• It has been observed that higher serum osteocalcin levels are relatively well correlated with increases in bone mineral density during treatment with anabolic bone formation drugs for osteoporosis, such as teriparatide. (wikipedia.org)
  • A cross-sectional study comparing the bone density, bone biochemical markers (osteocalcin, CTX) and three measures to assess physical performance: timed get-up-and-go test "TGUG", five-times-sit-to-stand test "5 TSTS" and 8-feet speed walk "8 FSW" of users and never users OC. (biomedcentral.com)
  • Many risk factors contribute to its development and it is now well recognized that a chronically hypoestrogenic state increases bone turnover that, in turn, causes a critical decrease in bone mineral density (BMD), an important determinant of fracture risk. (biomedcentral.com)
  • Such markers can also be useful in selected cases to improve the assessment of individual fracture risk when bone mineral density (BMD) measurement by itself does not provide a clear answer. (medscape.com)
  • A cross-sectional analysis of 1,662 community dwelling elderly Japanese men suggested that habitual natto intake was significantly associated with higher bone mineral density (BMD). (springer.com)
  • Booth SL, Broe KE, Peterson JW, Cheng DM, Dawson-Hughes B, Gundberg CM, Cupples LA, Wilson PW, Kiel DP (2004) Associations between vitamin K biochemical measures and bone mineral density in men and women. (springer.com)
  • Until recently, supporting evidence of a role for vitamin K in age-related bone loss was largely based on associations between dietary intakes or biological markers of vitamin K status and bone mineral density (BMD) or hip fracture. (dietitians.ca)
  • Fracture incidence was lower with a 5000 ug vitamin K1 treatment despite no effect on bone density. (dietitians.ca)
  • Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density or geometry in healthy postmenopausal North American women. (dietitians.ca)
  • The present study measured longitudinal changes in bone turnover markers in elderly patients with vertebral fracture and investigated the relationship among bone turnover markers, duration of bed rest and bone mineral density (BMD). (openorthopaedicsjournal.com)
  • Osteoporosis is related to the decrease of bone density, osteoporosis requires attention from dentists because it can also occurs in the jaw bone. (walshmedicalmedia.com)
  • Osteoporosis is calculated with a quantitative assessment of bone density, which is called Bone Mineral Density (BMD). (walshmedicalmedia.com)
  • The best imaging modalities to assess bone density are the Dual Energy examination methods X-ray Absorptiometry (DEXA). (walshmedicalmedia.com)
  • The osteoporotic jaw bone will experience the decrease of jaw bone density, the increase alveolar jaw bone resorption, and also the increase risk of periodontal disease and tooth loss. (walshmedicalmedia.com)
  • It is crucial for dentists and especially prosthodontist to diagnose jaw bone density, especially in postmenopausal women before prosthodontic treatment. (walshmedicalmedia.com)
  • O steoporosis is a medical condition in which the bones become brittle and fragile due to decreased bone mass and bone mineral density leading to frequent fragility fractures. (vigyanprasar.gov.in)
  • For perimenopausal women (women naturally approaching menopause) and having low bone density and other risk factors, are recommended estrogen and drugs for improved bone density and strength. (vigyanprasar.gov.in)
  • Bone Markers are indicators that increase in proportion to fracture risk, independent of bone mineral density. (vigyanprasar.gov.in)
  • Another one-year postmenopausal clinical trial conducted at Hyderabad and Medical research Centre, Kasturba Health Society, Mumbai, demonstrated anti-osteoporotic activity, maintenance of bone mineral density, relief from deteriorated musculoskeletal symptoms, and possible fracture reduction. (vigyanprasar.gov.in)
  • Previous research has linked moderate drinking with improved bone density - women who drink moderately have higher bone density than non-drinkers or heavy drinkers - but such observational studies connecting people's dietary or drinking patterns to health effects have not been able to determine cause and effect. (time.com)
  • Researchers tracked certain blood markers of bone health throughout, and found that these markers of bone density correlated positively with alcohol consumption: in other words, the more the women drank within the moderate range, the better their bone health looked. (time.com)
  • Although there is substantial evidence that moderate alcohol consumption correlates with higher bone mass density in postmenopausal women, it is much less clear whether consuming alcohol lowers the fracture rate," the authors note. (time.com)
  • 1 year) to see the bone density increase. (steroid-sarm.com)
  • It decreases bone resorption and bone turnover, increases bone mineral density (BMD) and decreases fracture incidence. (drugcentral.org)
  • 1 Magnesium citrate is a highly bioavailable form of magnesium 2 that helps to maintain bone mineral density: in healthy young men, regular magnesium supplementation has been shown to suppress bone turnover rates. (wellvishealth.ca)
  • In human participants with osteroporosis, supplementation with the plant-based boron compound calcium fructoborate was found to improve bone density. (wellvishealth.ca)
  • Diagnosis of osteoporosis is not based on evaluation of bone markers, and bone mineral density (BMD) assessment is still the criterion standard for evaluation and diagnosis. (medscape.com)
  • Following a parathyroidectomy there is a bone mineral density (BMD) improvement in patients with primary hyperparathyroidism. (thieme-connect.de)
  • Although bone density improves 2 years after surgery in patients with primary hyperparathyroidism and there is a restoration of bone turnover markers, TBS is not completely restored. (thieme-connect.de)
  • Bone mass can be determined by a bone mineral density test (BMD), such as a dual-energy x-ray absorptiometry (DXA). (naturalmedicinejournal.com)
  • 7 Wherever possible, healthcare providers can instruct clients about natural therapies that may be equally effective for specific health conditions, but present a substantially lower risk for interfering with bone density. (naturalmedicinejournal.com)
  • In young people the body makes new bone faster than it breaks down the old, so bone density increases, peaking at around the age of 30. (saga.co.uk)
  • But with advancing age, this remove-and-replace cycle can get out of balance, leading to increased bone loss and a drop in bone density. (saga.co.uk)
  • For women, after the menopause there is a drop in levels of oestrogen, the female hormone essential for bone health, leading to a rapid decline in bone density. (saga.co.uk)
  • Over my career, I have tested numerous fruits, including figs, dates, strawberries and raisins, and none of them come anywhere close to having the effect on bone density that dried plums, or prunes, have. (happyhealthylonglife.com)
  • Dried plum(s) significantly increased bone mineral density of the ulna & spine in comparison with dried apples. (happyhealthylonglife.com)
  • The findings of this present study confirm the ability of dried plums(s) in improving bone mineral density in postmenopausal women in part due to suppressing the rate of of bone turnover and bone resorption. (happyhealthylonglife.com)
  • Bone mineral density (BMD) of the whole-body, proximal femur and lumbar vertebrae was measured by dual-energy X-ray absorptiometry (DXA). (frontiersin.org)
  • A reduction in bone mineral density (BMD) of the axial and appendicular skeleton ranging from 7% to 15% has been reported in RA in studies employing a variety of densitometric techniques. (biomedcentral.com)
  • After 12 months, patients receiving infliximab had preservation of bone mineral density (BMD) in the lumbar spine and femoral neck whereas bone loss amounting to 3.9% and 2.5% was observed at the same sites, respectively, in the control group treated with methotrexate alone. (biomedcentral.com)
  • The effect of oral choline-stabilized orthosilicic acid (ch-OSA) on markers of bone turnover and bone mineral density (BMD) was investigated in a double-blind placebo-controlled trial. (biomedcentral.com)
  • The primary cause for the decline in bone mineral density (BMD) and increased susceptibility to fracture in women, is the decrease in circulating estrogens at the onset of menopause. (biomedcentral.com)
  • The following variables were measured and collected: age, gender, body mass index (BMI), bone mineral density (BMD), volume of bone cement injected, bone cement leakage, fractured vertebra segment, contact between bone cement and endplates, serum of calcium and phosphorus, and six kinds of bone turnover markers. (biomedcentral.com)
  • DXA scanners generate 2 dimensional images of complex 3 dimensional structures, and report bone density as the quotient of the bone mineral content divided by the bone area. (biomedcentral.com)
  • An obvious pitfall of this method is that a larger bone will convey superior strength, but may in fact have the same bone density as a smaller bone. (biomedcentral.com)
  • Current osteoporosis medications increase bone density and reduce fracture risk but the mechanisms of these actions vary. (biomedcentral.com)
  • Dual-energy X-ray absorptiometry (DXA) was introduced in the mid-1980s as a rapid and safe imaging modality to estimate bone mineral density (BMD) and predict skeletal fracture risk [ 2 ]. (biomedcentral.com)
  • Patients with type 2 diabetes mellitus usually have normal or even slightly elevated bone mineral density compared to age-appropriate controls. (dntb.gov.ua)
  • Bone mineral density is the primary component in bone strength, although the quality of the protein matrix is also important. (modern-psychiatry.com)
  • Bone mineral density is most easily measured with a dual-energy x-ray absorptiometry of the spine and hip. (modern-psychiatry.com)
  • It increases bone mineral density slightly more than calcium and vitamin D alone. (modern-psychiatry.com)
  • Some plant-derived natural products, mostly phytoestrogens (isoflavones, lignans, coumestanes, stilbenes) and many more novel estrogen-like compounds in plants have been greatly used to prevent depletion in bone mineral density. (ommegaonline.org)
  • Also IOF reported that Egyptian women have lower bone mineral density compared to western women and 28.4% of postmenopausal women in Egypt are expected to have osteoporosis [7] . (ommegaonline.org)
  • It noted that the incidence of fracture in male low than female due to men acquire a greater bone density than women as their body weight and physical activity are higher and androgen concentration increases bone density to higher levels than estrogen do [8] . (ommegaonline.org)
  • Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women. (cdc.gov)
  • Drinking moderately as part of a healthy lifestyle that includes a good diet and exercise may be beneficial for bone health, especially in postmenopausal women," said lead author Urszula Iwaniec in a statement. (time.com)
  • Dual-energy X-ray absorptiometry (DXA) was the first imaging tool widely utilized by clinicians to assess fracture risk, especially in postmenopausal women. (biomedcentral.com)
  • It included 40 healthy postmenopausal women under 65, just at the age at which the risk for osteoporosis and fractures starts to rise. (time.com)
  • The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism. (cdc.gov)
  • Vitamin K functions as a coenzyme for vitamin K-dependent carboxylase, an enzyme required for the synthesis of proteins involved in hemostasis (blood clotting) and bone metabolism and other diverse physiological functions [ 3 , 5 ]. (nih.gov)
  • In a review article Kuohung [ 7 ] could not find any consensus on whether or not Ocs use had a protective effect on BMD and bone metabolism. (biomedcentral.com)
  • Biochemical monitoring of bone metabolism depends upon measurement of enzymes and proteins released during bone formation and of degradation products produced during bone resorption. (medscape.com)
  • 2,5 Thus, we see substantial research regarding DHEA and its supplementation surrounding common concerns with aging: libido, bone health, body composition, metabolism, and skin integrity and appearance. (ndnr.com)
  • Of the Japanese men aged ≥65 years who participated in the baseline survey of the Fujiwara-kyo Osteoporosis Risk in Men study, 1,662 men without diseases or medications known to affect bone metabolism were examined for associations between self-reported natto intake or serum ucOC levels with lumbar spine or hip BMD. (springer.com)
  • Vitamin D is critical for bone and mineral metabolism, and it is established that vitamin D deficiency can cause rickets and osteomalacia. (bioscientifica.com)
  • Objectives: To investigate a 6-month intervention with an olive leaf extract (OLE) on knee functionality and biomarkers of bone/cartilage metabolism and inflammation. (zeyton.pt)
  • This expression across diverse tissue types indicates that its biologic functions may extend beyond bone metabolism. (biomedcentral.com)
  • Experimental silicon deprivation in rats [ 14 - 16 ] and chicks [ 17 , 18 ] demonstrated marked effects on growth and bone metabolism which in some studies resulted in aberrant connective tissue and bone mineralization (thinner cortex, less calcified bone matrix) and bone defects. (biomedcentral.com)
  • Recent studies have demonstrated the importance of bone as an endocrine organ that produces biologically active substances, which regulate both local bone metabolism and metabolic functions throughout the body. (dntb.gov.ua)
  • Among bone hormones, osteocalcin plays an important role as a coordinator of bone modeling processes, energy homeostasis, metabolism of glucose, lipids and minerals. (dntb.gov.ua)
  • Zhou R, Guo Q, Xiao Y, Guo Q, Huang Y, Li C, Luo X. Endocrine role of bone in the regulation of energy metabolism. (dntb.gov.ua)
  • The leaves contain several methoxy-isoflavones and a novel compound that improves the trabecular microarchitecture of the long bones, increases their biomechanical strength, and decreases clinical bone turnover markers (osteocalcin and CTX1), and expression of skeletal osteoclastogenic genes. (vigyanprasar.gov.in)
  • Objectives: Osteoporosis is a skeletal disorder characterized by impaired bone turnover and compromised bone strength, thereby predisposing to increased risk of fracture. (zeyton.pt)
  • The RANKL inhibitor denosumab acts to reduce skeletal-related events in patients with bone metastases. (biomedcentral.com)
  • Osteoporosis is a disease of the skeletal system that is characterized by deterioration of bone tissue, along with a decrease in bone mass. (naturalmedicinejournal.com)
  • Osteoporosis is defined as progressive skeletal disorder, characterised by low bone mass (osteopenia) and micro-architectural deterioration, resulting in an increase in bone fragility and increased risk to factures [ 1 ]. (biomedcentral.com)
  • Consistent with the physiological coupling of bone formation and resorption in skeletal remodeling, subsequent reductions in bone formation markers (i.e. osteocalcin and procollagen type 1 N-terminal peptide [PlNP]) were observed starting 1 month after the first dose of Prolia. (druglib.com)
  • This review retreats to basic principles in order to advance clinical management of fragility fractures by examining how skeletal biomechanics, size, shape, and ultra-structural properties are the ultimate predictors of bone strength. (biomedcentral.com)
  • Osteoporosis is a syndrome of dysadaptation which leads to low bone mass, bone micro architecture disruption of bone tissue, decreased skeletal strength and increased predisposition to fracture at different sites as the spine, hip or wrist [4,5] . (ommegaonline.org)
  • Urinary crosslinked N-terminal telopeptides of type I collagen (NTX) was measured as a marker of bone resorption. (openorthopaedicsjournal.com)
  • 3 In vitro osteoblast studies indicate that boron stimulates production of several proteins involved in maintaining bone structure, including type 1 collagen, osteocalcin and osteopontin. (wellvishealth.ca)
  • The biomarker N-terminal telopeptide (NTX) detected in urine, is reported in nmol of bone collagen equivalents/mmol creatinine. (medscape.com)
  • More than 90% of the protein in bone is composed of type 1 collagen. (medscape.com)
  • Degradation products that are derived from the enzymatic hydrolysis of type 1 collagen are therefore the most useful markers of bone resorption. (medscape.com)
  • Overall, there was a trend for ch-OSA to confer some additional benefit to Ca and Vit D3 treatment, especially for markers of bone formation, but only the marker for type I collagen formation (PINP) was significant at 12 months for the 6 and 12 mg Si dose ( vs . placebo) without a clear dose response effect. (biomedcentral.com)
  • A trend for a dose-corresponding increase was observed in the bone resorption marker, collagen type I C-terminal telopeptide (CTX-I). (biomedcentral.com)
  • Combined therapy of ch-OSA and Ca/Vit D3 had a potential beneficial effect on bone collagen compared to Ca/Vit D3 alone which suggests that this treatment is of potential use in osteoporosis. (biomedcentral.com)
  • We proposed this study of pre and post menopausal women assessing BMD, bone biochemical markers and physical performance among OC past users and comparable women who have never use Ocs. (biomedcentral.com)
  • In contrast, in post menopausal women, there was no difference in bone biochemical markers between OC users and the control. (biomedcentral.com)
  • Estrogen has largely been abandoned for post-menopausal women, but the use of very low dose estrogen (one half of a 0.625 mg tablet per day or very low dose patch) when combined with two weeks off estrogen every three-six months has been found helpful in preventing estrogen deficiency symptoms and is also quite good at preventing osteoporosis. (modern-psychiatry.com)
  • The suppression of bone turnover markers was evident by months and persisted throughout the 36-month and 24-month observation periods.In 31-week, open-label, radiocalcium kinetics study, 33 early postmenopausal women were randomized to treatment with once-daily raloxifene hydrochloride tablets 60 mg, cyclic estrogen/progestin (0.625 mg conjugated estrogens daily with mg medroxyprogesterone acetate daily for the first weeks of each month [hormone therapy]), or no treatment. (drugcentral.org)
  • Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. (wikipedia.org)
  • In its carboxylated form it binds calcium directly and thus concentrates in bone. (wikipedia.org)
  • We determined the levels of endotoxin, bone turnover markers, 25-OH vitamin D total and corrected calcium in 100 Saudi postmenopausal women with osteoporosis and 100 women without osteoporosis were taken under the supervision of qualified physicians in the primary care centers in Riyadh. (ntu.ac.uk)
  • In my work at the Osteoporosis Program I am seeing an increasing number of patients taking calcium supplements including vitamin K with marketers stressing its importance in bone health. (dietitians.ca)
  • Two-year randomized controlled trial of vitamin K1(phylloquinone) and vitamin D3 plus calcium on the bone health of older women. (dietitians.ca)
  • Ample intake of protein, calcium, and vitamin D may help prevent postmenopausal osteoporosis with nonpharmacologic means. (vigyanprasar.gov.in)
  • Vitamin D enhances calcium absorption and bone mineralisation, promotes maintenance of muscle function, and is crucial for musculoskeletal health. (bioscientifica.com)
  • A considerable amount of human evidence supports the well-recognised contribution of adequate serum 25-hydroxyvitamin D concentrations for bone homeostasis maintenance and prevention and treatment strategies for osteoporosis when combined with adequate calcium intake. (bioscientifica.com)
  • Cal Mag Berry Liquid + supports bone health with a combination of calcium and magnesium, plus boron and vitamins A, D and K. Calcium citrate is an organic form of calcium that is significantly better absorbed in postmenopausal women than inorganic calcium oxide. (wellvishealth.ca)
  • The treatment period was five weeks, and at the end we analyzed circulating levels of calcium, strontium magnesium and iron and bone turnover by measuring the resorption marker CTX (RatLaps ELISA) and the formation marker osteocalcin (RatMID ELISA). (dtu.dk)
  • Find out how a comprehensive nutrient regimen, including calcium, trace minerals, and vitamins D3 and K optimizes bone health and total health. (lifeextensioneurope.com)
  • Calcium accounts for 1-2% of adult human body weight, with more than 99% of total body calcium residing in the teeth and bones. (lifeextensioneurope.com)
  • Thus the skeleton is the body's only storehouse of the calcium we need to sustain life itself, yet as we age we see a progressive decrease in the amount of calcium in our bones. (lifeextensioneurope.com)
  • With regard to bone health, vitamin D not only promotes calcium absorption but also its proper deposition in bone tissue, where it helps maintain the skeleton's basic function as scaffold and protector of soft tissues. (lifeextensioneurope.com)
  • While calcium and vitamin D have been considered the mainstays of bone nutrition and osteoporosis prevention, several other minerals are also essential to good bone health. (lifeextensioneurope.com)
  • Ask anyone what's good for bones and most will respond, "calcium. (nutraceuticalsworld.com)
  • Mr. Anderson noted, "Calcium has long been recognized as a core bone-support ingredient, but over the last few years, studies have circulated showing that excessive calcium supplementation can lead to increased cardiovascular risk, which had an effect on calcium sales (i.e., they were observed dipping). (nutraceuticalsworld.com)
  • But to make sure that calcium is being directed to the bones where it is needed, and blocked from depositing in arteries and blood vessels, we need vitamin K2," Mr. Anderson explained. (nutraceuticalsworld.com)
  • So, we have seen an increase in bone-support products that feature calcium and vitamins D and now K2. (nutraceuticalsworld.com)
  • Several risk factors increase the chance of developing osteoporosis: family history, gender (women are 6 to 8 times more likely than men), being postmenopausal, advanced age, race (Caucasians are the most likely), low calcium intake, smoking, alcohol consumption, a sedentary lifestyle, 4 and soft drink consumption. (naturalmedicinejournal.com)
  • Isotonix Vitamin K2 with D3 contains vitamin K2, a form of vitamin K which supports calcium utilization, along with vitamin D3, the metabolically active form of vitamin D. Vitamin K supports the normal delivery of calcium to the bones, while vitamin D plays an important role in bone health, working with vitamin K to support normal absorption of calcium. (isotonix.com)
  • The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization. (isotonix.com)
  • Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. (isotonix.com)
  • Of all of these, vitamin K is the most important , since it helps build the bone protein matrix to hold the calcium in place. (modern-psychiatry.com)
  • The bone remodeling prevents fatigue damage and important in preserving calcium homeostasis and the loss of osteoblast - osteoclasts coupling lead to several metabolic bone diseases including osteoporosis, tumor related bone disease, rheumatoid arthritis [1,2] . (ommegaonline.org)
  • This randomized, double-blind, placebo- controlled clinical trial assessed the effect of zinc supplementation on serum zinc and calcium levels in postmenopausal osteoporotic women. (who.int)
  • RÉSUMÉ Le présent essai clinique randomisé, en double aveugle, contrôlé contre placebo, a évalué l'effet de la supplémentation en zinc sur les taux de zinc et de calcium sériques chez des femmes ostéoporotiques ménopausées. (who.int)
  • Les mesures anthropométriques, l'apport alimentaire en zinc et en calcium, les taux de zinc et de calcium sériques ont été évalués au début de l'étude puis à 60 jours. (who.int)
  • Les concentrations moyennes initiales en zinc sérique étaient nettement inférieures aux valeurs normales, mais les taux de calcium sérique moyens étaient normaux. (who.int)
  • Ikeda Y, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H (2006) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study. (springer.com)
  • 4 Insufficient vitamin K intake may increase bone fracture risk, and vitamin K supplementation has been shown to reduce bone turnover and improve bone strength. (wellvishealth.ca)
  • Two-hundred fifty-five physically inactive postmenopausal women (55-75 years) with 10-year major osteoporotic fracture risk (3%-35%) participated in this 18-month study. (frontiersin.org)
  • and the fracture risk in men is less than half of women starting at age 55 [ 6 ]. (biomedcentral.com)
  • For instance, one study which aimed to study the effectiveness of a glycoprotein called lactoferrin on bone formation used osteocalcin as a measure of osteoblast activity. (wikipedia.org)
  • An imbalance in osteoblast/osteoclast activity may be due to oxidative stress and the accumulation of glycosylation end products, which contributes to chronic inflammation and bone resorbtion in patients with diabetes. (dntb.gov.ua)
  • Matrix Gla-protein (MGP), a vitamin K-dependent protein present in vascular smooth muscle, bone, and cartilage, is the focus of considerable scientific research because it might help reduce abnormal calcification [ 9 ]. (nih.gov)
  • Osteocalcin is another vitamin K-dependent protein that is present in bone and may be involved in bone mineralization or turnover [ 5 ]. (nih.gov)
  • even in all healthy humans tested, a significant percentage of the extra-hepatic VKD proteins, which are activated by vitamin K2, e.g., osteocalcin and matrix Gla-protein, are only partly carboxylated and therefore inactive. (vitamindwiki.com)
  • The discovery of the receptor activator of nuclear factor κB (RANK) ligand (RANKL) pathway, a transmembrane protein belonging to the tumour necrosis factor (TNF) superfamily, and its inhibition by osteoprotogerin (OPG) has had important implications for bone physiology as well as inflammation research. (biomedcentral.com)
  • Prolia binds to RANKL, a transmembrane or soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. (druglib.com)
  • An acute stress response (ASR), colloquially known as the fight-or-flight response, stimulates osteocalcin release from bone within minutes in mice, rats, and humans. (wikipedia.org)
  • Dr Ritu Trivedi, Principal Scientist, Endocrinology Division of CSIR-Central Drug Research Institute (CDRI), Lucknow, and her scientific team have developed a novel medicine, Reunion, a product that prevents bone breakdown, stimulates new bone formation, and reduces bone turnover markers. (vigyanprasar.gov.in)
  • OPG was first characterized as a negative regulator of bone turnover. (biomedcentral.com)
  • OPG blocks the interaction of RANKL with RANK and thus acts as a physiological regulator of bone turnover. (biomedcentral.com)
  • Various biochemical markers are now available that allow a specific and sensitive assessment of the rate of bone formation and bone resorption of the skeleton. (medscape.com)
  • Prediction of bone loss with biochemical bone markers. (medscape.com)
  • Adapted from Ross PD, Knowlton W. Rapid bone loss is associated with increased levels of biochemical markers. (medscape.com)
  • Our goal was to assess whether short term treatment with strontium in ovariectomized rats would affect biochemical markers of bone turnover as well as promote a bone strength. (dtu.dk)
  • Changes in biochemical markers of bone turnover from baseline or between the groups were not statistically different. (biomedcentral.com)
  • Vitamin K's effect may have been on bone microarchitecture. (dietitians.ca)
  • However, data of bone microarchitecture are scarce. (thieme-connect.de)
  • Trabecular bone score (TBS) estimates bone microarchitecture and could provide valuable information in those patients. (thieme-connect.de)
  • These results remark the necessity of longer periods of study, to confirm if bone microarchitecture could be completely restored after surgery. (thieme-connect.de)
  • Parathyroidectomy improves bone geometry and microarchitecture in female patients with primary hyperparathyroidism: A one-year prospective controlled study using high-resolution peripheral quantitative computed tomography. (thieme-connect.de)
  • Bone microarchitecture of the distal non-dominant radius and tibia was measured by high-resolution peripheral quantitative computed tomography (HR-pQCT). (frontiersin.org)
  • Decreased bone quality and increased risk of fractures are associated with changes in bone microarchitecture and local humoral environment. (dntb.gov.ua)
  • during adulthood, most studies have reported that oral contraceptive (OC) pills had neutral, or possibly beneficial effect on bone health. (biomedcentral.com)
  • Habitual intake of natto was associated with a beneficial effect on bone health in elderly men, and this association is primarily due to vitamin K content of natto , although the lack of information on dietary nutrient intake, including vitamin K1 and K2, prevented us from further examining the association. (springer.com)
  • Giving vitamin K1 at 200 ug and 5000 ug per day appeared to have a positive effect on bone (1,2). (dietitians.ca)
  • These observations suggest that TNF blockade may have a beneficial effect on bone generally, not just on erosions in RA. (biomedcentral.com)
  • On the day it was taken, supplementation of DHEA significantly increased levels of DHEA, DHEA-S, and estrone in both men and women. (ndnr.com)
  • 3 In men, DHEA supplementation increased testosterone non-significantly, while in women, on day 8 a significant and dose-dependent increase in testosterone was seen. (ndnr.com)
  • It is shown that the level of osteocalcin in the blood serum is significantly reduced compared to healthy controls, both in patients with type 1 diabetes mellitus and, especially, in type 2 diabetes mellitus. (dntb.gov.ua)
  • Within 12-14 hours of resuming alcohol consumption, osteocalcin and CTx returned to values that did not differ from baseline," the authors note, concluding that the "small but significant increases in [these chemicals] after short-term abstinence provide substantial evidence that moderate alcohol consumption decreases bone turnover. (time.com)
  • Control of inflammation appears to be the most important strategy for prevention of bone loss in RA [ 3 ]. (biomedcentral.com)
  • Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function, and survival, thereby decreasing bone resorption and increasing bone mass and strength in both cortical and trabecular bone. (druglib.com)
  • After discontinuation of Prolia therapy, markers of bone resorption increased to levels 40% to 60% above pretreatment values but returned to baseline levels within 12 months. (druglib.com)
  • World Health Organisation (WHO) defines osteoporosis as a disease that is characterized by low bone mass and microarchitectural destruction of bone tissue, leading to bone fragility and increased risk of fracture. (walshmedicalmedia.com)
  • Anti-resorptive medications (bisphosphonates and denosumab) primarily increase endocortical bone by bolstering mineralization of endosteal resorption pits and thereby increase cortical thickness and reduce cortical porosity. (biomedcentral.com)
  • Injections of high levels of osteocalcin alone can trigger an ASR in the presence of adrenal insufficiency. (wikipedia.org)
  • The aim of the study is to evaluate circulating endotoxin levels and to study the association amongst endotoxin and bone turnover markers in a cohort of Saudi postmenopausal women with or without osteoporosis. (ntu.ac.uk)
  • 3 Supplementation of 25 mg of DHEA was adequate to restore DHEA-S levels to that of young adults, while at 50 mg the level remained in the normal range for young men but exceeded the upper normal level for healthy women. (ndnr.com)
  • When adjustment was made for undercarboxylated osteocalcin levels, this association was insignificant, showing the natto -bone association to be primarily mediated by vitamin K. (springer.com)
  • Elevated levels of NTX indicate increased bone turnover. (medscape.com)
  • In most cases, it is not known why men develop osteoporosis, although with advancing age, there is a decline in levels of testosterone, which helps to keep bone healthy. (saga.co.uk)
  • At the end of each dosing interval, CTX reductions were partially attenuated from a maximal reduction of ≥ 87% to ≥ 45% (range: 45% to 80%), as serum denosumab levels diminished, reflecting the reversibility of the effects of Prolia on bone remodeling. (druglib.com)
  • Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels. (medlineplus.gov)
  • Throughout life, bones constantly remodel themselves, building up new sections while breaking down old ones in turnover processes called formation and resorption. (time.com)
  • During their period of abstinence, the scientists saw negative changes in measures of bone formation and resorption. (time.com)
  • Bone homeostasis is maintained by the interplay between the receptor activator of nuclear factor kappa-B (RANK), its soluble activation ligand (RANKL), and OPG. (biomedcentral.com)
  • Raloxifene is an agonist in bone, and acts inhibiting bone loss. (bvsalud.org)
  • Digital images were obtained and the alveolar bone loss was measured (mm²) using an image analysis software. (bvsalud.org)
  • During the dissection process, the periosteum is detached from the alveolar bone, leading to a resorptive phase due to the stimulation offered by osteoclastic activity and loss of bone crest 2-4 . (bvsalud.org)
  • Therefore simple examination of osteocalcin can be used to predict mandibular bone loss. (walshmedicalmedia.com)
  • Along with increased incidences of fractures in older, postmenopausal women, osteoporosis may often lead to mobility loss and perhaps morbidity and death. (vigyanprasar.gov.in)
  • Low vitamin D status triggers secondary hyperparathyroidism, increases bone loss, and leads to muscle weakness. (bioscientifica.com)
  • Due to the growing aging population, loss of bone mass may be impacting more than 40 million people today," said Todd Johnson, senior director of marketing, human nutrition and pharma, Balchem/Albion Minerals , Layton, UT. (nutraceuticalsworld.com)
  • Generalised osteoporosis is just one of three bony manifestations of rheumatoid arthritis (RA), which also include erosions and localised juxta-articular bone loss of affected joints. (biomedcentral.com)
  • A few very early studies have also examined the effect of disease modifying drugs on bone loss in RA using older densitometric techniques like metacarpal morphometry. (biomedcentral.com)
  • Because of the differences in the mechanisms of the various drugs, there are likely benefits of selecting a treatment based on a patient's unique bone structure and pattern of bone loss. (biomedcentral.com)
  • Physical activity and environmental factors as nutrition can contribute to bone health as they modify both peak bone mass and following bone loss. (ommegaonline.org)
  • In clinical studies, treatment with 60 mg of Prolia resulted in reduction in the bone resorption marker serum type 1 C-telopeptide (CTX) by approximately 85% by 3 days, with maximal reductions occurring by 1 month. (druglib.com)