Bones contains stem cells. Medical search. Frequent questions

Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
In this study, Kalajzic and his team are the first to report the existence of these progenitor cells within cortical bone that can generate new bone-forming cells-osteoblasts-that can be used to help remodel a bone. (medicalxpress.com)
Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. (cipsm.de)
In summary our results indicate that infusion of BMMCs enriched with stem/progenitor cells is a safe and effective treatment for the early stages of ONFH in SCD patients. (bioskinrevive.com)
Although these stem and progenitor cells promote healthy bone repair in other contexts, they are inappropriately activated to cause a pathological bony protuberance in the context of arthritis," said Gage Crump , a professor of stem cell biology and regenerative medicine at USC. (usc.edu)
Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
Umbilical cord blood (UCB) and bone marrow (BM)-derived stem and progenitor cells possess two characteristics required for successful tissue regeneration: extensive proliferative capacity and the ability to differentiate into multiple cell lineages. (ox.ac.uk)
These results, therefore, provide a global view of the signaling and regulatory network that controls oxygen sensing in human adult stem/progenitor cells derived from hematopoietic tissues. (ox.ac.uk)
Within the Collaborative Research Centre (CRC) 1149 "Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma", we offer an exciting interdisciplinary project to understand the cellular and molecular mechanisms of glucocorticoid action in skeletal stem/progenitor cells during bone regeneration. (hotdailytrends.com)
Unraveling mechanisms of GC signaling in skeletal stem/progenitor cells will provide rationales for therapeutic approaches in the field of bone regeneration. (hotdailytrends.com)
Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. (cellsurgicalnetwork.com)
We investigated the effects of transplanting nonhematopoietic adult bone marrow stem/progenitor cells (multipotent stromal cells) into the corpus cavernosum in a rat model of bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)
CONCLUSIONS: Transplantation of adult stem/progenitor cells may provide an effective treatment for erectile dysfunction after radical prostatectomy. (cellsurgicalnetwork.com)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

To reach this conclusion, the researchers observed the stem cells within an ex vivo bone transplantation model. (medicalxpress.com)
Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
Transplantation experiments further verified the cell-autonomous nature of this phenotype. (cipsm.de)
Some clinical work popped up but it was mainly related to bone marrow loss after hematopoietic stem cell transplantation such as during treatment for blood cancers. (ipscell.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Data from preclinical transplantation studies suggested that stromal cell infusions not only prevent the occurrence of graft failure, but they have an immunomodulatory effect. (nih.gov)
Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation. (nih.gov)
2,732 nasal wash samples collected during the fi rst year gesting that these viruses might not cause respiratory ill- after allogeneic hematopoietic cell transplantation from 222 ness in immunocompetent children. (cdc.gov)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
Nucleoside analogs such as fludarabine or cladribine pose a risk of stem cell damage and leukemogenesis and should not be used as initial therapy in patients who are candidates for stem cell transplantation (SCT). (medscape.com)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
The hematopoietic stem cell transplantation units (HSCT) are recognized as places of high complexity treatments with relevant morbidity incidence. (bvsalud.org)

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
Background: Connective tissue progenitors (CTPs) from native bone marrow (BM) or their culture-expanded progeny, often referred to as mesenchymal stem/stromal cells, represents a promising strategy for treatment of cartilage injuries. (whiterose.ac.uk)
Clinical Relevance: The harvest technique of BM may be of major importance in determining the clinical success of BM mesenchymal stem/stromal cells in cartilage repair. (whiterose.ac.uk)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Cytokines and growth factors (interleukin-8 transforming growth factor-beta stromal cell-derived factor-1alpha and vascular endothelial growth factor) that mediate endogenous bone regeneration were also produced by expanded MSCs from SCD patients. (bioskinrevive.com)
The thrust of research in this area is focused on mesenchymal stem/stromal cells or MSCs, but several of these trials are not interventional studies using cells at all. (ipscell.com)
MSCs can be differentiated along different cell lineages of mesodermal origin including osteoblasts, chondrocytes, skeletal myocytes or visceral stromal cells 9 . (nature.com)
It also stimulated new growth in human bone marrow stromal cells in lab experiments. (sciencedaily.com)
There has been an increasing interest in recent years in the stromal cell system functioning in the support of hematopoiesis. (nih.gov)
The stromal cell system has been proposed to consist of marrow mesenchymal stem cells that are capable of self-renewal and differentiation into various connective tissue lineages. (nih.gov)
Dexter demonstrated in 1982 that an adherent stromal-like culture was able to support maintenance of hematopoietic stem as well as early B lymphopoeisis. (nih.gov)
Recent data from in vitro models demonstrating the essential role of stromal support in hematopoiesis shaped the view that cell-cell interactions in the marrow microenvironment are critical for normal hematopoietic function and differentiation. (nih.gov)
MATERIALS AND METHODS: Multipotent stromal cells were isolated from the bone marrow of transgenic green fluorescent protein rats by plastic adherence (rat multipotent stromal cells) or magnetic activated cell sorting using antibodies against p75 low affinity nerve growth factor receptor (p75 derived multipotent stromal cells). (cellsurgicalnetwork.com)
Immediately after injury 8 rats each were injected intracavernously with phosphate buffered saline (vehicle control), fibroblasts (cell control), rat multipotent stromal cells (cell treatment) or p75 derived multipotent stromal cells (cell treatment). (cellsurgicalnetwork.com)
Rats injected with typical multipotent stromal cells had partial erectile function rescue compared with animals that received p75 derived multipotent stromal cells. (cellsurgicalnetwork.com)
Enzyme-linked immunosorbent assay suggested that basic fibroblast growth factor secreted by p75 derived multipotent stromal cells protected the cavernous nerve after bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. (wakehealth.edu)

Mesenchymal stem cell therapy is one of the most commonly utilized cell therapies currently and evidence is mounting on the uses it may have for musculoskeletal diseases1,2. (ivis.org)
Stem cells most commonly used are those in the adult mesenchymal stem cell arena and are derived from bone marrow aspirates or fat harvest. (ivis.org)
Recent efforts demonstrated that the multiple mesenchymal lineages can be clonally derived from a single mesenchymal stem cell, supporting the proposed paradigm. (nih.gov)

Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Specific kinds of MSCs can readily generate bone in the lab with specific differentiation protocols so there is some logic to testing them. (ipscell.com)
Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. (nature.com)
Mesenchymal stem cells (MSCs) support chondrogenic differentiation and are an attractive cell source for cartilage tissue engineering. (nature.com)
Some of the main issues are identification of the optimal precursor cell types, establishment of growth and differentiation conditions that meet safety and good manufacturing practice standards, and manipulation of the surrounding environment to allow transplanted cells to survive and function. (sahmri.org.au)
Building on these efforts, Vunjak-Novakovic continued to perform complex cell biological studies that address fundamental problems such as the growth and differentiation of stem cells for functional skeletal and cardiac mechanics, the growth of mammalian cells in microgravity environment, and the role of chondrocytes in cartilage tissue biomechanics. (wikipedia.org)
Mechanisms of action may include differentiation of the CD34 cells into neurons, secretion of neurotrophic factors, transfer of mitochondria and release of mRNA. (medicalresearch.com)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
However, recent identification of spontaneous cell fusion and limited neuronal differentiation has tempered initial optimism. (ox.ac.uk)
Within the normal BM and in pathological conditions, areas of hypoxia may have a role in maintaining stem cell fate or determining the fine equilibrium between their proliferation and differentiation. (ox.ac.uk)
In this study, the transcriptional profiles and proliferation and differentiation potential of UCB CD133(+) cells and BM mesenchymal cells (BMMC) exposed to normoxia and hypoxia were analyzed and compared. (ox.ac.uk)
The differentiation potential of UCB CD133(+) clonogenic myeloid cells was unaltered by short exposures to hypoxia. (ox.ac.uk)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

But the cartilage regeneration capacity of these cells remains unpredictable because of cell heterogeneity. (whiterose.ac.uk)
Since the iliac crest remains a frequent site of BM harvest for musculoskeletal regeneration, the authors also compared the spatial distribution of these subsets in trabeculae of femoral head and iliac crest and found CD2711CD561 bone-lining cells in both tissues. (whiterose.ac.uk)
These cartilage outgrowths had many of the distinctive hallmarks of the cartilage seen during bone regeneration, suggesting further parallels between pathological bone spur formation and normal bone repair. (usc.edu)
Crump and fellow USC Stem Cell faculty member Francesca V. Mariani began studying the role of Sox9-positive cells in bone regeneration in 2013, with support from a $400,000 pilot grant from the Regenerative Medicine Initiative, funded by the Dean of the Keck School of Medicine of USC, as well as a $2.4 million Research Project Grant from the National Institutes of Health. (usc.edu)
We concluded that the use of mesenchymal stem cells represent new and effective therapeutic tools for bone regeneration in dentistry and medicine. (bvsalud.org)
The bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone. (sciencedaily.com)
We delivered the DNA to the cells, so that the cells produce the protein and that's how the protein is generated to enhance bone regeneration," explains Aliasger Salem, professor in the College of Pharmacy and a co-corresponding author on the paper, published in the journal Biomaterials . (sciencedaily.com)
When cells migrate into the scaffold, they meet with the plasmid, they take up the plasmid, and they get the encoding to start producing PDGF-B, which enhances bone regeneration. (sciencedaily.com)
Glucocorticoids (GCs) are steroid hormones that respond to stress, and GC signaling is important for bone regeneration. (hotdailytrends.com)
Adipose-derived stem cells have been shown to enhance bone healing and regeneration in numerous experimental models . (bvsalud.org)
The Laboratory of Bone Organ Modeling and Regeneration received the 2023 Article of the Year Award for their research generating human mini-bones in a laboratory setting which mimics the properties of real human bone. (lu.se)

The study also showed that the adult OCRs are distinct from mesenchymal stem cells (MSCs), which play a role in bone generation during development and adulthood. (sciencedaily.com)
Researchers presumed that MSCs were the origin of all bone, cartilage, and fat, but recent studies have shown that these cells do not generate young bone and cartilage. (sciencedaily.com)
The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults. (sciencedaily.com)
Within tendon and ligament injuries doses of 10-20 million per site is typically delivered and, based on delivery mechanisms, intralesional implantation of MSCs still seems to be the preferred and most efficacious method to deliver the cells. (ivis.org)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)

In these mice, a different colored fluorescent protein labeled each of eight distinct cell populations. (usc.edu)
This allowed the scientists to view the fluorescent labels under a microscope and trace how the various cell populations contribute to the formation of arthritic bone spurs. (usc.edu)
The proposed model describes the logical occurrence of discrete time delays, that by themselves present mathematical challenges, in the evolving cell populations under consideration. (ebi.ac.uk)
Because of their ready availability, their ability to be easily expanded, and reports of neural potential, bone marrow-derived populations have become the focus of intense study with regard to their potential clinical utility. (ox.ac.uk)
Both progenitor cell populations responded to hypoxic stimuli by stabilizing the hypoxia inducible factor (HIF)-1alpha protein. (ox.ac.uk)
A series of in vitro and in vivo analyses were performed to evaluate their characteristics as stem cell populations. (elsevierpure.com)
But when it comes to studying diverse populations of cells, this approach can fall short and an extra dimension is needed. (lu.se)

Cortical bone-derived stem cells (CBSCs) are reportedly essential for osteogenic lineages, bone maintenance and repair. (biomedcentral.com)

Your body will replace the donated bone marrow in about 4 to 6 weeks. (medlineplus.gov)

The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. (sciencedaily.com)
The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)
Previous studies indicated that exosomal miR-29a-3p derived from human bone mesenchymal stem cells (hBMSCs) could efficiently suppress cell migrative ability and vasculogenic mimicry in glioma [ 15 ]. (hindawi.com)
Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells. (ox.ac.uk)
In this study, we demonstrate the monoclonal neural and mesodermal potential of adult human bone marrow mesenchymal cells. (ox.ac.uk)
Human bone marrow stem cells (hBMSCs) represent a promising regenerative material because of their mutipotency, including their ability to regenerate collagenous soft tissues. (elsevierpure.com)

Can a vitamin transform natural killer cells into a cancer therapy? (medicalxpress.com)
high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
Holistic Care is one of the best stem cell clinics in Mexico and the top conventional and alternative medicine offering Stem Cell Therapy and Biological dentistry. (placidway.com)
Introduction Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). (bioskinrevive.com)
Could stem cell therapy help reduce the severity of osteoporosis? (ipscell.com)
In this regard, radiation therapy and accidental exposure to gamma (γ)-ray radiation have been shown to inhibit bone formation and increase the risk of fractures. (biomedcentral.com)
We offer advanced treatments like CAR T-cell therapy that result in excellent survival rates for our patients, and our program is recognized as a Top 50 Children's Cancer Program by U.S. News & World Report for 2023-2024. (hopkinsmedicine.org)
Although there is a plurality of experimental models in vivo (animal species) and clinical studies (anatomical sites), there is prevalence of preclinical trials of cell therapy (27.03%), indicating good tissue biocompatibility and the highest osteogenesis after graft. (bvsalud.org)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)

You have a background or ambitions in transgenic animal research, metabolic physiology, cell biology, molecular biology, and fluorescence/ confocal microscopy. (hotdailytrends.com)
Each year, the Lund Stem Cell Center recognizes notable scientific achievements made by our members in the fields of stem cell biology and regenerative medicine through our Article of the Year Award. (lu.se)
This recognition highlights the outstanding contributions made by our members in advancing the fields of stem cell biology and regenerative medicine. (lu.se)

Stem Cell Treatment in Puerto Vallarta Mexico presents regenerative medicine solutions based on proven medical innovation and research. (placidway.com)
The term Regenerative Medicine encompasses the use of stem cell therapies, growth factors and any biologic therapeutic that will enhance musculoskeletal repair. (ivis.org)
Her focus is on engineering human tissues for regenerative medicine, stem cell research and modeling of disease. (wikipedia.org)

A bone marrow transplant is when stem cells are removed from the bone marrow for transplant. (differencebetween.net)

Autologous bone marrow transplant is when people donate their own bone marrow. (medlineplus.gov)
SCOTS uses autologous bone marrow derived stem cells (BMSC) typically provided to the eyes by combining retrobulbar, subtenons and intravenous injections. (medicalresearch.com)

The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
The effects of melatonin on postradiation bone healing in vivo were evaluated by micro-CT and pathological analysis. (biomedcentral.com)
The study is novel in that the researchers directly delivered bone-producing instructions (using piece of DNA that encodes for a platelet-derived growth factor called PDGF-B) to existing bone cells in vivo, allowing those cells to produce the proteins that led to more bone production. (sciencedaily.com)
The histology and immunohistochemistry results revealed that WSC significantly increased the amount of collagen formed in vivo by both types of stem cells. (elsevierpure.com)

Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body's ability to repair bone injury--a process that declines significantly in old age," says Timothy C. Wang, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine at CUMC, who initiated this research. (sciencedaily.com)
So ultimately, I'm trying to find changes within these stem cells that we can target and develop new therapies. (selectscience.net)
Bone loss therapies using mesenchymal stem cells suggest a promising prospect for use in oral reconstructive surgeries. (bvsalud.org)
Neural stem cells (NSCs) have generated considerable interest because of their potential as a source of defined cells for drug screening or cell-based therapies for neurodegenerative diseases. (ox.ac.uk)

Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes. (sciencedaily.com)
The discovery by researchers at Columbia University Medical Center (CUMC) is reported today in the online issue of the journal Cell . (sciencedaily.com)
Researchers also showed that OCR stem cells, when transplanted to a fracture site, contribute to bone repair. (sciencedaily.com)
The researchers also suspect that OCR cells may play a role in soft tissue cancers. (sciencedaily.com)
Oct. 8, 2021 Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. (sciencedaily.com)
Researchers found out that endurance exercise triggers the stem cells to preferentially mature into bone. (scientificamerican.com)
A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers at the UConn School of Dental Medicine. (medicalxpress.com)
Hence, researchers have been exploring new approaches to osteoporosis like stem cells. (ipscell.com)
NYSCF researchers recently published a study outlining an exciting new bioengineering process (called Segmental Additive Tissue Engineering, or "SATE") that allows scientists to create large scale, personalized bone grafts from stem cells. (nyscf.org)
In the interview, the researchers underscored the problems with current treatments and the advantages of engineering bone grafts from stem cells. (nyscf.org)
With SATE, however, researchers can combine bioengineered segments of bone to replace large scale damage-a first for the field. (nyscf.org)
Someday, the use of bone transplants and alloplastic materials for bone reconstructions might become a thing of the past," the researchers say. (nyscf.org)
Researchers have created an implantable bio patch that regrows bone in a living body, using existing cells. (sciencedaily.com)
Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells. (sciencedaily.com)
The researchers then loaded the bio patch with synthetically created plasmids, each of which is outfitted with the genetic instructions for producing bone. (sciencedaily.com)
Aerial and cross-sectional scans showed the plasmid-encoded scaffolds had spurred enough new bone growth to nearly close the wound area, the researchers report. (sciencedaily.com)
It's no secret to readers here that DrJohn and DrGeorge have day jobs as stem cell researchers, both in the lab and the clinic, and have developed skincare products whose hero ingredients (human growth factors, cytokines, mRNAs,miRNAs, etc) derive from stem cells on permanent loan from bone marrow of young adult humans. (barefacedtruth.com)
In today's world of science, single-cell sequencing technologies allow researchers to examine the genetic details of individual cells, creating a treasure trove of data. (lu.se)

A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. (sciencedaily.com)
If you make a fracture in the mouse, these cells will come alive again, generate both bone and cartilage in the mouse--and repair the fracture. (sciencedaily.com)
Hypothesis: The harvest technique of BM may highly influence stem cell heterogeneity and, thus, cartilage formation because these cells have distinct spatial localization within BM from the same bone. (whiterose.ac.uk)
At the edge of the arthritic joint, these cells contributed to cartilage outgrowths that later turned into pathological bone spurs. (usc.edu)
Sarcoma is a cancer of connective tissues such as bones, muscles, cartilage, and blood vessels. (healthline.com)

but the overall therapeutic process lasts for a relatively long period, and a variety of complications may arise, such as pin loss, infection around the transmucosal pin, bone fracture, and restriction in joint motion [ 8 ]. (hindawi.com)
Bone marrow mesenchymal stem cells (BMSCs) have potential therapeutic benefits for the treatment of endometrial diseases and injury. (biologists.com)

Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
Bone marrow transplants are also used in cases where a person has cancers such as some types of lymphomas and leukemias, and multiple myeloma. (differencebetween.net)
Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)
Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)

Abstract: The cancer stem cell hypothesis has gained currency in recent times but concerns remain about its scientific foundations because of significant gaps that exist between research findings and comprehensive knowledge about cancer stem cells (CSCs). (ebi.ac.uk)

Many deaths, especially from bone cancer, have occurred in humans following long-term oral exposure to radium-226 and radium-228. (cdc.gov)

Jan. 29, 2020 Scientists used molecular motors to manipulate the protein matrix on which bone marrow-derived mesenchymal stem cells are grown. (sciencedaily.com)
Sierra H. Root et al, Perivascular osteoprogenitors are associated with transcortical channels of long bones, STEM CELLS (2020). (medicalxpress.com)
I found a review article from 2020 that listed 2 interventional trials of stem cells for osteoporosis, but neither had published data at that time and one was terminated. (ipscell.com)

Bone marrow is the soft, fatty tissue inside your bones. (medlineplus.gov)
To learn more about adipose stem cells (ASCs) and how they heal tissue and have the capacity to cure diseases visit our fat stem cell archives. (cosmeticsurg.net)
Given its high calcium content, bone tissue is sensitive to ionizing radiation and absorbs nearly 40% more radiation than the surrounding tissues [ 2 ]. (biomedcentral.com)
Cancer is a large group of diseases that occur when abnormal cells divide rapidly and can spread to other tissue and organs. (healthline.com)
Whilst it is clear that BMSSC-mediated osteogenesis has the capacity to integrate with pre-existing bone tissue, substantial progress in this and other approaches needs to be achieved for the accurate reassembly of functional complex organ systems. (sahmri.org.au)
It is anticipated that a concerted multidiscipline approach is required to facilitate the reality and great potential benefits of cell-based tissue engineering applications. (sahmri.org.au)
She also heads the laboratory for Stem Cells and Tissue Engineering at Columbia University. (wikipedia.org)
The focus of her research is on engineering functional human tissues, by an integrated use of stem cells, biomaterial scaffolds and bioreactors, which are culture systems designed to regulate and stimulate tissue development. (wikipedia.org)
The bone marrow remains the main source of tissue mesenchymal stem cells (79.31%), characterized by adherence, immunophenotyping and multipotency, which can promote osteogenesis in vitro. (bvsalud.org)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
The plasmid-seeded bio patch grew 44-times more bone and soft tissue in the affected area than with the scaffold alone, and was 14-fold higher than the affected area with no manipulation. (sciencedaily.com)
HR 4.4), and detection of a respiratory virus in the previ- marily from the kidney, bone marrow, and lymphoid tissue, ous 2 weeks predicted KIPyV detection (HR 3.4). (cdc.gov)
White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
We previously found that water-soluble chitin (WSC) enhances the ability of human periodontal ligament stem cells (hPDLSCs) to synthesize collagen tissue. (elsevierpure.com)
These findings suggest that the appropriate stem-cell source should be chosen based on the purpose of the required regenerated tissue. (elsevierpure.com)
Acute leukopenia, with almost total absence of granular leukocytes, leukoblastic groups and lymphoid tissue in the bone marrow, was reported in the case of a 36-year-old chemist who had worked with radium for 14 years (Reitter and Martland 1926). (cdc.gov)

Peripheral blood stem cell collection. (medlineplus.gov)
In this light, a mathematical model that considers hematopoietic dynamics in the diseased state of the bone marrow and peripheral blood is proposed and used to address findings about CSCs. (ebi.ac.uk)
Model analyses and simulations suggest that the emergence of the cancer stem cell population alongside other malignant cells engenders higher dimensions of complexity in the evolution of malignancy in the bone marrow and peripheral blood at the expense of healthy hematopoietic development. (ebi.ac.uk)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)

This is a new discovery of perivascular cells residing within the bone itself that can generate new bone forming cells," said Kalajzic. (medicalxpress.com)
Stem cells for bone have long been thought to be present within bone marrow and the outer surface of bone, serving as reserve cells that constantly generate new bone or participate in bone repair. (medicalxpress.com)
The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of Rheumatic Diseases . (usc.edu)
Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
The Division of Molecular Hematology (DMH) aims to generate new knowledge about the regulation of blood cell development by applying recent advances in stem cell technology, in order to dissect the molecular regulation of hematopoiesis. (lu.se)

There are many different types of stem cells - but they don't all have the same jobs in our bodies, and don't look the same (biochemically and functionally). (barefacedtruth.com)

Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. (cipsm.de)
Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. (cipsm.de)
Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis. (cipsm.de)

If you are a plastic surgeon fascinated with adult stem cells from adipose fat, it gives one time to transcribe your thoughts. (cosmeticsurg.net)
Translation:adipose fat contains a higher population of adult stem cells than bone marrow. (cosmeticsurg.net)
To intelligently employ bio-signaling molecules in one's medical practice (or one's home skincare regimen), there should be familiarity with the significant differences among the bio-signals patterns produced by adipose (fat) stem cells and bone marrow mesenchymal stem cells, and for completeness, fibroblasts. (barefacedtruth.com)
Adipose stem cells are most proficient at creating more fat cells, and at producing pro-inflammatory cytokine patterns. (barefacedtruth.com)
Adipose-Derived Stem Cells Enhance Graft Incorporation and Mineralization in a Murine Model of Irradiated Mandibular Nonvascularized Bone Grafting. (bvsalud.org)
The purpose of this study was to determine the impact of adipose-derived stem cells on nonvascularized bone graft incorporation in a murine model of irradiated mandibular reconstruction . (bvsalud.org)
Thirty isogenic rats were randomly divided into 3 groups nonvascularized bone graft (control), radiation with nonvascularized bone graft (XRT), and radiation with nonvascularized bone graft and adipose-derived stem cells (ASC). (bvsalud.org)
Adipose-derived stem cells enhance nonvascularized bone graft incorporation in the setting of human -equivalent radiation . (bvsalud.org)

The ability to use bone grafts grown from patients' own cells could help overcome these issues, which include limited bone transplant availability, risk of disease transmission, long recovery time, poor graft integration and remodeling, and biomaterial associated infections. (nyscf.org)
While engineering bone grafts from stem cells addresses many of the limitations surrounding current treatments, it has traditionally only been done for small defects. (nyscf.org)
The technique is also standardized, versatile, and easy to implement, allowing for bioengineered bone grafts to more quickly make the leap from bench to bedside, where the team hopes they will provide much-needed relief to patients. (nyscf.org)
However, the destructive effects of radiotherapy on native bone preclude the use of nonvascularized bone grafts in head and neck cancer patients . (bvsalud.org)

Bone marrow contains stem cells, which are immature cells that become blood cells. (medlineplus.gov)
The major cause of this syndrome is depletion of immature parenchymal stem cells in specific tissues. (cdc.gov)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

The cells or blood is then tested for special proteins, called human leukocytes antigens (HLAs). (medlineplus.gov)
Among them, bone morphogenic proteins (BMPs) are thought to be the most potent osteoinductive factors and play a key role in the process of bone formation during DO. (hindawi.com)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
All groups underwent mandibular reconstruction of a critical-sized defect with a nonvascularized bone graft from the contralateral hemimandible. (bvsalud.org)
After a 60-day recovery period, graft incorporation and bone mineralization were compared between groups. (bvsalud.org)
Compared with the control group , the XRT group demonstrated significantly decreased graft incorporation (P = 0.011), bone mineral density (P = 0.005), and bone volume fraction (P = 0.001). (bvsalud.org)
Compared with the XRT group, the ASC group achieved a significantly increased graft incorporation (P = 0.006), bone mineral density (P = 0.005), and bone volume fraction (P = 0.013). (bvsalud.org)

Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)

Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)

The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
BMSCs interact with uterus parenchymal cells by direct contact or indirect secretion of growth factors to promote functional recovery. (biologists.com)

Large bone defects resulting from trauma, congenital defects, neoplasm, failed arthroplasty, and infection are quite common [ 1 , 2 ], and the incidences of nonunion and delayed union are very high [ 3 ]. (hindawi.com)
It remains a great challenge for orthopedic surgeons to achieve osseous reconstruction for nonunion and bone defects. (hindawi.com)
The healing of bone defects can be challenging for clinicians to manage, especially after exposure to ionizing radiation. (biomedcentral.com)
This study suggested that melatonin could protect CBSCs against γ-ray radiation and assist in the healing of postradiation bone defects. (biomedcentral.com)
It also can be used to repair birth defects where there's missing bone around the head or face. (sciencedaily.com)

The miR-29a-3p level was decreased, and PTEN level was elevated in laryngocarcinoma tissues and the cancer cell lines. (hindawi.com)
In ways not achieved by any other research team, Vunjak-Novakovic's group has succeeded to control cell growth, metabolism and function of engineered human tissues. (wikipedia.org)

Flow cytometry analysis showed a significantly higher number of hematopoietic stem/endothelial progenitor cell markers in concentrated BMMCs when compared with bone marrow aspirate indicating an enrichment of these cell types. (bioskinrevive.com)

Further study could provide greater understanding of how to prevent and treat osteoporosis, osteoarthritis, or bone fractures. (sciencedaily.com)
Osteoporosis is a gradual loss of bone with aging to the point where fractures become likely. (ipscell.com)

These are a group of cancers that a genetic change is acquired within the very rare blood bone marrow stem cells. (selectscience.net)
Cancer occurs when genetic mutations in abnormal cells cause them to divide rapidly. (healthline.com)
The team created a scaffold seeded with plasmids containing the genetic information for producing bone. (sciencedaily.com)
Whether within the body or in a laboratory flask, growth factors and cytokines patterns are determined by the genetic material within the cells that produce them. (barefacedtruth.com)

People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
In this video, Jennifer O'Sullivan, MRC Weatherall Institute of Molecular Medicine, discusses her work studying the changes in rare bone marrow stem cells that lead to blood cancers. (selectscience.net)
Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
Cancers are named for the area in which they begin and the type of cell they are made of, even if they spread to other parts of the body. (healthline.com)

Anatomy67

Organisms16

Diseases20

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes50

Disciplines and Occupations4

Technology, Industry, Agriculture4

Information Science2

Named Groups1

Health Care1

Progenitor cells19

Transplantation22

Stromal23

Mesenchymal Stem3

Differentiation16

Regeneration11

MSCs5

Populations7

Lineages1

Donated bone marrow1

Human bone6

Therapy10

Biology3

Regenerative medicine3

Removed from the bone marrow1

Autologous2

Vivo5

Therapies4

Researchers18

Cartilage5

Therapeutic2

Transplants5

Abstract1

Humans1

20203

Tissue17

Peripheral blood4

Generate5

Types of stem cells1

Neural stem3

Adipose8

Grafts4

Immature3

Proteins3

Graft5

Donor's blood1

Osteoblasts and chondrocytes2

BMSCs2

Defects5

Tissues2

Marrow aspirate1

Fractures2

Genetic4

Cancers4