Bone specific alkaline phosphatase. Medical search. Frequent questions

The two we can measure are tartrate-resistant acid phosphatase and cathepsin K. (saveourbones.com)
In comparison with corresponding baseline values, only dried plum significantly decreased serum levels of bone turnover markers including bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b. (nih.gov)
in group 2 the reduction of bone formation and resorbtion markers was less significant, the level of tartrate resistant acid phosphatase increased. (cnaa.md)

Calcifications were amorphous areas surrounded by a fibrocartilaginous metaplasia containing hypertrophic chondrocyte-like cells that expressed tissue non-specific alkaline phosphatase (TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which are two key enzymes of the mineralization process. (iasp-pain.org)
There were no differences in mineralizing TNAP activity (S = 0.02, T = 0.02, C = 0.03 U/min/mg protein, p = 0.84) or in mineralized area (S = 0.05, T = 0.04, C = 0.04%, p = 0.92) among cells from different bone types. (biomedcentral.com)
There is no significant difference in mean doubling time, basal or mineralizing TNAP activity or mineralized area in osteoblasts derived from subchondral, cortical, or trabecular bone types from the canine femoral head. (biomedcentral.com)
Briefly, osteoblasts from subchondral and cortical bone types proliferated more rapidly than those from trabecular bone, and tissue non-specific alkaline phosphatase (TNAP) activity was enriched in trabecular human osteoblasts. (biomedcentral.com)
In this regard, he has identified several markers including FZD9, CD140b, tissue non-specific alkaline phosphatase (TNAP) in combination with other cell surface for prospective isolation of mesenchymal stromal cells (MSCs) from human bone marrow and placenta. (mdanderson.org)

AST is not specific to the liver and is also found in the kidney and cardiac and skeletal muscle. (aacc.org)
Primary endpoints were change in bone-alkaline phosphatase (ALP) concentration and time to skeletal-related events (SREs). (researchgate.net)
Bone-targeting properties of (223)Ra could also potentially be used for treating skeletal metastasis from other primary cancers. (researchgate.net)
An entire skeletal survey with plain radiographs to assess the extent of skeletal involvement is not recommended when bone scanning would be more sensitive and involve less radiation exposure. (medscape.com)
Skeletal or bone-specific alkaline phosphatase (BAP) is a tetrameric glycoprotein found on the cell surfaces of osteoblasts. (nexelis.com)
FIO is an ultra-rare skeletal disorder in which the collagen matrix (on which bone mineral is deposited) is disorganized, Dr. Matthew Drake of the Mayo Clinic told Reuters Health in an email, adding that no recognized therapy exists. (medscape.com)
Skeletal survey showed shortening of the 4th and 5th metacarpal bones bilaterally and minimal shortening of the 4th metatar- sal bones. (who.int)

Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner. (iasp-pain.org)
In the process of bone turnover cells called osteoclasts dissolve discrete portions of bone, transferring minerals like calcium and magnesium from the bone tissue into the blood. (saveourbones.com)
Ask anyone what's good for bones and most will respond, "calcium. (nutraceuticalsworld.com)
Mr. Anderson noted, "Calcium has long been recognized as a core bone-support ingredient, but over the last few years, studies have circulated showing that excessive calcium supplementation can lead to increased cardiovascular risk, which had an effect on calcium sales (i.e., they were observed dipping). (nutraceuticalsworld.com)
But to make sure that calcium is being directed to the bones where it is needed, and blocked from depositing in arteries and blood vessels, we need vitamin K2," Mr. Anderson explained. (nutraceuticalsworld.com)
So, we have seen an increase in bone-support products that feature calcium and vitamins D and now K2. (nutraceuticalsworld.com)
This development may be due to inadequate calcium intake in the face of increased demand from extensive bone remodeling. (medscape.com)
Chez les femmes préménopausées et postménopausées, la concentration sérique en 25-OHD, en phosphore et en calcium était stable dans la fourchette d'âge. (who.int)
These ad- calcium homeostasis and bone metabolism. (who.int)
are responsible for impairment in dietary use of drugs which may affect bone and calcium absorption. (who.int)
Clinical laboratory evaluation of rickets begins with assessment of serum calcium, phosphate, and alkaline phosphatase levels. (medscape.com)
Bone mineral density (lumbar spine and femur) was measured by DXA Lunar Prodigy Vision, and blood levels of vitamin B12, calcium, phosphorus, bone alkaline phosphatase (BAF), and parathyroid hormone were determined. (who.int)

In experiential studies, isoenzymes, which are distinct forms of alkaline phosphatase generated by these tumors, can raise the total volume of alkaline phosphatase in the blood. (wikipedia.org)
Although alkaline phosphatases are present in different body tissues and have different physiochemical properties, they are true isoenzymes because they catalyze the same reaction. (statpearls.com)

citation needed] If the cause for alkaline phosphatase elevation is unknown, isoenzyme studies using electrophoresis can confirm the source of the ALP. (wikipedia.org)
In six patients, however, resistance to these peptides was suggested by a subsequent elevation of alkaline phosphatase activity in spite of continued and augmented hormone administration. (jci.org)
It is, therefore, not a highly specific indicator of liver injury as its elevation can occur as a result of other injured tissues. (medicinenet.com)
A strong relationship exists between the extent of disease activity measured by scintigraphy and the degree of the elevation of alkaline phosphatase in persons with untreated Paget disease. (medscape.com)

In people with Paget disease, there is an abnormal breakdown of bone tissue in specific areas. (medlineplus.gov)
Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. (hindawi.com)
Over time, they form a fibrocartilaginous repair tissue in the defect and close the connection with the subchondral bone. (hindawi.com)
A focus is on the steps of mobilization of cells from the subchondral bone and repair tissue formation, including adherence of the bone marrow clot to the subchondral bone. (hindawi.com)
Hypophosphatasia (HPP) is an inborn error of metabolism caused by loss-of-function mutations in the biomineralization-associated alkaline phosphatase gene, encoding tissue-nonspecific alkaline phosphatase (TNSALP). (karger.com)
AST is widespread in tissues and therefore elevations may represent non-specific tissue damage. (drkaslow.com)
More recently, osteoblast cultures have been important in our understanding of drug mechanisms, tissue engineering and the osseointegration of bone with implants [ 2 ]. (biomedcentral.com)
Alkaline phosphatases are classified as tissue-specific and tissue-nonspecific types. (statpearls.com)
Alkaline phosphatases found in the intestine, placenta, and germinal tissue are tissue-specific. (statpearls.com)
The tissue-nonspecific alkaline phosphatases form most of the fraction circulating in serum and, therefore, are of clinical interest. (statpearls.com)
MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
The homeostasis of bone tissue is influenced by systemic factors of nutritional, pharmacological, endocrine and pathological origin. (bvsalud.org)
Thus, tissue loading in vivo resulted in increased TNFa, which increased PLF, which then induced anabolic bone formation, the latter results confirmed in vitro. (cdc.gov)

Certain bones, such as weight-bearing bones, are involved and the risk of fracture is higher. (medlineplus.gov)
Such markers can also be useful in selected cases to improve the assessment of individual fracture risk when bone mineral density (BMD) measurement by itself does not provide a clear answer. (medscape.com)
When it falls out of balance, bone quality is compromised, increasing fracture risk. (saveourbones.com)
The rate and balance of bone turnover impact the quality and strength of bones, implicating fracture risk. (saveourbones.com)
In fact, bone turnover has been shown to predict fracture risk independently of bone mineral density. (saveourbones.com)
This suggests that bone turnover may be a better tool for gauging bone health and fracture risk than bone mineral density alone. (saveourbones.com)
Bone turnover levels predict fracture risk independently of bone mineral density, making it an important tool for assessing bone health. (saveourbones.com)
The diagnosis of bone metastasis was made because of the existence of bone pain, or pathological fracture, or bone swelling and a bone-condensing or mixed or osteolytic radiological image. (scirp.org)
Decreases in bone mineral density (BMD): Consider assessment of BMD in patients with a history of pathologic fracture or other risk factors for osteoporosis or bone loss. (nih.gov)
Our understanding of the biology of osteoblasts is important as they underpin bone remodelling, fracture healing and processes such as osseointegration. (biomedcentral.com)
A comparative study of bone mineral density (BMD) and bone fracture was conducted in a fluorotic and a nonfluorotic area of the Nalgonda District, Andhra Pradesh, India. (fluoridealert.org)
Osteoporosis related bone fracture could seriously lower the quality of the elderly's life. (ijpsonline.com)
In early stage, patients with osteoporosis have few symptoms, but as the disease progresses, patients start to have symptoms such as back pain, loss of weight over time and bone fracture. (ijpsonline.com)
This drug can preserve and increase bone mass, reducing the risk of bone fracture, with low rates of adverse reaction upon administration 3-4 . (bvsalud.org)
He was found to have an elevated serum alkaline phosphatase, a pseudo-fracture of the right scapula, multiple rib fractures, bilateral coxa vara, and femoral neck fractures. (medscape.com)

For NHANES 2001, the HybritechTandem-MP Ostase ImmunoEnzymetric assay was used for quantitative measurement of Bone Alkaline Phosphatase (BAP), an indicator of osteoblastic activity, in human serum. (cdc.gov)
As an indicator of osteoblastic activity, BAP provides information on bone formation. (nexelis.com)

Serum osteocalcin is considered a specific marker of osteoblast function, as its levels correlate with the bone formation rate. (medscape.com)
Outcomes included bone density mean difference and serum concentrations of biomarkers (Procollagen type 1 N-terminal Propeptides, Osteocalcin, Bone specific alkaline phosphatase, and C-terminal Telopeptide of type 1 collagen). (galileo-training.com)
To assess bone formation, bone-specific alkaline phosphatase or osteocalcin is used. (medscape.com)
We then examined the effect of training or task performance with or without treatment with a rat specific TNFa antibody on inflammatory cytokines, osteocalcin (a bone formation marker), PLF, CTGF, and behavioral indicators of pain or discomfort. (cdc.gov)
TNFa in forelimb bone and muscles) and serum osteocalcin in 6-week HRHF animals. (cdc.gov)

citation needed] Breast carcinoma Colon cancer Leukemia - cancer of the bone marrow Lymphoma - cancer of the white blood cells Pancreatic cancer Lung cancer An alkaline phosphatase isoenzyme test can be done to check for elevated ALP levels. (wikipedia.org)
Intestinal alkaline phosphatase is coded by a separate gene, which is different from the gene that codes for placental alkaline phosphatase and the Regan isoenzyme (produced in excess amounts in Hodgkin lymphoma). (statpearls.com)

The combined use of BMD measurement and bone markers is likely to improve the assessment of the risk of fractures in those cases. (medscape.com)
Ironically, those drugs are prescribed to prevent fractures, but by unbalancing bone turnover, they can cause fractures . (saveourbones.com)
As the idea of brittle bones causing major fractures is fearsome when people think of growing elderly, women should be greatly concerned-80% of those affected by osteoporosis are women. (nutraceuticalsworld.com)
Bone biopsies conducted on patients who, over a long period, have been given bisphosphonates for treatment of osteoporosis and who had suffered fractures, detected the presence of giant osteoclasts suggesting that prolonged use could cause osteoclastic mutations and bone fractures 8 . (bvsalud.org)
FIO manifests clinically with generalized bone pain and multiple fractures of both the axial and appendicular skeletons. (medscape.com)
Patient 1 was a 48-year-old Indian man who presented with a 10-year history of generalized bone pain, multiple fractures, and muscle weakness and was bed-bound at the time of presentation. (medscape.com)
It has been described an association between low serum vitamin B12, osteoporosis and increased risk of bone fractures, but the studies are heterogeneous and the results are controversial. (who.int)

Serum total acid phosphatase is an osteoclastic enzyme that may be elevated in active Paget disease. (medscape.com)
In males, however, the clinical value of this finding is compromised, as acid phosphatase levels also may be elevated in the presence of metastatic prostate carcinoma. (medscape.com)

Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. (hindawi.com)
A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. (hindawi.com)
The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair. (hindawi.com)
They were first isolated from the bone marrow, and the potency of MSCs is currently being employed in the techniques of marrow stimulation for symptomatic small chondral defects. (hindawi.com)
If bone marrow fills a cartilage defect either as a result of marrow stimulation for chondral defects or the course of the spontaneous repair of osteochondral defects, a bone marrow clot forms within the cartilage defect. (hindawi.com)
In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
Moreover, the bone marrow clot provides a three-dimensional (3D) environment which supports the chondrogenesis of MSCs. (hindawi.com)
Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)
However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)

Elevated levels of the alkaline phosphatase enzyme are reported among those who have obesity. (wikipedia.org)
Alkaline phosphatase (or ALP) is another enzyme commonly measured when liver dysfunction is suspected. (aacc.org)
In healthy individuals, the circulating enzyme is primarily derived from the liver and bone. (statpearls.com)
Alkaline Phosphatase (ALP), an enzyme anchored in the membrane of osteoblast, plays an important role in the mineralization of bone and the expression of ALP is maximized during the osteoblast differentiation[ 4 ]. (ijpsonline.com)

Evaluation of bone mineral status can utilize measures of total bone mineral content and bone mineral density. (cdc.gov)
The Medical Establishment relies on bone mineral density (BMD) to assess bone health, diagnose osteoporosis and osteopenia, and prescribe drugs. (saveourbones.com)
Bone mineral density (BMD) of lumbar spine, forearm, hip and whole body was assessed at baseline and at the end of the study using dual-energy X-ray absorptiometry. (nih.gov)
OBJECTIVE: To investigate the association between plasma levels of vitamin B12 and bone mineral density in a group of asymptomatic women after menopause. (who.int)

Structures that are dense (such as bone) will appear white, air will be black, and other structures will be shades of gray depending on density. (mountsinai.org)
But there's more to bone health than just density. (saveourbones.com)
OBJECTIVE: To determine whole body vibration influence on human bone density and bone biomarkers. (galileo-training.com)
Random effects model (Hedges" g effect-size metric and 95% confidence-intervals) compared whole body vibration effect on bone density and bone biomarkers. (galileo-training.com)

Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. (researchgate.net)

Diagnosis of osteoporosis is not based on evaluation of bone markers, and BMD assessment is still the criterion standard for evaluation and diagnosis. (medscape.com)
However, mean values for markers of bone turnover are higher in patients with osteoporosis than in the matched controls. (medscape.com)
[ 6 ] Therefore, measurement of bone markers is not recommended to make a diagnosis of osteoporosis. (medscape.com)
These compounds all play a role in bone resorption, and you may recognize them from osteoporosis drugs. (saveourbones.com)
Work on human osteoblasts isolated from cortical, subchondral and trabecular bone types have shown significant variation in biological activity in vitro, and this effect was conserved across patients with osteoarthritis or osteoporosis [ 10 ]. (biomedcentral.com)
Low bone mass and osteoporosis are now regarded as serious health threats, according to the International Osteoporosis Foundation , which estimated that by 2020, adults aged 50 and older at risk of osteoporosis could reach as high as 61 million. (nutraceuticalsworld.com)
Osteoporosis is one of the most common bone diseases in the elderly. (ijpsonline.com)
As a quantitative measure of bone turnover, BAP provides useful information on bone remodeling in osteoporosis and Paget's disease. (nexelis.com)
rhGH is known to have an osteoanabolic effect and has been used with some success to treat osteoporosis and a specific type of osteomalacia. (medscape.com)

They are rather non-specific and any abnormalities must be carefully assessed. (drkaslow.com)
In addition, he commented, "whether rhGH can be used long-term is unclear, as we know that long-term exposure to high levels of growth hormone in adults may lead to adverse outcomes," such as an increased risk of diabetes, increased bone growth leading to joint abnormalities and increased pressure on nerves, which can result in carpal tunnel syndrome. (medscape.com)

Basically, the Regan isozenzyme is an alkaline phosphatase that is located in the placenta and associated with gonadal and urologic cancers. (wikipedia.org)
[1] Alkaline phosphatase is present in decreasing concentrations in the placenta, ileal mucosa, kidney, bone, and liver. (statpearls.com)

A vast amount of in vitro work has followed since and osteoblastic cell lines have been used as models for understanding numerous characteristics such as differentiation, cytokine and hormone regulation, bone matrix synthesis and the molecular mechanism of bone disease. (biomedcentral.com)
Because of increased osteoblastic activity and bone formation, bone-specific alkaline phosphatase (BSAP) levels are elevated. (medscape.com)

Calcitonin: This hormone is involved in bone metabolism. (medlineplus.gov)
Studies have shown that elevated levels may predict mortality independent of bone metabolism factors and liver function tests in CKD. (wikipedia.org)
Biochemical monitoring of bone metabolism depends upon measurement of enzymes and proteins released during bone formation and of degradation products produced during bone resorption. (medscape.com)
Alkaline phosphatase has been clinically available for several years as a marker for bone metabolism. (medscape.com)
We recruited 236 women, 1-10 years postmenopausal, not on hormone replacement therapy or any other prescribed medication known to influence bone metabolism. (nih.gov)

Trabecular isolate osteoblasts have the least variation of the bone types studied, and therefore should be considered a preferred source for primary osteoblast cultures. (biomedcentral.com)

Serum bone alkaline phosphatase is a marker of bone formation and urinary N-telopeptides are markers of bone resorption. (cdc.gov)
Collagen degradation products are a class of bone resorption marker generated when the collagen in bones is broken down during the resorption process. (saveourbones.com)
Procollagen I N -terminal peptide (PINP) has emerged as a sensitive serum marker for bone formation. (medscape.com)
Thus, the analysis of ALP activity is frequently used as a specific marker of differentiation of osteoblasts in vitro . (ijpsonline.com)

The alpha-emitter radium-223 ((223)Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
A Multidisciplinary Bone Metastases Clinic at Toronto Sunnybrook Regional Cancer Centre. (scirp.org)
Bone Metastases of Prostate Cancer: Contribution of Specific Determination of Bone Alkaline Phosphatase," Immuno-Analyse & Biologie Specialisee, Vol. 10, 1995, pp. 27-33. (scirp.org)

Bone biopsies showed "dramatic improvement" in mineralization. (medscape.com)

Cancers that are already present in certain organs and tissues can produce alkaline phosphatase elevations if metastasis is not present. (wikipedia.org)
3687 patients were hospitalized for active cancer, among them 81 had documented bone metastasis. (scirp.org)
75% of patients were more or equal to 50 years old at the discovery of the bone metastasis. (scirp.org)
Cancer of the prostate and breast are the main neoplasia responsible for bone metastasis in our series. (scirp.org)
Bone Metastasis Revealing Primary Tumor. (scirp.org)

The field of bone turnover markers has developed considerably in the past decade. (medscape.com)
For example, there are tests that can measure the bone remodeling process by assessing bone turnover markers (BTM). (saveourbones.com)
Today you'll learn about bone turnover markers, what they indicate, and which BTM tests provide the most accurate and useful results for assessing the health of your bones. (saveourbones.com)
By testing for these bone turnover markers, we can get a snapshot of bone turnover activity. (saveourbones.com)
We can measure bone turnover by testing for levels of bone turnover markers, which occur as byproducts of bone resorption and formation. (saveourbones.com)

Moreover, the BMA clot provides a three-dimensional environment, possibly further supporting chondrogenesis and protecting the subchondral bone from structural alterations. (hindawi.com)
Finally, it is possible that it protects the subchondral bone plate and the subarticular spongiosa from structural alterations of its microarchitecture. (hindawi.com)
The freehand technique attempts to secure strong fixation by aiming to preserve the subchondral bone. (imperial.ac.uk)

15 patients with Paget's bone disease were treated with varying schedules of porcine (3.8-157.5 MRCU/kg per wk) and/or salmon (1.5-210 MRCU/kg per wk) calcitonins over periods ranging from 4 to 24 months. (jci.org)
ACTONEL is indicated for treatment of Paget's disease of bone in men and women. (guidelinecentral.com)

Paget disease is a disorder that involves abnormal bone destruction and regrowth. (medlineplus.gov)
Elevated serum levels of alkaline phosphatase has been associated with chronic kidney disease (CKD). (wikipedia.org)
Chronic kidney disease Elevated alkaline phosphatase in patients with cancer normally spans[clarification needed] throughout the bones or liver. (wikipedia.org)
Normal levels of ALP range from (44 to 147) U/L (units per liter) and significantly elevated levels may be an indication of conditions such as various types of cancer, bone diseases such as Paget disease, liver diseases such as hepatitis, blood disorders, or other conditions. (wikipedia.org)
Elevated alkaline phosphatase is most commonly caused by liver disease or bone disorders. (wikipedia.org)
Hypercalcemia: Excessive administration of Paricalcitol Capsules can cause over suppression of PTH, hypercalcemia, hypercalciuria, hyperphosphatemia, and adynamic bone disease. (nih.gov)
Measurement of serum alkaline phosphatase-in some cases, bone-specific alkaline phosphatase (BSAP)-can be useful in the diagnosis of Paget disease. (medscape.com)
Hyperuricemia from Paget disease is more common in men than women and appears to be caused by the increased turnover of nucleic acids from high bone turnover. (medscape.com)
Plain radiographs are less sensitive than bone scan scintigraphy in the diagnosis of Paget disease. (medscape.com)
Computed tomography (CT) scanning and magnetic resonance imaging (MRI) are not needed for the diagnosis of Paget disease of bone. (medscape.com)
However, BSAP is more specific than total alkaline phosphatase for Paget disease. (medscape.com)
In patients with monostotic disease or local disease, the total alkaline phosphatase level may be normal. (medscape.com)
In patients with abnormal liver function or other causes of elevated alkaline phosphatase activity not due to bone, BSAP is a reasonable means of assessing Paget disease activity. (medscape.com)
BSAP had the highest diagnostic sensitivity (84%) in a comparative study of different markers of bone turnover in patients with Paget disease. (medscape.com)
Urinary hydroxyproline levels are elevated in Paget disease, as a reflection of increased osteoclastic activity and bone resorption. (medscape.com)
Quantification of change in the total bone volume by whole body CT scanning could be a reliable evaluation tool for disease progression in forthcoming clinical trials of FOP. (biomedcentral.com)
A promising alternative for orphan diseases is the drug repositioning strategy, in which a drug currently used for patients with a specific disease is applied to another disease [ 9 ]. (biomedcentral.com)
NEW YORK (Reuters Health) - Recombinant human growth hormone (rhGH) is a potential novel therapy for fibrogenesis imperfecta ossium (FIO), a very rare but disabling and ultimately fatal bone disease, a small study from India suggests. (medscape.com)
He appeared to have a family history of FIO, his mother and maternal uncle having died of a "disabling bone disease. (medscape.com)
[ 4 ] Females generally had markedly less bone disease than males, suggesting the random inactivation of the affected X chromosome in females, as might be expected from the Lyon hypothesis. (medscape.com)
[ 5 , 6 ] However, lowered serum phosphate levels correlated with an equal degree of renal tubular reduction of tubular time of maximal concentration (T max ) of phosphate in both sexes, pointing to an additional factor in the creation of the bone disease in affected males. (medscape.com)

Tissues that contain high levels of ALP include the liver, bile ducts, and bones. (wikipedia.org)
Even though alkaline phosphatases are present in many tissues throughout the body, their precise physiological function remains largely unknown. (statpearls.com)
We have previously developed a voluntary rat model of highly repetitive reaching that provides an opportunity to study effects of non-weight bearing muscular loads on bone and mechanisms of naturally occurring inflammation on upper limb tissues in vivo. (cdc.gov)

There are four categories of bone resorption markers. (saveourbones.com)

The majority of alkaline phosphatase in serum (more than 80%) is released from the liver and bone, and in small amounts from the intestine. (statpearls.com)

A study reported there were higher serum levels of alkaline phosphatase in obese than in the non-obese. (wikipedia.org)
Serum levels of alkaline phosphatase (ALP) and bone specific ALP (BAP) were significantly and synchronously increased with the occurrence of flare-ups. (biomedcentral.com)

Markers of bone resorption include collagen degradation products, non-collagenous proteins, osteoclastic enzymes, and osteocyte activity markers. (saveourbones.com)
The biomarker N-terminal telopeptide (NTX) detected in urine, is reported in nmol of bone collagen equivalents/mmol creatinine. (medscape.com)
More than 90% of the protein in bone is composed of type 1 collagen. (medscape.com)
Degradation products that are derived from the enzymatic hydrolysis of type 1 collagen are therefore the most useful markers of bone resorption. (medscape.com)
The pyridinium compounds PYD and DPD, as well as hydroxypyridinium cross-link collagen, are among the more specific markers. (medscape.com)
Several groups have developed tests based on specific antibodies that are raised against isolated collagen peptides that contain cross-links, as opposed to using the cross-links themselves. (medscape.com)
The underlying abnormality in FIO appears to be an acquired defect in bone collagen fibrillary arrangement. (medscape.com)

Various biochemical markers are now available that allow a specific and sensitive assessment of the rate of bone formation and bone resorption of the skeleton. (medscape.com)
Prediction of bone loss with biochemical bone markers. (medscape.com)
Adapted from Ross PD, Knowlton W. Rapid bone loss is associated with increased levels of biochemical markers. (medscape.com)
Routine biochemical measures are normal, except for an elevated serum alkaline phosphatase. (medscape.com)

Blood samples were collected at baseline, 3, 6 and 12 months to assess bone biomarkers. (nih.gov)

Elevated alkaline phosphatase occurs when levels of alkaline phosphatase (ALP) exceed the reference range. (wikipedia.org)
clarification needed] It is essential to use age-specific normal reference values, as healthy infants and children usually have levels that would be considered elevated in adults. (wikipedia.org)
With elevated alkaline phosphatase levels, there is an increase in disproportionate intracellular fat depots and thereby releasing itself into the bloodstream. (wikipedia.org)
it was found that elevated levels are associated with elevated serum C-reactive protein (CRP), which could reflect an inflammatory and atherogenic milieu, possibly an alternative cause for elevated serum alkaline phosphatase. (wikipedia.org)
Their presence and levels in blood or urine indicate how much bone resorption is occurring. (saveourbones.com)
These rebounds in alkaline phosphatase levels correlated with the appearance of calcitonin-binding substances and neutralizing material in serum. (jci.org)
Serum alkaline phosphatase levels will vary with age in normal individuals. (statpearls.com)
Levels are high during childhood and puberty due to bone growth and development. (statpearls.com)
[8] In individuals with blood groups O and B, serum alkaline phosphatase levels increase after consuming a fatty meal, due to contribution from the intestinal tract. (statpearls.com)
Measuring total alkaline phosphatase levels may be useful in patients with normal liver function. (medscape.com)
Approximately 20-30% of total hydroxyproline levels are from bone resorption. (medscape.com)
Elevated levels of NTX indicate increased bone turnover. (medscape.com)
PLF levels in forelimb bones and flexor digitorum muscles increased significantly in 6-week HRHF animals, increases attenuated by anti-TNFa treatment. (cdc.gov)

Isolation of osteoblasts from adult human bone was first undertaken in the 1970s [ 1 ]. (biomedcentral.com)

The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)

Then, cells called osteoblasts replace the dissolved bone with new material. (saveourbones.com)
Osteoclasts and osteoblasts work in turn to remove old, damaged bone and then replace it, resulting in strong bones that are in a continuous process of renewal. (saveourbones.com)
When osteoclasts outpace osteoblasts, it causes a loss of bone mass and with it a loss of the structural quality of bone. (saveourbones.com)
The opposite problem can also occur, in which osteoblasts outpace osteoclasts- resulting in new bone deposited over old and damaged bone. (saveourbones.com)
The material that osteoblasts deposit into the pits left by osteoclasts takes time to reach full strength and integration into the existing bone. (saveourbones.com)
Then osteoblasts add new bone material. (saveourbones.com)
There is therefore, a need to consider whether the bone type that osteoblasts are isolated from could influence their in vitro characteristics. (biomedcentral.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
This includes a degradation process, bone resorption, mediated by the action of osteoclasts and a building process, bone formation, mediated by osteoblasts. (nexelis.com)

The objective of the present study was to examine the extent to which dried plum reverses bone loss in osteopenic postmenopausal women. (nih.gov)
The findings of the present study confirmed the ability of dried plum in improving BMD in postmenopausal women in part due to suppressing the rate of bone turnover. (nih.gov)
Tamoxifen has partial ER-agonistic activity in bone and is protective in postmenopausal women but leads to accelerated bone loss in premenopausal women. (racgp.org.au)
Recommendations for assessing antiresorptive therapy efficacy in postmenopausal women using bone markers are summarized below. (medscape.com)

The most useful laboratory tests to screen for liver disorders are serum aminotransferases (the most commonly used liver tests), bilirubin, and alkaline phosphatase. (msdmanuals.com)

Bone biopsies may be indicated to evaluate for malignant transformation. (medscape.com)

The development of immunoassay-based markers with monoclonal antibodies directed to the bone-specific isoform of alkaline phosphatase has improved specificity and sensitivity. (medscape.com)

Noncollagenous proteins include bone sialoprotein. (saveourbones.com)

Therefore the SGPT/ALT is a much more specific indicator of liver dysfunction. (drkaslow.com)

Plain radiographs and bone scanning should be performed upon initial diagnosis. (medscape.com)

In adults with normal liver function, approximately 50% of the total alkaline phosphatase activity arises from the liver and 50% from the bone. (medscape.com)

The ethanol extract of Paeonia lactiflora Pall (Paeoniceae) significantly increased the differentiation of MC3T3-E1 preosteoblastic cells determined by alkaline phosphatase assay. (ijpsonline.com)

The efficacy of Pex for preventing heterotopic ossifications was evaluated by the presence of flare-ups, measurements of serum bone markers, and changes in the total bone volume calculated by the three-dimensional computed tomography (3D-CT) images. (biomedcentral.com)
Volumetric 3D-CT analysis demonstrated a significant increase in the total bone volume of Case 2 (378 cm 3 ) and Case 3 (833 cm 3 ) during the two-year study period. (biomedcentral.com)

Osteoclastic enzymes are secreted by osteoclasts to break down bone matrix proteins. (saveourbones.com)

However, the overall rate of bone turnover is also a factor that impacts the strength and quality of bone. (saveourbones.com)

Bone is constantly undergoing a metabolic process called remodeling. (nexelis.com)

This glycoprotein stimulates osteoclast-mediated bone resorption and can be measured in blood serum. (saveourbones.com)

[4] A single gene encodes it and is expressed in the liver, bone, and kidneys. (statpearls.com)

CONCLUSIONS: The freehand method resulted in significantly improved cortical bone seating compared to the prescribed adjusted angles. (imperial.ac.uk)

Anatomy4

Diseases3

Chemicals and Drugs8

Phenomena and Processes4

Tartrate-resistant a3

TNAP5

Skeletal7

Calcium12

Isoenzymes2

Elevation4

Tissue13

Fracture15

Indicator of osteoblastic activity2

Osteocalcin5

Isoenzyme2

Fractures7

Acid Phosphatase2

Marrow10

Enzyme4

Mineral4

Density4

Prostate-specifi1

Osteoporosis9

Abnormalities2

Placenta2

Osteoblastic2

Metabolism5

Osteoblast1

Marker4

Metastases4

Mineralization1

Metastasis5

Turnover markers5

Subchondral bone3

Paget's2

Disease21

Tissues3

Resorption markers1

Intestine1

Serum levels2

Collagen7

Biochemical4

Biomarkers1

Levels13

Human bone1

Outcomes1

Osteoblasts9

Postmenopausal women4

Commonly1

Malignant1

Sensitivity1

Sialoprotein1

SGPT1

Diagnosis1

Activity1

Differentiation1

Total2

Osteoclastic1

Rate of bone turnover1

Metabolic1

Glycoprotein1

Gene1

Cortical1