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  • multipotent
  • He adds, "This research takes us another step in that process by identifying the potential of these adult bone marrow cells, or a subset of them known as CD34+ bone marrow cells, to be 'multipotent,' meaning they could transform and function as the normal cells in several different organs. (eurekalert.org)
  • An ex vivo assay for examining the clonogenic potential of multipotent marrow cells was later reported in the 1970s by Friedenstein and colleagues. (wikipedia.org)
  • They are multipotent, so they have the potential to differentiate into a variety of cell types. (wikipedia.org)
  • vitro
  • Increased inorganic phosphate induces human endothelial cell apoptosis in vitro," The American Journal of Physiology-Renal Physiology , vol. 294, no. 6, pp. (hindawi.com)
  • These cells are then grown under controlled in vitro conditions in a lab, so that they can multiply and same time mature( also referred to as differentiated. (wikipedia.org)
  • Scientists from the University of Newcastle upon Tyne led by biologist Karim Nayernia discovered a method of creating partly developed sperm cells, otherwise known as "spermatogonial" stem cells, from the bone marrow of male volunteers, entirely in-vitro (outside the human body), and is seeking funding to see whether such techniques can be used to make female sperm. (wikipedia.org)
  • As a member of the clinical (Director Bayard Clarkson) and laboratory teams (Director Malcolm A.S. Moore), he carried out a systematic analysis of all patients with acute myeloid leukemia (AML) treated at MSKCC, defining the prognostic and predictive parameters of cell cytology, cell growth in vitro and enzymatic markers. (wikipedia.org)
  • researchers
  • When they extracted bone marrow from these glow-in-the-dark mice, they got glow-in-the-dark stem cells, which the researchers then injected into ordinary mice with bone fractures. (redorbit.com)
  • After experimenting with several different cocktails, the researchers hit on a mix that transformed 100 percent of cultured stem cells into those that looked like neurons in under an hour. (scientificamerican.com)
  • University of Maryland researchers previously developed a special culturing system to collect a select sample of these adult stem cells in bone marrow, which normally makes red and white blood cells and immune cells. (eurekalert.org)
  • The researchers say that proving the potential of these adult bone marrow stem cells opens new possibilities for scientific exploration, but that more research will be needed to see how this science can be translated to humans. (eurekalert.org)
  • Now researchers are reporting in the scientific journal EMBO that the bone marrow niche where HSC's form also ages, contributing to the problem. (eurekalert.org)
  • The researchers conducted a number of experiments to test the formation and vitality of cells in and near the bone marrow microenvironment. (eurekalert.org)
  • Researchers have grown solid jawbones and tracheas from human stem cells towards this end. (wikipedia.org)
  • Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells. (wikipedia.org)
  • osteoblasts
  • In adults, osteoblasts, responsible for osteogenesis, and hematopoietic cells, responsible for hematopoiesis, are closely associated in the bone marrow, suggesting a reciprocal relationship between the two. (jci.org)
  • In the bone marrow HSCs reside either next to osteoblasts on the endosteal niche or adjacent to endothelial cells of sinusoidal vessels. (jci.org)
  • Osteoblasts (expressing M-CSF, RANKL, and OPG and producing IL-7) may regulate lymphoid (expressing IL-7R) and osteoclast (derived from monocytes, expressing the M-CSF ligand c-Fms and RANK) cell development. (jci.org)
  • Conducting their study in mouse models, the scientists point to cells in the bone marrow called osteoblasts, which help form bone. (eurekalert.org)
  • Osteoblasts make a protein called osteopontin, which is important to supporting a vibrant bone marrow environment in the creation of blood-forming HSCs. (eurekalert.org)
  • Study authors say they observed reduced production of osteoblasts and other stroma cells in the endosteum of older mice. (eurekalert.org)
  • Although the word chondroblast is commonly used to describe an immature chondrocyte, the term is imprecise, since the progenitor of chondrocytes (which are mesenchymal stem cells) can differentiate into various cell types, including osteoblasts. (wikipedia.org)
  • therapies
  • If found to be safe and effective in humans, the pioneering method of combining ultrasound , stem cell and gene therapies could eventually replace grafting as a way to mend severely broken bones. (medicalnewstoday.com)
  • Also, for women there are no therapies that use autologous cells to regenerate the clitoris, sometimes removed in cases of female genital mutilation. (wikipedia.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • organs
  • In usual circumstances, when foreign cells (such as cells or organs from other people, or infectious bacteria) are put into a human body, its immune system will reject such cells or organs. (wikipedia.org)
  • Bioartificial organs, which use both synthetic and biological component, are also a focus area in research, such as with hepatic assist devices that use liver cells within an artificial bioreactor construct. (wikipedia.org)
  • grafts
  • More than 2 million bone grafts, frequently necessitated by severe injuries involving traffic accidents, war or tumor removal, are performed worldwide each year. (medicalnewstoday.com)
  • Unfortunately, bone grafts carry disadvantages," said Gazit, a professor of surgery at Cedars-Sinai. (medicalnewstoday.com)
  • The new technique developed by the Cedars-Sinai-led team could provide a much-needed alternative to bone grafts. (medicalnewstoday.com)
  • Tests showed that the bone grown in the gap was as strong as that produced by surgical bone grafts, said Gadi Pelled, PhD, DMD, assistant professor of surgery at Cedars-Sinai and the study's co-senior author. (medicalnewstoday.com)
  • patients
  • Stem cell technology could significantly reduce healing time, Spagnoli said, noting that the development could also help trauma patients. (redorbit.com)
  • In this review, we describe the main factors that impair bone health in diabetic patients and their clinical impact. (hindawi.com)
  • But at least there were representatives from some of these "unproven" clinics and interest groups who made some important points about the rights of patients and how the needs of patients are not being met by the current clinical trials model as it applies to stem cells. (cellmedicine.com)
  • This usually involves inserting a needle into the back of the patients hip bone and removing the sample from there. (wikipedia.org)
  • In patients with MS, autoreactive lymphocytes such as T and B cells cause damage to the CNS by attacking myelin proteins. (wikipedia.org)
  • Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests. (wikipedia.org)
  • A Phase III trial of PLX-(PAD)-peripheral arterial disease cells in the treatment of critical limb ischemia has been cleared to start enrolling patients by the U.S. Food and Drug Administration. (wikipedia.org)
  • There he contributed to the isolation of the blood stimulating growth factor G-CSF, which leads to a faster recovery of white blood cells after chemotherapy and radiation therapy protecting patients better against severe infections. (wikipedia.org)
  • scientists
  • In a study published March 2, scientists from the University of Ulm in Germany and Cincinnati Children's Hospital Medical Center in the United States propose rejuvenating the bone marrow niche where HSCs are created. (eurekalert.org)
  • Scientists Ernest A. McCulloch and James E. Till first revealed the clonal nature of marrow cells in the 1960s. (wikipedia.org)
  • In the late 1990s, this concept became a partial reality when scientists in Japan developed chicken female sperm by injecting bone marrow stem cells from a female chicken into a rooster's testicles. (wikipedia.org)
  • Scientists have identified the mesenchymal type of stem cell inside dental pulp. (wikipedia.org)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • extracellular matrix
  • Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells," Scientific Reports , vol. 3, article 3552, 2013. (hindawi.com)
  • The cells, which are long and thin, are widely dispersed and the adjacent extracellular matrix is populated by a few reticular fibrils but is devoid of the other types of collagen fibrils. (wikipedia.org)
  • In order to do this, doctors, such as Wake Forest's Anthony Atala, have experimented with stem cells and extracellular matrix to provide a framework for regenerating missing structures. (wikipedia.org)
  • Load-induced non-rupture tendinopathy in humans is associated with an increase in the ratio of collagen III:I proteins, a shift from large to small diameter collagen fibrils, buckling of the collagen fascicles in the tendon extracellular matrix, and buckling of the tenocyte cells and their nuclei. (wikipedia.org)
  • clinical
  • Many of the discoveries described herein may contribute to future clinical treatments for hematopoietic and bone-related disorders, including cancer. (jci.org)
  • Dr. David Steenblock of Mission Viejo, California, a pioneer in clinical applications of stem cells , is pleased to report the results of a 16 year old girl who suffered from cerebral palsy . (medicalnewstoday.com)
  • Since it is a simple procedure to collect stem cells from bone marrow, we hope that our research paves the way forward into clinical trials. (redorbit.com)
  • Some stem cell companies involved in clinical trials wanted the non-clinical trials clinics shut down. (cellmedicine.com)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • treatments
  • I heard a number like 250,000 people are not getting the stem cell treatments they need because of clogged research and regulatory hold-ups. (cellmedicine.com)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • Regenerative Medicine
  • Dr Sullivan, from the Center for Stem Cell Research and Regenerative Medicine at Tulane University School of Medicine, said, "Our research reveals an important mechanism behind the anti-inflammatory activity of stem cells in lung injury because blocking the activity of TSG6 using siRNA prevented most of the anti-inflammatory effects of hMSC. (redorbit.com)
  • Several different forms of stem cells have been identified and studied in the field of regenerative medicine. (wikipedia.org)
  • therapeutic
  • It's possible that pre-existing neurological conditions may alter stem cells' responsiveness as well as their therapeutic activity. (cellmedicine.com)
  • To help discover the therapeutic uses of these stem cells they are grown in laboratories or by using medication to stimulate new cell growth within the human body. (wikipedia.org)
  • Once inside the body the vector introduces the therapeutic gene into host cells, and the protein encoded by the newly inserted gene is then produced by the body's own cells. (wikipedia.org)
  • pluripotent
  • established a protocol for isolating and identifying the subpopulations of dental pulp pluripotent-like stem cells (DPPSC). (wikipedia.org)
  • 2000 First discovery of DPSCs reported by Dr. Songtao Shi of NIH 2005 NIH announces discovery of DPSCs by Dr. Irina Kerkis 2006 IDPSC Kerkis reported discovery of Immature Dental Pulp Stem Cells (IDPSC), a pluripotent sub-population of DPSC using dental pulp organ culture. (wikipedia.org)
  • 2001
  • Pluristem was founded in 2001 by Shai Meretzki of the Technion, who made use of a stem cell patent which was developed during his Ph.D studies at The Rappaport Faculty Of Medicine, Technion, under the supervision of Dr. Shosh Merchav, together with Professors Dov Zipori and Avinoam Kadouri from the Weizmann Institute of Science. (wikipedia.org)