• Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in a transfer of calcium from bone tissue to the blood. (wikipedia.org)
  • High levels of calcium, magnesium, phosphate and products of collagen will be released into the extracellular fluid as the osteoclasts tunnel into the mineralized bone. (wikipedia.org)
  • Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. (wikipedia.org)
  • High levels of calcium in the blood, on the other hand, leads to decreased PTH release from the parathyroid gland, decreasing the number and activity of osteoclasts, resulting in less bone resorption. (wikipedia.org)
  • Calcitonin decreases osteoclast activity, and decreases the formation of new osteoclasts, resulting in decreased resorption. (wikipedia.org)
  • Osteoclasts break down old bone and deliver it into your bloodstream (resorption), and osteoblasts build your bone where it needs to be reinforced (ossification). (colgate.com)
  • If you're missing a tooth due to tooth extraction, gum disease, or injury, the jawbone in the area of loss no longer receives stimuli, osteoclasts will begin to break down the jawbone, and osteoblasts will no longer prioritise rebuilding the bone structure there. (colgate.com)
  • Estrogen inhibits bone resorption by directly +6inducing apoptosis of the bone-resorbing osteoclasts. (imsociety.org)
  • In this study, we show that human Btk-deficient osteoclasts are defective at resorption activity in vitro owing to a dysregulation of the actin cytoskeletal function. (uea.ac.uk)
  • This study provides novel evidence that Btk signaling is crucial for optimal actin cytoskeletal organization and lacunar resorption in isolated osteoclasts. (uea.ac.uk)
  • Bone resorption depends on the secretion of proton and procathepsin L from osteoclasts into the extracellular lacunae. (orlaproteins.com)
  • The proton is generated by carbonic anhydrase II in osteoclasts and activity in the lacunae by a proton pump driven by vacuolar-type H + -ATPase at the ruffled border, and the secreted proton participates in the bone resorption. (orlaproteins.com)
  • Special cells called osteoclasts, break down old bone and release important nutrients into our bloodstream. (parkwaydentistry.ca)
  • Osteoclasts are multinucleated phagocytic cells that degrade bone to initiate normal bone remodeling and control bone loss by increasing their resorptive activity. (parkwaydentistry.ca)
  • In this blog we will explore the procedure by which osteoclasts-specialized cells within our skeletal system-break down the tissue in bones and release the minerals, resulting in a transfer of calcium from bone fluid to the blood. (assaygenie.com)
  • Osteoclasts play a key role in the process of bone resorption. (assaygenie.com)
  • Osteoclasts orginate from the fusion of macrophage-like cells in the bone marrow. (assaygenie.com)
  • Here, osteoclasts secrete hydrogen ions and enzymes like cathepsin K to dissolve the bone's mineral matrix, facilitating the breakdown and resorption of bone tissue. (assaygenie.com)
  • However, when the activity of these bone-resorbing osteoclasts exceeds that of the bone-depositing osteoblasts, bone loss occurs, which could lead to conditions such as osteoporosis . (assaygenie.com)
  • The process of bone resorption, as we have learned, is driven by osteoclasts. (assaygenie.com)
  • Bone resorption occurs mainly on the bone surface, by the osteoclasts (OC) on bone metabolism in continuous absorption. (frontiersin.org)
  • It inhibits bone resorption via actions on osteoclasts or osteoclast precursors. (medscape.com)
  • RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts. (nih.gov)
  • Cell fusion -mediated formation of multinuclear osteoclasts (OCs) plays a key role in bone resorption . (bvsalud.org)
  • Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. (handlebar-online.com)
  • The binding of RANKL to RANK stimulates these precursors to fuse, forming new osteoclasts which ultimately enhances the resorption of bone. (bionity.com)
  • During this "remodeling" process, osteoclasts remove mineralized bones, whereas osteoblasts form new bones. (sciencedaily.com)
  • Using this method, they explored the interplay between bone-destroying osteoclasts and bone-forming osteoblasts. (sciencedaily.com)
  • The longer the duration of menopause, the more estradiol function decreases, which causes osteoclasts to become active in bone resorption [3]. (bvsalud.org)
  • Some diseases with symptoms of decreased bone density are osteoporosis, and rickets. (wikipedia.org)
  • Through direct and indirect pathways, prolonged ethanol exposure increases fracture risk by decreasing bone mineral density and promoting osteoporosis. (wikipedia.org)
  • Diagnosis of osteoporosis is not based on evaluation of bone markers, and BMD assessment is still the criterion standard for evaluation and diagnosis. (medscape.com)
  • However, mean values for markers of bone turnover are higher in patients with osteoporosis than in the matched controls. (medscape.com)
  • [ 6 ] Therefore, measurement of bone markers is not recommended to make a diagnosis of osteoporosis. (medscape.com)
  • According to the Ministry of Health and Family Welfare , osteoporosis refers to a disease characterised by extremely fragile and less dense bones. (colgate.com)
  • Since both osteoporosis and periodontal diseases are bone resorptive diseases, it has been hypothesised that osteoporosis could be a risk factor for the progression of periodontal disease. (colgate.com)
  • Many things can speed up bone resorption including changes in our hormones (especially in women after menopause) to certain health conditions like osteoporosis, and even aging. (parkwaydentistry.ca)
  • Osteoporosis, rheumatoid arthritis, and certain cancers can cause rapid bone resorption. (parkwaydentistry.ca)
  • Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP). (frontiersin.org)
  • Osteoporosis (OP) is a metabolic disorder, which is characterized by the decrease of bone mass, and the increase of bone brittleness ( 1 ). (frontiersin.org)
  • The imbalance of bone formation and resorption is considered the main mechanism of osteoporosis. (frontiersin.org)
  • The compositions of the invention are useful for the treatment or prophylaxis of diseases or conditions which are characterized by increased bone resorption, such as Paget's disease, tumor-induced bone disease or particularly osteoporosis. (epo.org)
  • Pharmacologic therapy for osteoporosis includes most commonly the use of antiresorptive agents to decrease bone resorption, such as bisphosphonates, denosumab, and the selective estrogen-receptor modulator (SERM) raloxifene. (medscape.com)
  • Calcitonin is used for the treatment of postmenopausal osteoporosis in women more than 5 years post menopause with low bone mass relative to healthy premenopausal females. (medscape.com)
  • Osteoporosis (OP) is a skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased susceptibility to fractures (World Health Organization, 1994). (unm.edu)
  • Oct. 26, 2023 Research finds an overlap in the mechanism of hair color determination and bone resorption, which is associated with bone related diseases like osteoporosis. (sciencedaily.com)
  • In postmenopausal women with osteoporosis, diagnosed by bone mineral density (BMD) or prevalent vertebral fracture, zoledronic acid injection reduces the incidence of fractures (hip, vertebral and non-vertebral osteoporosis-related fractures). (nih.gov)
  • Uncoupling of bone formation and resorption by combined o estrogen and progestagen therapy in postmenopausal osteoporosis. (bvsalud.org)
  • Although it does not cause death, menopause can decrease quality of life and lead to degenerative diseases especially bone loss or osteoporosis [2]. (bvsalud.org)
  • Osteoporosis is characterized by bone mineral density (BMD), thus increasing bone fragility and fracture risk. (bvsalud.org)
  • Common treatments include drugs that increase bone mineral density. (wikipedia.org)
  • Ossification decreases due to a lack of stress, while resorption increases, leading to a net decrease in bone density. (wikipedia.org)
  • The effects of alcohol on bone mineral density (BMD) are well-known and well-studied in animal and human populations. (wikipedia.org)
  • Such markers can also be useful in selected cases to improve the assessment of individual fracture risk when bone mineral density (BMD) measurement by itself does not provide a clear answer. (medscape.com)
  • Contrary to expectation, XLA patients did not exhibit increased bone density or alterations in serum markers of bone turnover, indicating that a potential compensation mechanism normalizes bone homeostasis. (uea.ac.uk)
  • In XLA patients, however, these inherent osteoclast defects are corrected by increased inflammatory cytokine levels, restoring osteoclast activity and leading to the normalization of bone density. (uea.ac.uk)
  • Bone mineral density (BMD) of femur and spine was assessed by dual-energy X-ray absorptiometry (DXA). (unife.it)
  • Smoking can reduce bone density and increase the risk of fractures, potentially due to increased bone resorption. (parkwaydentistry.ca)
  • Smoking decreases bone density and increase the risk of fractures. (parkwaydentistry.ca)
  • Especially for those at risk, regular bone density tests can help in the early detection of increased bone resorption, allowing for early intervention. (parkwaydentistry.ca)
  • Background: Pre-exposure prophylaxis (PrEP) with emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) reduces the risk of HIV seroconversion but may promote bone mineral density (BMD) decline. (mssm.edu)
  • In contrast to DC-STAMP-knockout (KO) mice , which show the osteopetrotic phenotype , OC-STAMP-KO mice show no difference in systemic bone mineral density . (bvsalud.org)
  • QCT and pQCT offer the advantage of measuring the volumetric density of bones. (unm.edu)
  • In clinical trials, both treatments increase bone density, although sodium fluoride (NaF) increases and alendronate (bisphosphonate, ALN) decreases bone turnover. (fluoridealert.org)
  • Together with the earlier SAXS data these results may explain in part the increase in bone density and the improvement of biomechanical properties observed after ALN treatment in animals and in osteoporotic patients. (fluoridealert.org)
  • Evaluation of bone mineral status can utilize measures of total bone mineral content and bone mineral density. (cdc.gov)
  • If sustained, this pattern of BTM uncoupling may lead to bone loss and lower bone mineral density. (cdc.gov)
  • Introduction: Previous bone density studies have generally shown bone resorption around both cemented and uncemented total hip arthroplasty (THA) stems. (lu.se)
  • To analyze the relationship between age, body mass index (BMI), bone mineral density (BMD), and alveolar bone resorption with menopause duration in postmenopausal women. (bvsalud.org)
  • The longer the duration of menopause showed a tendency for lower bone density and higher age, BMI, and bone resorption. (bvsalud.org)
  • We aimed to investigate the contribution of neurons expressing transient receptor potential vanilloid subtype 1 (TRPV1) to alveolar bone homeostasis in periodontitis with diabetes. (physiciansweekly.com)
  • Alveolar bone was assessed by micro-computed tomography and tartrate-resistant acid phosphatase staining. (physiciansweekly.com)
  • Local ablation of TRPV1 eliminated facial heat hyperalgesia but aggravated alveolar bone damage and osteoclastogenesis in experimental periodontitis in both diabetic and non-diabetic rats. (physiciansweekly.com)
  • Background: Mucoperiosteal flap surgeries (MFS) are carried out to provide access to the alveolar bone and root surfaces in several clinical situations. (bvsalud.org)
  • Nevertheless, they lead to a variable degree of alveolar bone resorption. (bvsalud.org)
  • Objective: To evaluate the effect of raloxifene in preventing alveolar bone resorption after MFS using an experimental model of mouse mandibles. (bvsalud.org)
  • Digital images were obtained and the alveolar bone loss was measured (mm²) using an image analysis software. (bvsalud.org)
  • Conclusion: In this study, raloxifene did not inhibit alveolar bone resorption following MFS in male mice. (bvsalud.org)
  • In dentistry, surgical access to the alveolar bone is routinely conducted as part of different treatment approaches, including restoration, periodontal treatment, rehabilitation, endodontic treatment, and in the surgical removal of teeth and/or pathological processes. (bvsalud.org)
  • During the dissection process, the periosteum is detached from the alveolar bone, leading to a resorptive phase due to the stimulation offered by osteoclastic activity and loss of bone crest 2-4 . (bvsalud.org)
  • In our mouse model, systemic administration of anti-OC-STAMP-mAb suppressed the expression of CD9 mRNA , but not DC-STAMP mRNA , in periodontal tissue , along with diminished alveolar bone loss and reduced emergence of CD9+ OCps and tartrate-resistant acid phosphatase -positive multinuclear OCs. (bvsalud.org)
  • Objective: The purpose of this research was to determine alveolar bone resorption by measuring alveolar bone height in the mandible of partially edentulous female patients through panoramic radiograph Material and Methods: The method of this study was descriptive using 34 panoramic radiographs of partially edentulous mandible in female patients aged 20-45 years in Dental Radiology Installation of Unpad Dental Hospital from 2016 to 2017. (jdmfs.org)
  • Alveolar bone height was measured using Proximal RABL (Radiographic Alveolar Bone Loss) method with the help of Ez-Pax Plus software. (jdmfs.org)
  • Results: The highest average alveolar bone height was 3.5 mm and 12.96% of them occurred in 30-35 years age group. (jdmfs.org)
  • Conclusion: Alveolar bone height in partially edentulous mandible of female patients underwent resorption of mild classification according to proximal RABL method. (jdmfs.org)
  • Categorical determinations of age, BMI, BMD, and alveolar bone resorption were based on receiver operating characteristic (ROC) curves. (bvsalud.org)
  • There are a number of factors that can speed up the process of bone resorption. (parkwaydentistry.ca)
  • Some people who experience increased bone resorption and decreased bone formation are astronauts. (wikipedia.org)
  • It involves the creation and mineralization of new bone tissue, a task performed by cells called osteoblasts. (assaygenie.com)
  • OB release bone matrix rich in collagen type I and participate in the hydroxyapatite crystal formation in collagen fiber deposition process, namely bone mineralization process, eventually forming new bone. (frontiersin.org)
  • It appears to inhibit bone resorption without as much impact on bone formation and mineralization. (medscape.com)
  • Risedronate is a potent antiresorptive agent that does not affect bone mineralization. (medscape.com)
  • Osteoblasts are generally present on the outer layer of bone, just beneath the periosteum. (wikipedia.org)
  • For your jawbone, when you chew and bite, the force you exert through your teeth into your jaws sends signals to osteoblasts to keep that bone strong. (colgate.com)
  • Intermittent injections of parathyroid hormone (iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone (PTH) primarily results in increased bone resorption. (nih.gov)
  • This complex process is often paired with bone deposition, another critical physiological process performed by osteoblasts that aids in bone formation and repair. (assaygenie.com)
  • Bone formation is involved with a large number of osteoblasts (OB) under the periosteum. (frontiersin.org)
  • rather, PTH binds to osteoblasts, the cells responsible for creating bone. (handlebar-online.com)
  • Researchers show that intercellular communication via extracellular vesicles from bone-making osteoblasts is a key factor for this switch through a microRNA-mediated mechanism. (sciencedaily.com)
  • Osteoblasts act in a group to make bone over the course of several months. (sciencedaily.com)
  • Now, researchers at Osaka University established an advanced high-resolution microscopy system to visualize extracellular vesicles secreted and captured by mature osteoblasts in vivo and identified a subset of osteoblast-derived vesicles limiting bone formation and stimulating bone-resorbing osteoclast differentiation through a microRNA (miRNA)-mediated mechanism. (sciencedaily.com)
  • In this study, we established an advanced high-resolution microscopy system to visualize extracellular vesicles secreted and captured by mature osteoblasts in vivo and identified a subset of osteoblast-derived vesicles limiting bone formation and stimulating osteoclast differentiation, thus regulating the switch from bone formation to bone resorption through a microRNA (miRNA)-mediated mechanism," says Ishii. (sciencedaily.com)
  • Dec. 20, 2022 In our bones, specialized cells called osteoblasts are responsible for building up bone substance. (sciencedaily.com)
  • Bisphosphonates have a high affinity for hydroxyapatite crystals, and by binding at sites of active bone resorption, these agents can inhibit osteoclastic resorption. (medscape.com)
  • Increased blood flow to bone from reflex vasodilation, resulting in active bone resorption, contributes to bone and joint damage. (msdmanuals.com)
  • These agents decrease bone resorption and prevent bone loss from diminishing bone mass on an ongoing basis. (medscape.com)
  • The field of bone turnover markers has developed considerably in the past decade. (medscape.com)
  • In contrast to the bone turnover markers, the levels of inflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α) were significantly elevated in XLA patients' serum compared with control individuals. (uea.ac.uk)
  • This osteoclastic bone resorption mechanism is not only responsible for everyday bone turnover but also plays a pivotal role during bone growth, repair, and adaptation to mechanical use. (assaygenie.com)
  • In a comparative study using minipigs an inverse correlation has been reported between bone turnover and elastic modulus. (fluoridealert.org)
  • The reduced bone turnover induced by ALN, documented histomorphometrically could be at the origin of this phenomenon. (fluoridealert.org)
  • Flexor digitorum muscles and tendons, forelimb bones, and serum were assayed using ELISA for indicators of inflammation, tissue stress and repair, and bone turnover. (cdc.gov)
  • Sleep restriction with circadian disruption negatively alter bone turnover markers in women. (cdc.gov)
  • Purpose: The purpose of this work is to determine whether an uncoupling of bone turnover markers (BTMs) occurs in women exposed to the combination of sleep restriction with circadian disruption (SRCD), as previously reported in men. (cdc.gov)
  • It follows that an increase in vitamin D3 intake should lead to a decrease in bone resorption - it has been shown that oral administration of vitamin D does not linearly correlate to increased serum levels of calcifediol, the precursor to calcitriol. (wikipedia.org)
  • Serum osteocalcin is considered a specific marker of osteoblast function, as its levels correlate with the bone formation rate. (medscape.com)
  • Low doses of IGF-I constituted a real replacement therapy that normalized IGF-I serum levels improving the expression of most of these proteins closely involved in bone-forming, and reducing bone resorption by mechanisms related to osteoprotegerin, RANKL and PTH receptor. (biomedcentral.com)
  • The bone health status was also evaluated by assessing serum levels of bone alkaline phophatase (BAP) and collagen type 1 cross-linked C-telopeptide (CTX-1), markers of bone formation and resorption, respectively. (unife.it)
  • Methods: In a random sample of HIV-negative participants randomized to FTC/TDF PrEP (n = 50) or placebo (n = 50), serum parathyroid hormone (PTH), bone biomarkers (C-telopeptide, procollagen 1 intact N-terminal propeptide, and sclerostin), and plasma fibroblast growth factor 23 were measured at baseline and month 24, and the percentage change was compared between groups. (mssm.edu)
  • We observed a significantly greater percent increase in serum C-telopeptide in participants randomized to FTC/TDF vs placebo (P =. 03), suggesting an increase in bone remodeling. (mssm.edu)
  • Serum bone alkaline phosphatase is a marker of bone formation and urinary N-telopeptides are markers of bone resorption. (cdc.gov)
  • For NHANES 2001, the HybritechTandem-MP Ostase ImmunoEnzymetric assay was used for quantitative measurement of Bone Alkaline Phosphatase (BAP), an indicator of osteoblastic activity, in human serum. (cdc.gov)
  • Biochemical monitoring of bone metabolism depends upon measurement of enzymes and proteins released during bone formation and of degradation products produced during bone resorption. (medscape.com)
  • Alkaline phosphatase has been clinically available for several years as a marker for bone metabolism. (medscape.com)
  • In particular, evidences suggest that oxygen reactive species (ROS) are able to influence the balance between bone resorption and formation, responsible for PO is involved in bone metabolism and PO development. (unife.it)
  • Bone is an active metabolism tissue, which constantly undergoes bone remodeling. (frontiersin.org)
  • We evaluated the impact of FTC/TDF on biomarkers of bone remodeling and bone mineral metabolism in HIV-negative men and women enrolled in the Partners PrEP Study. (mssm.edu)
  • Functional coupling between these two cell types is critical for the maintenance of proper bone metabolism, and the mechanisms controlling the transition from bone-resorbing to bone-forming phases have been investigated. (sciencedaily.com)
  • Conclusions: These pilot data are similar to previous findings in men and suggest that SRCD negatively altered bone metabolism in women by decreasing markers of bone formation and, in young women, increasing a marker of bone resorption. (cdc.gov)
  • Journal of Bone and Mineral Research , 26 (1), 182-192. (uea.ac.uk)
  • These cells synthesize new bone matrix by laying down collagen fibers and promoting the deposition of mineral crystals within these fibers. (assaygenie.com)
  • This results in a hardened, mineral-rich new bone structure that replaces the areas affected by resorption. (assaygenie.com)
  • OC destroys the mineral and collagen matrix by secreting matrix metalloproteinases (MMPs), cathepsin K (CtsK), H + and Cl − , and eventually forming bone lacunae. (frontiersin.org)
  • The 40th Annual Meeting of the American Society for Bone and Mineral Research. (nii.ac.jp)
  • Bone remodeling occurs in different parts of the body throughout life to maintain bone architecture balance and systemic mineral homeostasis. (sciencedaily.com)
  • Small-angle X-ray scattering (SAXS) measurements of these bones revealed no structural deterioration of the collagen/mineral composite at the nanometer range for ALN-treated vertebra, whereas a slight increase of the average thickness of the mineral crystals as well as changes of the structure of the collagen/mineral composite were found in the bones of NaF-treated animals. (fluoridealert.org)
  • Pamidronate inhibits both normal and abnormal bone resorption. (medscape.com)
  • Alendronate inhibits osteoclast activity and bone resorption. (medscape.com)
  • By binding to calcium salts, alendronate blocks the transformation of calcium phosphate into hydroxyapatite and inhibits the formation, aggregation, and dissolution of hydroxyapatite crystals in bone. (medscape.com)
  • It inhibits osteoclastic bone resorption and has some analgesic effects in patients with fractures. (medscape.com)
  • Bone resorption rates are much higher in post-menopausal older women due to estrogen deficiency related with menopause. (wikipedia.org)
  • Sowers and colleagues have investigated potential associations between changes in bone resorption during the menopause transition and reproductive hormones, body mass index (BMI) and ethnicity [1]. (imsociety.org)
  • During the menopause transition, a decline in ovarian function beginning about 2 years before the FMP is followed by an increase in bone resorption and subsequently by bone loss. (imsociety.org)
  • Changes in bone resorption across the menopause transition: effects of reproductive hormones, body size, and ethnicity. (imsociety.org)
  • Menopause causes decreased levels of circulating estrogens which often results in rapid bone loss. (unm.edu)
  • Various biochemical markers are now available that allow a specific and sensitive assessment of the rate of bone formation and bone resorption of the skeleton. (medscape.com)
  • CONCLUSION: OS could play an important role in PO development by increasing the rate of bone resorption. (unife.it)
  • As people age the rate of bone resorption generally increases. (parkwaydentistry.ca)
  • Interestingly, the location and rate of bone deposition are directly influenced by the demands placed on the skeleton. (assaygenie.com)
  • Open 4-year postdoc position for the project "How bisphosphonates affect bone matrix and remodeling: implications for atypical femoral fractures" within my Molecular Bone Histology (MBH) lab, Denmark. (csr-mgh.org)
  • Fluoride stimulates bone formation, whereas bisphosphonates reduce bone resorption. (fluoridealert.org)
  • Normoxic inducers of HIF (CoCl(2), desferrioxamine, and l-mimosine) and 100 ng/ml ANGPTL4 stimulated osteoclastic resorption 2- to 3-fold in assays of lacunar dentine resorption, without affecting osteoclast viability. (ox.ac.uk)
  • Decreases in estrogen levels can accelerate bone resorption. (parkwaydentistry.ca)
  • Hormone replacement therapy (eg, estrogen, estrogen analogs) does not have a role in pediatric therapy unless the low bone mass is attributable to hypogonadism. (medscape.com)
  • As the aging process occurs, resorption exceeds formation. (wikipedia.org)
  • Depending on where in the body bone resorption occurs, additional problems like tooth loss can arise. (wikipedia.org)
  • If bone resorption occurs in the implant crest module, the gingival margin is in a more apical position (5, 6). (ac.ir)
  • The bone becomes more porous and fragile, exposing people to the risk of fractures. (wikipedia.org)
  • The combined use of BMD measurement and bone markers is likely to improve the assessment of the risk of fractures in those cases. (medscape.com)
  • But when resorption happens at a higher rate than it can be replaced, it can lead to a decrease in your bone mass and put you at higher risk for fractures and breakage. (colgate.com)
  • In certain severe cases-like when there is significant bone loss leading to fractures or other structural problems-surgery may be necessary. (parkwaydentistry.ca)
  • Fractures and bony healing may produce many loose pieces of cartilage or bone that can slough into the joint, causing a coarse, grating, often audible crepitus usually more unpleasant for the observer than for the patient. (msdmanuals.com)
  • In addition, there were also significant differences of these cytokine levels between the group of chronic otitis media with bone resorption and the group without bone resorption. (ejao.org)
  • Cholesteatoma;Cytokine;Bone resorption. (ejao.org)
  • During iPTH treatment, mice lacking ProCT develop increased bone resorption with excessive osteoclast formation in both the long bones and axial skeleton. (nih.gov)
  • Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. (csr-mgh.org)
  • Nonetheless, according to the ligature -induced periodontitis model, significantly lower level of bone resorption was found in OC-STAMP-KO mice compared to WT mice . (bvsalud.org)
  • Osteoblast-specific Waif1 cKO mice showed a high bone mass with reduction of both bone formation and resorption. (nii.ac.jp)
  • Waif1 cKO mice exhibited impaired bone mass recovery after RANKL injections, phenocopying osteoclast-specific Cthrc1 cKO mice. (nii.ac.jp)
  • To understand the spatiotemporal dynamics of bone remodeling in vivo , the researchers have established an intravital imaging technique to visualize the intact bone tissues of living mice. (sciencedaily.com)
  • Recent research indicates that calcitriol leads to a reduction in osteoclast formation, and bone resorption. (wikipedia.org)
  • Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. (frontiersin.org)
  • The mutual restriction between bone formation and bone resorption is a critical factor to ensure bones healthy and integrity during the life cycle. (frontiersin.org)
  • Excessive alcohol interferes with the balance of calcium in the body and affect bone health. (parkwaydentistry.ca)
  • Using topical antibiotics did not affect bone resorption after three months of implant placement. (ac.ir)
  • How does the release of PTH affect bone resorption? (handlebar-online.com)
  • According to the Indian Dental Association , gingivitis is an entry level form of periodontal disease, which attacks the gum tissue and eventually works its way to the jaw bone and causes permanent damage including loss of teeth. (colgate.com)
  • They break down bone tissue and release the stored minerals back into the bloodstream. (assaygenie.com)
  • Bone is a dynamic tissue with high remodeling capacity in response to the body's metabolic requirements. (bvsalud.org)
  • The studies conducted on dental implants over several years have demonstrated that the long-term success of implants depends on two factors: first, the direct relationship between bone and implants, and second, the development of soft and hard tissue around the coronal area of ​​the implant (1-3). (ac.ir)
  • In the presence of proper plaque control, the attachment of soft tissue in the coronal area of ​​the implant creates a suitable biological seal that prevents the penetration of microorganisms and bone resorption in the area adjacent to the implant. (ac.ir)
  • In most cases, performance of the HRHF task induced the greatest tissue degenerative changes, while performance of moderate level tasks induced bone adaptation and a suggestion of muscle adaptation. (cdc.gov)
  • It is also involved in bone resorption, the breakdown and removal of bone tissue that is no longer needed. (medlineplus.gov)
  • Osteogenesis Imperfecta and Paget's disease are examples of factors that can cause bone resorption. (parkwaydentistry.ca)
  • Treatment of Paget's disease of bone: a single 5 mg infusion. (nih.gov)
  • Maximum likelihood estimation in a repeated-measures model was used to assess the effects of SRCD and age on bone biomarkers. (cdc.gov)
  • Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)
  • Journal Article] WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation. (nii.ac.jp)
  • In conclusion, our results reveal a potential role of osteoblast-derived ProCT in the bone microenvironment that is required to limit bone resorption during iPTH. (nih.gov)
  • Conclusion: Cytokines may play a role in the bone resorption in aural cholesteatoma. (ejao.org)
  • Conclusion: This short stem seems to preserve proximal bone stock up to 5 years, exhibiting similar behaviour both with and without a collar. (lu.se)
  • Vitamin D increases absorption of calcium and phosphate in the intestinal tract, leading to elevated levels of plasma calcium, and thus lower bone resorption. (wikipedia.org)
  • Therefore, the purpose of the clinical series presented herein was to clinically evaluate long-term horizontal and vertical bone gain, as well as implant survival rate after reconstruction of severely atrophic edentulous maxillary ridges. (nih.gov)
  • The degree of bone resorption was classified clinically using with radiologic and operation findings. (ejao.org)
  • Adapted from Ross PD, Knowlton W. Rapid bone loss is associated with increased levels of biochemical markers. (medscape.com)
  • The present work extends this model so as to describe the rapid bone resorption observed, for example, in mandibulae around artificial implants. (elsevierpure.com)
  • Background and Objectives : Cytokines are reported to play an important role in bone resorptive process in chronic otitis media with or without aural cholesteatoma. (ejao.org)
  • The osteoblast communication via extracellular vesicles controls the dynamic transition from bone-forming to bone-resorbing phases in vivo and could be a target for new treatments for bone diseases. (sciencedaily.com)
  • These are the cells responsible for the resorption of bone. (wikipedia.org)
  • Your bones have two kinds of cells that do all the work to remodel your skeleton as needed. (colgate.com)
  • These unique, bone-resorbing cells have a primary function - to maintain and remodel bone structure. (assaygenie.com)
  • These multinucleated, giant cells attach to the bone surface, forming a specialized cell-to-bone contact area known as the 'sealing zone. (assaygenie.com)
  • These results provide evidence for Waif1 on stromal/osteoblastic cells as a receptor of osteoclast-secreted Cthrc1, and suggest that Waif1 serves an important coupling function of bone resorption to formation. (nii.ac.jp)
  • However, the spatial resolution of intravital bone imaging was insufficient to visualize structures smaller than cells. (sciencedaily.com)
  • In the present work, a model of partial IGF-I deficiency was used in order to provide insight into the mechanisms of the beneficial actions of IGF-I replacement therapy in bone. (biomedcentral.com)
  • Nevertheless, the mechanisms of the beneficial actions of IGF-I replacement therapy on bone are not entirely known yet. (biomedcentral.com)
  • Nevertheless, some factors, including surgical bone exposure, may lead to some imbalance in these mechanisms. (bvsalud.org)
  • Nevertheless, the molecular and cellular mechanisms terminating osteoblastic bone formation and promoting osteoclastic bone resorption remain elusive," explains senior author Masaru Ishii. (sciencedaily.com)
  • The magnitude of the increase in bone resorption is inversely associated with BMI. (imsociety.org)
  • Tubular resorption and secretion. (muni.cz)
  • Prediction of bone loss with biochemical bone markers. (medscape.com)
  • You may not notice the early stages of bone loss in your jaw. (colgate.com)
  • What Causes Bone Loss in the Jaw? (colgate.com)
  • If you wear dentures and they've become loose, it may be a result of bone loss, and they may require refitting. (colgate.com)
  • Low bone mass in the skeleton, which increases the risk of osteoporotic fracture, also may be associated with periodontal bone loss and tooth loss. (colgate.com)
  • A research study published in the Journal of Research in Medical and Dental Science revealed that there was vertical bone loss in the interproximal area after orthodontic treatment done both with and without extraction of the teeth. (colgate.com)
  • In addition to the symptoms noted above, jawbone loss can cause you to lose teeth and make it difficult or impossible to give you replacement teeth (implants, removable bridges, or dentures) without an oral surgeon first performing a bone graft. (colgate.com)
  • Ethnic differences in BMI, and corresponding ethnic differences in bone resorption, appear to account for much of the ethnic variation in perimenopausal bone loss. (imsociety.org)
  • Pei L, Tontonoz P. Fats loss is bones gain. (imsociety.org)
  • Bone loss due to osteoclastic activity. (reference.md)
  • Excessive bone resorption is found in most dental patients with gum disease and multiple tooth loss. (parkwaydentistry.ca)
  • Raloxifene is an agonist in bone, and acts inhibiting bone loss. (bvsalud.org)
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (nih.gov)
  • Implant survival, bone gain, intraoperative/postoperative complications and peri-implant bone loss were calculated up to the last follow-up exam. (nih.gov)
  • Mean peri-implant bone loss values were consistent within the standards for implant success (1.4 ± 1.0 mm). (nih.gov)
  • At patient-level, only one patient who had three implants presented with severe peri-implant bone loss. (nih.gov)
  • The presence of peri-implant inflammation can lead to the loss of implant if extended to the bone. (ac.ir)
  • Use of calcitonin-salmon injection is recommended in conjunction with adequate calcium and vitamin D intake to prevent the progressive loss of bone mass. (medscape.com)
  • It usually involves bone loss because of cessation of ovarian production of estrogens in women. (unm.edu)
  • Skeletal manifestations include a selective cortical bone loss. (medscape.com)
  • Bone loss seen on radiography was measured by drawing a vertical line from the cementoenamel in the distal part of the 36 teeth and the mesial portion of 46 teeth to the base of the bone marked by the lamina dura intact. (bvsalud.org)
  • When bone resorption in the jawbone has become so severe, a full mouth rehabilitation is usually required in order to bring the jawbone, teeth and gums back to a healthy, functional state and restore the patient's oral health and comfort. (parkwaydentistry.ca)
  • In cases of jawbone resorption, for example, bone grafting could be considered. (parkwaydentistry.ca)
  • These results demonstrate that HIF is sufficient to enhance osteoclast-mediated bone resorption and that ANGPTL4 can compensate for HIF-1α deficiency with respect to stimulation of osteoclast activity and also augments osteoblast proliferation and differentiation. (ox.ac.uk)
  • Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. (wikipedia.org)
  • Bone resorption is a fundamental biological process, instrumental in the maintenance of skeletal integrity and calcium homeostasis within our bodies. (assaygenie.com)
  • Alcohol can interfere with the balance of calcium in the body and affect the production of hormones that protect the bones, leading to increased bone resorption. (parkwaydentistry.ca)
  • Prevention is key in bone health. (parkwaydentistry.ca)
  • The present study aimed to assess the effect of topical antibiotics on the prevention of implant crestal bone resorption using fractal analysis. (ac.ir)
  • The prevention of bacterial infiltration in the abutment-implant interface aims to minimize inflammatory reactions and maintain the bone crest (7, 8). (ac.ir)
  • Slightly more calcium than phosphate is released from the breakdown of bone, and the intestinal absorption of phosphate (mediated by an increase in activated vitamin D) is not as dependent on vitamin D as is that of calcium. (bionity.com)