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Bone TransplantationHematopoietic Stem CellsHematopoietic Stem Cell TransplantationBone and BonesStem CellsBone RemodelingBone Marrow CellsBone MarrowTransplantation, HomologousHematopoiesisBone Marrow TransplantationBone DensityKidney TransplantationHematopoietic Stem Cell MobilizationAntigens, CD34Graft SurvivalBone ResorptionStem Cell TransplantationCell LineageTransplantsCell DifferentiationTissue DonorsStem Cell NicheMice, Inbred C57BLGraft vs Host DiseaseBone NeoplasmsGraft RejectionColony-Forming Units AssayBone DevelopmentImmunosuppressive AgentsTransplantation ConditioningBone DiseasesTransplantation, AutologousFlow CytometryAdult Stem CellsFetal BloodNeoplastic Stem CellsTime FactorsHematologic NeoplasmsCells, CulturedPlant StemsTransplantationTreatment OutcomeBone RegenerationHematopoietic SystemHeart TransplantationStem Cell FactorMultipotent Stem CellsCell SeparationCell ProliferationWhole-Body IrradiationTransplantation ChimeraRetrospective StudiesHistocompatibility TestingMesonephrosBone MatrixCord Blood Stem Cell TransplantationMice, SCIDLeukemiaPluripotent Stem CellsLung TransplantationMesenchymal Stromal CellsMice, Inbred NODMice, KnockoutHistocompatibilityChimerismGranulocyte Colony-Stimulating FactorCytomegalovirus InfectionsOsteoblastsLentivirusOsteogenesisRadiation ChimeraFetal Stem CellsFetal Tissue TransplantationMice, TransgenicMesenchymal Stem Cell TransplantationTransduction, GeneticImmunosuppressionProto-Oncogene Proteins c-kitCyclosporineBone SubstitutesBone Diseases, MetabolicMyeloid Progenitor CellsLymphopoiesisBone Morphogenetic ProteinsAntigens, CDFractures, BoneTacrolimusImmunocompromised HostTransplantation ImmunologyTissue and Organ ProcurementRetroviridaePeripheral Blood Stem Cell TransplantationInduced Pluripotent Stem CellsLiving DonorsNeural Stem CellsGenetic VectorsHematopoiesis, ExtramedullaryPostoperative ComplicationsBusulfan
TransplantationHSCTDonorRecipientsMaturing hematopoietic cellsProgenitorGraft versusTransplantationsDonorsPatients2023AbstractDiseased bone marrowGrow in the bone maEngraftmentFound in the bone maMesenchymalClinicalMultiple sclerosisPediatricAllogeneic transplantOutcomesCancersAutologous transplantPeripheral blood stemLeukemia2001Myelodysplastic syndromeHaploidenticalOccurs in the bone ma2021OrgansImmuneOrganPatient'sAutoimmuneBloodMarrow stem cells1999Umbilical cordPatientMSCsSurvivalEmbryonicHigh-dose chemotherapy
Transplantation59
HSCT6
  • Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
  • Bone marrow transplants, or hematopoietic stem cell transplantations (HSCT), treat more than 70 different diseases, including some types of leukemia, lymphoma, and sickle cell anaemia. (the-scientist.com)
  • Akari's pipeline includes a Phase 3 clinical trial program investigating nomacopan for severe pediatric hematopoietic stem cell transplant-related thrombotic microangiopathy (HSCT-TMA). (texomashomepage.com)
  • But is there any reason to think that hematopoietic stem cell transplants (HSCT) could 'reset' the immune system in MS? (closerlookatstemcells.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
Donor29
  • Stem cells are removed from another person, called a donor. (medlineplus.gov)
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
  • Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • Opportunities for improvement include bringing the lung donor yield in the 0-11 age group closer to the yield in adolescents, relaxing geographic allocation boundaries to ensure that pediatric lungs are offered first to children, and reserving deceased donor lobar transplant for circumstances where suitably sized donor organs are not available," they wrote. (medindia.net)
  • An entire left eye and a portion of the face were transplanted from a single donor during the 21-hour surgery. (medindia.net)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
  • The process is also less painful for the donor since a needle is not being placed into bone. (differencebetween.net)
  • The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
  • The procedure in which bone marrow is extracted from a donor does require the use of either a local or a general anesthetic. (differencebetween.net)
  • The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
  • In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
  • Collecting cord blood is less complicated, painful, and risky for the donor than collecting bone marrow. (medicalnewstoday.com)
  • Stem cell transplants remove blood-forming stem cells from a healthy donor, and then inject them into a patient, where they take hold and grow in the bone marrow. (stanford.edu)
  • Technicians process stem cells from the donor to elimi-nate alpha-beta T cells, immune cells that instigate graft-versus-host disease. (stanford.edu)
  • As a re-sult, patients can be safely transplanted us-ing stem cells from a donor with only 5 of 10 matching HLA antigens -- such as a parent. (stanford.edu)
  • Allogeneic HCT confers superior survival in transplant-eligible patients with high-risk MDS and an available donor. (curetoday.com)
  • For an allogeneic stem cell transplant , after the bone marrow is destroyed, the patient receives blood-forming stem cells from another person - the donor," the American Cancer Society explained. (curetoday.com)
  • Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
  • Previously, he had been exploring ways to manipulate the immune system in leukemia patients to be able to give them highly mismatched donor stem cell transplants, and one of his colleagues wondered if the approach might also work for autoimmune diseases. (closerlookatstemcells.org)
  • Understanding how hematopoietic stem cells are made during embryonic development is important because it could teach us how to make such cells in the laboratory, and possibly allow circumvention of donor immune compatibility issues. (ca.gov)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
  • However, the donor was unable to postpone her trip, and the recipient was in urgent need of the transplant. (cdc.gov)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
  • After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)
Recipients9
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • Bertram Kasiske, MD, of the Scientific Registry of Transplant Recipients (SRTR) in Minneapolis, led a team that examined the validity of those data. (medindia.net)
  • The researchers analyzed information from the Scientific Registry of Transplant Recipients, which includes data on all donors, wait-listed candidates, and transplant recipients in the United States. (medindia.net)
  • Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
  • If given in tandem with solid-organ transplants, they could also remove the need for immune-suppressing therapy in organ recipients. (stanford.edu)
  • The procedure, which was not available at any other U.S. hospital when the brothers received it last year, is now offered to most transplant recipients at Packard Children's. (stanford.edu)
  • Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • Despite advances in the field, transplant recipients may face several avoidable risks. (who.int)
Maturing hematopoietic cells1
  • Another CFU, the colony-forming unit-spleen (CFU-S), was the basis of an in vivo clonal colony formation, which depends on the ability of infused bone marrow cells to give rise to clones of maturing hematopoietic cells in the spleens of irradiated mice after 8 to 12 days. (wikipedia.org)
Progenitor6
  • Stem and progenitor cells can be taken from the pelvis, at the iliac crest, using a needle and syringe. (wikipedia.org)
  • It was used extensively in early studies, but is now considered to measure more mature progenitor or transit-amplifying cells rather than stem cells[citation needed]. (wikipedia.org)
  • However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
  • At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
Graft versus1
  • Stem cell transplant side effects can include low blood counts and graft-versus-host disease and can potentially be life-threatening, according to the American Cancer Society. (curetoday.com)
Transplantations2
  • Low T Cell Numbers Resembling T-B+ SCID in a Patient with Wiskott-Aldrich Syndrome and the Outcome of Two Hematopoietic Stem Cell Transplantations. (medscape.com)
  • When it comes to hematopoietic stem cell transplantations, these are the important cells. (lu.se)
Donors7
  • Donors who are not related to you, yet still match, may be found through national bone marrow registries. (medlineplus.gov)
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • Cord blood does not contain many stem cells, which means that adults needing a transplant will require cord blood stem cells from multiple donors. (medicalnewstoday.com)
  • A method that broadens the pool of potential donors for stem cell transplants recently saved two young brothers from a severe genetic disease. (stanford.edu)
  • Before she came to Stanford, their doctor Alice Bertaina , MD, PhD, developed a technique that greatly reduces the risk of graft vs. host disease and broadens the potential pool of stem cell donors. (stanford.edu)
  • And while 70 percent of Caucasian patients are successfully matched, only 17 percent of black people in the United States are as lucky, according to The New York Stem Cell Foundation , likely because only 8 percent of donors in US registries are black. (the-scientist.com)
  • The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)
Patients21
  • We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
  • A 28-year-old brain-dead man had his kidneys, lungs, and liver successfully transplanted into four critically ill patients at multiple hospitals in India. (medindia.net)
  • It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
  • Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems. (scienceblog.com)
  • They then injected the patients with their own immune stem cells, obtained from the patients' blood before the chemotherapy, to create a new immune system. (scienceblog.com)
  • In previous studies, Burt had transplanted immune stem cells into late-stage MS patients. (scienceblog.com)
  • But traditional stem cell transplants are so risky that they've usually been offered only to patients who would otherwise die. (stanford.edu)
  • Antibody-based hematopoietic stem cell transplants may transform the treatment of patients with blood and immune diseases including cancers. (stanford.edu)
  • All patients achieved initial mixed hematopoietic chimerism with two patients rejecting their graft and recovering host hematopoiesis. (aacrjournals.org)
  • The latest study findings were reached via genetic analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 multicenter study of comparing different therapy options among 309 patients with MDS ages 50 to 75 with International Prognostic Scoring System (IPSS) intermediate-2 or high-risk MDS. (curetoday.com)
  • The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
  • The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)
  • Most of the patients in my clinic are blood and bone marrow transplant patients and patients with plasma cell diseases such as multiple myeloma, amyloidosis, POEMS syndrome, and Waldenstrom's macroglobulinemia. (dukehealth.org)
  • For years now, bone marrow transplants have been used to treat patients with leukemia and other blood disorders. (closerlookatstemcells.org)
  • For example, in their phase II trial with 24 patients who failed conventional therapy, Drs. Atkins and Freeman found that a very high dose of chemotherapy followed by purified autologous hematopoietic stem cell transplants appeared to have the most impact on preventing ongoing inflammatory activity and progression in these patients. (closerlookatstemcells.org)
  • Dr. Atkins highlights a few priorities for better understanding how to use hematopoietic stem cells transplants for MS. The first is finding the minimal dose of chemotherapy that will effectively destroy the immune system without being too toxic, and the second is to understand which patients could benefit most from this therapy and whether it would be better to start the therapy earlier during the treatment pathway. (closerlookatstemcells.org)
  • Under immunosuppression conditions, all infectious foci can be activated and, for this reason, all active infections in hematopoietic stem cell pre-transplant patients must be eradicated prior to transplant so as to prevent or reduce the risk of systemic complications in these patients. (bvsalud.org)
  • The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)
  • 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
  • Cytomegalovirus Glycoprotein Polymorphisms and Increasing Viral Load in Non-Transplant Patients with Hematological Malignancies Undergoing Chemotherapy: A Prospective Observational Study. (cdc.gov)
  • Specialty care area for the care of patients who undergo bone marrow (stem cell) transplant for the treatment of various disorders. (cdc.gov)
20231
  • Bone Marrow Transplant;58(7): 801-810, 2023 07. (bvsalud.org)
Abstract2
  • Bone 2002(2): 436-9 [ PubMed abstract ]. (lu.se)
  • Bone Marrow Transplant 1998(10): 941-6 [ PubMed abstract ]. (lu.se)
Diseased bone marrow1
Grow in the bone ma1
Engraftment4
  • One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
  • A key milestone in a patient's recovery, neutrophil engraftment is a measure of how quickly the stem cells a patient receives in a bone marrow transplant are established and begin to make healthy new cells. (biospace.com)
  • Additionally, the study met key secondary endpoints related to the speed of platelet engraftment, decrease in infections and reduction in hospitalizations, all significant clinical measures in bone marrow transplant. (biospace.com)
  • The research interests in my lab are on the development of new approaches to enhance hematopoietic stem cell engraftment and reconstitution following blood and bone marrow transplant. (dukehealth.org)
Found in the bone ma1
Mesenchymal3
  • Here, by developing injectable, void-forming hydrogels that decouple pore formation from elasticity, we show that mesenchymal stem cell (MSC) osteogenesis in vitro , and cell deployment in vitro and in vivo , can be controlled by modifying, respectively, the hydrogel's elastic modulus or its chemistry. (nature.com)
  • It comprises of two types of stem cells, that are hematopoietic and mesenchymal stem cells. (powershow.com)
  • PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
Clinical5
  • I focus my research and clinical work on treating blood and bone marrow cancers. (dukehealth.org)
  • But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
  • A randomized clinical trial at Memorial Sloan Kettering Cancer Center (MSK) has shown that fecal microbiota transplants (FMTs) can reestablish the health-promoting bacteria that are often damaged by intense antibiotic treatment in people who have stem cell or bone marrow transplants for blood cancer. (mskcc.org)
  • Since then, people with certain forms of MS have received autologous hematopoietic stem cell transplants in clinical trials worldwide, and many lessons have been learned along the way. (closerlookatstemcells.org)
  • This is the next step for Drs. Atkins and Freeman who are organizing a phase III randomized clinical trial to compare the hematopoietic stem cell transplant approach in people with MS who have highly active disease, and who have failed one or two conventional drugs, against individuals with MS who are treated with the best available, approved drug therapy. (closerlookatstemcells.org)
Multiple sclerosis2
  • Hematopoietic Stem Cells: a New Transplant Paradigm for Multiple Sclerosis? (closerlookatstemcells.org)
  • Stem cells harvested from a person's own bone marrow or blood, can safely slow progression of the most common form of the autoimmune disease, multiple sclerosis, or MS as it's usually known, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry. (news-medical.net)
Pediatric1
  • In an accompanying editorial, Stuart Sweet, MD, PhD, of Washington University in St. Louis, and Mark Barr, MD, of the University of Southern California in Los Angeles, noted that there are several other factors that should be considered as officials and the transplant community consider whether changes to pediatric lung allocation are warranted. (medindia.net)
Allogeneic transplant1
  • Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
Outcomes2
  • Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • Earlier work from MSK physician-scientists Eric Pamer, MD, and Marcel van den Brink, MD, PhD , has shown that out-of-balance intestinal microbes can contribute to serious side effects that can affect outcomes after stem cell transplants. (mskcc.org)
Cancers5
Autologous transplant1
Peripheral blood stem1
Leukemia2
20011
  • Bone Marrow Transplant 28, no. 6 (September 2001): 634-36. (duke.edu)
Myelodysplastic syndrome1
  • Hematopoietic cell transplant is currently the only known cure for myelodysplastic syndrome. (curetoday.com)
Haploidentical1
Occurs in the bone ma2
20212
Organs3
  • These stem cells come from developed organs and tissues in the body. (healthline.com)
  • Of the 70 000 or so solid organs transplanted annually, 50 000 are kidney replacements, more than one-third of the latter operations are done in low- or medium-income countries. (who.int)
  • The supply of cadaveric organs is limited by an inadequately informed and educated public, inefficient or non-existent organizations for procuring transplant material, and cultural and religious barriers in some countries. (who.int)
Immune9
  • A vaccine that stimulates CD8 T regulatory cells helps to prevent self-destructive immune reactions in autoimmune diseases and organ transplant rejection. (medindia.net)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Cord blood stem cells may support the immune system during cancer treatments. (medicalnewstoday.com)
  • We focus on destroying only the immune component of the bone marrow and then regenerate the immune component, which makes the procedure much safer and less toxic than traditional chemotherapy for cancer," Burt said. (scienceblog.com)
  • This will help prevent the immune system from rejecting an organ transplant. (healthline.com)
  • Keep in mind that these are the stem cells that power the blood and immune systems, churning out billions of blood cells every day. (closerlookatstemcells.org)
  • Scientists first tested the approach in animals with an MS-like disease and showed that radiation or chemotherapy followed by a bone marrow stem cell transplant could help to control the immune system. (closerlookatstemcells.org)
  • Hematopoietic stem cells are an important population of cells that continuously produce and replace red blood and immune system cells during life. (ca.gov)
  • Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously replenish all blood and immune cells during the lifetime of an individual. (ca.gov)
Organ2
  • Patient has undergone prior solid organ and/or non-autologous hematopoietic stem cell or bone marrow transplant. (mayo.edu)
  • Those who have had/or are planning to have an organ transplant or a hematopoietic cell transplant (also known as stem cell or bone marrow transplant), and those with autoimmune diseases are at increased risk for squamous cell skin cancer. (nccn.org)
Patient's2
Autoimmune1
  • The processing method allowed Ronnie and Levi to receive a stem cell transplant from their father, who does not have the autoimmune disease. (stanford.edu)
Blood48
Marrow stem cells1
19992
  • The investigators looked specifically at mortality rates by age for candidates registered on the lung transplant waiting list between January 1, 1999, and December 31, 2011. (medindia.net)
  • In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)
Umbilical cord2
Patient5
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)
  • We are progressing well with our manufacturing readiness activities in response to the clear feedback from the FDA regarding registration of our commercial manufacturing facilities and are actively building our launch readiness capabilities, including market access and support services, to ensure a positive patient experience at transplant at the time of potential FDA approval. (biospace.com)
  • Aim: Present a case report of dental care provided to a non-Hodgkin lymphoma patient with an urgent need for hematopoietic stem cell transplant. (bvsalud.org)
MSCs9
  • When the hydrogels were used to transplant MSCs, the hydrogel's elasticity regulated bone regeneration, with optimal bone formation at 60 kPa. (nature.com)
  • Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
  • The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
  • Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
  • It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
  • When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
  • Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
  • Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
  • MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
Survival1
  • These problems can be partially circumvented by using macroporous biomaterials that improve the survival of transplanted stem cells and provide molecular cues to direct cell phenotype. (nature.com)
Embryonic9
High-dose chemotherapy2
  • Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
  • Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)