because circulating levels of high molecular weight kininogen, a precursor of bradykinin, decrease during anaphylactic shock in humans. (ahajournals.org)
  • Accordingly, we postulate that bradykinin is a protective mediator of cardiac anaphylaxis. (ahajournals.org)
  • After intravenous administration of Evans blue dye, we perfused normal saline followed by bradykinin or platelet-activating factor, another inflammatory mediator, intraarticularly via needles placed in the knee joint. (asahq.org)
  • Bradykinin is an inflammatory mediator consisting of nine amino acids. (diff.org)
  • 13 Because cardiac anaphylaxis is associated with marked ischemia caused by an array of coronary-vasoconstricting agents 1 and ischemia increases bradykinin outflow from the heart, 10 we questioned whether bradykinin production is increased during cardiac anaphylaxis and, if so, whether this nonapeptide may function as a mitigating factor against threatening vasoconstricting mediators. (ahajournals.org)
  • Bradykinin (BK) is a nonapeptide that contributes to inflammatory responses, mediates pain signals and influences blood pressure. (diva-portal.org)
  • Bradykinin is a physiologically and pharmacologically active nonapeptide produced in the body in response to many kinds of injuries. (phdify.com)
  • We offer Bradykinin RB2/BDKRB2 RNAi for use in common research applications. (novusbio.com)
  • Each Bradykinin RB2/BDKRB2 RNAi is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Our Bradykinin RB2/BDKRB2 RNAi can be used in a variety of model species: Human. (novusbio.com)
  • Choose from our Bradykinin RB2/BDKRB2 RNAi. (novusbio.com)
  • The present study showed that bradykinin precursor, kininogen, is present in arterial blood of the fetal lamb by 61 days of gestation and that its concentration increases toward term. (ahajournals.org)
  • Kininogen concentrations in left atrial blood decreased within 1 to 2 minutes after beginning ventilation with O 2 , and free bradykinin was detected in left atrial blood. (ahajournals.org)
  • Associated with a mean increase in brachial arterial blood Po 2 to 44 mm Hg, a value equivalent to that in the ventilated exteriorized fetus, kininogen concentration fell, and free bradykinin was detected in the brachial arterial blood of 3 of the 6 fetuses. (ahajournals.org)
  • The hypothesis is presented diat bradykinin is produced from kininogen in the lungs of the fetal lamb when oxygenated, and that the maximal rate of production occurs during the first few minutes after expansion of the lungs or exposure of the ewe and fetus to hyperbaric O 2 . (ahajournals.org)
  • The formation of bradykinin in human plasma is basically due to interaction of three proteins (Hageman factor, prekallikrein and high molecular weight kininogen) to anionic surfaces (Figures 1a and 1b). (phdify.com)
  • We found that bradykinin directly triggered GLUT4myc translocation and increased the rate of glucose uptake in a dose-dependent manner in these cells. (diabetesjournals.org)
  • Hydroxylation of Pro-383 occurs prior to the release of bradykinin. (abcam.com)
  • The data suggest that bradykinin may play a regulatory role in the central control of blood pressure by stimulating sites that are near the dorsal and dorsal lateral surfaces of the medulla and accessible to kinins in cerebrospinal fluid and in the cerebral arterial circulation. (biomedsearch.com)
  • These data strongly suggest that bradykinin, acting via B2R, acts as an important signal directing the invasion of glioma cells toward blood vessels," concluded Montana and Sontheimer in their paper. (oncologynurseadvisor.com)
  • The increase in circulating bradykinin was associated with a decrease in the circulating level of bradykininogen, the precursor of bradykinin. (ahajournals.org)
  • In the present study, we report that cardiac bradykinin production is increased during anaphylaxis and that anaphylactic coronary vasoconstriction and ischemic arrhythmias, which are aggravated by bradykinin B 2 -receptor blockade, are in contrast alleviated by inhibitors of bradykinin breakdown. (ahajournals.org)
  • Using this approach, it was found that some bradykinin analogs are effective inhibitors of bradykinin. (wipo.int)
  • We conclude that bradykinin modulates glomerular and tubular function in an age-dependent manner. (physiology.org)
  • We conclude that bradykinin, by activating multiple kinases in dorsal horn neurons, potentiates glutamatergic synaptic transmission to produce pain hypersensitivity. (duke.edu)
  • This tPA-triggered generation of bradykinin could participate in the deleterious effects of thrombolysis and is a potential target to improve neurological outcome in tPA-treated patients. (frontiersin.org)
  • Uncontrolled generation of bradykinin, on the other hand, occurs when complement-1 inhibitor (C1-INH) is either deficient or non-functioning. (biomedcentral.com)
  • The physiological role of C1-INH is to control the generation of bradykinin after activation of the contact system. (biomedcentral.com)
  • Effect of histamine and bradykinin on lymph and tissue fluid composition in the rabbit hindlimb: evidence for two compartments in tissue fluid. (biomedsearch.com)
  • In the rabbit hindleg lymph and tissue fluid were collected before and during close intraarterial infusions of histamine (2.5 and 10 micrograms/min) or bradykinin (0.4 microgram/min). (biomedsearch.com)
  • Lymph flow decreased in the controls and it was not significantly influenced by histamine but was in the majority of animals (14 of 20) grossly augmented by bradykinin. (biomedsearch.com)
  • A significant share is mediated by mast-cell mediators such as histamine, but a substantial proportion are unrelated to mast-cell activation and mediated by bradykinin (Bk-AE). (biomedcentral.com)
  • Bradykinin injected into the fourth cerebral ventricle of unanesthetized rats produced a pressor effect with a shorter latency and a larger maximal effect than when injected in the third or lateral ventricles. (biomedsearch.com)
  • Montana and Sontheimer also learned that bradykinin acts as a chemoattractant, guiding glioma cells toward blood vessels in the brains of rats. (oncologynurseadvisor.com)
  • Results: Bradykinin increased plasma extravasation eight- to ninefold above baseline in both pentobarbital- and isoflurane-anesthetized rats. (asahq.org)
  • Venom Bradykinin-Related Peptides (BRPs) and Its Multiple Biological Roles, An Integrated View of the Molecular Recognition and Toxinology Gandhi Rádis Baptista, IntechOpen, DOI: 10.5772/52872. (intechopen.com)
  • BRADYKININ is a nine-amino acid peptide with a molecular weight of 1.06 kDa. (diff.org)
  • The purpose of this study is to evaluate the effectiveness of HOE-140, a bradykinin receptor blocker, at reducing symptoms in people with ACE inhibitor-associated angioedema. (clinicaltrials.gov)
  • Hence, we investigated whether the effect of an ACE inhibitor on the lower limit of CBF autoregulation is mediated by the potentiation of bradykinin-mediated vasodilatation. (ahajournals.org)
  • The signalling pathway was confirmed by the use of PD098059 [the inhibitor of MAPK kinase-1 (MEK-1) activation], AACOCF3 (an inhibitor of cPLA2) and indomethacin (an inhibitor of cyclo-oxygenase), which all reduced bradykinin-stimulated cAMP synthesis. (strath.ac.uk)
  • We offer Bradykinin RB1/BDKRB1 Lysates for use in common research applications: Western Blot. (novusbio.com)
  • Our Bradykinin RB1/BDKRB1 Lysates can be used in a variety of model species: Human. (novusbio.com)
  • Choose from our Bradykinin RB1/BDKRB1 Lysates. (novusbio.com)
  • Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. (wikipedia.org)
  • Prostaglandins are known to enhance the inflammatory and nociceptive actions of other chemical mediators of inflammation such as bradykinin. (jneurosci.org)
  • Conclusion: Halothane, but not isoflurane or pentobarbital, inhibits both baseline and bradykinin-induced peripheral plasma extravasation, demonstrating that volatile anesthetics differentially modulate this important component of inflammation. (asahq.org)
  • Bradykinin acts through two receptor subtypes in mammals and generates a variety of responses including pain, inflammation and hypotension. (diva-portal.org)
  • Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway. (diabetesjournals.org)
  • Intracellular INK pathway and TNF-alpha might provide key links between inflammatory mediators like IL-1 beta and airway hyperresponsiveness to bradykinin. (lu.se)
  • To evaluate the hypothesis that sphingosine-1-phosphate (S1P) and cAMP attenuate increased permeability of individually perfused mesenteric microvessels through a common Rac1-dependent pathway, we measured the attenuation of the peak hydraulic conductivity (L p ) in response to the inflammatory agent bradykinin (BK) by either S1P or cAMP. (elsevier.com)
  • Figures 1a and 1b show the tissue and plasma biosynthetic pathway of bradykinin. (phdify.com)