- Brachyury functions as a transcription factor within the T-box family of genes. (wikipedia.org)
- Tbxt is the founding member of the T-box family which in mammals currently consists of 18 T-box genes. (wikipedia.org)
- It effects transcription of genes required for mesoderm formation and cellular differentiation. (wikipedia.org)
- Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories. (nih.gov)
- A regulatory factor X transcription factor that is required for the expression of MHC CLASS II GENES . (online-medical-dictionary.org)
- This increase suggests Sox11 expression is trophic factor sensitive and that it may contribute to the transcriptional control of genes involved in the increased survival and axonal projections that has been documented in these transgenic animals (Albers et al. (pitt.edu)
- These data suggest that the developmentally regulated transcription factor Sox11 is induced in adult neurons after injury to promote neurite growth and axon regeneration and inhibit apoptosis by regulating genes associated with each of these distinct biological pathways. (pitt.edu)
- An arrayed collection of siRNA reagents for RNAi screening, targeting human genes involved with transcription factors ON-TARGET plus siRNA is guaranteed to silence, and is modified to reduce off-targets for fewer false positives. (horizondiscovery.com)
- Transcription factors perform this function alone, or with other proteins in a complex, by promoting (as an activator) or blocking (as a repressor) the recruitment of RNA polymerase to specific genes. (horizondiscovery.com)
- Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
- The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
- In particular, mutations in DNA binding sites recognized by transcription factors can alter regulator binding affinities and, consequently, expression of target genes. (biomedcentral.com)
- The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
- The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
- Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
- There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
- T-box transcription factor T, also known as Brachyury protein, is encoded for in humans by the TBXT gene. (wikipedia.org)
- Because of the role that the transcription factor plays in spinal development, it is cited as being the protein that is primarily responsible for tail development in mammals. (wikipedia.org)
- On the basis of this action, the SOX2 protein is called a transcription factor. (medlineplus.gov)
- The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
- STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
- Nakashima K , Hiyoshi S , Ohno K , Prognostic factors in dogs with protein-losing enteropathy . (avma.org)
- A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
- A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. (bvsalud.org)
- Inactivation of TCF7L2 protein attained by removing the high-mobility group (HMG)-box DNA binding domain in mature adipocytes in vivo leads to whole-body glucose intolerance and hepatic insulin resistance. (medscape.com)
- In a stem-loop structure, genetic material trapped within the loop is recognized by transcription-coupled nucleotide excision repair (TC NER) proteins as damage due to RNA polymerase being ostensibly stalled at the neck of the loop. (wikipedia.org)
- Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
- A newly recognized family of transcription factors that appear to have important roles in sensory neuron biology is the Sox family of high-mobility group (HMG) domain proteins. (pitt.edu)
- The Human ON-TARGETplus siRNA Transcription factors Library targets proteins that bind DNA in a sequence-specific manner and thereby control the transfer, or transcription, of genetic information from DNA to RNA. (horizondiscovery.com)
- The forkhead box class O (FOXO) transcription factor FOXO3a has been suggested to function as a tumor suppressor in breast cancer. (ntu.edu.tw)
- FoxO transcription factors are considered effectors of the pathway regulating hepatic glucose production. (jci.org)
- The binding sites of T-box transcription factor TBX5 and NK-2 transcription factor-related locus 5 Nkx2.5, which were expressed at higher levels in aortic smooth muscle cells than in T cells, were located within the −387 to +97 NFAT3 promoter region, exhibiting the maximum enhancer activity. (aai.org)
- The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
- The disease is due to mutations in the transcription factor TBX5 , which is important in the development of both the heart and upper limbs. (medscape.com)
- Molecular genetic studies reveal that the disease is caused by mutations that inactivate the transcription factor TBX5 . (medscape.com)
- The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. (ox.ac.uk)
- RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)
- RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
- Tbxt was cloned by Bernhard Herrmann and colleagues and proved to encode a 436 amino acid embryonic nuclear transcription factor. (wikipedia.org)
- The rise in Sox11 in response to enhanced trophic factor level and axotomy has led us to hypothesize that Sox11 is an essential transcriptional regulator in both embryonic and adult systems that is trophic factor responsive. (pitt.edu)
- Pax6 is a transcription factor present during embryonic development. (biolegend.com)
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (nih.gov)
- Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. (nih.gov)
- We report that haploinsufficiency for the forkhead transcription factor Foxo1 reverses beta cell failure in Irs2(-/-) mice through partial restoration of beta cell proliferation and increased expression of the pancreatic transcription factor pancreas/duodenum homeobox gene-1 (Pdx1). (nih.gov)
- Here, we show that during chronic murine lymphocytic choriomeningitis virus infection, activation of AKT and mTOR are impaired in antiviral cytotoxic T lymphocytes (CTLs), resulting in enhanced activity of the transcription factor FoxO1. (nih.gov)
- through the coordinated actions of several transcription factors (TFs) In this study, we examined the dynamics of several key transcription factors (TFs) - PPARγ, C/EBPβ, CREB, NFAT, FoxO1, and SREBP-1c - during adipogenic differentiation (week 1) and ensuing lipid accumulation. (tufts.edu)
- Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver results in steatosis arising from increased triglyceride accumulation and decreased fatty acid oxidation. (jci.org)
- Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
- A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. (yeastgenome.org)
- For instance, a previous study by the authors validated that USF1 binds to the core promoter of APOBEC3G and increases its transcription level in hepatocytes ( 7 ). (spandidos-publications.com)
- Near-atomic resolution visualization of human transcription promoter opening. (expasy.org)
- Orthologous to human HBP1 (HMG-box transcription factor 1). (nih.gov)
- Brachyury overexpression also repressed E-cadherin transcription, an effect partially mediated by Slug. (jci.org)
- Tbxt binds to a specific DNA element, a near palindromic sequence TCACACCT through a region in its N-terminus, called the T-box. (wikipedia.org)
- The Danio rerio ortholog is known as ntl (no tail) TBXT is a transcription factor observed in vertebrate organisms. (wikipedia.org)
- Further analysis of transcription factors with conserved binding motifs can reveal cell regulatory pathways crucial for the survivability of various human cancers. (biomedcentral.com)
- The Role of MB0, MBI and MBII in Interaction and Dynamics of the Master Regulatory Transcription Factor c-Myc. (lu.se)
- Human transcription factor IIIC box B binding subunit. (nih.gov)
- Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is negatively controlled by its NTD (N-terminal domain) that lies between amino acids 1 and 124. (elsevierpure.com)
- Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. (spandidos-publications.com)
- Upstream transcription factor (USF) 1 belongs to the basic helix-loop-helix leucine zipper family and serves as a cellular transcription factor (TF). (spandidos-publications.com)
- A large twin study demonstrated that 81 % of the variance of the disease was attributed to additive genetic effects, whereas the remaining 19 % was attributed to unique, unshared environmental factors [10]. (springer.com)
- Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
- This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
- Genetic analysis of the paired box transcription factor (PAX8) gene in a cohort of Polish patients with primary congenital hypothyroidism and dysgenetic thyroid glands. (cdc.gov)
- Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
- To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
- Purification and characterization of two forms of human transcription factor IIIC. (nih.gov)
- For example, we have applied light-activatable cMOs to interrogate transcription factor function during zebrafish notochord, pancreas, and vascular patterning. (cdc.gov)
- In a screen of transcriptional activity in transgenic animals that overexpress either NGF or GDNF in the skin (NGF-OE and GDNF-OE mice), the transcription factor Sox11 was significantly increased in developing neurons of the trigeminal ganglia. (pitt.edu)
- Mechanistic studies revealed sex-determining region Y-box 2 (SOX2), a self-renewal associated transcription factor, as a key driver of FSC acquisition and fibrogenesis. (cdc.gov)
- Chromatin immunoprecipitation assays identified SOX2-binding sites on COL1A1 and COL1A2, indicating SOX2 as a transcription factor in collagen synthesis. (cdc.gov)
- Scholars@Duke publication: Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. (duke.edu)
- Mechanistically, Foxi2 stimulated AgRP expression by directly binding to it and activating its transcription. (figshare.com)
- Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
- Abnormalities in cardiac conduction can occur due to a variety of factors, including developmental and congenital defects, acquired injury or ischemia of portions of the conduction system, or less commonly due to inherited diseases that alter cardiac conduction system function. (medscape.com)
- SOX1 is a 39 kDa transcription factor that belongs to the SOXB1 subgroup. (novusbio.com)
- The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells. (nih.gov)
- As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system 11 . (biolegend.com)
- We will present first molecular data showing how these boxes interact with critical transcription factors as well as with each other in a highly specific but also highly dynamic manner, and how these interactions can be interrupted. (lu.se)
- A hypothesis formed: if the membrane can successfully initiate the regeneration process, perhaps there are unknown factors in the synovial fluid that may interfere with the healing process. (forbes.com)
- Here, using the dRNA-seq technique in combination with ANNOgesic analysis, we successfully mapped and annotated transcription start sites (TSS) of both E. faecalis V583 and E. faecium AUS0004 at single nucleotide resolution. (frontiersin.org)
- Located within the intrinsically disordered N-terminus part of c-Myc are the highly conserved so-called Myc boxes (MB0-IV), which are crucial for Myc function and interaction with other transcription factors. (lu.se)