Bordetella pertussis toxin. Medical search. Frequent questions

M. Lucia Tondella, CDC Pertussis Working Group1 mal cough, apnea, and posttussive vomiting. (cdc.gov)
Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the causative agent of pertussis or whooping cough. (wikipedia.org)
The paroxysmal cough precedes a crowing inspiratory sound characteristic of pertussis. (wikipedia.org)
Bordetella pertussis, the causative agent of whooping cough, secretes among various toxins an adenylate cyclase (CyaA) that displays a unique mechanism of cell invasion, which involves a direct translocation of its N-terminal catalytic domain (AC, 400 residues) across the plasma membrane of the eukaryotic targeted cells. (pasteur.fr)
Bordetella pertussis is the agent responsible for whooping cough, a disease that is currently on the rise. (pasteur.fr)
Pertussis (whooping cough) is a highly contagious infection of the respiratory tract caused by the bacterium Bordetella pertussis . (canada.ca)
Pertussis may be milder in adolescents and adults but symptoms can range from asymptomatic infection to a very prolonged, debilitating cough. (canada.ca)
Pertussis is a common and often unrecognized cause of cough persisting for over 2 weeks in adolescents and adults. (canada.ca)
Whooping cough (pertussis) is a very contagious respiratory infection that causes a distinctive "whooping" cough. (clevelandclinic.org)
Whooping cough, also called pertussis, is a very contagious upper respiratory infection . (clevelandclinic.org)
However, adults can develop serious cases of whooping cough, especially if they haven't received the pertussis vaccine. (clevelandclinic.org)
Before the development of the pertussis vaccine, there were hundreds of thousands of cases of whooping cough each year in the U.S. (clevelandclinic.org)
Symptoms of whooping cough (pertussis) range from fever to violent coughing episodes. (clevelandclinic.org)
A type of bacteria called Bordetella pertussis causes whooping cough. (clevelandclinic.org)
B. bronchiseptica" is closely related to "Bordetella pertussis" and "Bordetella parapertussis", causing pertussis or whooping cough in humans [2]. (kenyon.edu)
The human pathogen Bordetella pertussis targets the respiratory epithelium and causes whooping cough. (uni-wuerzburg.de)
Pertussis, also known as whooping cough, is a highly contagious infectious disease caused by the bacterium Bordetella pertussis , a Gram-negative, aerobic, non-motile coccobacillus. (wikidoc.org)
It is the pathogen responsible for pertussis (whooping cough). (wikidoc.org)
Whooping cough (pertussis) has reached epidemic levels in the U.S. - the highest in five decades. (wakeup-world.com)
The CDC would like to keep the American population ignorant about this startling fact: Our current pertussis epidemic is caused by a deadly new strain of Bordetella pertussis bacterium (ptxP3) and its emergence is directly connected to the whooping cough vaccine. (wakeup-world.com)
Whooping Cough Epidemic Caused by Virulent New Pertussis Strain - And It's the Result of Vaccine" Gaia Health. (wakeup-world.com)
Whooping Cough: Worst Year For Pertussis in 5 Decades, CDC Says" Mike Stobbe, July 19, 2012. (wakeup-world.com)
1 year with and without pertussoid cough were investigated for the presence of B. pertussis/parapertussis using culture and real-time polymerase chain reaction (PCR). (pasteur.fr)
Diseases of the Upper and Lower Respiratory Tract A. Whooping cough (Pertussis) 1. (slideserve.com)
Pertussis or whooping cough, mainly caused by Bordetella pertussis , is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. (frontiersin.org)
Whooping cough, also referred to as pertussis, is a severe respiratory disease that can be life threatening in newborns and non-vaccinated young children. (frontiersin.org)
The main causative agent of whooping cough is Bordetella pertussis ( 2 ), a gram negative coccobacillus which is able to colonize the human upper respiratory tract by attaching to the ciliated cells. (frontiersin.org)
Other Bordetella species, such as Bordetella parapertussis ( 3 ) and Bordetella holmesii ( 4 ), can cause diseases similar to pertussis, albeit usually with much less severe symptoms than typical whooping cough caused by B. pertussis . (frontiersin.org)
It is estimated that whooping cough causes globally around 200,000 deaths per year and more than 24 million new pertussis cases in children younger than 5 years were reported in 2014 ( 5 ), in spite of the wide usage of efficacious pertussis vaccines ( 6 ). (frontiersin.org)
Although the pertussis incidence has dramatically decreased since the first introduction of these vaccines ( 7 ), whooping cough remains a major global public health problem, mostly in resource-poor countries. (frontiersin.org)
Bordetella pertussis , the causative agent of whooping cough, is a highly clonal pathogen of the respiratory tract. (biomedcentral.com)
Bordetella pertussis causes whooping cough, a highly communicable disease that killed roughly 279,000 people and infected 17.6 million people globally in a recent typical year [ 1 ]. (biomedcentral.com)
Peter Sebo interconnects Whooping cough, Secretion, Immune system, Immunity and Pertussis vaccine in the investigation of issues within Bordetella pertussis. (research.com)
So the term 'whooping cough' comes essentially from the sound that a person that suffers from pertussis disease makes while coughing. (cdc.gov)
Usually these patients with pertussis experience around the second week after the onset of the symptoms a fit of coughing, followed by a high-pitched whoop sound, and hence the name of whooping cough. (cdc.gov)
Pertussis (whooping cough) is a respiratory tract infection characterized by a paroxysmal cough. (medscape.com)
Pertussis, commonly known as whooping cough, is a respiratory tract infection characterized by a paroxysmal cough. (medscape.com)
Bordetella parapertussis also has been associated with whooping cough in humans. (medscape.com)
In the prevaccination era, pertussis (ie, whooping cough) was a leading cause of infant death. (medscape.com)
Pertussis should be included in the differential diagnosis of protracted cough with cyanosis or vomiting, persistent rhinorrhea, and marked lymphocytosis. (medscape.com)
The test detects antibodies against the toxin of the bacterium Bordetella pertussis , which causes whooping cough. (lifelab1.com)
Pertussis is also known as whooping cough. (medscape.com)
In most cases, a negative pertussis result indicates the absence of whooping cough. (medscape.com)

The adenylate cyclase (CyaA) of Bordetella pertussis is able to deliver CD8(+) T cell epitopes into the cytosol of CD11b(+) dendritic cells (DC) following its specific interaction with the alpha(M)beta(2) integrin (CD11b/CD18). (ox.ac.uk)
Indeed, we previously showed that CyaA toxins carrying a single cytotoxic T lymphocyte (CTL) epitope can induce efficient protective and therapeutic antitumor immunity in mice. (ox.ac.uk)
Post-translational acylation controls the folding and functions of the CyaA RTX toxin. (nih.gov)
In particular, the bacterium produces the CyaA toxin. (pasteur.fr)
Scientists from the Institut Pasteur are investigating CyaA, one of the major toxins of Bordetella pertussis. (pasteur.fr)
Its virulence factor adenylate cyclase toxin (CyaA) plays an important role in the course of infection. (uni-wuerzburg.de)
Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. (tcd.ie)
His primary scientific interests are in Bordetella pertussis, Microbiology, cyaA, Adenylate Cyclase Toxin and Virulence. (research.com)
His primary areas of investigation include Adenylate Cyclase Toxin, cyaA, Bordetella pertussis, Escherichia coli and Microbiology. (research.com)

B. pertussis, B. parapertussis and B. bronchiseptica form a closely related phylogenetical group. (wikipedia.org)
Specific diagnostic tools were applied for the first time in a Tunisian prospective study in order to get a first estimation of the prevalence of Bordetella pertussis/parapertussis infections and to evaluate their use to determine the epidemiologic characteristics of these infections in Tunisian infants. (pasteur.fr)
When possible, patients' household contacts provided nasopharyngeal aspirates (NPAs) for RT-PCR detection of B. pertussis/parapertussis or single-serum samples for anti-PT IgG quantification. (pasteur.fr)
All except 1 NPAs were negative by conventional culture, whereas PCR gave positive signals for 126 specimens (21%): B. pertussis, B. parapertussis, and Bordetella spp. (pasteur.fr)
The simultaneous presence of B. pertussis and B. parapertussis was noted in 8% of the cases. (pasteur.fr)
The genomes of B. pertussis and the two closely related species, B. bronchiseptica and B. parapertussis , were screened for homopolymeric tracts longer than expected on the basis of chance, given their nucleotide compositions. (biomedcentral.com)
The most common causative organism is Bordetella pertussis (see the image below), though Bordetella parapertussis also has been associated with this condition in humans. (medscape.com)
Humans are the sole reservoir for B pertussis and B parapertussis . (medscape.com)
B parapertussis is less common than B pertussis and produces a clinical illness that is similar to, but milder than, that produced by B pertussis . (medscape.com)

It plays the role of a bond-breaking agent in a novel ELISA (enzyme-linked immunosorbent assay technique for measuring the avidity index (AI) of IgG-anti-PT (Immunoglobulin G-anti-pertussis toxin) antibodies. (sigmaaldrich.com)
Human IgG antibody Laboratories manufactures the pertussis antibodies igm results reagents distributed by Genprice. (chipgrade.com)
The Pertussis Antibodies Igm Results reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (chipgrade.com)
Overview of Immunization Immunity can be achieved Actively by using antigens (eg, vaccines, toxoids) Passively by using antibodies (eg, immune globulins, antitoxins) A toxoid is a bacterial toxin that has been modified. (msdmanuals.com)

The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. (wikipedia.org)
Another toxin that inhibits the immune response is the adenylate cyclase toxin. (wikipedia.org)
This toxin has an intrinsic adenylate cyclase activity, increasing intracellular cAMP almost immediately. (wikipedia.org)
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes. (ox.ac.uk)
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes. (nih.gov)
Adenylate cyclase activity of Bordetella organisms. (microbiologyresearch.org)
B. bronchiseptica" also produces many toxins such as bifunctional adenylate cyclase and dermonecrotic toxins. (kenyon.edu)
B. pertussis utilizes virulence factors - including pertussis toxin (PT), filamentous hemagglutinin (FHA), fimbriae (FIM), adenylate cyclase toxin (ACT), tracheal cytotoxin (TCT), lipooligosaccharide (LOS), and dermonecrotic toxin (DNT) - to attach, proliferate, and and evade the host immune system. (wikidoc.org)
Adenylate cyclase toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells. (tcd.ie)
His Adenylate Cyclase Toxin research is multidisciplinary, incorporating elements of Toxin, Molecular biology, Cell biology, Cytotoxic T cell and Lipid bilayer. (research.com)
Bordetella adenylate cyclase toxin: a swift saboteur of host defense. (research.com)
Peter Sebo has researched Adenylate Cyclase Toxin in several fields, including Cyclase, Biophysics, Membrane, Cell membrane and Molecular biology. (research.com)
His Adenylate Cyclase Toxin research incorporates themes from Cyclase, Adenylyl cyclase, Antigen, Cell membrane and Macrophage. (research.com)
His studies in Adenylate Cyclase Toxin integrate themes in fields like Cyclase, Adenylate kinase and Cell membrane. (research.com)
With the addition of adenosine diphosphate-ribose onto the inhibitory G protein, adenylate cyclase is stimulated by the pertussis toxin, which has 2 components: subunit A and subunit B. Subunit A has the adenosine diphosphate-ribosylating activity. (medscape.com)

Candidate acellular pertussis vaccines, produced by multinational manufacturers, are now available due to advances in the methods of purifying and preparing these components. (cdc.gov)
Household exposure and ecologic studies among Japanese children vaccinated at greater than or equal to 2 years of age, have suggested efficacy of the BIKEN and other acellular pertussis vaccines when combined with diphtheria and tetanus toxoids as DTaP (4-7). (cdc.gov)
Furthermore, studies in mouse models have revealed that B. pertussis infection, but not immunization with current acellular pertussis vaccines induces resident memory T cells, which may also contribute to protection against colonization by B. pertussis . (frontiersin.org)
However, surprisingly, its prevalence is also strongly increasing in westernized countries ( 8 ), especially since the switch from the first-generation, whole-cell vaccines to the new-generation, acellular pertussis vaccines. (frontiersin.org)

Simultaneous vaccination against diphtheria, tetanus, and pertussis during infancy and childhood has been a recommended routine practice in the United States since the late 1940s. (cdc.gov)
Routine vaccination with whole-cell vaccines has been highly effective in reducing the burden of disease and deaths due to pertussis (3). (cdc.gov)
Several clinical trials, which compare relative protective efficacy of primary vaccination utilizing diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccines with that of whole-cell vaccines administered to infants, are in progress or development. (cdc.gov)
Pertussis is endemic worldwide and occurs year round, even in regions with high vaccination coverage. (canada.ca)
The primary prevention method for pertussis is vaccination with multiple doses of the DTaP vaccine during childhood and adolescence/adulthood. (wikidoc.org)
Patients who had been infected with pertussis or who have received vaccination against pertussis in the past may be re-infected in the future, but typically experience a milder course of the disease. (wikidoc.org)
The persistence of pertussis in the face of intense vaccination is unexpected because B. pertussis is extremely homogeneous, implying a limited ability to adapt. (wakeup-world.com)
Even though the CDC is aware of the link between vaccination and a new super-strain pertussis bacterium, their 'solution' for the epidemic is to increase vaccine use. (wakeup-world.com)
Progressive or unstable neurologic conditions are reasons to defer vaccination with a pertussis-containing vaccine, including BOOSTRIX. (nih.gov)
It means that pertussis is reappearing again with increasing incidence rates despite the high vaccination coverage, of course, in most of the countries. (cdc.gov)
Due to the DBS test, it is possible to determine the previous contact with the tetanus bacterium toxin or to use the test results to evaluate the effectiveness of the vaccination. (lifelab1.com)
For more information, see DTaP/Tdap/Td Advisory Committee on Immunization Practices Vaccine Recommendations and Centers for Disease Control and Prevention (CDC): Diphtheria, Tetanus, and Pertussis Vaccination . (msdmanuals.com)
Despite the fact that pertussis can be prevented through vaccination, its incidence has increased in recent years, owing to a decline in immunity from previous vaccinations and a decrease in the vaccination rate. (medscape.com)
The newer acellular pertussis vaccine (DTaP), which is approved for adults, has a significantly better adverse effect profile compared with the older DPT vaccine, which should help increase vaccination rates. (medscape.com)

of pertussis-containing vaccines. (cdc.gov)
Current pertussis vaccines protect against disease, but not against colonization by and transmission of Bordetella pertussis , whereas natural infection protects against both. (mdpi.com)
Whole-cell pertussis vaccines in the United States have been and continue to be prepared from suspensions of killed Bordetella pertussis whole bacterial cells. (cdc.gov)
these concerns have led to attempts to develop safer pertussis vaccines that have high efficacy. (cdc.gov)
Epidemiological and experimental evidence has shown that the vaccines fail to prevent B. pertussis infection and transmission, although they are very effective in preventing disease. (frontiersin.org)
So, we get vaccines for our dogs against Bordetella . (cdc.gov)
We do get vaccines for our dogs against Bordetella . (cdc.gov)
The mutation rate of a virus is considerably higher than that of a bacterium, meaning that in this case, in our case, Bordetella pertussis does not evolve that fast except for the antigen genes that are used in the commercial vaccines. (cdc.gov)
Acellular (a) pertussis (P) vaccines contain semipurified or purified components of Bordetella pertussis . (msdmanuals.com)

Description: Protein-based AB5-type exotoxin Pertussis toxin (PT) is produced by the bacterium Bordetella pertussis. (chipgrade.com)
A photomicrograph of the bacterium Bordetella pertussis, using Gram stain technique. (medscape.com)
Pertussis Pertussis is a highly communicable disease occurring mostly in children and adolescents and caused by the gram-negative bacterium Bordetella pertussis . (msdmanuals.com)

A known bacterial toxin, which has a health adverse effect in the lungs, is the pertussis toxin from Bordetella pertussis . (biomedcentral.com)

Like B. bronchiseptica, B. pertussis can express a flagellum-like structure, even if it has been historically categorized as a nonmotile bacteria. (wikipedia.org)
these organisms produced significantly more toxin than did bacteria in phase I from other species, or those in phases III and IV. (microbiologyresearch.org)
Pertussis is primarily a toxin-mediated disease in which toxins produced by the bacteria are responsible for the majority of its clinical features. (canada.ca)
Bordetella produces a pertussis toxin (Ptx) and filamentous hemagglutinin (Fha) A) These help the bacteria to attach to and destroy the respiratory epithelium resulting in a build-up of mucus 3. (slideserve.com)
ADP-ribosyltransferases including toxins secreted by Vibrio cholera, Pseudomonas aerurginosa, and other pathogenic bacteria inactivate the function of human target proteins by attaching ADP-ribose onto a critical amino acid residue. (indexindex.com)
In this study, we analyzed three bacterial toxins and five culture supernatants of selected bacteria with known toxicity as model agents exposed to the lung epithelial cell line NuLi-1. (biomedcentral.com)

The National Advisory Committee on Immunization (NACI) recommends immunization against pertussis. (canada.ca)
As a result of widespread immunization programs, proper nutrition and good medical care pertussis incidence has decreased in high income countries. (canada.ca)
Pertussis can be prevented by immunization. (canada.ca)
BOOSTRIX is a vaccine indicated for active booster immunization against tetanus, diphtheria, and pertussis in individuals aged 10 years and older. (nih.gov)
Prevention through immunization remains the best defense in the fight against pertussis. (medscape.com)

A supplementary statement on the use of diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) was issued February 7, 1992 (2) after the licensure of ACEL-IMUNE (Registered), prepared by Lederle Laboratories. (cdc.gov)
An initial dose of BOOSTRIX is administered 5 years or more after the last dose of the Diphtheria and Tetanus Toxoids and Acellular Pertussis (DTaP) series or 5 years or more after a dose of Tetanus and Diphtheria Toxoids Adsorbed (Td). (nih.gov)

The World Health Organization (WHO) has estimated that, there are between 20-40 million cases of pertussis worldwide, 95% of which were in developing countries. (canada.ca)
According to the World Health Organization (WHO), there were more than 151,000 cases of pertussis worldwide in 2018. (clevelandclinic.org)

The causative agent of pertussis was identified and isolated by Jules Bordet and Octave Gengou in 1906. (wikipedia.org)
B pertussis , a gram-negative pleomorphic bacillus, is the main causative organism for pertussis. (medscape.com)

Bordetella pertussis is a Gram-negative , aerobic , non-motile, non-spore-forming coccobacillus . (wikidoc.org)
Pertussis is a respiratory tract infection caused by the gram-negative coccobacillus Bordetella pertussis . (medscape.com)

Pertussis is an infection of the respiratory system characterized by a "whooping" sound when the person breathes in. (wikipedia.org)
Bacterial toxins damage the host at the site of bacterial infection or distant from the site. (springer.com)
The live attenuated vaccine BPZE1 was developed to mimic immunogenicity of natural infection without causing disease, and in preclinical models protected against pertussis disease and B. pertussis colonization after a single nasal administration. (mdpi.com)
The virulence of Bordetella bronchiseptica in gnotobiotic piglets was studied by intranasal infection with 11 cultures derived from eight strains isolated from pigs (4), dogs (2), a human subject and a monkey. (microbiologyresearch.org)
Intranasal infection with Bordetella bronchiseptica in gnotobiotic piglets. (microbiologyresearch.org)
An agglutination test for the detection of Bordetella bronchiseptica infection in swine. (microbiologyresearch.org)
Babies are especially vulnerable to infection because they can't receive the pertussis vaccine until they're at least 2 months old. (clevelandclinic.org)
Rhinovirus, C pneumoniae , and B pertussis are found in the sputum or pharyngeal swab specimens of asthmatic subjects without concurrent symptoms of infection or asthma exacerbation, as well as in some healthy controls. (bmj.com)
Given the high infection rate of B. pertussis , effective control of the disease likely requires prevention of infection and transmission in addition to protection against disease. (frontiersin.org)
In this review we summarize the available literature on the role of mucosal immunity in the prevention of B. pertussis infection. (frontiersin.org)
Several studies have shown that secretory IgA may be instrumental in the control of B. pertussis infection. (frontiersin.org)
This vaccine is a live attenuated B. pertussis strain delivered nasally in order to mimic the natural route of infection. (frontiersin.org)
Culture testing is the criterion standard for B pertussis infection, owing to its high specificity (100%) for identification. (medscape.com)

CDC also performs characterization of B. pertussis isolates by molecular sub-typing, vaccine immunogens deficiency, and whole genome sequencing methods for outbreak support and other public health concerns. (cdc.gov)
Upon request, the laboratory can test for the presence of diphtheria toxin by the Elek assay for C. diphtheriae and C. ulcerans isolates. (cdc.gov)

They include both the hydrolysis resistant GTP analogs, GTP-γ-S and GDP-β-S, that hold the Gα subunit in active and inactive conformations, respectively, and various bacterial toxins. (sigmaaldrich.com)
Subunit B binds the toxin to the cell surface receptors, thereby inhibiting chemokine receptors, with the result being lymphocytosis. (medscape.com)

Due to its ability to induce mucosal immunity it is expected that this approach will contribute to improved control of pertussis. (frontiersin.org)

Bacterial toxins can be single proteins or oligomeric protein complexes that are organized with distinct AB structure-function properties. (springer.com)
Bacterial toxins also catalyze the non-covalent modification of host protein function or can modify host cell properties through direct protein-protein interactions. (springer.com)
3D representation of pertussis toxin, made up of 6 complex protein subunits. (whoopingcough.net)
It was concluded that SHR cells do not appear to have an alteration in endothelin-1 activated, pertussis toxin sensitive G-protein coupling to IP formation or in the dependence of inositol phosphate formation on extracellular calcium. (strath.ac.uk)

12 days later (March 26) he was brought to his healthcare FR3749 ( 4 ) was undertaken by multilocus sequence typ- provider (HCP) with symptoms consistent with pertussis. (cdc.gov)
Early pertussis symptoms may resemble those of the common cold. (clevelandclinic.org)
Symptoms of pertussis begin to lessen after four weeks, although bouts of coughing can recur for months after symptoms start. (clevelandclinic.org)
Bordetella pertussis positive individuals had lower FEV 1 /FVC (77.1% v 80.7%, p = 0.012) and more asthma symptoms than B pertussis negative cases. (bmj.com)

CDC is actively researching new laboratory methods to better identify and characterize other Bordetella and Corynebacterium species. (cdc.gov)
Cross-species polymerase chain reaction (PCR) and database mining identified the orthologs of these ADP-ribosylating toxins in humans and the mouse. (indexindex.com)
But the dog's Bordetella belongs to the species Bordetella bronchiseptica , which is not the same as the one that produces disease in humans. (cdc.gov)

A toxin-mediated disease caused by Corynebacterium diphtheriae 2. (slideserve.com)

Therefore, protection at the level of the respiratory mucosa may be helpful for an improved control of pertussis. (frontiersin.org)

The incidence of pertussis is approximately 1.5 to 3.0 per 100,000 individuals, with approximately 5,000 to 7,000 cases reported annually. (wikidoc.org)
[ 3 ] Recent estimates put the worldwide incidence of pertussis at 48.5 million cases, with close to 295,000 deaths per year. (medscape.com)

Pasteurella multocida toxin (PMT, produced by Pasteurella multocida ) offers the possibility to discriminate between Gα q and Gα 11 proteins, since it stimulates inositol phosphate formation in a strictly Gα q -dependent manner. (sigmaaldrich.com)

Tdap, [tetanus, A nasopharyngeal swab specimen was collected from the diphtheria, and pertussis]), and changes to circulating B. infant on March 26, 2013, for testing at a commercial labo- pertussis strains, which led to a mismatch with vaccine ratory. (cdc.gov)
Nine HPTs were genotyped in a collection of 90 geographically and temporally diverse B. pertussis strains using the polymerase chain reaction/ligase detection reaction (PCR/LDR) assay. (biomedcentral.com)
Six HPTs were polymorphic in this collection of B. pertussis strains. (biomedcentral.com)
Of note, one of these polymorphic HPTs was found in the fimX promoter, where a single base insertion variant was present in seven strains, all of which were isolated prior to introduction of the pertussis vaccine. (biomedcentral.com)

BOOSTRIX may be administered as an additional dose 9 years or more after the initial dose of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap). (nih.gov)
Severe allergic reaction (e.g., anaphylaxis) after a previous dose of any tetanus toxoid-, diphtheria toxoid-, or pertussis antigen-containing vaccine or to any component of BOOSTRIX. (nih.gov)

B. pertussis attaches to the cilia of the respiratory epithelial cells , proliferates and produces virulence factors that paralyze the cilia, and causes inflammation of the respiratory tract, which interferes with the clearing of pulmonary secretions. (wikidoc.org)

they had received 2, 1, and 3 doses, respectively, www.cdc.gov/pertussis/surv-reporting/cases-by-year. (cdc.gov)
Tdap contains lower doses of diphtheria and pertussis components (indicated by the lower case d and p ). (msdmanuals.com)
World Health Organization (WHO) estimates suggest that in 2008, approximately 82% of all infants worldwide received 3 doses of pertussis vaccine, which prevented approximately 687,000 deaths. (medscape.com)

The earliest outbreaks of pertussis were recognized by Bahaodwole Razi in 1502 in Persia and by Guillaume de Baillou in 1578 in France. (wikidoc.org)
CDC's pertussis and diphtheria laboratorians and epidemiologists can assist health departments during pertussis outbreaks or when a doctor suspects a case of diphtheria. (cdc.gov)

After purification, filamentous hemagglutinin (FHA) and pertussis toxin (PT) are combined to obtain a 1:1 ratio and are then treated with formaldehyde to inactivate PT. (cdc.gov)

Humans are the only known reservoir for B. pertussis. (wikipedia.org)

Bordetella pertussis is a Gram-negative aerobic bacterium. (canada.ca)
Bordetella bronchiseptica", stain RB50, is a small (0.4 by 8.0 um), gram negative, rod shaped beta-proteobacteria belonging to the Bordetellae family. (kenyon.edu)
Bordetella pertussis is a gram- negative bacterium that is responsible for the highly contagious respiratory disease known as pertussis. (cdc.gov)

Yet, compared to systemic responses, mucosal immune responses have attracted relatively little attention in the context of pertussis vaccine development. (frontiersin.org)

One dose of acellular pertussis-containing vaccine (Tdap) vaccine should be administered to adults if they have not previously received pertussis vaccine in adulthood (18 years of age and older). (canada.ca)

Pertussis is usually suspected based on clinical findings and confirmed by either nasopharyngeal culture, polymerase chain reaction (PCR), or serology. (wikidoc.org)

Young infants are also at highest risk of pertussis-associated complications. (canada.ca)

The clinical course of pertussis is divided into three stages. (canada.ca)

Respiratory specimens were analysed by RT-PCR for rhinovirus, enterovirus and respiratory syncytial virus and by PCR for adenovirus, Chlamydia pneumoniae , Mycoplasma pneumoniae and Bordetella pertussis . (bmj.com)

The disease pertussis was first described by French physician Guillaume de Baillou after the epidemic of 1578. (wikipedia.org)

Yamasaki S, Sato T, Hidaka Y, Ozaki H, Ito H, Hirayama T, Takeda Y, Sugimura T, Tai A, Shimonishi Y (1990) Structure-activity relationship of Escherichia coli heat-stable enterotoxin: Role of Ala residue at position 14 in toxin-receptor interaction. (springer.com)
His Bordetella pertussis study incorporates themes from Cyclase activity, Fatty acylation and Escherichia coli. (research.com)

B. pertussis infects its host by colonizing lung epithelial cells. (wikipedia.org)
Another example, the alpha-toxin of Staphylococcus aureus is also involved in pneumonia and attacks pulmonary epithelial cells. (biomedcentral.com)
The toxin forms transmembrane pores, which leads to the collapse of the cells and epithelial cells can no longer exercise their barrier function [ 6 ]. (biomedcentral.com)

Cholera toxin (CTX, produced by Vibrio cholerae ) is responsible for the infectious gastro-enteritis known as cholera. (sigmaaldrich.com)

Anatomy8

Organisms8

Diseases6

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes14

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Cough43

CyaA9

Parapertussis9

Antibodies4

Adenylate cyclase15

Acellular pertussis vaccines4

Vaccination14

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Bacterial Toxin1

Bacteria6

Immunization5

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Cases of pertussis worldwide2

Causative2

Coccobacillus2

Infection13

Isolates2

Subunit2

Immunity1

Protein4

Symptoms4

Species3

Corynebacterium1

Control of pertussis1

Incidence2

Proteins1

Strains4

Toxoid2

Respiratory Tract1

Doses3

Outbreaks2

Filamentous1

Humans1

Gram3

Vaccine Development1

Tdap1

Polymerase chain re1

Complications1

Clinical1

Specimens1

Guillaume de Bail1

Escherichia2

Epithelial3

Cholera1