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  • ligand-bindin
  • Dimerization starts in the endoplasmic reticulum with the interaction of N-terminal LIVBP domains, then "zips up" through the ligand-binding domain into the transmembrane ion pore. (wikipedia.org)
  • and 3) whether predictions of mechanism of action could be inferred by comparing molecular interactions between the ligand-binding domain and each compound with those of cyclothiazide and CX614. (aspetjournals.org)
  • adaptor
  • A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. (nih.gov)
  • Catalyzes
  • Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (uniprot.org)
  • ions
  • While glutamate may "open" the pore, the ions cannot travel through the channel due to the magnesium block. (learner.org)
  • Sites
  • iv) a site or sites that recognizes Zn 2+ and prevents channel activation, and (v) a site or sites within the receptor channel for binding of drugs such as phencyclidine (PCP)-like, MK-801 and ketamine. (springer.com)
  • The channel opens when two sites are occupied, and increases its current as more binding sites are occupied. (wikipedia.org)
  • channel
  • Here, we demonstrate that the linker region between the M3 and S2 domains, which in current structural models is thought to transduce ligand-binding energy into channel opening, additionally has an essential role in receptor biogenesis. (jneurosci.org)
  • This domain is modeled as a critical linker that transduces ligand-binding energy into channel gating ( Jin and Gouaux, 2003 ). (jneurosci.org)
  • application
  • In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. (uniprot.org)