Receptors, EndothelinReceptor, Endothelin AReceptor, Endothelin BEndothelinsSulfonamidesEndothelin-1Antihypertensive AgentsHypertension, PulmonaryPeptides, CyclicPhenylpropionatesViper VenomsEndothelin-3Eisenmenger ComplexEndothelin-2SulfonesVasoconstrictionAzepinesSkin UlcerPurinesIloprostHemodynamicsScleroderma, SystemicBlood PressureExercise ToleranceIsoxazolesVasoconstrictor AgentsPyrrolidinesEpoprostenolVasodilator AgentsRats, Sprague-DawleyAspartic Acid EndopeptidasesRats, WistarPulmonary ArteryOligopeptidesPiperidinesVascular ResistanceConnective Tissue DiseasesPyridazinesThiophenesDose-Response Relationship, DrugAdministration, OralEndothelium, VascularIndansPhosphodiesterase 5 InhibitorsPiperazinesNitric OxideTreatment OutcomeMetalloendopeptidasesHypertensionRats, Inbred WKYThromboangiitis ObliteransProtein PrecursorsMuscle, Smooth, VascularDrug Therapy, CombinationKidneyRenal CirculationHypertrophy, Right VentricularRNA, MessengerAngiotensin IIPoisonsMyocardiumCompassionate Use TrialsRaynaud DiseaseRats, Inbred SHRDouble-Blind MethodPulmonary CirculationSplanchnic CirculationHand DermatosesCells, CulturedRegional Blood FlowHypertension, PortalDisease Models, AnimalMonocrotalineHeart Defects, CongenitalTime FactorsTetrazolesCoronary VesselsPyrimidinesIndolesExercise TestNG-Nitroarginine Methyl EsterVasodilationPeptidesDrug InteractionsEnzyme InhibitorsNitric Oxide SynthasePulmonary Wedge PressureOrganic Anion TransportersSwineLosartanReninDioxolesAngiotensin Receptor AntagonistsDansyl CompoundsAnoxiaPhosphodiesterase InhibitorsArterial PressureTaurocholic AcidLaser-Doppler FlowmetryHeart Rate